Prevention of Post-OP AFib Using Combination of CardiaMend and Amiodarone (CAMP POAF)

Inclusion Criteria: Subject aged 20-85 years old. Patients able to provide written informed consent, understand, and be willing to comply with study-related procedures. Participants who are scheduled to undergo open-chest cardiac surgery via complete median sternotomy. Includes: Coronary artery bypass graft (CABG) or valve repair/replacement, or Inclusionary valve repair/replacement procedures for the primary reason for surgery include: aortic valve repair/replacement, mitral valve repair/replacement. Note: Left atrial appendage (LAA) procedures are allowed if CABG and/or valve repair or replacement is the qualifying surgical procedure, but is not a qualifying surgical procedure on its own. In sinus rhythm at the time of office visit and prior EKG (note: continuous EKG monitoring for 48 hours is not required). Exclusion Criteria: Subject unable to give voluntary written informed consent, is unlikely to cooperate or is legally incompetent, including subjects who are institutionalized by court or official order, or in a dependency relationship with, testing center or investigator. Any condition which could interfere with the subject's ability to comply with the study. Ongoing participation in an interventional clinical study or during the preceding 30 days. Female subjects who are pregnant, breastfeeding, were pregnant within the last three months, or are planning to become pregnant during the course of the study. Active skin or deep infection at the site of implantation. History of chronic wounds or wound-healing disorders. Known connective tissue diseases (e.g. Ehlers-Danlos syndrome, Epidermolysis bullosa, Marfan syndrome, Osteogenesis imperfecta). Immune-suppressed subjects, immune-deficiency subjects (properly managed diabetes mellitus is not an exclusion criterion). Concomitant oral or IV systemic corticosteroid therapy and/or other constant anti-inflammatory therapies. The subject has an implantable cardiac device (i.e., cardiac resynchronization therapy devices with and without defibrillator capabilities (CRTs and CRT-Ds), implantable cardioverter-defibrillators (ICD) and pacemakers). Known history of atrial fibrillation or paroxysmal atrial fibrillation. History of ablation for atrial fibrillation. Patients already receiving amiodarone as a treatment for atrial fibrillation or ventricular arrhythmias. Disease of the left pleura, previous intervention in the left pleural space, or chest deformity. Subjects with end-stage chronic-renal disease / dialysis. Subjects with heart failure (BNP>1000), low ejection fraction (<35%), end stage renal disease (on dialysis or creatinine >1.8). STS risk >5.5% for 30 day mortality. Patients electing to receive an ablative procedure for atrial fibrillation during the index operation.