Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients. (TOX-AKI)

This is an interventional diagnostic trial for Acute Kidney Injury focused on measuring acute kidney injury, septic shock, uremic toxins, indoxyl sulfate, mortality Read More

Inclusion Criteria:

• Patients over 18 years hospitalized in the medical intensive care unit in Amiens university hospital
• Presence of a septic shock (sepsis associated with a persistent hypotension after fluid resuscitation and requiring vasopressors to maintain MAP > 65 mmHg and/or serum lactate level > 2 mmol/ L).
• Evidence of AKI (KDIGO > or equal1) in the 72 hours following the admission in the ICU: diuresis < 0.5ml / kg / h for 6 to12 hours or > or equal 1.5 to1.9 fold increase or > 26.5 micromol / l in serum creatinine from baseline
• signed written informed consent form
• covered by national health insurance

Exclusion Criteria:

• known pre hospitalization (in the last 3 month preceding the hospitalization) advanced chronic kidney disease defined by an estimated glomerular filtration rate < 60 ml / min / 1.73m square
• Pregnancy
• Presence or strong clinical suspicion of renal obstruction
• Moribund patients (expected life < 48h)
• Cardio respiratory arrest
• Hemoglobin level below 10 g / dl