Program to Reduce Incontinence by Diet and Exercise (PRIDE)

Inclusion Criteria: aged ≥ 30 years and not institutionalized body mass index 25 to 50 kg/m2 urinary incontinence symptoms for > 3 months by self-report and record > 10 incontinent episodes per week on a 7-day urinary diary able to complete a behavioral run-in consisting of self-monitoring of food and activity report having a primary health care provider able to understand and sign informed consent and complete baseline questionnaires agree to not initiate new treatment for incontinence or weight reduction, including behavioral, pharmacological or surgical therapies, for the duration of the study Exclusion Criteria: current use, or use within the previous month of medical therapy for incontinence currently pregnant or gave birth in the previous 6 months current urinary tract infection (dipstick urinalysis positive for leukocyte esterase, nitrites or blood) or report having > 4 urinary tract infections in the preceding year incontinence of neurologic or functional origin (by history) self-report of prior anti-incontinence or urethral surgery, pelvic cancer or pelvic irradiation self-report of significant medical conditions of the genitourinary tract (genitourinary fistula, interstitial cystitis, symptomatic pelvic organ prolapse) report a medical condition that would affect the safety and/or efficacy of a weight management program involving diet and physical activity, including type 2 diabetes requiring medical therapy that may cause hypoglycemia, chronic steroid use or uncontrolled hypertension (systolic blood pressure >180 mm Hg or diastolic blood pressure > 100 mm Hg); women with a history of coronary heart disease may participate with written approval from their primary care physician currently engaged in an active weight loss program and/or experienced a 10% or greater weight reduction in the past 3 months report being unable to walk 2 blocks (1/4 mile) without stopping report conditions that, in the judgment of the Clinical Center Principal Investigator, render potential participants unlikely to follow the protocol for 18 months, including illness likely to be terminal within 2 years, plans to move, substance abuse or other significant psychiatric problems, or dementia participating in another research study that involves investigational drugs or can potentially confound the results of PRIDE