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Prolonged Sitting on Responses to Short-Term Exercise Training

Primary Purpose

Atherosclerosis, Metabolic Syndrome

Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Prolonged sitting with exercise
Active walking with exercise.
Sponsored by
University of Texas at Austin
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Atherosclerosis

Eligibility Criteria

18 Years - 35 Years (Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • 18 to 35 years

Exclusion Criteria:

  • cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
  • respiratory problems
  • musculoskeletal problems that prevent prolonged sitting or exercise
  • obesity
  • susceptibility to fainting
  • pregnancy

Sites / Locations

  • University of Texas at Austin Human Performance Laboratory

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Active Comparator

Arm Label

Sitting with Exercise

Walking with exercise

Arm Description

Subjects will complete a short term training protocol while sitting >11 hours per day. This training will be preceded by a VO2max test to aid in setting the correct intensity for training. Subjects will be asked to complete three high fat tolerance tests. One to establish a baseline, the second to determine the acute effects of training, and a third at the completion of training to determine the cumulative effect of exercise training.

Subjects will complete a short term training protocol while sitting <5 hours per day. This training will be preceded by a VO2max test to aid in setting the correct intensity for training. Subjects will be asked to complete three high fat tolerance tests. One to establish a baseline, the second to determine the acute effects of training, and a third at the completion of training to determine the cumulative effect of exercise training.

Outcomes

Primary Outcome Measures

Plasma Triglycerides
Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

Secondary Outcome Measures

Plasma Insulin
Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test
Plasma glucose
Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

Full Information

First Posted
October 9, 2017
Last Updated
September 29, 2021
Sponsor
University of Texas at Austin
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1. Study Identification

Unique Protocol Identification Number
NCT03352063
Brief Title
Prolonged Sitting on Responses to Short-Term Exercise Training
Official Title
Effect of Prolonged Sitting on Metabolic and Cardiovascular Responses to Short-Term Exercise Training
Study Type
Interventional

2. Study Status

Record Verification Date
September 2021
Overall Recruitment Status
Completed
Study Start Date
July 17, 2018 (Actual)
Primary Completion Date
April 30, 2020 (Actual)
Study Completion Date
May 30, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Texas at Austin

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
Prolonged sitting has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of prolonged sitting on response to a HFTT after a short term training period.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Atherosclerosis, Metabolic Syndrome

7. Study Design

Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Model Description
Subjects will be randomly assigned to either the sitting plus exercise or walking plus exercise.
Masking
None (Open Label)
Allocation
Randomized
Enrollment
12 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Sitting with Exercise
Arm Type
Active Comparator
Arm Description
Subjects will complete a short term training protocol while sitting >11 hours per day. This training will be preceded by a VO2max test to aid in setting the correct intensity for training. Subjects will be asked to complete three high fat tolerance tests. One to establish a baseline, the second to determine the acute effects of training, and a third at the completion of training to determine the cumulative effect of exercise training.
Arm Title
Walking with exercise
Arm Type
Active Comparator
Arm Description
Subjects will complete a short term training protocol while sitting <5 hours per day. This training will be preceded by a VO2max test to aid in setting the correct intensity for training. Subjects will be asked to complete three high fat tolerance tests. One to establish a baseline, the second to determine the acute effects of training, and a third at the completion of training to determine the cumulative effect of exercise training.
Intervention Type
Behavioral
Intervention Name(s)
Prolonged sitting with exercise
Intervention Description
Subjects will commit to sitting more than 11 hours per day and taking less than 5000 steps per day while participating in exercise training.
Intervention Type
Behavioral
Intervention Name(s)
Active walking with exercise.
Intervention Description
Subjects will commit to sitting less than 5 hours per day and taking more than 10000 steps per day while participating in exercise training.
Primary Outcome Measure Information:
Title
Plasma Triglycerides
Description
Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test
Time Frame
6 hours
Secondary Outcome Measure Information:
Title
Plasma Insulin
Description
Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test
Time Frame
6 hours
Title
Plasma glucose
Description
Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test
Time Frame
6 hours

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
35 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: 18 to 35 years Exclusion Criteria: cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.) respiratory problems musculoskeletal problems that prevent prolonged sitting or exercise obesity susceptibility to fainting pregnancy
Facility Information:
Facility Name
University of Texas at Austin Human Performance Laboratory
City
Austin
State/Province
Texas
ZIP/Postal Code
78712
Country
United States

12. IPD Sharing Statement

Plan to Share IPD
No
Citations:
PubMed Identifier
34398061
Citation
Burton HM, Wolfe AS, Vardarli E, Satiroglu R, Coyle EF. Background Inactivity Blunts Metabolic Adaptations to Intense Short-Term Training. Med Sci Sports Exerc. 2021 Sep 1;53(9):1937-1944. doi: 10.1249/MSS.0000000000002646.
Results Reference
derived

Learn more about this trial

Prolonged Sitting on Responses to Short-Term Exercise Training

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