Prolotherapy Intervention Effect in Patient With Knee Osteoarthritis
Knee Osteoarthritis
About this trial
This is an interventional treatment trial for Knee Osteoarthritis focused on measuring Knee Osteoarthritis, COMP, uCTX-II, Prolotherapy, Functional Outcome
Eligibility Criteria
Inclusion Criteria:
- The patient provides consent to be part of the research.
- The diagnosis of Knee Osteoarthritis was made based on clinical criteria/radiology American College of Rheumatology (ACR) 2012 with radiology grading according to Kellgren-Lawrence 2-3
Exclusion Criteria:
- The Patient has received other forms of intraarticular injection therapy.
- The patient has received Non Steroid Anti inflammation drug (NSAID) therapy for one week before the start of the intervention.
- The patient has one or more contraindications for prolotherapy (e.g., Abscess, cellulitis, or septic arthritis).
Drop Out Criteria :
- The patient has undergone a strenuous physical activity that precipitates a degree of complication (i.e., joint effusion).
- The use of NSAID within one week after the intervention.
- The patient does not adhere to the intervention.
- The patient developed or being diagnosed with osteoarthritis or other forms of inflammatory disease in other joints.
Sites / Locations
- Hasanuddin University, Faculty of Medicine
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Sodium Hyaluronate
Prolotherapy
Hyaluronate sodium injection is performed intra-articularly using 2 mL of Adant® Disposable. The treatment will be given five times, on day 1st, 8th, 15th, 22nd, and 29th
Prolotherapy injection is performed intra-articularly and extra-articularly by a physician. Intra-articular injection with 25% dextrose will be carried out with the following details: 5 mL of 40% dextrose, 2 mL of lidocaine, and 1 mL of aqua dest are inserted into the 10-mL syringe, then 5 mL are injected with the superolateral approach. An extra-articular injection with 15% dextrose will be carried out with the following details: in the 10-mL syringe 4 mL of 40% dextrose, 2 mL lidocaine, and 4 mL of distilled water are injected, to make a total of 30-40 mL injections. Treatment will be carried out on day 1st, 29th, and 57th.