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Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors

Primary Purpose

Hepatitis B Infection, Malignant Solid Neoplasm

Status

Active

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Best Practice

Entecavir

Tenofovir Alafenamide

Tenofovir Disoproxil Fumarate

About this trial

This is an interventional prevention trial for Hepatitis B Infection

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Patients must be diagnosed with stage I-III solid tumor malignancy; patients with only carcinoma in situ or with stage IV disease are excluded
Patients must not have been diagnosed with a malignancy other than the current malignancy within the past five years, with the exception of basal cell or squamous cell skin cancer, or non-invasive (in situ) malignancies of the cervix, breast, or skin
Patients must not have lymphoma, leukemia, or myeloma
Patients must not have primary liver cancer, known cirrhosis, or evidence of any malignancy that involves the liver
Patients must be planning to receive systemic anti-cancer therapy (either single agent or some combination of systemic cytotoxic therapy, systemic immunotherapy or systemic targeted therapy) for this solid tumor
Patients must not have been previously treated with the same anti-cancer therapy regimen that is now anticipated; the anti-cancer therapy does not have to be first-line therapy; prior and/or concurrent radiotherapy is allowed
Patients must be registered =< 28 days prior to the planned start date of anti-cancer therapy; if the patient has started systemic anti-cancer therapy, patient must be registered =< 42 days after the initiation of first cycle of anti-cancer therapy
Patients who have received prior anti-cancer therapy must have discontinued all previous therapies (excluding planned anti-cancer therapy to occur in conjunction with this study) >= 1 day prior to registration to this study
Patients must not have had any cancer therapy regimen that includes anti-CD20
Patients must not be receiving antiviral medications active against HBV, including: adefovir, entecavir, lamivudine, telbivudine, tenofovir disoproxil fumarate, tenofovir alafenamide (TAF), or any other Food and Drug Administration (FDA) approved agents for the treatment of hepatitis B; patients who have previously received antiviral medication must not have required any antiviral medication active against HBV >= 90 days prior to registration to this study
Patients must not have had hematopoietic stem cell transplantation therapy
Patients receiving any of the following medications must discontinue them (under the supervision of their treating physician) prior to registration, and must not be planning to take them during protocol therapy: acyclovir, aminoglycosides, oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, valacyclovir, high-dose nonsteroidal anti-inflammatory drugs (NSAIDs), ("high-dose" based on package insert), and St. John's wort
Patients must have results for the following HBV tests done within 28 days prior to registration: HBsAg AND anti-HBc (total immunoglobulin [Ig] or IgG, but not IgM only) AND hepatitis B surface antibody (anti-HBs); for the anti-HBs test, quantitative or qualitative (including "indeterminate") results are allowable
Patients must have tested positive for HBsAg or anti-HBc (total Ig, IgG, but not IgM) and must have baseline HBV deoxyribonucleic acid (DNA) completed =< 42 days prior to registration
Complete blood count (CBC) must be completed =< 28 days prior to registration; results do not need to be in the institutional limits of normal
International normalized ratio (INR) must be completed =< 28 days prior to registration; results must < 1.2 x institutional limits of normal
Alanine aminotransferase (ALT) must be obtained =< 28 days prior to registration; ALT must be =< 1.5 x institutional ULN
Total bilirubin must be obtained =< 28 days prior to registration; total bilirubin must be =< 1.5 x institutional ULN
Creatinine results must be obtained =< 28 days prior to registration; creatinine must be =< 1.5 x institutional ULN
Patients must not have known current active hepatitis C infection (HCV); active HCV is defined by a detectable HCV ribonucleic acid (RNA) level; Note: HCV testing is not required for eligibility
Patients must not have a history of human immunodeficiency (HIV) infection; patients with unknown HIV status must have HIV testing completed =< 365 days prior to registration
Patients must have Zubrod performance status of 0-2
Patients must not be pregnant or nursing, as the safety of the study drug in pregnant and nursing women has not been established; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures
Patients must have specimens collected for submission as outlined
Patients must be offered the opportunity to participate in optional translational medicine studies as outlined
Patients with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator)
Patients may have concurrent participation in other clinical trials that entail cytotoxic, immunotherapy, targeted therapy; surgical treatment; radiotherapy treatment; or any combination thereof
Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines
As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Sites / Locations

Mercy Hospital Fort Smith
Kaiser Permanente-Anaheim
Kaiser Permanente-Deer Valley Medical Center
Kaiser Permanente-Baldwin Park
Kaiser Permanente-Bellflower
Epic Care-Dublin
Kaiser Permanente Dublin
Bay Area Breast Surgeons Inc
Epic Care Partners in Cancer Care
Kaiser Permanente-Fontana
Kaiser Permanente-Fremont
Fresno Cancer Center
Kaiser Permanente-Fresno
Kaiser Permanente - Harbor City
Kaiser Permanente-Irvine
Tibor Rubin VA Medical Center
Kaiser Permanente Los Angeles Medical Center
Los Angeles County-USC Medical Center
USC / Norris Comprehensive Cancer Center
Kaiser Permanente West Los Angeles
Contra Costa Regional Medical Center
Kaiser Permanente-Modesto
USC Norris Oncology/Hematology-Newport Beach
Alta Bates Summit Medical Center - Summit Campus
Bay Area Tumor Institute
Kaiser Permanente Oakland-Broadway
Kaiser Permanente-Oakland
Kaiser Permanente-Ontario
Kaiser Permanente - Panorama City
Keck Medical Center of USC Pasadena
Kaiser Permanente-Rancho Cordova Cancer Center
Kaiser Permanente-Redwood City
Kaiser Permanente-Richmond
Kaiser Permanente-Riverside
Rohnert Park Cancer Center
Kaiser Permanente-Roseville
The Permanente Medical Group-Roseville Radiation Oncology
Kaiser Permanente Downtown Commons
Kaiser Permanente-South Sacramento
South Sacramento Cancer Center
Kaiser Permanente - Sacramento
Kaiser Permanente-San Diego Zion
Kaiser Permanente-San Francisco
Kaiser Permanente-Santa Teresa-San Jose
Kaiser Permanente San Leandro
Kaiser Permanente-San Marcos
Kaiser Permanente-San Rafael
Kaiser San Rafael-Gallinas
Kaiser Permanente Medical Center - Santa Clara
Kaiser Permanente-Santa Rosa
Kaiser Permanente Cancer Treatment Center
Kaiser Permanente-South San Francisco
Kaiser Permanente-Stockton
Kaiser Permanente Medical Center-Vacaville
Kaiser Permanente-Vallejo
Kaiser Permanente-Walnut Creek
Epic Care Cyberknife Center
Kaiser Permanente-Woodland Hills
Broward Health North
Broward Health Medical Center
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Hawaii Cancer Care - Savio
Pali Momi Medical Center
Queen's Cancer Center - Pearlridge
The Cancer Center of Hawaii-Pali Momi
The Queen's Medical Center - West Oahu
Hawaii Cancer Care Inc - Waterfront Plaza
Island Urology
Queen's Cancer Cenrer - POB I
Queen's Medical Center
Straub Clinic and Hospital
University of Hawaii Cancer Center
Hawaii Cancer Care Inc-Liliha
Hawaii Diagnostic Radiology Services LLC
Kuakini Medical Center
Queen's Cancer Center - Kuakini
The Cancer Center of Hawaii-Liliha
Kaiser Permanente Moanalua Medical Center
Kapiolani Medical Center for Women and Children
Castle Medical Center
Wilcox Memorial Hospital and Kauai Medical Clinic
Saint Alphonsus Cancer Care Center-Boise
Saint Alphonsus Cancer Care Center-Caldwell
Kootenai Health - Coeur d'Alene
Walter Knox Memorial Hospital
Idaho Urologic Institute-Meridian
Saint Alphonsus Medical Center-Nampa
Kootenai Clinic Cancer Services - Post Falls
Kootenai Cancer Clinic
Saint Anthony's Health
Rush - Copley Medical Center
Northwestern University
Carle on Vermilion
Carle Physician Group-Effingham
Carle Physician Group-Mattoon/Charleston
Good Samaritan Regional Health Center
Carle Cancer Center
The Carle Foundation Hospital
Rush-Copley Healthcare Center
Cancer Center of Kansas - Chanute
Cancer Center of Kansas - Dodge City
Cancer Center of Kansas - El Dorado
Central Care Cancer Center - Garden City
Central Care Cancer Center - Great Bend
Cancer Center of Kansas-Independence
Cancer Center of Kansas-Kingman
Lawrence Memorial Hospital
Kansas Institute of Medicine Cancer and Blood Center
Minimally Invasive Surgery Hospital
Cancer Center of Kansas-Liberal
Cancer Center of Kansas-Manhattan
Cancer Center of Kansas - McPherson
Cancer Center of Kansas - Newton
Menorah Medical Center
Cancer Center of Kansas - Parsons
Cancer Center of Kansas - Pratt
Cancer Center of Kansas - Salina
Cancer Center of Kansas - Wellington
Associates In Womens Health
Cancer Center of Kansas-Wichita Medical Arts Tower
Cancer Center of Kansas - Wichita
Cancer Center of Kansas - Winfield
Ochsner LSU Health Monroe Medical Center
LSU Health Sciences Center at Shreveport
Fairview Ridges Hospital
Minnesota Oncology - Burnsville
Cambridge Medical Center
Mercy Hospital
Fairview Southdale Hospital
Unity Hospital
Fairview Clinics and Surgery Center Maple Grove
Minnesota Oncology Hematology PA-Maplewood
Saint John's Hospital - Healtheast
Abbott-Northwestern Hospital
Hennepin County Medical Center
Health Partners Inc
Monticello Cancer Center
New Ulm Medical Center
Fairview Northland Medical Center
North Memorial Medical Health Center
Park Nicollet Clinic - Saint Louis Park
Regions Hospital
United Hospital
Saint Francis Regional Medical Center
Lakeview Hospital
Ridgeview Medical Center
Rice Memorial Hospital
Minnesota Oncology Hematology PA-Woodbury
Fairview Lakes Medical Center
University of Mississippi Medical Center
Saint Louis Cancer and Breast Institute-Ballwin
Central Care Cancer Center - Bolivar
Cox Cancer Center Branson
Centerpoint Medical Center LLC
Freeman Health System
Mercy Hospital Joplin
Research Medical Center
Delbert Day Cancer Institute at PCRMC
Mercy Clinic-Rolla-Cancer and Hematology
Heartland Regional Medical Center
Saint Louis Cancer and Breast Institute-South City
Mercy Hospital South
Mercy Hospital Saint Louis
Mercy Hospital Springfield
CoxHealth South Hospital
Mercy Hospital Washington
Community Hospital of Anaconda
Billings Clinic Cancer Center
Bozeman Deaconess Hospital
Benefis Healthcare- Sletten Cancer Institute
Great Falls Clinic
Saint Peter's Community Hospital
Kalispell Regional Medical Center
Community Medical Hospital
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
Mercy Hospital Oklahoma City
Saint Alphonsus Medical Center-Baker City
Saint Alphonsus Medical Center-Ontario
Kaiser Permanente Northwest
Prisma Health Cancer Institute - Spartanburg
Prisma Health Cancer Institute - Easley
Prisma Health Cancer Institute - Butternut
Prisma Health Cancer Institute - Faris
Prisma Health Greenville Memorial Hospital
Prisma Health Cancer Institute - Eastside
Prisma Health Cancer Institute - Greer
Prisma Health Cancer Institute - Seneca
M D Anderson Cancer Center
Kaiser Permanente Washington
Cancer Center of Western Wisconsin
Billings Clinic-Cody
Welch Cancer Center
FHP Health Center-Guam

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Arm Label

Group A (TAF, TDF, entecavir)

Group B (TAF, TDF, entecavir)

Group C (TAF, TDF, entecavir, usual care)

Arm Description

Patients receive TAF PO QD or TDF PO QD or entecavir PO QD immediately or within 42 days after initial dose of chemotherapy. Treatment continues for up to 6 months after the last dose of chemotherapy or a maximum of 24 months in the absence of disease progression or unacceptable toxicity.

Patients receive TAF PO QD or TDF PO QD or entecavir PO QD after HBV reactivation during chemotherapy. Treatment continues for up to 6 months after the last dose of chemotherapy or a maximum of 24 months in the absence of disease progression or unacceptable toxicity.

Patients receive TAF PO QD or TDF PO QD or entecavir PO QD at the discretion of the physician during usual care. Treatment continues for up to 6 months after discontinuation of usual care or a maximum of 24 months in the absence of disease progression or unacceptable toxicity.

Outcomes

Primary Outcome Measures

Time until adverse liver outcome, assessed by incidence of adverse liver outcome

Graded according to Common Terminology Criteria for Adverse Events (CTCAE) version (v.) 4.0. Adverse liver outcome defined as liver-related death or liver failure (ascites, hepatic encephalopathy or impaired hepatic synthetic function defined as total bilirubin >= 5 mg/dL or international normalized ration [INR] >= 2.0) not due to disease progression in the liver. The study will recruit patients with multiple different cancer types, but predominantly lung, breast, colon, prostate, gynecological, and head and neck cancers. Estimates of adverse liver outcomes at 1 year will be derived using cumulative incidence to account for the competing risk of death. The final analysis will rely on Cox regression, adjusting for the stratification factors.

Secondary Outcome Measures

Incidence of hepatitis B Virus (HBV) reactivation among patients with solid malignancies and chronic or past HBV infection during or after completion of anti-cancer therapy

Estimates of HBV reactivation at one year will be derived using cumulative incidence to account for competing risks. Under this scenario, a sample size of n=222 patients for each randomized study will allow the investigators to estimate the confidence interval to within +/- 6% (based on the upper bound of the 95% confidence interval using an exact binomial in patients with complete follow-up), if the assumed incidence is at least 20%. Thus, this sample size will allow the confidence interval to be estimated to within +/- 31.1% of the assumed incidence (the "relative accuracy", defined as: (95% confidence interval [CI] upper bound - p)/p], where p is the assumed incidence).

HBV reactivation rate

The investigators will compare HBV reactivation rates by arm within each randomized trial. Based on a two-sample survival design accounting for the competing risk of death (~20% deaths at 1 year [hazard rate of 0.223]), and a one-sided alpha=0.05 test, then n=222 patients (111 per arm) will give 81% power to detect a hazard ratio for HBV reactivation for experimental to standard arms of 0.47, representing a 53% reduction in the hazard risk of HBV reactivation in the first year (from a hazard=0.223 down to hazard = 0.105), or an absolute reduction of 50% (from 20% down to 10%). Multivariable Cox regression will compare the effect of intervention assignment, adjusting for the stratification factors specified in the main clinical study.

Hepatitis flare

Defined as alanine aminotransferase (ALT) > 3 x baseline and > 100 U/L.

Initiation of upon indication tenofovir alafenamide (TAF) therapy

Cancer therapy interruption

Defined as dose reduction, treatment delay, or termination of anti-cancer therapy due to hepatic-related reasons other than disease progression in the liver.

Death due to any cause

Full Information

NCT ID

NCT03887702

First Posted

March 21, 2019

Last Updated

June 7, 2023

Sponsor

SWOG Cancer Research Network

Collaborators

National Cancer Institute (NCI)

1. Study Identification

Unique Protocol Identification Number

NCT03887702

Brief Title

Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors

Official Title

A Phase III Randomized Trial of Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus (HBV) Infection Receiving Anti-Cancer Therapy for Solid Tumors

Study Type

Interventional

2. Study Status

Record Verification Date

June 2023

Overall Recruitment Status

Active, not recruiting

Study Start Date

January 17, 2020 (Actual)

Primary Completion Date

July 1, 2024 (Anticipated)

Study Completion Date

February 28, 2027 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

SWOG Cancer Research Network

Collaborators

National Cancer Institute (NCI)

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

This phase III trial studies the effect of tenofovir alafenamide in preventing liver complications in patients with current or past hepatitis B virus (HBV) who are receiving anti-cancer therapy for solid tumors. People with chronic or past HBV who are undergoing therapy for cancer are at an increased risk for changes in the liver which could be minor or severe. Tenofovir alafenamide is a drug that acts against infections caused by HBV and may help reduce the chance that HBV gets worse or comes back in patients receiving anti-cancer therapy for solid tumors.

Detailed Description

PRIMARY OBJECTIVES: I. To compare the effect of prophylactic anti-HBV therapy versus upon indication anti-HBV therapy on time-to-adverse liver outcomes of liver failure or liver-related death in patients with chronic HBV infection (hepatitis B surface antigen positive [HBsAg+] and antibody to hepatitis B core antigen positive [anti-HBc+]) receiving anti-cancer therapy for solid tumors. II. To compare the effect of upon indication anti-HBV therapy versus usual care on time-to-adverse liver outcomes of liver failure or liver-related death in patients with past HBV infection (hepatitis B surface antigen negative [HBsAg-] and anti-HBc+) receiving anti-cancer therapy for solid tumors. SECONDARY OBJECTIVES: I. Using time-to-event analysis, to compare the effect of anti-HBV therapy versus upon indication anti-HBV therapy on HBV reactivation, on the combined endpoint of adverse liver outcomes (liver failure or liver-related death) and HBV reactivation, and on HBV flare by arm in patients with chronic HBV infection receiving anti-cancer therapy for solid tumors. II. Using time-to-event analysis, to compare the effect of upon indication anti-HBV therapy versus usual care on HBV reactivation, on the combined endpoint of adverse liver outcomes (liver failure or liver-related death) and HBV reactivation, and on HBV flare by arm in patients with past HBV infection receiving anti-cancer therapy for solid tumors. TRANSLATIONAL OBJECTIVES: I. To compare baseline and changes in overall immune status and HBV-specific immune response in patients with solid tumors and chronic or past HBV infection receiving anti-cancer therapy, and to compare the differences in these immune responses by HBV reactivation status. II. To identify demographic and clinical predictors and correlative immunologic biomarkers of HBV reactivation after receipt of anti-cancer therapy in patients with solid tumors and chronic or past HBV infection. OUTLINE: Patients are randomized to 1 of 3 groups. GROUP A (Cohorts 1a & 2a): Patients receive tenofovir alafenamide (TAF) orally (PO) once daily (QD) or tenofovir disoproxil fumarate (TDF) PO QD or entecavir PO QD immediately or within 42 days after initial dose of chemotherapy. Treatment continues for up to 6 months after the last dose of chemotherapy or a maximum of 24 months in the absence of disease progression or unacceptable toxicity. GROUP B (Cohorts 1b & 2b): Patients receive TAF PO QD or TDF PO QD or entecavir PO QD after HBV reactivation during chemotherapy. Treatment continues for up to 6 months after the last dose of chemotherapy or a maximum of 24 months in the absence of disease progression or unacceptable toxicity. GROUP C (Cohort 3): Patients receive TAF PO QD or TDF PO QD or entecavir PO QD at the discretion of the physician during usual care. Treatment continues for up to 6 months after discontinuation of usual care or a maximum of 24 months in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 4 weeks for up to 24 months.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Hepatitis B Infection, Malignant Solid Neoplasm

7. Study Design

Primary Purpose

Prevention

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

Outcomes Assessor

Allocation

Randomized

Enrollment

444 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Group A (TAF, TDF, entecavir)

Arm Type

Experimental

Arm Description

Arm Title

Group B (TAF, TDF, entecavir)

Arm Type

Experimental

Arm Description

Arm Title

Group C (TAF, TDF, entecavir, usual care)

Arm Type

Experimental

Arm Description

Intervention Type

Other

Intervention Name(s)

Best Practice

Other Intervention Name(s)

standard of care, standard therapy

Intervention Description

Receive best practice

Intervention Type

Drug

Intervention Name(s)

Entecavir

Other Intervention Name(s)

Baraclude, BMS-200475-01, ETV, SQ-34676, SQ34676

Intervention Description

Given PO

Intervention Type

Drug

Intervention Name(s)

Tenofovir Alafenamide

Other Intervention Name(s)

GS 7340, GS-7340, TFV Alafenamide

Intervention Description

Given PO

Intervention Type

Drug

Intervention Name(s)

Tenofovir Disoproxil Fumarate

Other Intervention Name(s)

PMPA Prodrug, TDF, Tenofovir DF, Viread

Intervention Description

Given PO

Primary Outcome Measure Information:

Title

Time until adverse liver outcome, assessed by incidence of adverse liver outcome

Description

Time Frame

From the start of study treatment up to 24 months

Secondary Outcome Measure Information:

Title

Incidence of hepatitis B Virus (HBV) reactivation among patients with solid malignancies and chronic or past HBV infection during or after completion of anti-cancer therapy

Description

Time Frame

Up to 24 months

Title

HBV reactivation rate

Description

Time Frame

Up to 24 months

Title

Hepatitis flare

Description

Defined as alanine aminotransferase (ALT) > 3 x baseline and > 100 U/L.

Time Frame

Up to 24 months

Title

Initiation of upon indication tenofovir alafenamide (TAF) therapy

Time Frame

Up to 24 months

Title

Cancer therapy interruption

Description

Defined as dose reduction, treatment delay, or termination of anti-cancer therapy due to hepatic-related reasons other than disease progression in the liver.

Time Frame

Up to 24 months

Title

Death due to any cause

Time Frame

From date of randomization up to 24 months

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Patients must be diagnosed with stage I-III solid tumor malignancy; patients with only carcinoma in situ or with stage IV disease are excluded Patients must not have been diagnosed with a malignancy other than the current malignancy within the past five years, with the exception of basal cell or squamous cell skin cancer, or non-invasive (in situ) malignancies of the cervix, breast, or skin Patients must not have lymphoma, leukemia, or myeloma Patients must not have primary liver cancer, known cirrhosis, or evidence of any malignancy that involves the liver Patients must be planning to receive systemic anti-cancer therapy (either single agent or some combination of systemic cytotoxic therapy, systemic immunotherapy or systemic targeted therapy) for this solid tumor Patients must not have been previously treated with the same anti-cancer therapy regimen that is now anticipated; the anti-cancer therapy does not have to be first-line therapy; prior and/or concurrent radiotherapy is allowed Patients must be registered =< 28 days prior to the planned start date of anti-cancer therapy; if the patient has started systemic anti-cancer therapy, patient must be registered =< 42 days after the initiation of first cycle of anti-cancer therapy Patients who have received prior anti-cancer therapy must have discontinued all previous therapies (excluding planned anti-cancer therapy to occur in conjunction with this study) >= 1 day prior to registration to this study Patients must not have had any cancer therapy regimen that includes anti-CD20 Patients must not be receiving antiviral medications active against HBV, including: adefovir, entecavir, lamivudine, telbivudine, tenofovir disoproxil fumarate, tenofovir alafenamide (TAF), or any other Food and Drug Administration (FDA) approved agents for the treatment of hepatitis B; patients who have previously received antiviral medication must not have required any antiviral medication active against HBV >= 90 days prior to registration to this study Patients must not have had hematopoietic stem cell transplantation therapy Patients receiving any of the following medications must discontinue them (under the supervision of their treating physician) prior to registration, and must not be planning to take them during protocol therapy: acyclovir, aminoglycosides, oxcarbazepine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, valacyclovir, high-dose nonsteroidal anti-inflammatory drugs (NSAIDs), ("high-dose" based on package insert), and St. John's wort Patients must have results for the following HBV tests done within 28 days prior to registration: HBsAg AND anti-HBc (total immunoglobulin [Ig] or IgG, but not IgM only) AND hepatitis B surface antibody (anti-HBs); for the anti-HBs test, quantitative or qualitative (including "indeterminate") results are allowable Patients must have tested positive for HBsAg or anti-HBc (total Ig, IgG, but not IgM) and must have baseline HBV deoxyribonucleic acid (DNA) completed =< 42 days prior to registration Complete blood count (CBC) must be completed =< 28 days prior to registration; results do not need to be in the institutional limits of normal International normalized ratio (INR) must be completed =< 28 days prior to registration; results must < 1.2 x institutional limits of normal Alanine aminotransferase (ALT) must be obtained =< 28 days prior to registration; ALT must be =< 1.5 x institutional ULN Total bilirubin must be obtained =< 28 days prior to registration; total bilirubin must be =< 1.5 x institutional ULN Creatinine results must be obtained =< 28 days prior to registration; creatinine must be =< 1.5 x institutional ULN Patients must not have known current active hepatitis C infection (HCV); active HCV is defined by a detectable HCV ribonucleic acid (RNA) level; Note: HCV testing is not required for eligibility Patients must not have a history of human immunodeficiency (HIV) infection; patients with unknown HIV status must have HIV testing completed =< 365 days prior to registration Patients must have Zubrod performance status of 0-2 Patients must not be pregnant or nursing, as the safety of the study drug in pregnant and nursing women has not been established; women/men of reproductive potential must have agreed to use an effective contraceptive method; a woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months; in addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation; however, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures Patients must have specimens collected for submission as outlined Patients must be offered the opportunity to participate in optional translational medicine studies as outlined Patients with impaired decision-making capacity are eligible as long as their neurological or psychological condition does not preclude their safe participation in the study (e.g., tracking pill consumption and reporting adverse events to the investigator) Patients may have concurrent participation in other clinical trials that entail cytotoxic, immunotherapy, targeted therapy; surgical treatment; radiotherapy treatment; or any combination thereof Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Jessica P Hwang

Organizational Affiliation

SWOG Cancer Research Network

Official's Role

Principal Investigator

Facility Information:

Facility Name

Mercy Hospital Fort Smith

City

Fort Smith

State/Province

Arkansas

ZIP/Postal Code

72903

Country

United States

Facility Name

Kaiser Permanente-Anaheim

City

Anaheim

State/Province

California

ZIP/Postal Code

92806

Country

United States

Facility Name

Kaiser Permanente-Deer Valley Medical Center

City

Antioch

State/Province

California

ZIP/Postal Code

94531

Country

United States

Facility Name

Kaiser Permanente-Baldwin Park

City

Baldwin Park

State/Province

California

ZIP/Postal Code

91706

Country

United States

Facility Name

Kaiser Permanente-Bellflower

City

Bellflower

State/Province

California

ZIP/Postal Code

90706

Country

United States

Facility Name

Epic Care-Dublin

City

Dublin

State/Province

California

ZIP/Postal Code

94568

Country

United States

Facility Name

Kaiser Permanente Dublin

City

Dublin

State/Province

California

ZIP/Postal Code

94568

Country

United States

Facility Name

Bay Area Breast Surgeons Inc

City

Emeryville

State/Province

California

ZIP/Postal Code

94608

Country

United States

Facility Name

Epic Care Partners in Cancer Care

City

Emeryville

State/Province

California

ZIP/Postal Code

94608

Country

United States

Facility Name

Kaiser Permanente-Fontana

City

Fontana

State/Province

California

ZIP/Postal Code

92335

Country

United States

Facility Name

Kaiser Permanente-Fremont

City

Fremont

State/Province

California

ZIP/Postal Code

94538

Country

United States

Facility Name

Fresno Cancer Center

City

Fresno

State/Province

California

ZIP/Postal Code

93720

Country

United States

Facility Name

Kaiser Permanente-Fresno

City

Fresno

State/Province

California

ZIP/Postal Code

93720

Country

United States

Facility Name

Kaiser Permanente - Harbor City

City

Harbor City

State/Province

California

ZIP/Postal Code

90710

Country

United States

Facility Name

Kaiser Permanente-Irvine

City

Irvine

State/Province

California

ZIP/Postal Code

92618

Country

United States

Facility Name

Tibor Rubin VA Medical Center

City

Long Beach

State/Province

California

ZIP/Postal Code

90822

Country

United States

Facility Name

Kaiser Permanente Los Angeles Medical Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90027

Country

United States

Facility Name

Los Angeles County-USC Medical Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90033

Country

United States

Facility Name

USC / Norris Comprehensive Cancer Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90033

Country

United States

Facility Name

Kaiser Permanente West Los Angeles

City

Los Angeles

State/Province

California

ZIP/Postal Code

90034

Country

United States

Facility Name

Contra Costa Regional Medical Center

City

Martinez

State/Province

California

ZIP/Postal Code

94553-3156

Country

United States

Facility Name

Kaiser Permanente-Modesto

City

Modesto

State/Province

California

ZIP/Postal Code

95356

Country

United States

Facility Name

USC Norris Oncology/Hematology-Newport Beach

City

Newport Beach

State/Province

California

ZIP/Postal Code

92663

Country

United States

Facility Name

Alta Bates Summit Medical Center - Summit Campus

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

Bay Area Tumor Institute

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

Kaiser Permanente Oakland-Broadway

City

Oakland

State/Province

California

ZIP/Postal Code

94611

Country

United States

Facility Name

Kaiser Permanente-Oakland

City

Oakland

State/Province

California

ZIP/Postal Code

94611

Country

United States

Facility Name

Kaiser Permanente-Ontario

City

Ontario

State/Province

California

ZIP/Postal Code

91761

Country

United States

Facility Name

Kaiser Permanente - Panorama City

City

Panorama City

State/Province

California

ZIP/Postal Code

91402

Country

United States

Facility Name

Keck Medical Center of USC Pasadena

City

Pasadena

State/Province

California

ZIP/Postal Code

91105

Country

United States

Facility Name

Kaiser Permanente-Rancho Cordova Cancer Center

City

Rancho Cordova

State/Province

California

ZIP/Postal Code

95670

Country

United States

Facility Name

Kaiser Permanente-Redwood City

City

Redwood City

State/Province

California

ZIP/Postal Code

94063

Country

United States

Facility Name

Kaiser Permanente-Richmond

City

Richmond

State/Province

California

ZIP/Postal Code

94801

Country

United States

Facility Name

Kaiser Permanente-Riverside

City

Riverside

State/Province

California

ZIP/Postal Code

92505

Country

United States

Facility Name

Rohnert Park Cancer Center

City

Rohnert Park

State/Province

California

ZIP/Postal Code

94928

Country

United States

Facility Name

Kaiser Permanente-Roseville

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

The Permanente Medical Group-Roseville Radiation Oncology

City

Roseville

State/Province

California

ZIP/Postal Code

95678

Country

United States

Facility Name

Kaiser Permanente Downtown Commons

City

Sacramento

State/Province

California

ZIP/Postal Code

95814

Country

United States

Facility Name

Kaiser Permanente-South Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95823

Country

United States

Facility Name

South Sacramento Cancer Center

City

Sacramento

State/Province

California

ZIP/Postal Code

95823

Country

United States

Facility Name

Kaiser Permanente - Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95825

Country

United States

Facility Name

Kaiser Permanente-San Diego Zion

City

San Diego

State/Province

California

ZIP/Postal Code

92120

Country

United States

Facility Name

Kaiser Permanente-San Francisco

City

San Francisco

State/Province

California

ZIP/Postal Code

94115

Country

United States

Facility Name

Kaiser Permanente-Santa Teresa-San Jose

City

San Jose

State/Province

California

ZIP/Postal Code

95119

Country

United States

Facility Name

Kaiser Permanente San Leandro

City

San Leandro

State/Province

California

ZIP/Postal Code

94577

Country

United States

Facility Name

Kaiser Permanente-San Marcos

City

San Marcos

State/Province

California

ZIP/Postal Code

92078

Country

United States

Facility Name

Kaiser Permanente-San Rafael

City

San Rafael

State/Province

California

ZIP/Postal Code

94903

Country

United States

Facility Name

Kaiser San Rafael-Gallinas

City

San Rafael

State/Province

California

ZIP/Postal Code

94903

Country

United States

Facility Name

Kaiser Permanente Medical Center - Santa Clara

City

Santa Clara

State/Province

California

ZIP/Postal Code

95051

Country

United States

Facility Name

Kaiser Permanente-Santa Rosa

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95403

Country

United States

Facility Name

Kaiser Permanente Cancer Treatment Center

City

South San Francisco

State/Province

California

ZIP/Postal Code

94080

Country

United States

Facility Name

Kaiser Permanente-South San Francisco

City

South San Francisco

State/Province

California

ZIP/Postal Code

94080

Country

United States

Facility Name

Kaiser Permanente-Stockton

City

Stockton

State/Province

California

ZIP/Postal Code

95210

Country

United States

Facility Name

Kaiser Permanente Medical Center-Vacaville

City

Vacaville

State/Province

California

ZIP/Postal Code

95688

Country

United States

Facility Name

Kaiser Permanente-Vallejo

City

Vallejo

State/Province

California

ZIP/Postal Code

94589

Country

United States

Facility Name

Kaiser Permanente-Walnut Creek

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94596

Country

United States

Facility Name

Epic Care Cyberknife Center

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94597

Country

United States

Facility Name

Kaiser Permanente-Woodland Hills

City

Woodland Hills

State/Province

California

ZIP/Postal Code

91367

Country

United States

Facility Name

Broward Health North

City

Deerfield Beach

State/Province

Florida

ZIP/Postal Code

33064

Country

United States

Facility Name

Broward Health Medical Center

City

Fort Lauderdale

State/Province

Florida

ZIP/Postal Code

33316

Country

United States

Facility Name

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

City

Savannah

State/Province

Georgia

ZIP/Postal Code

31405

Country

United States

Facility Name

Hawaii Cancer Care - Savio

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

Pali Momi Medical Center

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

Queen's Cancer Center - Pearlridge

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

The Cancer Center of Hawaii-Pali Momi

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

The Queen's Medical Center - West Oahu

City

'Ewa Beach

State/Province

Hawaii

ZIP/Postal Code

96706

Country

United States

Facility Name

Hawaii Cancer Care Inc - Waterfront Plaza

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Island Urology

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Queen's Cancer Cenrer - POB I

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Queen's Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Straub Clinic and Hospital

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

University of Hawaii Cancer Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Hawaii Cancer Care Inc-Liliha

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Hawaii Diagnostic Radiology Services LLC

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Kuakini Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Queen's Cancer Center - Kuakini

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

The Cancer Center of Hawaii-Liliha

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Kaiser Permanente Moanalua Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96819

Country

United States

Facility Name

Kapiolani Medical Center for Women and Children

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96826

Country

United States

Facility Name

Castle Medical Center

City

Kailua

State/Province

Hawaii

ZIP/Postal Code

96734

Country

United States

Facility Name

Wilcox Memorial Hospital and Kauai Medical Clinic

City

Lihue

State/Province

Hawaii

ZIP/Postal Code

96766

Country

United States

Facility Name

Saint Alphonsus Cancer Care Center-Boise

City

Boise

State/Province

Idaho

ZIP/Postal Code

83706

Country

United States

Facility Name

Saint Alphonsus Cancer Care Center-Caldwell

City

Caldwell

State/Province

Idaho

ZIP/Postal Code

83605

Country

United States

Facility Name

Kootenai Health - Coeur d'Alene

City

Coeur d'Alene

State/Province

Idaho

ZIP/Postal Code

83814

Country

United States

Facility Name

Walter Knox Memorial Hospital

City

Emmett

State/Province

Idaho

ZIP/Postal Code

83617

Country

United States

Facility Name

Idaho Urologic Institute-Meridian

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83642

Country

United States

Facility Name

Saint Alphonsus Medical Center-Nampa

City

Nampa

State/Province

Idaho

ZIP/Postal Code

83686

Country

United States

Facility Name

Kootenai Clinic Cancer Services - Post Falls

City

Post Falls

State/Province

Idaho

ZIP/Postal Code

83854

Country

United States

Facility Name

Kootenai Cancer Clinic

City

Sandpoint

State/Province

Idaho

ZIP/Postal Code

83864

Country

United States

Facility Name

Saint Anthony's Health

City

Alton

State/Province

Illinois

ZIP/Postal Code

62002

Country

United States

Facility Name

Rush - Copley Medical Center

City

Aurora

State/Province

Illinois

ZIP/Postal Code

60504

Country

United States

Facility Name

Northwestern University

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60611

Country

United States

Facility Name

Carle on Vermilion

City

Danville

State/Province

Illinois

ZIP/Postal Code

61832

Country

United States

Facility Name

Carle Physician Group-Effingham

City

Effingham

State/Province

Illinois

ZIP/Postal Code

62401

Country

United States

Facility Name

Carle Physician Group-Mattoon/Charleston

City

Mattoon

State/Province

Illinois

ZIP/Postal Code

61938

Country

United States

Facility Name

Good Samaritan Regional Health Center

City

Mount Vernon

State/Province

Illinois

ZIP/Postal Code

62864

Country

United States

Facility Name

Carle Cancer Center

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

The Carle Foundation Hospital

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

Rush-Copley Healthcare Center

City

Yorkville

State/Province

Illinois

ZIP/Postal Code

60560

Country

United States

Facility Name

Cancer Center of Kansas - Chanute

City

Chanute

State/Province

Kansas

ZIP/Postal Code

66720

Country

United States

Facility Name

Cancer Center of Kansas - Dodge City

City

Dodge City

State/Province

Kansas

ZIP/Postal Code

67801

Country

United States

Facility Name

Cancer Center of Kansas - El Dorado

City

El Dorado

State/Province

Kansas

ZIP/Postal Code

67042

Country

United States

Facility Name

Central Care Cancer Center - Garden City

City

Garden City

State/Province

Kansas

ZIP/Postal Code

67846

Country

United States

Facility Name

Central Care Cancer Center - Great Bend

City

Great Bend

State/Province

Kansas

ZIP/Postal Code

67530

Country

United States

Facility Name

Cancer Center of Kansas-Independence

City

Independence

State/Province

Kansas

ZIP/Postal Code

67301

Country

United States

Facility Name

Cancer Center of Kansas-Kingman

City

Kingman

State/Province

Kansas

ZIP/Postal Code

67068

Country

United States

Facility Name

Lawrence Memorial Hospital

City

Lawrence

State/Province

Kansas

ZIP/Postal Code

66044

Country

United States

Facility Name

Kansas Institute of Medicine Cancer and Blood Center

City

Lenexa

State/Province

Kansas

ZIP/Postal Code

66219

Country

United States

Facility Name

Minimally Invasive Surgery Hospital

City

Lenexa

State/Province

Kansas

ZIP/Postal Code

66219

Country

United States

Facility Name

Cancer Center of Kansas-Liberal

City

Liberal

State/Province

Kansas

ZIP/Postal Code

67905

Country

United States

Facility Name

Cancer Center of Kansas-Manhattan

City

Manhattan

State/Province

Kansas

ZIP/Postal Code

66502

Country

United States

Facility Name

Cancer Center of Kansas - McPherson

City

McPherson

State/Province

Kansas

ZIP/Postal Code

67460

Country

United States

Facility Name

Cancer Center of Kansas - Newton

City

Newton

State/Province

Kansas

ZIP/Postal Code

67114

Country

United States

Facility Name

Menorah Medical Center

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66209

Country

United States

Facility Name

Cancer Center of Kansas - Parsons

City

Parsons

State/Province

Kansas

ZIP/Postal Code

67357

Country

United States

Facility Name

Cancer Center of Kansas - Pratt

City

Pratt

State/Province

Kansas

ZIP/Postal Code

67124

Country

United States

Facility Name

Cancer Center of Kansas - Salina

City

Salina

State/Province

Kansas

ZIP/Postal Code

67401

Country

United States

Facility Name

Cancer Center of Kansas - Wellington

City

Wellington

State/Province

Kansas

ZIP/Postal Code

67152

Country

United States

Facility Name

Associates In Womens Health

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas-Wichita Medical Arts Tower

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas - Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Cancer Center of Kansas - Winfield

City

Winfield

State/Province

Kansas

ZIP/Postal Code

67156

Country

United States

Facility Name

Ochsner LSU Health Monroe Medical Center

City

Monroe

State/Province

Louisiana

ZIP/Postal Code

71202

Country

United States

Facility Name

LSU Health Sciences Center at Shreveport

City

Shreveport

State/Province

Louisiana

ZIP/Postal Code

71103

Country

United States

Facility Name

Fairview Ridges Hospital

City

Burnsville

State/Province

Minnesota

ZIP/Postal Code

55337

Country

United States

Facility Name

Minnesota Oncology - Burnsville

City

Burnsville

State/Province

Minnesota

ZIP/Postal Code

55337

Country

United States

Facility Name

Cambridge Medical Center

City

Cambridge

State/Province

Minnesota

ZIP/Postal Code

55008

Country

United States

Facility Name

Mercy Hospital

City

Coon Rapids

State/Province

Minnesota

ZIP/Postal Code

55433

Country

United States

Facility Name

Fairview Southdale Hospital

City

Edina

State/Province

Minnesota

ZIP/Postal Code

55435

Country

United States

Facility Name

Unity Hospital

City

Fridley

State/Province

Minnesota

ZIP/Postal Code

55432

Country

United States

Facility Name

Fairview Clinics and Surgery Center Maple Grove

City

Maple Grove

State/Province

Minnesota

ZIP/Postal Code

55369

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Maplewood

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Saint John's Hospital - Healtheast

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Abbott-Northwestern Hospital

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55407

Country

United States

Facility Name

Hennepin County Medical Center

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55415

Country

United States

Facility Name

Health Partners Inc

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55454

Country

United States

Facility Name

Monticello Cancer Center

City

Monticello

State/Province

Minnesota

ZIP/Postal Code

55362

Country

United States

Facility Name

New Ulm Medical Center

City

New Ulm

State/Province

Minnesota

ZIP/Postal Code

56073

Country

United States

Facility Name

Fairview Northland Medical Center

City

Princeton

State/Province

Minnesota

ZIP/Postal Code

55371

Country

United States

Facility Name

North Memorial Medical Health Center

City

Robbinsdale

State/Province

Minnesota

ZIP/Postal Code

55422

Country

United States

Facility Name

Park Nicollet Clinic - Saint Louis Park

City

Saint Louis Park

State/Province

Minnesota

ZIP/Postal Code

55416

Country

United States

Facility Name

Regions Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55101

Country

United States

Facility Name

United Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55102

Country

United States

Facility Name

Saint Francis Regional Medical Center

City

Shakopee

State/Province

Minnesota

ZIP/Postal Code

55379

Country

United States

Facility Name

Lakeview Hospital

City

Stillwater

State/Province

Minnesota

ZIP/Postal Code

55082

Country

United States

Facility Name

Ridgeview Medical Center

City

Waconia

State/Province

Minnesota

ZIP/Postal Code

55387

Country

United States

Facility Name

Rice Memorial Hospital

City

Willmar

State/Province

Minnesota

ZIP/Postal Code

56201

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Woodbury

City

Woodbury

State/Province

Minnesota

ZIP/Postal Code

55125

Country

United States

Facility Name

Fairview Lakes Medical Center

City

Wyoming

State/Province

Minnesota

ZIP/Postal Code

55092

Country

United States

Facility Name

University of Mississippi Medical Center

City

Jackson

State/Province

Mississippi

ZIP/Postal Code

39216

Country

United States

Facility Name

Saint Louis Cancer and Breast Institute-Ballwin

City

Ballwin

State/Province

Missouri

ZIP/Postal Code

63011

Country

United States

Facility Name

Central Care Cancer Center - Bolivar

City

Bolivar

State/Province

Missouri

ZIP/Postal Code

65613

Country

United States

Facility Name

Cox Cancer Center Branson

City

Branson

State/Province

Missouri

ZIP/Postal Code

65616

Country

United States

Facility Name

Centerpoint Medical Center LLC

City

Independence

State/Province

Missouri

ZIP/Postal Code

64057

Country

United States

Facility Name

Freeman Health System

City

Joplin

State/Province

Missouri

ZIP/Postal Code

64804

Country

United States

Facility Name

Mercy Hospital Joplin

City

Joplin

State/Province

Missouri

ZIP/Postal Code

64804

Country

United States

Facility Name

Research Medical Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64132

Country

United States

Facility Name

Delbert Day Cancer Institute at PCRMC

City

Rolla

State/Province

Missouri

ZIP/Postal Code

65401

Country

United States

Facility Name

Mercy Clinic-Rolla-Cancer and Hematology

City

Rolla

State/Province

Missouri

ZIP/Postal Code

65401

Country

United States

Facility Name

Heartland Regional Medical Center

City

Saint Joseph

State/Province

Missouri

ZIP/Postal Code

64506

Country

United States

Facility Name

Saint Louis Cancer and Breast Institute-South City

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63109

Country

United States

Facility Name

Mercy Hospital South

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63128

Country

United States

Facility Name

Mercy Hospital Saint Louis

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

Mercy Hospital Springfield

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65804

Country

United States

Facility Name

CoxHealth South Hospital

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65807

Country

United States

Facility Name

Mercy Hospital Washington

City

Washington

State/Province

Missouri

ZIP/Postal Code

63090

Country

United States

Facility Name

Community Hospital of Anaconda

City

Anaconda

State/Province

Montana

ZIP/Postal Code

59711

Country

United States

Facility Name

Billings Clinic Cancer Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Bozeman Deaconess Hospital

City

Bozeman

State/Province

Montana

ZIP/Postal Code

59715

Country

United States

Facility Name

Benefis Healthcare- Sletten Cancer Institute

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Great Falls Clinic

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Saint Peter's Community Hospital

City

Helena

State/Province

Montana

ZIP/Postal Code

59601

Country

United States

Facility Name

Kalispell Regional Medical Center

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Community Medical Hospital

City

Missoula

State/Province

Montana

ZIP/Postal Code

59804

Country

United States

Facility Name

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

City

New York

State/Province

New York

ZIP/Postal Code

10032

Country

United States

Facility Name

Mercy Hospital Oklahoma City

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73120

Country

United States

Facility Name

Saint Alphonsus Medical Center-Baker City

City

Baker City

State/Province

Oregon

ZIP/Postal Code

97814

Country

United States

Facility Name

Saint Alphonsus Medical Center-Ontario

City

Ontario

State/Province

Oregon

ZIP/Postal Code

97914

Country

United States

Facility Name

Kaiser Permanente Northwest

City

Portland

State/Province

Oregon

ZIP/Postal Code

97227

Country

United States

Facility Name

Prisma Health Cancer Institute - Spartanburg

City

Boiling Springs

State/Province

South Carolina

ZIP/Postal Code

29316

Country

United States

Facility Name

Prisma Health Cancer Institute - Easley

City

Easley

State/Province

South Carolina

ZIP/Postal Code

29640

Country

United States

Facility Name

Prisma Health Cancer Institute - Butternut

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Cancer Institute - Faris

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Greenville Memorial Hospital

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Cancer Institute - Eastside

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29615

Country

United States

Facility Name

Prisma Health Cancer Institute - Greer

City

Greer

State/Province

South Carolina

ZIP/Postal Code

29650

Country

United States

Facility Name

Prisma Health Cancer Institute - Seneca

City

Seneca

State/Province

South Carolina

ZIP/Postal Code

29672

Country

United States

Facility Name

M D Anderson Cancer Center

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

Kaiser Permanente Washington

City

Seattle

State/Province

Washington

ZIP/Postal Code

98112

Country

United States

Facility Name

Cancer Center of Western Wisconsin

City

New Richmond

State/Province

Wisconsin

ZIP/Postal Code

54017

Country

United States

Facility Name

Billings Clinic-Cody

City

Cody

State/Province

Wyoming

ZIP/Postal Code

82414

Country

United States

Facility Name

Welch Cancer Center

City

Sheridan

State/Province

Wyoming

ZIP/Postal Code

82801

Country

United States

Facility Name

FHP Health Center-Guam

City

Tamuning

ZIP/Postal Code

96913

Country

Guam

12. IPD Sharing Statement

Learn more about this trial

Prophylactic Antiviral Therapy in Patients With Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors

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