Prophylactic Early PN in HPT/BMT
Hematologic Neoplasms
About this trial
This is an interventional prevention trial for Hematologic Neoplasms
Eligibility Criteria
Inclusion Criteria:
- Patients who are about to commence conditioning chemoradiotherapy for allogeneic haematopoietic progenitor/stem cell transplantation, who have a haematological malignancy, who are not meeting 80% of their Caloric needs via oral or enteral intakes, and who are not malnourished.
Exclusion Criteria:
- Patients who are already receiving parenteral nutrition at time of screening.
- Patients with a documented licensing contraindication to parenteral nutrition.
Sites / Locations
- Royal North Shore HospitalRecruiting
- Royal Adelaide HospitalRecruiting
- Christchurch Hospital, CDHBRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Standard Care
Early supplemental parenteral nutrition
The control group in this study is pragmatic standard nutrition care. Currently after a bone marrow transplant in Australia, patients are normally fed orally for as long as possible. If oral intake fails to provide sufficient calories for a period of two to three days, enteral or parenteral nutrition may be provided.
Supplemental prophylactic early parenteral nutrition will be commenced 1 day prior to conditioning chemoradiotherapy in patients who are not already malnourished. Supplemental parenteral nutrition continues throughout conditioning chemoradiotherapy and stem cell transplant. The dose of supplemental parenteral nutrition will be dependent on the total calories also received from oral and/or enteral nutrition intake.