Prophylactic Frequent Premature Ventricular complexeS sUPPression on Left ventriculaR Function impairmEnt in aSymptomatic patientS (SUPPRESS)
Premature Ventricular Contractions, Ventricular Dysfunction, Left
About this trial
This is an interventional prevention trial for Premature Ventricular Contractions
Eligibility Criteria
Inclusion Criteria: Inclusion criteria (all must be present): 18 ≤ Age ≤ 85 PVC burden ≥ to 10% regardless of current or preexisting antiarrhythmic drug intake (for instance, a patient under betablocker therapy because of his PVCs or hypertension can be included) Asymptomatic status Normal (>or= 55%) LVEF. Patients with underlying cardiomyopathy can be included as long as LV function remains preserved. Signed informed consent Exclusion criteria (any of them): Pregnant woman or Female of childbearing potential without effective method of birth control or nursing woman. Patients that can't undergo MRI study De novo requirement for antiarrhythmic drug prescription for another indication (e.g. atrial fibrillation…) The physician already decided that the patient requires drug initiation or escalation; Ischemic cardiomyopathy requiring revascularization (PCI or surgery) History of LV dysfunction Participation in another research involving the human person Patient under legal protection Non affiliation to a social security scheme
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Experimental group
Control group
Patients treated for PVCs with drug therapy and/or catheter ablation/ medical treatment including drug administration ± catheter ablation (Ablation can be performed if the PVC burden remain >10% after 2 lines of AAD treatment).
Patients with therapeutic abstention or no treatment modification such as drug therapy/ Therapeutic abstention or no modification of therapy