Prophylactic Lisinopril to Prevent Anthracycline Cardiomyopathy.
Cardiomyopathy Due to Drug, Heart Failure, Systolic
About this trial
This is an interventional prevention trial for Cardiomyopathy Due to Drug
Eligibility Criteria
Inclusion Criteria:
- Diagnosed with a type of cancer and intended to be on an anthracycline chemotherapy regimen by treating oncologist.
Exclusion Criteria:
- Inability or unwillingness to give informed consent
- Subjects with a contraindication to angiotensin converting enzyme inhibitors such as history of angioedema or hypersensitivity related to previous treatment with an angiotensin converting enzyme inhibitor
- Subjects with a history of hereditary or idiopathic angioedema
- Subjects currently taking aliskiren (major drug interaction-)
- Subjects currently taking a neprilysin inhibitor (e.g. sacubitril or entresto)
- Subjects already on treatment with angiotensin converting enzyme inhibitors, or taking lithium
- Renal insufficiency defined as creatinine clearance <30
- Women <50 who capable of child bearing who have not had surgical contraception such as hysterectomy or tubal ligation
- Oncologic life expectancy shorter than 12 months
- Systolic blood pressure <90 mmHg prior to enrollment
Sites / Locations
- Genesys Regional Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Lisinopril treatment
Placebo Oral Tablet
These patients will be initiated at 5mg lisinopril daily by the research nurse at the time of enrollment. The drug will then be titrated up by the research nurse in a stepwise fashion from 5mg, to 10mg, and then to 20mg once a day every 1 to 3 weeks according to their regular/scheduled next office visits. Blood pressure will be monitored at every visit by the research nurse if it is less than or equal to 90 mmHg
These patients will be started on the placebo medication at the time of enrollment. According to their regular scheduled visits every 1 to 3 weeks, they will meet with the research nurse and be given a new placebo medication to take once a day.