Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

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Primary Purpose

Status

Completed

Phase

Not Applicable

Locations

United States

Study Type

Interventional

Intervention

Ceftriaxone sodium

Ampicillin sodium

Amoxicillin trihydrate

About this trial

This is an interventional treatment trial for HIV Infections focused on measuring Salmonella Infections, AIDS-Related Opportunistic Infections, Acquired Immunodeficiency Syndrome, Amoxicillin, Ceftriaxone

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Exclusion Criteria Co-existing Condition: Patients with the following are excluded: Type I hypersensitivity to beta-lactam antibiotics. Not expected to survive 12 weeks. In a coma or with other central nervous system (CNS) impairment. Patients with the following are excluded: Type I hypersensitivity to beta-lactam antibiotics. Not expected to survive 12 weeks. In a coma or with other central nervous system (CNS) impairment. Prior Medication: Excluded within 48 hours of study entry: Treatment with an antibiotic active in vitro against Salmonella. HIV infection, AIDS, or AIDS related complex (ARC). Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.

Sites / Locations

Los Angeles County - USC Med Ctr

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

NCT ID

NCT00002052

First Posted

November 2, 1999

Last Updated

June 23, 2005

Sponsor

University of Southern California

1. Study Identification

Unique Protocol Identification Number

NCT00002052

Brief Title

Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

Official Title

Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

Study Type

Interventional

2. Study Status

Record Verification Date

August 1989

Overall Recruitment Status

Completed

Study Start Date

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Primary Completion Date

undefined (undefined)

Study Completion Date

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3. Sponsor/Collaborators

Name of the Sponsor

University of Southern California

4. Oversight

5. Study Description

Brief Summary

To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

HIV Infections, Salmonella Infections

Keywords

Salmonella Infections, AIDS-Related Opportunistic Infections, Acquired Immunodeficiency Syndrome, Amoxicillin, Ceftriaxone

7. Study Design

Primary Purpose

Treatment

Study Phase

Not Applicable

8. Arms, Groups, and Interventions

Intervention Type

Drug

Intervention Name(s)

Ceftriaxone sodium

Intervention Type

Drug

Intervention Name(s)

Ampicillin sodium

Intervention Type

Drug

Intervention Name(s)

Amoxicillin trihydrate

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

No

Eligibility Criteria

Exclusion Criteria Co-existing Condition: Patients with the following are excluded: Type I hypersensitivity to beta-lactam antibiotics. Not expected to survive 12 weeks. In a coma or with other central nervous system (CNS) impairment. Patients with the following are excluded: Type I hypersensitivity to beta-lactam antibiotics. Not expected to survive 12 weeks. In a coma or with other central nervous system (CNS) impairment. Prior Medication: Excluded within 48 hours of study entry: Treatment with an antibiotic active in vitro against Salmonella. HIV infection, AIDS, or AIDS related complex (ARC). Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.

Facility Information:

Facility Name

Los Angeles County - USC Med Ctr

City

Los Angeles

State/Province

California

ZIP/Postal Code

90033

Country

United States

HIV Infections, Salmonella Infections

About this trial

Eligibility Criteria

Sites / Locations

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

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