Prospective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic Treatment
Demineralization, Tooth, Caries,Dental, White Spot Lesion
About this trial
This is an interventional prevention trial for Demineralization, Tooth focused on measuring orthodontics, demineralizatiion, fluoride, Diagnodent
Eligibility Criteria
Inclusion Criteria:
Subjects about to undergo multi-bracketed fixed orthodontic treatment will be invited to participate in this study.
Exclusion Criteria:
- History of fixed orthodontic treatment
- Presence of any developmental defects of enamel (DDE) on labial surfaces of teeth
- Presence of any dental anomalies or direct/indirect labial restorations on teeth
- History of long-term antibiotic usage
- Presence of untreated cavitated lesions
- Plaque level greater than 25%
- Patients requiring complicated orthognathic surgeries
Sites / Locations
- The University of Hong Kong
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Active Comparator
Experimental
Standard of care
Standard of care + Fluoride varnish
Standard of care + Fluoride varnish with Tricalcium phosphate
Control will receive standard oral hygiene instructions (OHI every three months)
Intervention 1 will receive standard OHI and application of topical fluoride varnish containing 5% NaF (Duraphat varnish®, Colgate-Palmolive (UK) Ltd., Guildford, Surrey, UK) every three months
Intervention 2 will receive standard OHI and application of topical fluoride varnish containing 5% NaF + TCP (Clinpro white varnishTM, 3M ESPE, St Paul, MN, USA) every three months