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Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure

Primary Purpose

Psychogenic Movement Disorders, Non-epileptic Seizures

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
National Institute of Neurological Disorders and Stroke (NINDS)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Psychogenic Movement Disorders focused on measuring Conversion Disorder, Somatoform Disorder, Involuntary Movement, Childhood Abuse, Depression, Psychogenic Movement Disorder, PMD, Non-Epileptic Seizure, NES, Healthy Volunteer, HV

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesAccepts Healthy Volunteers

INCLUSION CRITERIA: Patients for dissociation study: Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist. Or a diagnosis of NES based on video-EEG. The diagnosis will be made by an epileptologist. Males or females Age 18 or older Able to provide informed consent Patients for cognitive study: Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist. Age 18 or older Males or females Able to provide informed consent Normal volunteers for cognitive study: Normal volunteers age 18 or older will be included Males or females Able to provide informed consent EXCLUSION CRITERIA: Patients for dissociation study: Diagnosis of probable or possible PMD using Fahn and Williams criteria. Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy. Patients with a medical condition that prevents them from taking part in the study. Patients with current suicidal ideation. Patients with a psychotic disorder. Patients with active substance abuse within the last 6 months. Patients below the age of 18. Patients who are not capable of consent. Patients with an IQ less than 55. Patients currently involved in lawsuits. Patients for cognitive study: Diagnosis of probable or possible PMD using Fahn and Williams criteria Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy Patients with a medical condition that prevents them from taking part in the study. Patients with a history of a neurological disorder (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits. Patients with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds. Patients with a psychotic disorder or bipolar disorder Patients with a current major depression Patients with current moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25) Patients with current attention deficit hyperactivity disorder. Patients with active substance abuse within the last 6 months. Patient with current suicidal ideation. Patients below the age of 18. Patients who are not capable of consent. Patients with an IQ less than 55. Patients currently involved in lawsuits. Normal volunteers for cognitive study: Normal volunteers younger than 18 years Normal volunteers with an active medical condition that might prevent participation. Normal volunteers with a history of neurological disorders (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits Normal volunteers with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds Normal volunteers with a psychotic disorder or bipolar disorder Normal volunteers with a current major depression Normal volunteers with moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25) Normal volunteers with active substance abuse within the last 6 months Normal volunteers with current attention deficit hyperactivity disorder Normal volunteers with an IQ less than 55 Normal volunteers who are not capable of consent

Sites / Locations

  • National Institutes of Health Clinical Center, 9000 Rockville Pike

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
November 17, 2005
Last Updated
June 30, 2017
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
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1. Study Identification

Unique Protocol Identification Number
NCT00255411
Brief Title
Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure
Official Title
Neuropsychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure
Study Type
Observational

2. Study Status

Record Verification Date
February 24, 2009
Overall Recruitment Status
Completed
Study Start Date
November 9, 2005 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
February 24, 2009 (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)

4. Oversight

5. Study Description

Brief Summary
This study will explore how the mind and the brain work to cause movement symptoms or seizures in people who do not have a recognized neurological or medical disorder. The study includes a check for psychiatric disorders, symptoms and their severity; psychiatric and personality questionnaires; and neuropsychological testing. Normal, healthy volunteers, people who have movement symptoms not due to a brain or medical disorder and people who have seizures not due to epilepsy may be eligible for this study. All candidates must be 18 years of age or older. All participants have a medical history, physical examination and psychological evaluation, including completion of questionnaires. People with movement symptoms or seizures have a symptoms evaluation. Some participants also undergo neuropsychological testing, including questionnaires, pen-and-paper or computerized tests, and motor tasks.
Detailed Description
Objectives The objectives of this study are (1) to investigate the relationship between childhood abuse and dissociative experiences in both psychogenic movement disorders (PMD) and non-epileptic seizures (NES) and (2) to investigate the relationship between childhood abuse and both PMD and NES. The secondary objective of the study is to investigate if measures of response inhibition differ between PMD subjects compared to normal controls. This study is part of a larger study investigating the psychological and biological correlates of conversion disorder. Study population We intend to study adult patients with diagnoses of PMD seen by the Human Motor Control Section clinic or patients with diagnoses of NES seen by the Epilepsy clinic and normal controls. Design A psychiatric assessment, measurement scales and neuropsychological testing will be administered to the PMD and NES patients and normal controls. Outcome measures The first primary outcome measure will be the comparison of the different subtypes of childhood abuse (as measured by the Childhood Trauma Interview) and the severity of dissociation (as measured by the Dissociative Experiences Scale). The second primary outcome measure will be the comparison of frequencies of different subtypes of childhood abuse (as measured by the Childhood Trauma Interview) between PMD, NES and normal control groups. The secondary outcome measure will be the comparison of stop-signal reaction time as measured with the stop-signal task.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Psychogenic Movement Disorders, Non-epileptic Seizures
Keywords
Conversion Disorder, Somatoform Disorder, Involuntary Movement, Childhood Abuse, Depression, Psychogenic Movement Disorder, PMD, Non-Epileptic Seizure, NES, Healthy Volunteer, HV

7. Study Design

Enrollment
190 (false)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
INCLUSION CRITERIA: Patients for dissociation study: Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist. Or a diagnosis of NES based on video-EEG. The diagnosis will be made by an epileptologist. Males or females Age 18 or older Able to provide informed consent Patients for cognitive study: Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist. Age 18 or older Males or females Able to provide informed consent Normal volunteers for cognitive study: Normal volunteers age 18 or older will be included Males or females Able to provide informed consent EXCLUSION CRITERIA: Patients for dissociation study: Diagnosis of probable or possible PMD using Fahn and Williams criteria. Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy. Patients with a medical condition that prevents them from taking part in the study. Patients with current suicidal ideation. Patients with a psychotic disorder. Patients with active substance abuse within the last 6 months. Patients below the age of 18. Patients who are not capable of consent. Patients with an IQ less than 55. Patients currently involved in lawsuits. Patients for cognitive study: Diagnosis of probable or possible PMD using Fahn and Williams criteria Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy Patients with a medical condition that prevents them from taking part in the study. Patients with a history of a neurological disorder (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits. Patients with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds. Patients with a psychotic disorder or bipolar disorder Patients with a current major depression Patients with current moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25) Patients with current attention deficit hyperactivity disorder. Patients with active substance abuse within the last 6 months. Patient with current suicidal ideation. Patients below the age of 18. Patients who are not capable of consent. Patients with an IQ less than 55. Patients currently involved in lawsuits. Normal volunteers for cognitive study: Normal volunteers younger than 18 years Normal volunteers with an active medical condition that might prevent participation. Normal volunteers with a history of neurological disorders (e.g. dementia, cerebrovascular accident, neurodegenerative disorder, inflammatory disorders or infections of the central nervous system) that may result in cognitive deficits Normal volunteers with a history of traumatic brain injury resulting in loss of consciousness or amnesia lasting for more than a few seconds Normal volunteers with a psychotic disorder or bipolar disorder Normal volunteers with a current major depression Normal volunteers with moderate to severe anxiety (Hamilton Anxiety Rating Scale greater than 25) Normal volunteers with active substance abuse within the last 6 months Normal volunteers with current attention deficit hyperactivity disorder Normal volunteers with an IQ less than 55 Normal volunteers who are not capable of consent
Facility Information:
Facility Name
National Institutes of Health Clinical Center, 9000 Rockville Pike
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
7872143
Citation
Williams DT, Ford B, Fahn S. Phenomenology and psychopathology related to psychogenic movement disorders. Adv Neurol. 1995;65:231-57. No abstract available.
Results Reference
background
PubMed Identifier
10644789
Citation
Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics. J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):207-10. doi: 10.1136/jnnp.68.2.207.
Results Reference
background
PubMed Identifier
15718217
Citation
Stone J, Carson A, Sharpe M. Functional symptoms and signs in neurology: assessment and diagnosis. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1(Suppl 1):i2-12. doi: 10.1136/jnnp.2004.061655. No abstract available.
Results Reference
background

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Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure

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