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Psychological Treatment of Overweight Binge Eaters

Primary Purpose

Binge Eating Disorder, Cognitive Therapy/Methods, Mental Disorders/Epidemiology

Status
Completed
Phase
Phase 1
Locations
United States
Study Type
Interventional
Intervention
Cognitive Behavioral Therapy (CBT)
Interpersonal Therapy (IPT)
Sponsored by
Washington University School of Medicine
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Binge Eating Disorder focused on measuring Body Mass Index, Bulimia/therapy, Comorbidity, Interpersonal Relations, Psychotherapy/methods

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • DSM-IV research criteria for binge-eating disorder
  • Average of greater than or equal to 2 days of binge eating per week for at least 6 months' duration
  • Marked stress regarding binge eating
  • At least 3 to 5 associated behavioral features (e.g. eating when not physically hungry) Other study criteria
  • 18-65 years old
  • Body mass index, 27-48 kg/m squared

Exclusion Criteria:

  • Pregnant or planning to become pregnant
  • Taking weight-affecting or psychotropic medications
  • Psychiatric conditions warranting immediate treatment
  • Current enrollment in psychotherapy or a weight loss program

Sites / Locations

  • Yale University
  • Yale University

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Binge Eating Disorder/Therapy

Arm Description

Outcomes

Primary Outcome Measures

To investigate the short and long-term efficacy of two treatments for binge eating among the overweight: Group Cognitive-Behavior (CBT) and Group Interpersonal Therapy (IPT).
Assessments of binge eating and associated eating disorder paychopathology, general psychological functioning, and weight occurred before treatment, at post treatment, and at 4-month intervals up to 12 months following treatment.

Secondary Outcome Measures

Full Information

First Posted
August 31, 2010
Last Updated
September 22, 2010
Sponsor
Washington University School of Medicine
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1. Study Identification

Unique Protocol Identification Number
NCT01208272
Brief Title
Psychological Treatment of Overweight Binge Eaters
Official Title
A Randomized Comparison of Group-Behavioral Therapy and Group Interpersonal Psychotherapy for the Treatment of Overweight Individuals With Binge-Eating Disorder
Study Type
Interventional

2. Study Status

Record Verification Date
September 2010
Overall Recruitment Status
Completed
Study Start Date
April 1994 (undefined)
Primary Completion Date
March 1998 (Actual)
Study Completion Date
March 1999 (Actual)

3. Sponsor/Collaborators

Name of the Sponsor
Washington University School of Medicine

4. Oversight

5. Study Description

Brief Summary
Cognitive-behavioral therapy (CBT) has documented efficacy for the treatment of binge eating disorder (BED). Interpersonal psychotherapy (IPT) has been shown to reduce binge eating but its long-term impact and time course on other BED-related symptoms remain largely unknown. This study compares the effects of group CBT and group IPT across BED-related symptoms among overweight individuals with BED.
Detailed Description
Cognitive-behavioral therapy (CBT) has documented efficacy for the treatment of binge eating disorder (BED). Interpersonal psychotherapy (IPT) has been shown to reduce binge eating but its long-term impact and time course on other BED-related symptoms remain largely unknown. This study compares the effects of group CBT and group IPT across BED-related symptoms among overweight individuals with BED. METHODS: One hundred sixty-two overweight patients meeting DSM-IV criteria for BED were randomly assigned to 20 weekly sessions of either group CBT or group IPT. Assessments of binge eating and associated eating disorder psychopathology, general psychological functioning, and weight occurred before treatment, at posttreatment, and at 4-month intervals up to 12 months following treatment. RESULTS: Binge-eating recovery rates were equivalent for CBT and IPT at posttreatment (64 [79%] of 81 vs 59 [73%] of 81) and at 1-year follow-up (48 [59%] of 81 vs 50 [62%] of 81). Binge eating increased slightly through follow-up but remained significantly below pretreatment levels. Across treatments, patients had similar significant reductions in associated eating disorders and psychiatric symptoms and maintenance of gains through follow-up. Dietary restraint decreased more quickly in CBT but IPT had equivalent levels by later follow-ups. Patients' relative weight decreased significantly but only slightly, with the greatest reduction among patients sustaining recovery from binge eating from posttreatment to 1-year follow-up. CONCLUSIONS: Group IPT is a viable alternative to group CBT for the treatment of overweight patients with BED. Although lacking a nonspecific control condition limits conclusions about treatment specificity, both treatments showed initial and long-term efficacy for the core and related symptoms of BED.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Binge Eating Disorder, Cognitive Therapy/Methods, Mental Disorders/Epidemiology, Obesity/Epidemiology, Obesity/Therapy
Keywords
Body Mass Index, Bulimia/therapy, Comorbidity, Interpersonal Relations, Psychotherapy/methods

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 1, Phase 2
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
162 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Binge Eating Disorder/Therapy
Arm Type
Experimental
Intervention Type
Behavioral
Intervention Name(s)
Cognitive Behavioral Therapy (CBT)
Intervention Type
Behavioral
Intervention Name(s)
Interpersonal Therapy (IPT)
Primary Outcome Measure Information:
Title
To investigate the short and long-term efficacy of two treatments for binge eating among the overweight: Group Cognitive-Behavior (CBT) and Group Interpersonal Therapy (IPT).
Description
Assessments of binge eating and associated eating disorder paychopathology, general psychological functioning, and weight occurred before treatment, at post treatment, and at 4-month intervals up to 12 months following treatment.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: DSM-IV research criteria for binge-eating disorder Average of greater than or equal to 2 days of binge eating per week for at least 6 months' duration Marked stress regarding binge eating At least 3 to 5 associated behavioral features (e.g. eating when not physically hungry) Other study criteria 18-65 years old Body mass index, 27-48 kg/m squared Exclusion Criteria: Pregnant or planning to become pregnant Taking weight-affecting or psychotropic medications Psychiatric conditions warranting immediate treatment Current enrollment in psychotherapy or a weight loss program
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Denise E Wilfley, Ph.D.
Organizational Affiliation
Washington University School of Medicine
Official's Role
Principal Investigator
Facility Information:
Facility Name
Yale University
City
New Haaven
State/Province
Connecticut
ZIP/Postal Code
06511-3516
Country
United States
Facility Name
Yale University
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06511-3516
Country
United States

12. IPD Sharing Statement

Citations:
PubMed Identifier
12150647
Citation
Wilfley DE, Welch RR, Stein RI, Spurrell EB, Cohen LR, Saelens BE, Dounchis JZ, Frank MA, Wiseman CV, Matt GE. A randomized comparison of group cognitive-behavioral therapy and group interpersonal psychotherapy for the treatment of overweight individuals with binge-eating disorder. Arch Gen Psychiatry. 2002 Aug;59(8):713-21. doi: 10.1001/archpsyc.59.8.713.
Results Reference
result
PubMed Identifier
22282429
Citation
Hilbert A, Bishop ME, Stein RI, Tanofsky-Kraff M, Swenson AK, Welch RR, Wilfley DE. Long-term efficacy of psychological treatments for binge eating disorder. Br J Psychiatry. 2012 Mar;200(3):232-7. doi: 10.1192/bjp.bp.110.089664. Epub 2012 Jan 26.
Results Reference
derived

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Psychological Treatment of Overweight Binge Eaters

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