Quality and Biologic Characteristics of Red Blood Concentrates Obtained From Individuals With Elevated Ferritin.
Hereditary Hemochromatosis, Hyperferritinemia
About this trial
This is an interventional other trial for Hereditary Hemochromatosis
Eligibility Criteria
Inclusion Criteria: Age:18-75 years Body weight > 50 Kg Haemoglobin ≥ 135 g/l (males), ≥ 125 g/l (females) In subjects of the HH and non-HH group: ferritin values >500 ng/ml, which must have been measured in the last three months before the inclusion in the study (either at the Blood Donation service or elsewhere), not followed by a blood donation or a phlebotomy In subjects of the HH group: genetic test demonstrating the presence of p.C282Y homozygous or p.C282Y/p.H63D compound heterozygous HFE-gene mutation In subjects of the control group: ferritin values < 300 ng/ml (males) or < 200 ng/ml (females) Written informed consent to the participation in the study Exclusion Criteria: Inadequate vein access for whole blood collection Body weight < 50 kg Chronic viral infection (hepatitis B or C, HIV) Previous acute coronary heart disease Previous or current history of epilepsy Other severe conditions that could significantly increase the phlebotomy risk, based on individual medical evaluation No informed consent Pregnancy (according to the information on the standard blood donor questionnaire)
Sites / Locations
- Blutspendedienst SRK beider Basel
- Interregionale Blutspende SRK
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Other
Hereditary hemochromatosis
secondary hyperferritinemia
healthy blood donor with normal ferritin value.
Individual with ferritin >500 ng/mL and documented homozygous or compound heterozygous HFE-gen mutation.
Individual with ferritin >500 ng/mL, not fulfilling the criteria for hereditary hemochromatosis.
Healthy comparator.