Quantitative D-dimer Level and Anticoagulant Therapy in Idiopathic Intracranial Hypertension
Idiopathic Intracranial Hypertension
About this trial
This is an interventional treatment trial for Idiopathic Intracranial Hypertension focused on measuring IIH, D-dimer, microthrombi, anticoagulation
Eligibility Criteria
Inclusion Criteria:
- IIH patients of both sexes fulfilling the modified Dandy criteria
Exclusion Criteria:
- disturbed conscious level, focal neurological signs, seizures, cerebral venous sinus thrombosis or stenosis, deep venous thrombosis or pulmonary embolism, malignancy, and acute nephritic syndrome.
- Patients with signs of disseminated intravascular coagulopathy and septic sinus thrombosis
- patients with a history of cerebral granuloma or infection, cerebrovascular stroke, head trauma or surgery.
- pregnant females or those who terminated their pregnancy in the last four weeks were also excluded.
Sites / Locations
- Fayoum University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
No Intervention
Group A
Group B
Control group
12 IIH patients for whom serum D-dimer was assessed by ELISA.They received acetazolamide and anticoagulant LMWH in the prophylactic dose for 2 weeks then continued on acetazolamide. Follow up after 1 and 6 months through HIT6 test and ophthalmological assessment (visual acuity, Frisen classification for papilledema, visual field, and visual evoked potentials)
12 IIH patients for whom serum D-dimer was assessed by ELISA. They received acetazolamide only. Follow up after 1 and 6 months through HIT6 test and ophthalmological assessment (visual acuity, Frisen classification for papilledema, visual field, and visual evoked potentials)
24 healthy subjects for whom serum D-dimer was assessed by ELISA.