Race, Natriuretic Peptides and Physiological Perturbations
Healthy, Pre Hypertension
About this trial
This is an interventional other trial for Healthy focused on measuring Racial differences
Eligibility Criteria
Inclusion Criteria:
- 18 to 40 years
- Blood pressure less than 140/90 mm Hg
- Able to perform exercise capacity test
- BMI 18-25 kg/m2
- Willing to adhere to study drug
Exclusion Criteria:
- History of cardiovascular disease or use of medications for CVD
- History of hypertension or use of BP lowering medications
- Blood pressure less than 100/60 mm Hg
- Heart rate less than 60 beats/min
- Depression
- Diabetes or use of anti-diabetic medications
- Renal disease (eGFR < 60ml/min/1.73m2)
- Current or prior smokers
- Pregnant or use of Hormone Replacement Therapy (HRT) or oral contraceptives (OCP) or steroids
Sites / Locations
- University of Alabama at BirminghamRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
African-American
Caucasians (White)
Healthy lean (BMI 18-25 kg/m2) African-American participants will be enrolled and each will undergo a physical exam and screening tests to determine participants' eligibility. Participants will perform exercise capacity VO2 max determination test, followed by 3 days of standardized meals and exercise challenge test. After exercise challenge test, all the participants will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day.
Healthy lean (BMI 18-25 kg/m2) white participants will be enrolled and each will undergo a physical exam and screening tests to determine participants' eligibility. Participants will perform exercise capacity VO2 max determination test, followed by 3 days of standardized meals and exercise challenge test. After exercise challenge test, all the participants will receive metoprolol succinate starting at 50mg/day, titrated bi-weekly up to 200 mg/day.