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Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission

Primary Purpose

Lung Cancer

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
radiation therapy
Sponsored by
Gustave Roussy, Cancer Campus, Grand Paris
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an interventional treatment trial for Lung Cancer focused on measuring limited stage small cell lung cancer

Eligibility Criteria

undefined - 70 Years (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Histologically proven limited stage small cell lung cancer Complete response to induction therapy (at least on chest x-ray) Normal brain CT scan or MRI less than 1 month prior to study No metastases (including ipsilateral lung metastases and malignant pleural effusion) PATIENT CHARACTERISTICS: Age: 70 and under Performance status: WHO 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Cardiovascular: No prior cerebrovascular disease Other: No epilepsy requiring permanent oral medication No other prior malignancy except skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics No concurrent chemotherapy Endocrine therapy: Concurrent steroids allowed Radiotherapy: Concurrent thoracic radiotherapy allowed Surgery: Not specified Other No other concurrent antitumoral agent

Sites / Locations

  • M.D. Anderson Cancer Center at University of Texas
  • Cancer Therapy Centre at Campbelltown Hospital
  • Radiation Oncology Victoria
  • Ziekenhuis Netwerk Antwerpen Middelheim
  • Universiteit Gent
  • Hopital de Jolimont
  • Cazk Groeninghe - Campus Maria's Voorzienigheid
  • Clinique Saint-Joseph
  • Clinique Sainte Elisabeth
  • Instituto Nacional de Cancer
  • Instituto de Radiomedicina
  • Clinica Renaca - Gocchi
  • Rui Jin Hospital
  • Hospital Militar Central
  • Bank Of Cyprus Oncology Centre
  • Masaryk Memorial Cancer Institute
  • First Medical Clinic of Charles University Hospital
  • Clinique De Rochebelle
  • Centre de Traitement Hautes - Energies
  • Centre Paul Papin
  • Centre Hospitalier Victor Dupouy
  • C.H.G. Beauvais
  • Polyclinique Bordeaux Nord Aquitaine
  • Centre Regional Francois Baclesse
  • Centre Jean Perrin
  • Centre de Radiotherapie
  • Centre Hospitalier Sud Francilien - Site Corbeil
  • Centre Hospitalier Universitaire Henri Mondor
  • Hopital Intercommunal De Creteil
  • Centre de Lutte Contre le Cancer Georges-Francois Leclerc
  • Centre De Radiotherapie Charlebourg
  • Centre Guillaume Le Conquerant
  • Centre Hospital Regional Universitaire de Limoges
  • C.R.T.T.
  • C.H. General De Montbelliard
  • Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
  • CRLCC Nantes - Atlantique
  • Centre Antoine Lacassagne
  • CHR D'Orleans - Hopital de la Source
  • Institut Curie - Section Medicale
  • Centre Hospitalier Lyon Sud
  • Institut Jean Godinot
  • Centre Frederic Joliot
  • Centre du Rouget
  • Centre Hospitalier Prive Des Yvelines
  • Hopitaux Universitaire de Strasbourg
  • Centre Medico-Chirurgical Foch
  • Hopital d'Instruction des Armes Sainte-Anne
  • Centre d'Oncologie Saint-Yves
  • Institut Gustave Roussy
  • Universitaetsklinikum Essen
  • University Hospital of Heraklion
  • Evaggelismos Hospital
  • Sotiria Hospital Chest Diseases
  • Venizelion Gr.
  • University of Patras Medical School
  • Chaim Sheba Medical Center
  • Tel-Aviv Sourasky Medical Center
  • Ospedale Bellaria
  • Universita Degli Studi Di Pisa
  • Ospedale Ostetrico Ginecologica Sant Anna
  • Osaka National Hospital
  • Samsung Medical Center
  • Institute of Oncology at Vilnius University
  • Institute of Radiotherapy and Oncology
  • Akademisch Ziekenhuis Vrije Universiteit - Medisch Centrum
  • Arnhems Radiotherapeutisch Instituut
  • Nijmegen Cancer Center at Radboud University Medical Center
  • University Medical Center Rotterdam at Erasmus Medical Center
  • Medical University of Gdansk
  • Institute of Oncology
  • Regional Lung Diseases Hospital
  • Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
  • Hospital Santa Maria
  • Institutul Oncologic - Universitatea de Medicina
  • Institute of Oncology and Radiology of Serbia
  • Groote Schuur Hospital
  • Hospital Virgen de la Arrixaca
  • Hospital Virgen de las Nieves
  • Centre Hospitalier Universitaire Vaudois
  • Marmara University Hospital
  • Christie Hospital N.H.S. Trust
  • Northern Centre for Cancer Treatment at Newcastle General Hospital
  • Mount Vernon Cancer Centre at Mount Vernon Hospital
  • Nottingham City Hospital NHS Trust
  • New Cross Hospital
  • Western General Hospital
  • Beatson Oncology Centre
  • Raigmore Hospital
  • Nevill Hall Hospital
  • Royal Gwent Hospital
  • Velindre Cancer Center at Velinde Hospital
  • Cancer Research Centre at Weston Park Hospital

Outcomes

Primary Outcome Measures

Incidence of brain metastases 2 years after randomization

Secondary Outcome Measures

Overall survival and disease-free survival 2 years after randomization
Quality of life as assessed by Quality of Life Questionnaire (QLQ)-C30/BN20 before randomization, at 6 and 12 months, and annually thereafter
Treatment late sequelae as assessed by Late Effect of Normal Tissue - Subjective Objective Management Analytic scale, brain CT scan, or MRI before randomization and then annually thereafter

Full Information

First Posted
April 6, 2000
Last Updated
March 12, 2014
Sponsor
Gustave Roussy, Cancer Campus, Grand Paris
Collaborators
European Organisation for Research and Treatment of Cancer - EORTC
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1. Study Identification

Unique Protocol Identification Number
NCT00005062
Brief Title
Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission
Official Title
A Phase III Trial Comparing High Versus Standard Dose of Prophylactic Cranial Irradiation (PCI) in Limited Small Cell Lung Cancer Complete Responders
Study Type
Interventional

2. Study Status

Record Verification Date
March 2014
Overall Recruitment Status
Completed
Study Start Date
September 1999 (undefined)
Primary Completion Date
December 2005 (Actual)
Study Completion Date
December 2005 (Actual)

3. Sponsor/Collaborators

Name of the Sponsor
Gustave Roussy, Cancer Campus, Grand Paris
Collaborators
European Organisation for Research and Treatment of Cancer - EORTC

4. Oversight

5. Study Description

Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells and prevent the spread of cancer to the brain. It is not yet known if standard-dose radiation therapy is more effective than high-dose radiation therapy in preventing the spread of limited-stage small cell lung cancer cells to the brain. PURPOSE: This randomized phase III trial is comparing two different regimens of radiation therapy to see how well they work in treating patients with limited-stage small cell lung cancer in complete remission.
Detailed Description
OBJECTIVES: Compare high-dose versus standard-dose prophylactic cranial radiotherapy in terms of the incidence of brain metastases and overall and disease free survival at 2 years in patients with limited stage small cell lung cancer in complete remission. Evaluate the quality of life and late sequelae in this patient population treated with these regimens. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center, age (60 and under vs over 60), and interval between the start of induction therapy and date of randomization (90 days or less vs 91-180 days vs more than 180 days). Patients are randomized into one of two treatment arms according to the prophylactic cranial radiotherapy dose. Arm I: Patients receive standard-dose prophylactic cranial radiotherapy (10 fractions/12 days). Arm II: Patients receive high-dose prophylactic cranial radiotherapy administered over 16 or 24 days based on the choice of their treatment center. 18 fractions/24 days (conventional radiotherapy) OR 24 fractions/16 days (accelerated hyperfractionated radiotherapy) Patients with isolated brain failure may undergo further radiotherapy. Quality of life is assessed prior to randomization, at 6 months, at 1 year, and then annually thereafter. Patients are followed at least every 6 months for 2 years and then annually thereafter. PROJECTED ACCRUAL: A total of 700 patients will be accrued for this study within 3 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Lung Cancer
Keywords
limited stage small cell lung cancer

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Allocation
Randomized

8. Arms, Groups, and Interventions

Intervention Type
Radiation
Intervention Name(s)
radiation therapy
Primary Outcome Measure Information:
Title
Incidence of brain metastases 2 years after randomization
Secondary Outcome Measure Information:
Title
Overall survival and disease-free survival 2 years after randomization
Title
Quality of life as assessed by Quality of Life Questionnaire (QLQ)-C30/BN20 before randomization, at 6 and 12 months, and annually thereafter
Title
Treatment late sequelae as assessed by Late Effect of Normal Tissue - Subjective Objective Management Analytic scale, brain CT scan, or MRI before randomization and then annually thereafter

10. Eligibility

Sex
All
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven limited stage small cell lung cancer Complete response to induction therapy (at least on chest x-ray) Normal brain CT scan or MRI less than 1 month prior to study No metastases (including ipsilateral lung metastases and malignant pleural effusion) PATIENT CHARACTERISTICS: Age: 70 and under Performance status: WHO 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Cardiovascular: No prior cerebrovascular disease Other: No epilepsy requiring permanent oral medication No other prior malignancy except skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics No concurrent chemotherapy Endocrine therapy: Concurrent steroids allowed Radiotherapy: Concurrent thoracic radiotherapy allowed Surgery: Not specified Other No other concurrent antitumoral agent
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Cecile Le Pechoux, MD
Organizational Affiliation
Gustave Roussy, Cancer Campus, Grand Paris
First Name & Middle Initial & Last Name & Degree
Suresh Senan
Organizational Affiliation
Free University Medical Center
Facility Information:
Facility Name
M.D. Anderson Cancer Center at University of Texas
City
Houston
State/Province
Texas
ZIP/Postal Code
77030-4009
Country
United States
Facility Name
Cancer Therapy Centre at Campbelltown Hospital
City
Campbelltown
State/Province
New South Wales
ZIP/Postal Code
2560
Country
Australia
Facility Name
Radiation Oncology Victoria
City
East Melbourne
State/Province
Victoria
ZIP/Postal Code
3002
Country
Australia
Facility Name
Ziekenhuis Netwerk Antwerpen Middelheim
City
Antwerpen
ZIP/Postal Code
2020
Country
Belgium
Facility Name
Universiteit Gent
City
Ghent
ZIP/Postal Code
B-9000
Country
Belgium
Facility Name
Hopital de Jolimont
City
Haine Saint Paul
ZIP/Postal Code
7100
Country
Belgium
Facility Name
Cazk Groeninghe - Campus Maria's Voorzienigheid
City
Kortrijk
ZIP/Postal Code
B-8500
Country
Belgium
Facility Name
Clinique Saint-Joseph
City
Liege
ZIP/Postal Code
B 4000
Country
Belgium
Facility Name
Clinique Sainte Elisabeth
City
Namur
ZIP/Postal Code
50000
Country
Belgium
Facility Name
Instituto Nacional de Cancer
City
Copacabana
State/Province
Rio de Janeiro
ZIP/Postal Code
CEP 22040-010
Country
Brazil
Facility Name
Instituto de Radiomedicina
City
Santiago
ZIP/Postal Code
10
Country
Chile
Facility Name
Clinica Renaca - Gocchi
City
Vina Del Mar
Country
Chile
Facility Name
Rui Jin Hospital
City
Shanghai
ZIP/Postal Code
200025
Country
China
Facility Name
Hospital Militar Central
City
Bogota
Country
Colombia
Facility Name
Bank Of Cyprus Oncology Centre
City
Nicosia
ZIP/Postal Code
2006 Strovolos
Country
Cyprus
Facility Name
Masaryk Memorial Cancer Institute
City
Brno
ZIP/Postal Code
656 53
Country
Czech Republic
Facility Name
First Medical Clinic of Charles University Hospital
City
Prague
ZIP/Postal Code
128 08
Country
Czech Republic
Facility Name
Clinique De Rochebelle
City
Ales
ZIP/Postal Code
F-30100
Country
France
Facility Name
Centre de Traitement Hautes - Energies
City
Amiens
ZIP/Postal Code
80000
Country
France
Facility Name
Centre Paul Papin
City
Angers
ZIP/Postal Code
49036
Country
France
Facility Name
Centre Hospitalier Victor Dupouy
City
Argenteuil
ZIP/Postal Code
95107
Country
France
Facility Name
C.H.G. Beauvais
City
Beauvais
ZIP/Postal Code
60000
Country
France
Facility Name
Polyclinique Bordeaux Nord Aquitaine
City
Boucher
ZIP/Postal Code
33300
Country
France
Facility Name
Centre Regional Francois Baclesse
City
Caen
ZIP/Postal Code
14076
Country
France
Facility Name
Centre Jean Perrin
City
Clermont-Ferrand
ZIP/Postal Code
63011
Country
France
Facility Name
Centre de Radiotherapie
City
Compiegne
ZIP/Postal Code
60200
Country
France
Facility Name
Centre Hospitalier Sud Francilien - Site Corbeil
City
Corbeil
ZIP/Postal Code
91100
Country
France
Facility Name
Centre Hospitalier Universitaire Henri Mondor
City
Creteil
ZIP/Postal Code
94010
Country
France
Facility Name
Hopital Intercommunal De Creteil
City
Creteil
ZIP/Postal Code
94010
Country
France
Facility Name
Centre de Lutte Contre le Cancer Georges-Francois Leclerc
City
Dijon
ZIP/Postal Code
21079
Country
France
Facility Name
Centre De Radiotherapie Charlebourg
City
La Garenne Colombes
ZIP/Postal Code
92250
Country
France
Facility Name
Centre Guillaume Le Conquerant
City
Le Havre
ZIP/Postal Code
76600
Country
France
Facility Name
Centre Hospital Regional Universitaire de Limoges
City
Limoges
ZIP/Postal Code
87042
Country
France
Facility Name
C.R.T.T.
City
Meudon La Foret
ZIP/Postal Code
92360
Country
France
Facility Name
C.H. General De Montbelliard
City
Montbelliard
ZIP/Postal Code
25200
Country
France
Facility Name
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
City
Montpellier
ZIP/Postal Code
34298
Country
France
Facility Name
CRLCC Nantes - Atlantique
City
Nantes-Saint Herblain
ZIP/Postal Code
44805
Country
France
Facility Name
Centre Antoine Lacassagne
City
Nice
ZIP/Postal Code
06189
Country
France
Facility Name
CHR D'Orleans - Hopital de la Source
City
Orleans
ZIP/Postal Code
45067
Country
France
Facility Name
Institut Curie - Section Medicale
City
Paris
ZIP/Postal Code
75005
Country
France
Facility Name
Centre Hospitalier Lyon Sud
City
Pierre Benite
ZIP/Postal Code
69495
Country
France
Facility Name
Institut Jean Godinot
City
Reims
ZIP/Postal Code
51056
Country
France
Facility Name
Centre Frederic Joliot
City
Rouen
ZIP/Postal Code
76000
Country
France
Facility Name
Centre du Rouget
City
Sarcelles
ZIP/Postal Code
95250
Country
France
Facility Name
Centre Hospitalier Prive Des Yvelines
City
Sartrouville
ZIP/Postal Code
78500
Country
France
Facility Name
Hopitaux Universitaire de Strasbourg
City
Strasbourg
ZIP/Postal Code
67100
Country
France
Facility Name
Centre Medico-Chirurgical Foch
City
Suresnes
ZIP/Postal Code
92151
Country
France
Facility Name
Hopital d'Instruction des Armes Sainte-Anne
City
Toulon
ZIP/Postal Code
83800
Country
France
Facility Name
Centre d'Oncologie Saint-Yves
City
Vannes
ZIP/Postal Code
56001
Country
France
Facility Name
Institut Gustave Roussy
City
Villejuif
ZIP/Postal Code
F-94805
Country
France
Facility Name
Universitaetsklinikum Essen
City
Essen
ZIP/Postal Code
D-45122
Country
Germany
Facility Name
University Hospital of Heraklion
City
Heraklion
State/Province
Crete
ZIP/Postal Code
71110
Country
Greece
Facility Name
Evaggelismos Hospital
City
Athens
ZIP/Postal Code
10676
Country
Greece
Facility Name
Sotiria Hospital Chest Diseases
City
Athens
Country
Greece
Facility Name
Venizelion Gr.
City
Heraklion
ZIP/Postal Code
71306
Country
Greece
Facility Name
University of Patras Medical School
City
Rio Patras
ZIP/Postal Code
GR-26500
Country
Greece
Facility Name
Chaim Sheba Medical Center
City
Tel Hashomer
ZIP/Postal Code
52621
Country
Israel
Facility Name
Tel-Aviv Sourasky Medical Center
City
Tel-Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
Ospedale Bellaria
City
Bologna
ZIP/Postal Code
I-40139
Country
Italy
Facility Name
Universita Degli Studi Di Pisa
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
Ospedale Ostetrico Ginecologica Sant Anna
City
Turin
ZIP/Postal Code
10126
Country
Italy
Facility Name
Osaka National Hospital
City
Osaka
ZIP/Postal Code
540-0006
Country
Japan
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Institute of Oncology at Vilnius University
City
Vilnius
ZIP/Postal Code
08660
Country
Lithuania
Facility Name
Institute of Radiotherapy and Oncology
City
Skopje
ZIP/Postal Code
1000
Country
Macedonia, The Former Yugoslav Republic of
Facility Name
Akademisch Ziekenhuis Vrije Universiteit - Medisch Centrum
City
Amsterdam
ZIP/Postal Code
1007 MB
Country
Netherlands
Facility Name
Arnhems Radiotherapeutisch Instituut
City
Arnhem
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
Nijmegen Cancer Center at Radboud University Medical Center
City
Nijmegen
ZIP/Postal Code
6500 HB
Country
Netherlands
Facility Name
University Medical Center Rotterdam at Erasmus Medical Center
City
Rotterdam
ZIP/Postal Code
3000 CA
Country
Netherlands
Facility Name
Medical University of Gdansk
City
Gdansk
ZIP/Postal Code
80 211
Country
Poland
Facility Name
Institute of Oncology
City
Lodz
ZIP/Postal Code
93509
Country
Poland
Facility Name
Regional Lung Diseases Hospital
City
Poznan
ZIP/Postal Code
60 569
Country
Poland
Facility Name
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
City
Warsaw
ZIP/Postal Code
02 781
Country
Poland
Facility Name
Hospital Santa Maria
City
Lisbon
ZIP/Postal Code
1649-035
Country
Portugal
Facility Name
Institutul Oncologic - Universitatea de Medicina
City
Cluj-Napoca
ZIP/Postal Code
3400
Country
Romania
Facility Name
Institute of Oncology and Radiology of Serbia
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Groote Schuur Hospital
City
Cape Town
ZIP/Postal Code
7925
Country
South Africa
Facility Name
Hospital Virgen de la Arrixaca
City
El Palmar
ZIP/Postal Code
30120
Country
Spain
Facility Name
Hospital Virgen de las Nieves
City
Granada
ZIP/Postal Code
18014
Country
Spain
Facility Name
Centre Hospitalier Universitaire Vaudois
City
Lausanne
ZIP/Postal Code
CH-1011
Country
Switzerland
Facility Name
Marmara University Hospital
City
Istanbul
ZIP/Postal Code
81190
Country
Turkey
Facility Name
Christie Hospital N.H.S. Trust
City
Manchester
State/Province
England
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Facility Name
Northern Centre for Cancer Treatment at Newcastle General Hospital
City
Newcastle-Upon-Tyne
State/Province
England
ZIP/Postal Code
NE4 6BE
Country
United Kingdom
Facility Name
Mount Vernon Cancer Centre at Mount Vernon Hospital
City
Northwood
State/Province
England
ZIP/Postal Code
HA6 2RN
Country
United Kingdom
Facility Name
Nottingham City Hospital NHS Trust
City
Nottingham
State/Province
England
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Facility Name
New Cross Hospital
City
Wolverhampton
State/Province
England
ZIP/Postal Code
WV10 0QP
Country
United Kingdom
Facility Name
Western General Hospital
City
Edinburgh
State/Province
Scotland
ZIP/Postal Code
EH4 2XU
Country
United Kingdom
Facility Name
Beatson Oncology Centre
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G11 6NT
Country
United Kingdom
Facility Name
Raigmore Hospital
City
Inverness
State/Province
Scotland
ZIP/Postal Code
1V2 3UJ
Country
United Kingdom
Facility Name
Nevill Hall Hospital
City
Gwent
State/Province
Wales
Country
United Kingdom
Facility Name
Royal Gwent Hospital
City
Newport Gwent
State/Province
Wales
ZIP/Postal Code
NP9 2UB
Country
United Kingdom
Facility Name
Velindre Cancer Center at Velinde Hospital
City
Cardiff
ZIP/Postal Code
CF4 7XL
Country
United Kingdom
Facility Name
Cancer Research Centre at Weston Park Hospital
City
Sheffield
ZIP/Postal Code
S10 2SJ
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
19386548
Citation
Le Pechoux C, Dunant A, Senan S, Wolfson A, Quoix E, Faivre-Finn C, Ciuleanu T, Arriagada R, Jones R, Wanders R, Lerouge D, Laplanche A; Prophylactic Cranial Irradiation (PCI) Collaborative Group. Standard-dose versus higher-dose prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer in complete remission after chemotherapy and thoracic radiotherapy (PCI 99-01, EORTC 22003-08004, RTOG 0212, and IFCT 99-01): a randomised clinical trial. Lancet Oncol. 2009 May;10(5):467-74. doi: 10.1016/S1470-2045(09)70101-9. Epub 2009 Apr 20.
Results Reference
background
Citation
Pechoux CL, Hatton M, Kobierska A, et al.: Randomized trial of standard dose to a higher dose prophylactic cranial irradiation (PCI) in limited-stage small cell cancer (SCLC) complete responders (CR): primary endpoint analysis (PCI99-01, IFCT 99-01, EORTC 22003-08004, RTOG 0212). [Abstract] J Clin Oncol 26 (Suppl 15): A-LBA7514, 2008.
Results Reference
background
PubMed Identifier
21139020
Citation
Le Pechoux C, Laplanche A, Faivre-Finn C, Ciuleanu T, Wanders R, Lerouge D, Keus R, Hatton M, Videtic GM, Senan S, Wolfson A, Jones R, Arriagada R, Quoix E, Dunant A; Prophylactic Cranial Irradiation (PCI) Collaborative Group. Clinical neurological outcome and quality of life among patients with limited small-cell cancer treated with two different doses of prophylactic cranial irradiation in the intergroup phase III trial (PCI99-01, EORTC 22003-08004, RTOG 0212 and IFCT 99-01). Ann Oncol. 2011 May;22(5):1154-1163. doi: 10.1093/annonc/mdq576. Epub 2010 Dec 7.
Results Reference
result

Learn more about this trial

Radiation Therapy in Patients With Limited-Stage Small Cell Lung Cancer in Complete Remission

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