Radiation Therapy Plus Chemotherapy in Treating Patients With Supratentorial Glioblastoma Multiforme
Brain and Central Nervous System Tumors
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring adult glioblastoma, adult giant cell glioblastoma, adult gliosarcoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histopathologically confirmed supratentorial glioblastoma multiforme or gliosarcoma Diagnosis by surgical biopsy or resection required The following tumor types are specifically excluded: Astrocytoma with atypical or anaplastic features Well differentiated astrocytomas Tumors originating in the brain stem Tumors located within 10 mm of the optic chiasm Infratentorial tumors Multifocal malignant glioma Recurrent malignant glioma Well circumscribed contrast-enhancing tumor on pre- and postoperative contrast-enhanced CT or MRI with a maximum diameter (in any direction) of 40 mm required Tumors that do not enhance on postoperative CT or MRI excluded Concurrent enrollment on RTOG-9308 encouraged PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 60-100% Life expectancy: At least 3 months Hematopoietic: ANC at least 1,500 Platelets at least 100,000 Hb at least 10 g/dl (may transfuse) Hepatic: Bilirubin no greater than 2.0 mg/dl SGOT or SGPT no greater than 2 x normal Renal: Creatinine no greater than 1.5 mg/dl BUN no greater than 25 mg/dl Pulmonary: Chest x-ray normal If abnormal or if there is a history of pulmonary disease, pulmonary function studies (including DLCO) must be at least 75% of predicted Other: Neurologic function status 0-3 No AIDS No major medical or psychiatric illness that would preclude protocol therapy or follow-up No second malignancy within 5 years except: Nonmelanomatous skin cancer In situ carcinoma of the uterine cervix PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to the head and neck Surgery: No more than 5 weeks between surgery and initiation of treatment Recovery from surgery and any postoperative complications required
Sites / Locations
- Veterans Affairs Medical Center - Birmingham
- University of Alabama Comprehensive Cancer Center
- Huntsville Hospital System
- Urology Associates - Mobile AL
- MBCCOP - University of South Alabama
- Alabama Oncology, LLC
- Radiation Oncology Associates of West Alabama
- Providence Cancer Therapy Center
- St. Joseph's Hospital and Medical Center
- Arizona Cancer Center
- Providence Saint Joseph Medical Center - Burbank
- Mount Diablo Medical Center
- California Cancer Center
- Saint Agnes Cancer Center
- Glendale Memorial Hospital and Health Center
- Sutter Health Western Division Cancer Research Group
- Loma Linda University Medical Center
- Veterans Affairs Medical Center - Long Beach
- Kaiser Permanente Medical Center - Los Angeles
- USC/Norris Comprehensive Cancer Center
- Jonsson Comprehensive Cancer Center, UCLA
- Beckman Research Institute, City of Hope
- Veterans Affairs Outpatient Clinic - Martinez
- CCOP - Bay Area Tumor Institute
- Cancer Care Center
- Mercy Medical Center - Redding
- Radiation Oncology Center - Sacramento
- UCSF Cancer Center and Cancer Research Institute
- O'Connor Hospital
- Santa Cruz Radiation Oncology Medical Group, Inc.
- CCOP - Santa Rosa Memorial Hospital
- Stanford University
- David Grant Medical Center
- Radiation Oncology Center - Walnut Creek
- Memorial Hospital Cancer Center
- University of Colorado Cancer Center
- Bridgeport Hospital
- Whittingham Cancer Center
- CCOP - Christiana Care Health Services
- Walter Reed Army Medical Center
- Lykes Center for Radiation Therapy
- Halifax Medical Center
- Radiation Therapy Associates - Fort Myers
- University of Florida Health Science Center
- Health First Holmes Regional Medical Center
- CCOP - Mount Sinai Medical Center
- Sylvester Cancer Center, University of Miami
- Baptist Hospital of Miami
- Florida Radiation Oncology Group
- MD Anderson Cancer Center Orlando
- Gulf Coast Cancer Treatment Center
- West Florida Cancer Institute - Pensacola
- Bayfront Medical Center
- Sarasota Radiation and Medical Oncology Center
- H. Lee Moffitt Cancer Center and Research Institute
- Emory University Hospital - Atlanta
- CCOP - Atlanta Regional
- Medical Center/John B. Amos Community Cancer Center
- InterCommunity Cancer Center at Rome
- South Georgia Medical Center
- Northwest Community Hospital
- Northwestern Memorial Hospital
- University of Chicago Cancer Research Center
- Ingalls Memorial Hospital
- Loyola University Medical Center
- Lutheran General Cancer Care Center
- Methodist Medical Center of Illinois
- CCOP - Central Illinois
- CCOP - Carle Cancer Center
- St. John's Medical Center
- Clarion Health Partners Inc.
- Community Hospitals of Indianapolis - Regional Cancer Center
- Ball Memorial Hospital
- Memorial Hospital of South Bend
- St. Joseph's Radiation Oncology Center
- Wendt Regional Cancer Center of Finley Hospital
- University of Iowa Hospitals and Clinics
- Medical Center at Bowling Green
- Veterans Affairs Medical Center - Lexington
- Albert B. Chandler Medical Center, University of Kentucky
- James Graham Brown Cancer Center
- Louisville Radiation Oncology
- Merle M. Mahr Cancer Center
- Western Baptist Hospital
- Mary Bird Perkins Cancer Center
- Romagosa Radiation Oncology Center
- East Jefferson General Hospital
- MBCCOP - LSU Medical Center
- Tulane University School of Medicine
- CCOP - Ochsner
- Maine Medical Center
- Anne Arundel Oncology Center
- Marlene & Stewart Greenebaum Cancer Center, University of Maryland
- Greater Baltimore Medical Center and Cancer Center
- Harbor Hospital Center
- Radiation Oncology Affiliates of Maryland, P.A.
- Johns Hopkins Oncology Center
- Massachusetts General Hospital Cancer Center
- Joint Center for Radiation Therapy
- Cape Cod Hospital
- Veterans Affairs Medical Center - Boston (Jamaica Plain)
- Veterans Affairs Medical Center - Ann Arbor
- CCOP - Ann Arbor Regional
- University of Michigan Comprehensive Cancer Center
- Barbara Ann Karmanos Cancer Institute
- Henry Ford Hospital
- McLaren Regional Cancer Center
- Hurley Medical Center
- CCOP - Kalamazoo
- Sparrow Regional Cancer Center
- Marquette General Hospital
- MidMichigan Regional Medical Center
- St. Mary's Medical Center
- Mayo Clinic Cancer Center
- CCOP - Metro-Minnesota
- Ellis Fischel Cancer Center - Columbia
- CCOP - Kansas City
- Veterans Affairs Medical Center - Saint Louis
- St. Louis University Health Sciences Center
- Mallinckrodt Institute of Radiology
- Cancer Research for the Ozarks
- CCOP - Cancer Research for the Ozarks
- CCOP - Montana Cancer Consortium
- Methodist Cancer Center - Omaha
- CCOP - Missouri Valley Cancer Consortium
- CCOP - Southern Nevada Cancer Research Foundation
- Norris Cotton Cancer Center
- Elliot Regional Cancer Center
- Veterans Affairs Medical Center - East Orange
- John F. Kennedy Medical Center
- Trinitas Hosptial - Jersey Street Campus
- South Jersey Hospital - Millville
- Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County
- Newark Beth Israel Medical Center
- Community Medical Center
- St. Francis Medical Center
- Saint Joseph Medical Center
- Cancer Center of Albany Medical Center
- Veterans Affairs Medical Center - Albany
- Albert Einstein Comprehensive Cancer Center
- State University of New York Health Science Center at Brooklyn
- New York Methodist Hospital
- Roswell Park Cancer Institute
- Finger Lakes Radiation Oncology, P.C.
- CCOP - North Shore University Hospital
- Beth Israel Medical Center
- Kaplan Cancer Center
- Memorial Sloan-Kettering Cancer Center
- Champlain Valley Physicians Hospital Medical Center
- Vassar Brothers Hospital
- Genesee Hospital - Rochester
- University of Rochester Cancer Center
- New York Medical College
- Lineberger Comprehensive Cancer Center, UNC
- Northeast Medical Center
- East Carolina University School of Medicine
- Catawba Memorial Hospital
- CCOP - Southeast Cancer Control Consortium
- Comprehensive Cancer Center of Wake Forest University Baptist Medical Center
- Meritcare Roger Maris Cancer Center
- UNI-MED Medical Center
- Akron General Medical Center
- Akron City Hospital
- Christ Hospital
- Ireland Cancer Center
- University Hospitals of Cleveland
- Cleveland Clinic Cancer Center
- CCOP - Columbus
- Arthur G. James Cancer Hospital - Ohio State University
- Veterans Affairs Medical Center - Dayton
- CCOP - Dayton
- CCOP - Toledo Community Hospital Oncology Program
- St. John Medical Center
- Samaritan Regional Cancer Center
- CCOP - Columbia River Program
- Lehigh Valley Hospital
- St. Luke's Hospital Regional Cancer Center
- Penn State Geisinger Medical Center
- Mercy Catholic Medical Center, Mercy Fitzgerald Divison
- Delaware County Memorial Hospital
- Penn State Geisinger Cancer Center
- Allegheny University Hospitals- Hahnemann
- University of Pennsylvania Cancer Center
- Veterans Affairs Medical Center - Philadelphia
- Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- Albert Einstein Cancer Center
- University of Pittsburgh Cancer Institute
- Mercy Hospital of Pittsburgh
- Western Pennsylvania Hospital
- Reading Hospital and Medical Center
- Mercy Hospital Cancer Center - Scranton
- Grand View Hospital
- Wilkes Barre General Hospital
- CCOP - MainLine Health
- York Hospital
- Roger Williams Medical Center/BUSM
- Medical University of South Carolina
- CCOP - Greenville
- CCOP - Upstate Carolina
- Jackson-Madison County General Hospital
- Baptist Regional Cancer Center - Knoxville
- CCOP - Baptist Cancer Institute
- University of Tennessee, Memphis Cancer Center
- Vanderbilt Cancer Center
- Harrington Cancer Center
- Julie and Ben Rogers Cancer Institute
- University of Texas Medical Branch
- University of Texas - MD Anderson Cancer Center
- Wilford Hall - 59th Medical Wing
- Joe Arrington Cancer Research and Treatment Center
- Bayshore Medical Center
- East Texas Medical Center - Cancer Institute
- Dixie Regional Medical Center
- LDS Hospital
- CCOP - Southwestern Vermont Regional Cancer Center
- Vermont Cancer Center
- Green Mountain Oncology Group
- Veterans Affairs Medical Center - White River Junction
- Martha Jefferson Hospital
- Cancer Center, University of Virginia HSC
- Virginia Baptist Hospital
- Naval Medical Center, Portsmouth
- Massey Cancer Center
- Swedish Cancer Institute
- Virginia Mason Medical Center
- Deaconess Medical Center
- Yakima Valley Memorial Hospital
- Schiffler Oncology Center
- St. Vincent Hospital
- Gundersen Lutheran Medical Foundation
- Veterans Affairs Medical Center - Madison
- Southern Wisconsin Radiotherapy Center
- University of Wisconsin Comprehensive Cancer Center
- Marshfield Clinic
- Community Memorial Hospital
- St. Joseph's Hospital
- Columbia Hospital
- St. Luke's Medical Center
- Medical College of Wisconsin
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
- Southeastern Wisconsin Regional Cancer Center
- Waukesha Memorial Hospital
- Tom Baker Cancer Center - Calgary
- Cross Cancer Institute
- British Columbia Cancer Agency - Vancouver Island Cancer Centre
- Doctor Leon Richard Oncology Centre
- Saint John Regional Hospital
- Nova Scotia Cancer Centre
- Cancer Care Ontario-Hamilton Regional Cancer Centre
- Kingston Regional Cancer Centre
- Cancer Care Ontario-London Regional Cancer Centre
- Ottawa Regional Cancer Centre - Civic Campus
- Northeastern Ontario Regional Cancer Centre, Sudbury
- Northwestern Ontario Regional Cancer Centre, Thunder Bay
- Toronto Sunnybrook Regional Cancer Centre
- Princess Margaret Hospital
- Centre Hospitalier de l'Universite de Montreal
- McGill University Department of Oncology
- Saskatoon Cancer Centre