Radiation Therapy With and Without Combination Chemotherapy in Patients With Resected Anaplastic Oligodendroglioma
Brain and Central Nervous System Tumors
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring recurrent adult brain tumor, adult anaplastic oligodendroglioma, adult mixed glioma
Eligibility Criteria
DISEASE CHARACTERISTICS: Newly diagnosed oligodendroglioma or oligoastrocytoma (with at least 25% oligodendral elements) Low-grade oligodendroastrocytoma or oligodendroglioma that is recurrent after surgery without radiotherapy is allowed Prior partial or gross total resection of tumor (or biopsy only in case of no further surgical option) required At least 3 of the following histologic anaplastic features: High cellularity Endothelial abnormalities Nuclear abnormalities Necrosis Mitoses PATIENT CHARACTERISTICS: Age: 16 to 69 Performance status: ECOG 0-2 Life expectancy: At least 3 months Hematopoietic: WBC at least 3,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.4 mg/dL Renal: Creatinine no greater than 1.3 mg/dL Creatinine clearance at least 60 mL/min Other: Not pregnant or nursing Fertile patients must use effective contraception No active or uncontrolled infection No other disease, including malignancy, that would preclude study No neurologic or psychiatric disturbance that would preclude study PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics No prior radiotherapy to the skull Surgery: See Disease Characteristics
Sites / Locations
- Kaiser Franz Josef Hospital
- Academisch Ziekenhuis der Vrije Universiteit Brussel
- Hopital Universitaire Erasme
- Hopital de Jolimont
- U.Z. Gasthuisberg
- Turku University Central Hospital
- Centre Hospitalier Regional de Lille
- CHU de la Timone
- CHU de Nancy - Hopital Neurologique
- CRLCC Nantes - Atlantique
- Hopital Pasteur
- Centre Antoine Lacassagne
- C.H.R. de Nimes - Hopital Caremeau
- CHU Pitie-Salpetriere
- Centre Eugene Marquis
- Institut Gustave Roussy
- Neurologische Klinik der Henriettenstiftung
- Klinikum der Friedrich-Schiller Universitaet Jena
- National Institute of Neurosurgery
- Azienda Ospedaliera di Padova
- Universita di Padova
- Medisch Centrum Haaglanden
- Vrije Universiteit Medisch Centrum
- Academisch Medisch Centrum
- Academisch Ziekenhuis Groningen
- University Medical Center Nijmegen
- Rotterdam Cancer Institute
- St. Elisabeth Ziekenhuis
- Dr. Bernard Verbeeten Instituut
- Academisch Ziekenhuis Utrecht
- Instituto Portugues de Oncologia de Francisco Gentil
- University Hospital of Linkoping
- Umea Universitet
- Centre Hospitalier Universitaire Vaudois
- Nottingham General Hospital
- Nottingham City Hospital NHS Trust
- Queen's Medical Centre
- Royal South Hants Hospital
- Southampton General Hospital
- Royal Marsden Hospital