Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma
Brain and Central Nervous System Tumors
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring recurrent adult brain tumor, adult glioblastoma, adult anaplastic astrocytoma, adult giant cell glioblastoma, adult gliosarcoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed newly diagnosed unresectable glioblastoma multiforme (GBM), recurrent GBM, or recurrent anaplastic astrocytoma (AA) MRI scan documenting gadolinium enhanced tumor volume of at least 5 cm3, but no greater than 60 cm^3 Recurrent GBM and AA must be documented by MRI after the most recent treatment and before any planned surgical debulking At least 5 days since prior surgical debulking No planned resection of newly diagnosed GBM before or during study No bilateral noncontiguous gadolinium enhancing tumors No satellite lesions greater than 1.5 cm from anticipated location of interstitial catheter tip No more than 2 satellite lesions PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 60-100% Life expectancy: Not specified Hematopoietic: Platelet count at least 100,000/mm^3 Absolute neutrophil count at least 1,500/mm^3 WBC at least 3,000/mm^3 Hepatic: Hepatitis B surface antigen negative Bilirubin no greater than 2.5 times upper limit of normal (ULN) SGOT and SGPT no greater than 3 times ULN Alkaline phosphatase no greater than 3 times ULN Lactic dehydrogenase no greater than 3 times ULN Prothrombin time no greater than 1.5 times ULN Renal: Creatinine clearance at least 50 mL/min Cardiovascular: No significant unstable cardiovascular disease No New York Heart Association class III/IV heart disease No evidence of myocardial infarction within the past 3 months Other: Not pregnant Negative pregnancy test Fertile patients must use effective contraception Human antichimeric antibody (HACA) titer no greater than 48 ng/mL No anatomical or physiological considerations that would preclude study participation No active autoimmune disease, active infection, or traumatic injury requiring treatment HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 4 weeks since prior intravenous chemotherapy or Gliadel wafers Endocrine therapy: Not specified Radiotherapy: At least 8 weeks since prior external beam or gamma knife radiotherapy Surgery: See Disease Characteristics Other: At least 30 days since prior investigational treatment
Sites / Locations
- Carolina Neurosurgery and Spine Associates
- Temple University
- Medical University of South Carolina
- Huntsman Cancer Institute