Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery
Brain and Central Nervous System Tumors
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring adult grade I meningioma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed newly diagnosed benign intracranial meningioma WHO grade I Any location except orbital meningioma Mitotic index < 4 (total counts per 10 high-power field) AND MIB-1 labeling index < 4% The following histologies are not allowed (i.e., WHO grade II or III): Atypical Clear cell Choroid Rhabdoid Papillary Anaplastic Must have undergone non-radical resection* within the past 7 months Post-operative MRI (performed 4 months after surgery) demonstrating stages 3, 4, or 5 NOTE: *Biopsy only is considered non-radical resection and may be classified as stage 4 or 5 according to tumor volume No brain invasion No hemangiopericytoma No fibrous dysplasia or intra-osseous meningioma No multiple meningiomas or meningiomatosis Not part of neurofibromatosis type II PATIENT CHARACTERISTICS: Age 18 and over Performance status WHO 0-2 Life expectancy Not specified Hematopoietic Not specified Hepatic Not specified Renal Not specified Cardiovascular No serious congestive heart failure Other HIV negative No other malignancy except basal cell skin cancer or carcinoma in situ of the cervix No other disease that would preclude 5-year follow up after study completion No psychological, familial, sociological, or geographical condition that would preclude study compliance or study follow up PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy Not specified Endocrine therapy Not specified Radiotherapy No prior radiotherapy to the meninges or brain that would preclude study treatment Surgery See Disease Characteristics Other No prior randomization to this study
Sites / Locations
- University Hospital Schleswig-Holstein - Kiel Campus
- Radiotherapeutisch Instituut-(Riso)
- University Medical Center Rotterdam at Erasmus Medical Center
- Hopital Cantonal Universitaire de Geneve