Back to resultsRandomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (REMAP-CAP)
Primary Purpose
Community-acquired Pneumonia, Influenza, COVID-19
Status
Recruiting
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Ceftriaxone
Moxifloxacin or Levofloxacin
Piperacillin-tazobactam
Ceftaroline
Amoxicillin-clavulanate
Standard course macrolide
Extended course macrolide
No systemic corticosteroid
Fixed-duration Hydrocortisone
Shock-dependent hydrocortisone
Fixed-duration higher dose Hydrocortisone
No antiviral agent for influenza
Five-days oseltamivir
Ten-days oseltamivir
No antiviral agent for COVID-19
Lopinavir / Ritonavir
Hydroxychloroquine
Hydroxychloroquine + lopinavir/ritonavir
Ivermectin
No immune modulation for COVID-19
Interferon beta-1a
Anakinra
Tocilizumab
Sarilumab
Local standard venous thromboprophylaxis
Therapeutic dose anticoagulation
Conventional low dose thromboprophylaxis
Intermediate dose thromboprophylaxis
Continuation of therapeutic dose anticoagulation
No immunoglobulin
Convalescent plasma
Delayed administration of convalescent plasma
No vitamin C
Vitamin C
No antiplatelet
Aspirin
P2Y12 inhibitor
No simvastatin
Simvastatin
Placebo
Eritoran
Apremilast
Clinician-preferred mechanical ventilation strategy
Protocolised mechanical ventilation strategy
No renin-angiotensin system inhibitor
Angiotensin converting enzyme inhibitor
Angiotensin Receptor Blockers
ARB + DMX-200
No cysteamine
Cysteamine
Fixed-duration dexamethasone
Baloxavir Marboxil
Five-days oseltamivir + baloxavir marboxil
Ten-days oseltamivir + baloxavir marboxil
No endothelial modulator
Imatinib
Sponsored by
About this trial
This is an interventional treatment trial for Community-acquired Pneumonia, Influenza, COVID-19 focused on measuring Pneumonia, Lung Diseases, Respiratory Tract Diseases, Respiratory Tract Infections, Anti-Bacterial Agents, Moxifloxacin, Levofloxacin, Antibiotics, Hydrocortisone, Anti-Infective Agents, Ceftriaxone, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Oseltamivir, COVID-19, Influenza, Intensive care, Critical care, SARS-CoV-2, Vitamin C, Therapeutic Anticoagulation, Statin, Invasive Mechanical Ventilation, Convalescent plasma, Eritoran, Apremilast, DMX-200, Ivermectin
Eligibility Criteria
REMAP-CAP PLATFORM INCLUSION CRITERIA:
Adult patient admitted to an ICU for severe CAP within 48 hours of hospital admission with:
- symptoms or signs or both that are consistent with lower respiratory tract infection AND
- Radiological evidence of new onset consolidation (in patients with pre-existing radiological changes, evidence of new infiltrate)
Up to 48 hours after ICU admission, receiving organ support with one or more of:
- Non-invasive or Invasive ventilatory support;
- Receiving infusion of vasopressor or inotropes or both
PLATFORM EXCLUSION CRITERIA:
Healthcare-associated pneumonia:
- Prior to this illness, is known to have been an inpatient in any healthcare facility within the last 30 days
- Resident of a nursing home or long term care facility
- Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
- Previous participation in this REMAP within the last 90 days
REMAP-COVID PLATFORM INCLUSION CRITERIA
1. Adult patients (≥ 18 years) admitted to hospital with acute illness due to suspected or proven pandemic infection.
REMAP-COVID PLATFORM EXCLUSION CRITERIA
- Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
- Patient is expected to be discharged from hospital today or tomorrow
- More than 14 days have elapsed while admitted to hospital with symptoms of an acute illness due to suspected or proven pandemic infection.
- Previous participation in this REMAP within the last 90 days
DOMAIN-SPECIFIC ELIGIBLE CRITERIA:
Each domain may have additional eligibility criteria. Refer to the study website for more information (www.remapcap.org).
Sites / Locations
- University of FloridaRecruiting
- Augusta University
- University of Illinois HealthRecruiting
- Tulane Medical Center
- University of MichiganRecruiting
- Memorial Sloan Kettering Cancer CenterRecruiting
- Wake Forest Baptist Health
- The Ohio State University Wexner Medical CenterRecruiting
- Oregon Health and Science UniversityRecruiting
- University of Pittsburgh Medical CentreRecruiting
- Brown University - Rhode Island Hospital
- Canberra HospitalRecruiting
- Bankstown-Lidcombe HospitalRecruiting
- Blacktown HospitalRecruiting
- Campbelltown HospitalRecruiting
- Sutherland HospitalRecruiting
- Concord HospitalRecruiting
- Dubbo Base HospitalRecruiting
- Northern Beaches HospitalRecruiting
- Nepean HospitalRecruiting
- St. George HospitalRecruiting
- Liverpool HospitalRecruiting
- John Hunter HospitalRecruiting
- Orange Health Service
- St Vincent's Hospital SydneyRecruiting
- Prince of Wales HospitalRecruiting
- Royal Prince Alfred Hospital
- Royal North Shore HospitalRecruiting
- Wollongong HospitalRecruiting
- Wagga Wagga Base Hospital
- Westmead HospitalRecruiting
- Royal Darwin Hospital,
- Sunshine Coast University Hospital
- The Prince Charles HospitalRecruiting
- Mater Hospital BrisbaneRecruiting
- Princess Alexandra HospitalRecruiting
- Caboolture HospitalRecruiting
- Queen Elizabeth II Jubilee HospitalRecruiting
- Logan Hospital
- Redcliffe Hospital
- Rockhampton Hospital
- Gold Coast University HospitalRecruiting
- Toowoomba HospitalRecruiting
- Townsville HospitalRecruiting
- Royal Adelaide HospitalRecruiting
- The Queen Elizabeth HospitalRecruiting
- Lyell McEwin HospitalRecruiting
- Flinders Medical CentreRecruiting
- Launceston HospitalRecruiting
- Ballarat Base HospitalRecruiting
- Bendigo HospitalRecruiting
- Casey HospitalRecruiting
- Box Hill HospitalRecruiting
- Monash Medical CentreRecruiting
- Dandenong HospitalRecruiting
- Angliss Hospital
- Footscray HospitalRecruiting
- University Hosptial GeelongRecruiting
- The Alfred HospitalRecruiting
- Royal Melbourne HospitalRecruiting
- St Vincent's Hospital MelbourneRecruiting
- Maroondah HospitalRecruiting
- Sunshine HospitalRecruiting
- Werribee Mercy HospitalRecruiting
- St John of God Hospital MidlandRecruiting
- St John of God Hospital Murdoch
- Royal Perth HospitalRecruiting
- Sir Charles Gairdner HospitalRecruiting
- Fiona Stanley HospitalRecruiting
- St John of God SubiacoRecruiting
- AZ Sint-Jan
- CHU de Charleroi - Hôpital Civil Marie Curie
- Universitair Ziekenhuis Antwerp
- Universitair Ziekenhuis GentRecruiting
- Foothills Medical Centre
- Peter Lougheed Centre
- Rockyview General Hospital
- South Health Campus
- Royal Alexandra Hospital, AlbertaRecruiting
- University of Alberta HospitalRecruiting
- Surrey Memorial Hospital
- St Boniface General HospitalRecruiting
- Health Sciences Centre WinnipegRecruiting
- Grace HospitalRecruiting
- Dr. Everett Chalmers Regional Hospital
- The Moncton Hospital
- The Saint John General Hospital
- William Osler Health SystemRecruiting
- Brantford General HospitalRecruiting
- Hamilton general HospitalRecruiting
- Juravinski HospitalRecruiting
- St. Joseph's Healthcare HamiltonRecruiting
- Kingston Health Sciences Centre
- Grand River HospitalRecruiting
- St Mary's General HospitalRecruiting
- The Ottawa HospitalRecruiting
- Niagara HealthRecruiting
- Thunder Bay General Hospital
- Sunnybrook Health Sciences CentreRecruiting
- St. Michael's Hospital Unity Health TorontoRecruiting
- Mount Sinai HospitalRecruiting
- Toronto General HospitalRecruiting
- Toronto Western HospitalRecruiting
- St Joseph's Health Centre
- CIUSS Chaudieres-Appalaches (Levis)
- Hospital Maisonneuve-Rosemont
- Hôpital Fleury
- Centre Hospitalier de l'Universite de MontrealRecruiting
- McGill University Health CentreRecruiting
- Hopital du Sacre-Coeur de MontrealRecruiting
- CHU de Québec - Université LavalRecruiting
- IUCPQ-ULRecruiting
- Centre Hospitalier de l'Université de SherbrookeRecruiting
- Regina General HospitalRecruiting
- Universidad de La SabanaRecruiting
- General County Hospital PožegaRecruiting
- University Hospital Centre ZagrebRecruiting
- University Hospital for Infectious DiseasesRecruiting
- Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie
- Charité - Universitätsmedizin Berlin - Nephrologie
- Vivantes Klinikum Neukölln
- Universitätsklinikum Köln
- Universitätsklinikum Frankfurt
- University Medical Center Hamburg-Eppendorf (UKE)
- Medizinische Hochschule Hannover
- Universitätsklinikum JenaRecruiting
- Universitätsklinikum LeipzigRecruiting
- Universitäts Klinikum Tübingen
- Universitätsklinikum Würzburg
- Jósa András County HospitalRecruiting
- Csolnoky Ferenc Kórház - Veszprem County Hospital
- Almási Balogh Pál KórházRecruiting
- Apollo Main Hospital
- Apollo First Med HospitalRecruiting
- Apollo Vanagaram Hospital
- Apollo Speciality Hospital - OMRRecruiting
- Beaumont Hospital
- St. Vincent's University HospitalRecruiting
- University Hospital GalwayRecruiting
- St Marianna University School of MedicineRecruiting
- Yokohama City University HospitalRecruiting
- St. Marianna University Yokohama City Seibu HospitalRecruiting
- Saiseikai Kumamoto HospitalRecruiting
- Osaka City General HospitalRecruiting
- Nerima Hikarigaoka HospitalRecruiting
- Tokyo Metropolitan Bokutoh HospitalRecruiting
- Itabashi Chuo Medical CenterRecruiting
- Tokyo bay Urayasu-Ichikawa Medical CenterRecruiting
- Wakayama Medical UniversityRecruiting
- Chitwan Medical CollegeRecruiting
- Grande International HospitalRecruiting
- Hospital for Advanced Medicine and Surgery (HAMS)Recruiting
- Nepal MedicitiRecruiting
- Meander Medisch CentrumRecruiting
- Jeroen Bosch ZiekenhuisRecruiting
- Martini Hospital Groningen
- University Medical Center Groningen
- Leiden University Medical CenterRecruiting
- Canisius Wilhelmina ZiekenhuisRecruiting
- Radboud University Medical Center
- University Medical Center UtrechtRecruiting
- North Shore HospitalRecruiting
- CVICU, Auckland City HospitalRecruiting
- DCCM, Auckland City HospitalRecruiting
- Middlemore HospitalRecruiting
- Christchurch HospitalRecruiting
- Waikato HospitalRecruiting
- Taranaki Base HospitalRecruiting
- Rotorua HospitalRecruiting
- Tauranga HospitalRecruiting
- Wellington Regional HospitalRecruiting
- Whangarei HospitalRecruiting
- Ziauddin University Hospital Clifton CampusRecruiting
- Abbasi Shaheed HospitalRecruiting
- National Institute of Cardiovascular Diseases, KarachiRecruiting
- South City Hospital, KarachiRecruiting
- Ziauddin University North Nazimabad CampusRecruiting
- Centro Hospitalar do Medio TejoRecruiting
- Hospital Lusíadas Lisbon
- Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes"Recruiting
- King Abdulaziz Medical CityRecruiting
- Institut Hospital del Mar d'Investigacions Mèdiques
- Hospital Universitario Reina SofiaRecruiting
- Basildon HospitalRecruiting
- Basingstoke and North Hampshire Hospital
- Royal United Hospital, BathRecruiting
- Queen Elizabeth Hospital BirminghamRecruiting
- Birmingham City HospitalRecruiting
- Blackburn HospitalRecruiting
- Pilgrim's HospitalRecruiting
- Royal Bournemouth HospitalRecruiting
- Royal Sussex County HospitalRecruiting
- Southmead HospitalRecruiting
- Bristol Royal HospitalRecruiting
- Queen's Hospital, BurtonRecruiting
- Royal Papworth HospitalRecruiting
- Addenbrookes HospitalRecruiting
- Cumberland Royal InfirmaryRecruiting
- Ashford & St Peters Hospital Trust
- Chesterfield Royal HospitalRecruiting
- Countess of Chester HospitalRecruiting
- Colchester HospitalRecruiting
- University Hospital CoventryRecruiting
- North Manchester General HospitalRecruiting
- Darlington Memorial HospitalRecruiting
- Darent Valley HospitalRecruiting
- Russells Hall HospitalRecruiting
- University Hospital of North DurhamRecruiting
- Royal Devon and Exeter HospitalRecruiting
- Frimley Park HospitalRecruiting
- Queen Elizabeth HospitalRecruiting
- Medway Maritime HospitalRecruiting
- James Paget Kings Lynn HospitalRecruiting
- Royal Surrey County HospitalRecruiting
- Northwick Park HospitalRecruiting
- Hereford County HospitalRecruiting
- Barnet HospitalRecruiting
- Huddersfield Hospital
- King George HospitalRecruiting
- Ipswich HospitalRecruiting
- Kettering HospitalRecruiting
- Leeds Teaching Hospitals NHS TrustRecruiting
- Leicester Royal InfirmaryRecruiting
- Glenfield HospitalRecruiting
- Lincoln County HospitalRecruiting
- Liverpool Heart and Chest HospitalRecruiting
- Alder Hey HospitalRecruiting
- Royal Liverpool HospitalRecruiting
- University Hospital AintreeRecruiting
- Croydon University HospitalRecruiting
- Royal London HospitalRecruiting
- Whipps Cross HospitalRecruiting
- Newham HospitalRecruiting
- St Barts HosptialRecruiting
- North Middlesex HospitalRecruiting
- Royal Free HospitalRecruiting
- St Thomas' HospitalRecruiting
- Guy's HospitalRecruiting
- King's College HospitalRecruiting
- St George's HospitalRecruiting
- Royal Marsden HospitalRecruiting
- Ryal BromptonRecruiting
- Hammersmith HospitalRecruiting
- St Mary's HospitalRecruiting
- Charing Cross HospitalRecruiting
- Luton and Dunstable University Hospital
- Maidstone Hospital - Maidstone and Tunbridge Wells NHS TrustRecruiting
- Manchester Royal InfirmaryRecruiting
- The Christie HospitalRecruiting
- Wythenshawe HospitalRecruiting
- Queen Elizabeth Hospital, WoolwichRecruiting
- The James Cook University HospitalRecruiting
- Milton Keynes University HospitalRecruiting
- Royal Victoria Infirmary, NewcastleRecruiting
- Newcastle Freeman HospitalRecruiting
- Northampton General HospitalRecruiting
- Norfolk and Norwich University HospitalRecruiting
- City Hospital NottinghamRecruiting
- Queen's Medical Centre - Nottingham University Hospitals NHS TrustRecruiting
- George Eliot HospitalRecruiting
- Royal Oldham HospitalRecruiting
- Princess Royal University HospitalRecruiting
- John Radcliffe HospitalRecruiting
- Derriford HospitalRecruiting
- Poole Hospital NHS Foundation TrustRecruiting
- Queen Alexandra Hospital - Portsmouth Hospitals NHS TrustRecruiting
- Whiston Hospital
- Royal Preston HospitalRecruiting
- Royal Berkshire HospitalRecruiting
- Alexandra Hospital, RedditchRecruiting
- Queen's Hospital RomfordRecruiting
- Rotherham General HospitalRecruiting
- Salford Royal HospitalRecruiting
- Salisbury District HospitalRecruiting
- Royal Hallamshire HospitalRecruiting
- Northern General HospitalRecruiting
- Wexham Park HospitalRecruiting
- South Tyneside District HospitalRecruiting
- Southampton General HospitalRecruiting
- Stepping Hill HospitalRecruiting
- University Hospital of North TeesRecruiting
- Royal Stoke University HospitalRecruiting
- Sunderland HospitalRecruiting
- King's Mill HospitalRecruiting
- Great Western HospitalRecruiting
- Western General HospitalRecruiting
- Musgrove Park HospitalRecruiting
- Torbay and South Devon HospitalRecruiting
- Royal Cornwall HospitalRecruiting
- Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS TrustRecruiting
- Harefield Hospital
- Watford General HospitalRecruiting
- Southend University HospitalRecruiting
- West Cumberland HospitalRecruiting
- Royal Albert Edward InfirmaryRecruiting
- Royal Hampshire HospitalRecruiting
- Arrow Park HospitalRecruiting
- New Cross HospitalRecruiting
- Worcester Royal HospitalRecruiting
- York HospitalRecruiting
- York HospitalRecruiting
- Antrim Area HospitalRecruiting
- Royal Victoria Hospital, BelfastRecruiting
- Mater HospitalRecruiting
- Belfast City HospitalRecruiting
- Altnagelvin HospitalRecruiting
- Aberdeen Royal InfirmaryRecruiting
- Ninewells HospitalRecruiting
- Royal Infirmary of EdinburghRecruiting
- Glasgow Royal InfirmaryRecruiting
- Queen Elizabeth University Hospital, GlasgowRecruiting
- Royal Alexandra Hospital, GlasgowRecruiting
- Neville Hall Hospital
- Glan Clywd HospitalRecruiting
- Princess of Wales HospitalRecruiting
- University Hospital of WalesRecruiting
- Glangwilli HospitalRecruiting
- Grange University HospitalRecruiting
- Royal Gwent Hospital
- Royal Glamorgan HospitalRecruiting
- Morriston HospitalRecruiting
- Wrexham Maelor HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Arm 11
Arm 12
Arm 13
Arm 14
Arm 15
Arm 16
Arm Type
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
Other
Arm Label
Antibiotic Domain
Macrolide Duration Domain
Corticosteroid Domain
Influenza Antiviral Domain
COVID-19 Antiviral Domain
COVID-19 Immune Modulation Domain
Anticoagulation Domain
Immunoglobulin Domain
Vitamin C Domain
Simvastatin Domain
Antiplatelet Domain
Mechanical Ventilation Domain
COVID-19 Immune Modulation (2) Domain
ACE2 RAS Domain
Cysteamine Domain
Endothelial Domain
Arm Description
Patients with community-acquired pneumonia admitted to participating intensive care units and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions. Note: the ceftaroline + macrolide intervention has been closed to recruitment.
Patients with community-acquired pneumonia admitted to participating intensive care units who have been allocated to a beta-lactam antibiotic intervention in the Antibiotic Domain will be randomised to either a standard course or extended course of macrolide therapy
Patients with community acquired pneumonia (CAP) admitted to participating intensive care units will be randomised to a steroid use strategy. Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19.
Patients with community-acquired pneumonia admitted to participating intensive care units with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin. Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control. This domain is now closed.
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions. Note: this domain is now closed.
Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy. Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation.
Immunosuppressed patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive no immunoglobulin for COVID-19, or to receive high-titre convalescent plasma. Note: an earlier version of this domain was not restricted to immunosuppressed patients.
Patients admitted to participating hospitals with community-acquired pneumonia will be randomised to receive no vitamin C, or vitamin C. Note: this domain is now closed.
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no simvastatin, or simvastatin. Note: this domain is now closed.
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no antiplatelet, aspirin, or site-preferred P2Y12 inhibitor.
Patients with community-acquired pneumonia admitted to participating intensive care units who are intubated and receiving invasive mechanical ventilation will be randomised to protocolised mechanical ventilation strategy, or clinician-preferred mechanical ventilation strategy
Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive one of three interventions. Note: this domain is now closed.
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies. Note: this domain is now closed.
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no cysteamine, or cysteamine.
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no endothelial modulator or enteral imatinib.
Outcomes
Primary Outcome Measures
All-cause mortality
Days alive and not receiving organ support in ICU
Primary end-point for patients with suspected or proven COVID-19 pandemic infection
Secondary Outcome Measures
ICU Mortality
ICU length of stay
Hospital length of stay
Ventilator free days
Organ failure free days
All-cause mortality
Health-related Quality of life assessment
EQ5D-5L and WHODAS 2.0 (not completed in all regions)
Proportion of intubated patients who receive a tracheostomy
Destination at time of hospital discharge
Characterised as home, rehabilitation hospital, nursing home or long-term care facility, or another acute hospital
Readmission to the index ICU during the index hospitalization
World Health Organisation 8-point ordinal scale outcome
Full Information
NCT ID
NCT02735707
First Posted
December 11, 2015
Last Updated
June 1, 2023
Sponsor
UMC Utrecht
Collaborators
Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, National Intensive Care Surveillance MORU
1. Study Identification
Unique Protocol Identification Number
NCT02735707
Brief Title
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Acronym
REMAP-CAP
Official Title
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Study Type
Interventional
2. Study Status
Record Verification Date
June 2023
Overall Recruitment Status
Recruiting
Study Start Date
April 11, 2016 (Actual)
Primary Completion Date
February 2026 (Anticipated)
Study Completion Date
February 2028 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
UMC Utrecht
Collaborators
Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, National Intensive Care Surveillance MORU
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia.
The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia.
In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19.
REMAP-COVID is a sub-platform of REMAP-CAP that evaluates treatments specific to COVID-19 in the United States of America.
Detailed Description
Community-acquired pneumonia (CAP) that is of sufficient severity to require admission to an intensive care unit (ICU) is associated with substantial mortality.
Patients with pneumonia who are being treated in an ICU will receive therapy that consists of many different treatments, as many as 20 or 30. These treatments act together to treat both the infection and its effects on the body. When treating a patient, doctors choose from many different treatments, most of which are known or believed to be safe and effective. However, doctors don't always know which treatment option is the better one, as individuals or groups of individuals may respond differently. This study aims to help doctors understand which treatments work best.
This clinical study has been designed in a way that allows the information from patients already in the study to help new patients joining the study. Most studies aren't able to do that. REMAP-CAP has been designed to:
Evaluate multiple treatment strategies, at the same time, in the same patient.
Reach platform conclusions when sufficient data is accrued, rather than when a pre-specified sample size is reached
Utilise data that is already accrued to increase the likelihood that patients within the trial are randomised to treatments that are more likely to be beneficial
New questions can be substituted into the trial as initial questions are answered, meaning that the trial can be perpetual or open-ended
Interactions between interventions in different domains can be evaluated
It is reasonable to presume that any pandemic respiratory infection of major significance to public health will manifest as life-threatening respiratory infection including Severe Acute Respiratory illness and severe Community Acquired Pneumonia (CAP) with concomitant admission to hospital, and for some patients, admission to an Intensive Care Unit (ICU). Previous pandemics and more localized outbreaks of respiratory emerging infections have resulted in severe CAP and ICU admission.
Previous pandemics and outbreaks of emerging infectious diseases have outlined the urgent need for evidence, preferably from Randomized Controlled Trials (RCTs), to guide best treatment. However, there are substantial challenges associated with being able to organize such trials when the time of onset of a pandemic and its exact nature are unpredictable. As an adaptive platform trial that enrolls patients during the interpandemic period, REMAP-CAP is ideally positioned to adapt, in the event of a respiratory pandemic, to evaluate existing treatments as well as novel approaches.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Community-acquired Pneumonia, Influenza, COVID-19
Keywords
Pneumonia, Lung Diseases, Respiratory Tract Diseases, Respiratory Tract Infections, Anti-Bacterial Agents, Moxifloxacin, Levofloxacin, Antibiotics, Hydrocortisone, Anti-Infective Agents, Ceftriaxone, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Oseltamivir, COVID-19, Influenza, Intensive care, Critical care, SARS-CoV-2, Vitamin C, Therapeutic Anticoagulation, Statin, Invasive Mechanical Ventilation, Convalescent plasma, Eritoran, Apremilast, DMX-200, Ivermectin
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Factorial Assignment
Model Description
Adaptive Bayesian Platform Trial evaluating multiple interventions in multiple domains
Masking
None (Open Label)
Allocation
Randomized
Enrollment
10000 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Antibiotic Domain
Arm Type
Other
Arm Description
Patients with community-acquired pneumonia admitted to participating intensive care units and requiring empiric antibiotic therapy will be randomised one of five antibiotic interventions.
Note: the ceftaroline + macrolide intervention has been closed to recruitment.
Arm Title
Macrolide Duration Domain
Arm Type
Other
Arm Description
Patients with community-acquired pneumonia admitted to participating intensive care units who have been allocated to a beta-lactam antibiotic intervention in the Antibiotic Domain will be randomised to either a standard course or extended course of macrolide therapy
Arm Title
Corticosteroid Domain
Arm Type
Other
Arm Description
Patients with community acquired pneumonia (CAP) admitted to participating intensive care units will be randomised to a steroid use strategy.
Note: this domain is now closed to patients with suspected or proven COVID-19. It remains open to patients with CAP without COVID-19.
Arm Title
Influenza Antiviral Domain
Arm Type
Other
Arm Description
Patients with community-acquired pneumonia admitted to participating intensive care units with microbiological testing confirmed influenza infection will be randomised to one of six interventions.
Arm Title
COVID-19 Antiviral Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to no ivermectin or ivermectin.
Note: an earlier version of this domain evaluated lopinavir-ritonavir, hydroxychloroquine, and combination lopinavir-ritonavir and hydroxychloroquine against a 'no antiviral' control.
This domain is now closed.
Arm Title
COVID-19 Immune Modulation Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five interventions.
Note: this domain is now closed.
Arm Title
Anticoagulation Domain
Arm Type
Other
Arm Description
Patients admitted to participating intensive care units with suspected or microbiological testing confirmed COVID-19 will be randomised to an anticoagulation strategy.
Note: A previous version of this domain evaluated local standard venous thromboprophylaxis against therapeutic dose anticoagulation.
Arm Title
Immunoglobulin Domain
Arm Type
Other
Arm Description
Immunosuppressed patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive no immunoglobulin for COVID-19, or to receive high-titre convalescent plasma.
Note: an earlier version of this domain was not restricted to immunosuppressed patients.
Arm Title
Vitamin C Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with community-acquired pneumonia will be randomised to receive no vitamin C, or vitamin C.
Note: this domain is now closed.
Arm Title
Simvastatin Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no simvastatin, or simvastatin.
Note: this domain is now closed.
Arm Title
Antiplatelet Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to receive no antiplatelet, aspirin, or site-preferred P2Y12 inhibitor.
Arm Title
Mechanical Ventilation Domain
Arm Type
Other
Arm Description
Patients with community-acquired pneumonia admitted to participating intensive care units who are intubated and receiving invasive mechanical ventilation will be randomised to protocolised mechanical ventilation strategy, or clinician-preferred mechanical ventilation strategy
Arm Title
COVID-19 Immune Modulation (2) Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with microbiological testing confirmed COVID-19 will be randomised to receive one of three interventions.
Note: this domain is now closed.
Arm Title
ACE2 RAS Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with suspected or microbiological testing confirmed COVID-19 will be randomised to one of up to five renin-angiotensin system blockade strategies.
Note: this domain is now closed.
Arm Title
Cysteamine Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no cysteamine, or cysteamine.
Arm Title
Endothelial Domain
Arm Type
Other
Arm Description
Patients admitted to participating hospitals with severe community-acquired pneumonia, including patients with suspected or proven influenza or COVID-19, will be randomised to receive no endothelial modulator or enteral imatinib.
Intervention Type
Drug
Intervention Name(s)
Ceftriaxone
Intervention Description
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Intervention Type
Drug
Intervention Name(s)
Moxifloxacin or Levofloxacin
Intervention Description
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Intervention Type
Drug
Intervention Name(s)
Piperacillin-tazobactam
Intervention Description
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Intervention Type
Drug
Intervention Name(s)
Ceftaroline
Intervention Description
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Intervention Type
Drug
Intervention Name(s)
Amoxicillin-clavulanate
Intervention Description
The duration and dose of empiric antibiotics will be determined by the treating clinician and local guidelines or practice.
Intervention Type
Drug
Intervention Name(s)
Standard course macrolide
Intervention Description
Standard course of macrolide therapy, discontinued between study day 3 and the end of study day 5.
The dosing of and route of administration is not protocolised, the following guidance is provided:
Initial IV administration of a macrolide is strongly preferred
The preferred IV macrolide is azithromycin, but IV clarithromycin may be substituted.
The preferred enteral macrolide is azithromycin, but enteral clarithromycin or roxithromycin may be substituted.
Intervention Type
Drug
Intervention Name(s)
Extended course macrolide
Intervention Description
Extended course of macrolide therapy discontinued at the end of study day 14 or hospital discharge (whichever occurs first).
The dosing of and route of administration is not protocolised, the following guidance is provided:
Initial IV administration of a macrolide is strongly preferred
The preferred IV macrolide is azithromycin, but IV clarithromycin may be substituted.
The preferred enteral macrolide is azithromycin, but enteral clarithromycin or roxithromycin may be substituted.
Intervention Type
Other
Intervention Name(s)
No systemic corticosteroid
Intervention Description
Patients are not to receive any systemic corticosteroids, including hydrocortisone, to study day 28 or hospital discharge (whichever occurs first).
Intervention Type
Drug
Intervention Name(s)
Fixed-duration Hydrocortisone
Intervention Description
50mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days.
Intervention Type
Drug
Intervention Name(s)
Shock-dependent hydrocortisone
Intervention Description
50mg IV hydrocortisone every 6 hours while the patient is in septic shock
Intervention Type
Drug
Intervention Name(s)
Fixed-duration higher dose Hydrocortisone
Intervention Description
100mg of intravenous hydrocortisone will be administered every 6 hours for up to 7 days.
Note: this intervention was only available to patients with suspected or proven COVID-19 and is now closed.
Intervention Type
Other
Intervention Name(s)
No antiviral agent for influenza
Intervention Description
No antiviral agent intended to be active against influenza infection is to be administered
Intervention Type
Drug
Intervention Name(s)
Five-days oseltamivir
Intervention Description
Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first)
Intervention Type
Drug
Intervention Name(s)
Ten-days oseltamivir
Intervention Description
Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first)
Intervention Type
Other
Intervention Name(s)
No antiviral agent for COVID-19
Intervention Description
No antiviral agent intended to be active against SARS-CoV-2 infection is to be administered
Intervention Type
Drug
Intervention Name(s)
Lopinavir / Ritonavir
Intervention Description
Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Hydroxychloroquine
Intervention Description
Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first).
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Hydroxychloroquine + lopinavir/ritonavir
Intervention Description
Lopinavir/ritonavir 400/100mg administered enterally, or 5ml 80/20mg per mL solution suspension via gastric tube, every 12 hours. Administered for a minimum of 5 days, including if discharged from ICU prior to end of study day 5. For patients discharged from ICU between study day 6 and study day 14, lopinavir/ritonavir is ceased at ICU discharge. Lopinavir/ritonavir is ceased at the end of study day 14 if the patient remains in ICU.
Loading dose of 800mg hydroxychloroquine administered enterally every 6 hours until 2 doses have been administered. Subsequently, 400mg hydroxychloroquine will be administered enterally every 12 hours for 12 doses or ICU discharge (whichever occurs first).
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Ivermectin
Intervention Description
Ivermectin administered enterally at a dose of 0.2 mg/kg once daily with a maximum daily dose of 24mg/day.
Intervention Type
Other
Intervention Name(s)
No immune modulation for COVID-19
Intervention Description
No immune modulating agent intended to be active against COVID-19 is to be administered.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Interferon beta-1a
Other Intervention Name(s)
IFN-β1a
Intervention Description
IFN-β1a 10 μg will be administered as an intravenous bolus injection via a central or peripheral line. IFN-β1a will be administered once daily for 6 days or until ICU discharge, whichever occurs first.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Anakinra
Intervention Description
A loading dose of 300mg anakinra will be administered as a bolus via central or peripheral line. This is followed by maintenance doses of 100mg of anakinra administered every 6 hours.
In patients with renal impairment, anakinra will be administered on alternate days.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Tocilizumab
Intervention Description
Tocilizumab will be administered as a single dose of 8mg/kg estimated or measured body weight, with a maximum total dose of 800mg.
Note: this intervention is now closed.
Tocilizumab will be administered as an IV infusion via central or peripheral line over a one-hour period.
Intervention Type
Drug
Intervention Name(s)
Sarilumab
Intervention Description
Sarilumab will be administered as a single dose of 400mg, via IV infusion through peripheral or central line over a one-hour period.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Local standard venous thromboprophylaxis
Intervention Description
Standard venous thromboprophylaxis that complies with local guidelines or usual practice will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Therapeutic dose anticoagulation
Intervention Description
Patients will be administered either low molecular weight heparin (LMWH) or unfractionated heparin (UFH) to achieve systemic anticoagulation. Either agent may be used and the same patient may be switched between UFH and LMWH at the discretion of the treating clinician.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Conventional low dose thromboprophylaxis
Intervention Description
Low dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain.
Intervention Type
Drug
Intervention Name(s)
Intermediate dose thromboprophylaxis
Intervention Description
Intermediate dose thromboprophylaxis will be administered for 14 days following randomisation or until hospital discharge, whichever occurs first. Dosing is outlined in the relevant protocol documents for this domain.
Intervention Type
Drug
Intervention Name(s)
Continuation of therapeutic dose anticoagulation
Intervention Description
Patients already receiving therapeutic dose anticoagulation at the time of randomisation to this intervention will be administered either unfractionated heparin by IV infusion or low-molecular weight heparin to achieve systemic anticoagulation according to local practice for acute VTE treatment for 14 days following randomisation or until hospital discharge, whichever occurs first.
Intervention Type
Other
Intervention Name(s)
No immunoglobulin
Intervention Description
No immunoglobulin intended to be active against SARS-CoV-2 infection is to be administered.
Note: this intervention is now closed.
Intervention Type
Biological
Intervention Name(s)
Convalescent plasma
Intervention Description
Patients will receive at least one and no more than two units of ABO compatible convalescent plasma within 48 hours of randomisation.
Note: this intervention is now closed.
Intervention Type
Biological
Intervention Name(s)
Delayed administration of convalescent plasma
Intervention Description
Note: this intervention is now closed.
Intervention Type
Other
Intervention Name(s)
No vitamin C
Intervention Description
No high dose intravenous vitamin C is to be administered
Intervention Type
Drug
Intervention Name(s)
Vitamin C
Intervention Description
Intravenous Vitamin C 50mg/kg administered every 6 hours for 16 doses
Intervention Type
Other
Intervention Name(s)
No antiplatelet
Intervention Description
No antiplatelet agent or NSAID to be administered.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
Aspirin
Other Intervention Name(s)
acetylsalicylic acid
Intervention Description
Aspirin administered at either 75mg or 100mg once per day for 14 days or until hospital discharge, whichever occurs first.
Note: this intervention is now closed.
Intervention Type
Drug
Intervention Name(s)
P2Y12 inhibitor
Other Intervention Name(s)
Clopidogrel, Prasugrel, Ticagrelor
Intervention Description
Site-selected P2Y12 inhibitor:
Clopidogrel: administered 75 mg once per day for 14 days or until hospital discharge, whichever occurs first.
Prasugrel: If patient is aged less than 75 years and measured or estimated weight if 60kg or more, and initial loading dose of prasugrel 60 mg will be administered, followed by maintenance dose of 10 mg per day.
Ticagrelor: administered enterally at 60mg twice daily for 14 days or until hospital discharge, whichever occurs first.
Note: this intervention is now closed.
Intervention Type
Other
Intervention Name(s)
No simvastatin
Intervention Description
No simvastatin intended to be active against COVID-19 is to be administered
Intervention Type
Drug
Intervention Name(s)
Simvastatin
Intervention Description
Simvastatin 80mg administered once daily via enteral route, while the patient remains in hospital up to 28 days after randomisation
Intervention Type
Other
Intervention Name(s)
Placebo
Intervention Type
Drug
Intervention Name(s)
Eritoran
Intervention Description
Eritoran initiated with a 26.24 mg loading dose (6.56 mg/h IV for 4 hours), followed by a second 13.12 mg loading dose (6.56 mg/h IV for 2 hours) at 12 hours after initiation. Patients will then receive twenty-six 6.56 mg maintenance doses (3.28 mg/h IV for 2 hours) every 12 hours thereafter (total of 14 days). Dosing will be stopped if the patient is discharged from hospital
Intervention Type
Drug
Intervention Name(s)
Apremilast
Intervention Description
Apremilast administered 30mg twice daily for 14 days or until hospital discharge, whichever occurs first.
Note: this intervention is now closed.
Intervention Type
Procedure
Intervention Name(s)
Clinician-preferred mechanical ventilation strategy
Intervention Description
Clinician-preferred ventilation strategy, including mode of ventilation and all ventilatory parameters
Intervention Type
Procedure
Intervention Name(s)
Protocolised mechanical ventilation strategy
Intervention Description
Invasive mechanical ventilation strategy delivered as outlined in relevant protocol documents for this domain.
Intervention Type
Other
Intervention Name(s)
No renin-angiotensin system inhibitor
Intervention Description
No RAS inhibitor (i.e. no ACEi or ARB) is to be administered up to the end of study day 10.
Intervention Type
Drug
Intervention Name(s)
Angiotensin converting enzyme inhibitor
Other Intervention Name(s)
Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril
Intervention Description
Site-preferred ACEi agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first.
Intervention Type
Drug
Intervention Name(s)
Angiotensin Receptor Blockers
Other Intervention Name(s)
Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan
Intervention Description
Site-preferred ARB agent administered as directed by the treating clinician for 10 days or until hospital discharge, whichever occurs first.
Intervention Type
Drug
Intervention Name(s)
ARB + DMX-200
Intervention Description
Site-preferred ARB agent administered in combination with DMX-200 for 10 days or until hospital discharge, whichever occurs first.
ARB administered as directed by the treating clinician. DMX-200 administered enterally at a dose of 120mg twice daily.
Intervention Type
Other
Intervention Name(s)
No cysteamine
Intervention Description
No cysteamine to be administered until the end of study day 10 or hospital discharge, whichever occurs first.
Intervention Type
Drug
Intervention Name(s)
Cysteamine
Intervention Description
Cysteamine administered every 8 hours at a dose of 5 mg/kg estimated or measured body weight (maximum dose of 500mg), for ten days or until ICU discharge, whichever occurs first.
Intervention Type
Drug
Intervention Name(s)
Fixed-duration dexamethasone
Intervention Description
6 mg of IV or enteral dexamethasone will be administered daily for up to 10 days while in hospital.
Intervention Type
Drug
Intervention Name(s)
Baloxavir Marboxil
Intervention Description
Baloxavir marboxil administered on days 1 and 4 post-randomisation.
Intervention Type
Drug
Intervention Name(s)
Five-days oseltamivir + baloxavir marboxil
Intervention Description
Oseltamivir administered enterally twice daily for 5 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation.
Intervention Type
Drug
Intervention Name(s)
Ten-days oseltamivir + baloxavir marboxil
Intervention Description
Oseltamivir administered enterally twice daily for 10 days or until hospital discharge (whichever occurs first), in addition to baloxavir marboxil administered on days 1 and 4 post-randomisation.
Intervention Type
Other
Intervention Name(s)
No endothelial modulator
Intervention Description
No endothelial modulator (imatinib or another tyrosine kinase inhibitor targeting the same pathway as imatinib) is to be administered.
Intervention Type
Drug
Intervention Name(s)
Imatinib
Intervention Description
Enteral imatinib will be administered as a single 800mg loading dose (study day 1) followed by 400mg daily until study day 14 or discharge.
Primary Outcome Measure Information:
Title
All-cause mortality
Time Frame
Day 90
Title
Days alive and not receiving organ support in ICU
Description
Primary end-point for patients with suspected or proven COVID-19 pandemic infection
Time Frame
Day 21
Secondary Outcome Measure Information:
Title
ICU Mortality
Time Frame
Day 90
Title
ICU length of stay
Time Frame
Day 90
Title
Hospital length of stay
Time Frame
Day 90
Title
Ventilator free days
Time Frame
Day 28
Title
Organ failure free days
Time Frame
Day 28
Title
All-cause mortality
Time Frame
6 months
Title
Health-related Quality of life assessment
Description
EQ5D-5L and WHODAS 2.0 (not completed in all regions)
Time Frame
6 months
Title
Proportion of intubated patients who receive a tracheostomy
Time Frame
Day 28
Title
Destination at time of hospital discharge
Description
Characterised as home, rehabilitation hospital, nursing home or long-term care facility, or another acute hospital
Time Frame
Free text Day 90
Title
Readmission to the index ICU during the index hospitalization
Time Frame
Day 90
Title
World Health Organisation 8-point ordinal scale outcome
Time Frame
Hospital discharge
Other Pre-specified Outcome Measures:
Title
Occurrence of multi-resistant organism colonisation/infection
Description
Antibiotic Domain specific outcome
Time Frame
Day 90, censored at hospital discharge
Title
Occurrence clostridium difficile
Description
Antibiotic Domain specific outcome
Time Frame
Day 90, censored at hospital discharge
Title
Occurrence of serious ventricular arrhythmia (including ventricular fibrillation) or sudden unexpected death
Description
Macrolide Duration Domain specific outcome.
Time Frame
Day 90, censored at hospital discharge
Title
Change from baseline influenza virus levels in upper and lower respiratory tract specimens
Description
Antiviral Domain specific outcome. Only required at selected sites.
Time Frame
Day 3, up to Day 7
Title
Confirmed deep vein thrombosis
Description
Domain-specific outcome for Anticoagulation, Immunoglobulin, and Antiplatelet Domains.
Time Frame
Between randomisation and hospital discharge
Title
Confirmed pulmonary embolism
Description
Domain-specific outcome for Anticoagulation, Immunoglobulin, and Antiplatelet Domains.
Time Frame
Between randomisation and hospital discharge
Title
Confirmed ischaemic cerebrovascular event
Description
Domain-specific outcome for Anticoagulation, Immunoglobulin, and Antiplatelet Domains.
Time Frame
Between randomisation and hospital discharge
Title
Total red blood cell units transfused
Description
Domain-specific outcome for Anticoagulation and Antiplatelet Domains.
Time Frame
Between randomisation and end of study day 15
Title
Confirmed acute myocardial infarction
Description
Domain-specific outcome for Anticoagulation, Immunoglobulin, and Antiplatelet Domains.
Time Frame
Between randomisation and hospital discharge
Title
Peak troponin
Description
Domain-specific outcome for Anticoagulation and Antiplatelet Domains.
Time Frame
Between randomisation and end of study day 15
Title
Major bleeding event
Description
Domain-specific outcome for Anticoagulation and Antiplatelet Domains.
Time Frame
Between randomisation and end of study day 15
Title
Other confirmed thrombotic event, including mesenteric ischaemia and limb ischaemia
Description
Domain-specific outcome for Anticoagulation, Immunoglobulin, and Antiplatelet Domains.
Time Frame
Between randomisation and hospital discharge
Title
Acute kidney injury (KDIGO stage >= 2 acute kidney injury)
Description
Domain-specific outcome for ACE2 RAS Domain
Time Frame
Between randomisation and 7 days
Title
Change from baseline to peak creatinine
Description
Domain-specific outcome for ACE2 RAS Domain
Time Frame
Between randomisation and 14 days
Title
Angioedema
Description
Domain-specific outcome for ACE2 RAS Domain
Time Frame
Between randomisation and end of study day 12
Title
Change from baseline AST, ALT and bilirubin
Description
Domain-specific outcome for ACE2 RAS Domain
Time Frame
Between randomisation and 14 days
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
REMAP-CAP PLATFORM INCLUSION CRITERIA:
Adult patient admitted to an ICU for severe CAP within 48 hours of hospital admission with:
symptoms or signs or both that are consistent with lower respiratory tract infection AND
Radiological evidence of new onset consolidation (in patients with pre-existing radiological changes, evidence of new infiltrate)
Up to 48 hours after ICU admission, receiving organ support with one or more of:
Non-invasive or Invasive ventilatory support;
Receiving infusion of vasopressor or inotropes or both
PLATFORM EXCLUSION CRITERIA:
Healthcare-associated pneumonia:
Prior to this illness, is known to have been an inpatient in any healthcare facility within the last 30 days
Resident of a nursing home or long term care facility
Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
Previous participation in this REMAP within the last 90 days
REMAP-COVID PLATFORM INCLUSION CRITERIA
1. Adult patients (≥ 18 years) admitted to hospital with acute illness due to suspected or proven pandemic infection.
REMAP-COVID PLATFORM EXCLUSION CRITERIA
Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
Patient is expected to be discharged from hospital today or tomorrow
More than 14 days have elapsed while admitted to hospital with symptoms of an acute illness due to suspected or proven pandemic infection.
Previous participation in this REMAP within the last 90 days
DOMAIN-SPECIFIC ELIGIBLE CRITERIA:
Each domain may have additional eligibility criteria. Refer to the study website for more information (www.remapcap.org).
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Cameron Green, MSc
Email
info@remapcap.org
First Name & Middle Initial & Last Name or Official Title & Degree
Svenja Peters, MSc
Email
EU.remapcap@umcutrecht.nl
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Steve Webb, Prof
Organizational Affiliation
Monash University, Study Chair REMAP-CAP Australia
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Colin McArthur, Dr
Organizational Affiliation
Medical Research Institute of New Zealand, Study Chair REMAP-CAP New Zealand
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Marc Bonten, Prof
Organizational Affiliation
UMC Utrecht, Study Chair REMAP-CAP Europe
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Lennie Derde, MD
Organizational Affiliation
UMC Utrecht, Coordinating Investigator REMAP-CAP Europe
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
John Marshall, Prof
Organizational Affiliation
Unity Health Toronto, Study Chair REMAP-CAP Canada
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Derek Angus, Prof
Organizational Affiliation
University of Pittsburgh Medical Center, Study Chair REMAP-CAP USA
Official's Role
Study Chair
Facility Information:
Facility Name
University of Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hadi Hatoum, MD
Facility Name
Augusta University
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jose Vazquez, MD
Facility Name
University of Illinois Health
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeffrey Jacobson, MD
Facility Name
Tulane Medical Center
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joshua Denson, MD
Facility Name
University of Michigan
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Hyzy, MD
Facility Name
Memorial Sloan Kettering Cancer Center
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen Pastores, MD
Facility Name
Wake Forest Baptist Health
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157-1009
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ashish Khanna, MD
Facility Name
The Ohio State University Wexner Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matthew Exline, MD
Facility Name
Oregon Health and Science University
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239-3098
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Akram Khankhana, MD
Facility Name
University of Pittsburgh Medical Centre
City
Pittsburgh
State/Province
Pennsylvania
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephanie Mongomery
Facility Name
Brown University - Rhode Island Hospital
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mitchell Levy, MD
Facility Name
Canberra Hospital
City
Canberra
State/Province
Australian Capital Territory
ZIP/Postal Code
2605
Country
Australia
Individual Site Status
Recruiting
Facility Name
Bankstown-Lidcombe Hospital
City
Bankstown
State/Province
New South Wales
ZIP/Postal Code
2200
Country
Australia
Individual Site Status
Recruiting
Facility Name
Blacktown Hospital
City
Blacktown
State/Province
New South Wales
ZIP/Postal Code
2148
Country
Australia
Individual Site Status
Recruiting
Facility Name
Campbelltown Hospital
City
Campbelltown
State/Province
New South Wales
ZIP/Postal Code
2560
Country
Australia
Individual Site Status
Recruiting
Facility Name
Sutherland Hospital
City
Caringbah
State/Province
New South Wales
ZIP/Postal Code
2229
Country
Australia
Individual Site Status
Recruiting
Facility Name
Concord Hospital
City
Concord
State/Province
New South Wales
ZIP/Postal Code
2139
Country
Australia
Individual Site Status
Recruiting
Facility Name
Dubbo Base Hospital
City
Dubbo
State/Province
New South Wales
ZIP/Postal Code
2830
Country
Australia
Individual Site Status
Recruiting
Facility Name
Northern Beaches Hospital
City
Frenchs Forest
State/Province
New South Wales
ZIP/Postal Code
2086
Country
Australia
Individual Site Status
Recruiting
Facility Name
Nepean Hospital
City
Kingswood
State/Province
New South Wales
ZIP/Postal Code
2750
Country
Australia
Individual Site Status
Recruiting
Facility Name
St. George Hospital
City
Kogarah
State/Province
New South Wales
ZIP/Postal Code
2217
Country
Australia
Individual Site Status
Recruiting
Facility Name
Liverpool Hospital
City
Liverpool
State/Province
New South Wales
ZIP/Postal Code
2170
Country
Australia
Individual Site Status
Recruiting
Facility Name
John Hunter Hospital
City
Newcastle
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
Individual Site Status
Recruiting
Facility Name
Orange Health Service
City
Orange
State/Province
New South Wales
ZIP/Postal Code
2800
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
St Vincent's Hospital Sydney
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Individual Site Status
Recruiting
Facility Name
Prince of Wales Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2031
Country
Australia
Individual Site Status
Recruiting
Facility Name
Royal Prince Alfred Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2050
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Royal North Shore Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2065
Country
Australia
Individual Site Status
Recruiting
Facility Name
Wollongong Hospital
City
Sydney
State/Province
New South Wales
ZIP/Postal Code
2500
Country
Australia
Individual Site Status
Recruiting
Facility Name
Wagga Wagga Base Hospital
City
Wagga Wagga
State/Province
New South Wales
ZIP/Postal Code
2650
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Westmead Hospital
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Individual Site Status
Recruiting
Facility Name
Royal Darwin Hospital,
City
Darwin
State/Province
Northern Territory
ZIP/Postal Code
0810
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Sunshine Coast University Hospital
City
Birtinya
State/Province
Queensland
ZIP/Postal Code
4575
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
The Prince Charles Hospital
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4032
Country
Australia
Individual Site Status
Recruiting
Facility Name
Mater Hospital Brisbane
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Individual Site Status
Recruiting
Facility Name
Princess Alexandra Hospital
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
Individual Site Status
Recruiting
Facility Name
Caboolture Hospital
City
Caboolture
State/Province
Queensland
ZIP/Postal Code
4510
Country
Australia
Individual Site Status
Recruiting
Facility Name
Queen Elizabeth II Jubilee Hospital
City
Coopers Plains
State/Province
Queensland
ZIP/Postal Code
4110
Country
Australia
Individual Site Status
Recruiting
Facility Name
Logan Hospital
City
Logan
State/Province
Queensland
ZIP/Postal Code
4129
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Redcliffe Hospital
City
Redcliffe
State/Province
Queensland
ZIP/Postal Code
4020
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Rockhampton Hospital
City
Rockhampton
State/Province
Queensland
ZIP/Postal Code
4700
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Gold Coast University Hospital
City
Southport
State/Province
Queensland
ZIP/Postal Code
4215
Country
Australia
Individual Site Status
Recruiting
Facility Name
Toowoomba Hospital
City
Toowoomba
State/Province
Queensland
ZIP/Postal Code
4350
Country
Australia
Individual Site Status
Recruiting
Facility Name
Townsville Hospital
City
Townsville
State/Province
Queensland
ZIP/Postal Code
4814
Country
Australia
Individual Site Status
Recruiting
Facility Name
Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Individual Site Status
Recruiting
Facility Name
The Queen Elizabeth Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Individual Site Status
Recruiting
Facility Name
Lyell McEwin Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5112
Country
Australia
Individual Site Status
Recruiting
Facility Name
Flinders Medical Centre
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Individual Site Status
Recruiting
Facility Name
Launceston Hospital
City
Launceston
State/Province
Tasmania
ZIP/Postal Code
7250
Country
Australia
Individual Site Status
Recruiting
Facility Name
Ballarat Base Hospital
City
Ballarat
State/Province
Victoria
ZIP/Postal Code
3350
Country
Australia
Individual Site Status
Recruiting
Facility Name
Bendigo Hospital
City
Bendigo
State/Province
Victoria
ZIP/Postal Code
3550
Country
Australia
Individual Site Status
Recruiting
Facility Name
Casey Hospital
City
Berwick
State/Province
Victoria
ZIP/Postal Code
3806
Country
Australia
Individual Site Status
Recruiting
Facility Name
Box Hill Hospital
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Individual Site Status
Recruiting
Facility Name
Monash Medical Centre
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Individual Site Status
Recruiting
Facility Name
Dandenong Hospital
City
Dandenong
State/Province
Victoria
ZIP/Postal Code
3175
Country
Australia
Individual Site Status
Recruiting
Facility Name
Angliss Hospital
City
Ferntree Gully
State/Province
Victoria
ZIP/Postal Code
3156
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Footscray Hospital
City
Footscray
State/Province
Victoria
ZIP/Postal Code
3011
Country
Australia
Individual Site Status
Recruiting
Facility Name
University Hosptial Geelong
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
Individual Site Status
Recruiting
Facility Name
The Alfred Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3004
Country
Australia
Individual Site Status
Recruiting
Facility Name
Royal Melbourne Hospital
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3050
Country
Australia
Individual Site Status
Recruiting
Facility Name
St Vincent's Hospital Melbourne
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Individual Site Status
Recruiting
Facility Name
Maroondah Hospital
City
Ringwood East
State/Province
Victoria
ZIP/Postal Code
3135
Country
Australia
Individual Site Status
Recruiting
Facility Name
Sunshine Hospital
City
Sunshine
State/Province
Victoria
ZIP/Postal Code
3021
Country
Australia
Individual Site Status
Recruiting
Facility Name
Werribee Mercy Hospital
City
Werribee
State/Province
Victoria
ZIP/Postal Code
3030
Country
Australia
Individual Site Status
Recruiting
Facility Name
St John of God Hospital Midland
City
Midland
State/Province
Western Australia
ZIP/Postal Code
6056
Country
Australia
Individual Site Status
Recruiting
Facility Name
St John of God Hospital Murdoch
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Individual Site Status
Not yet recruiting
Facility Name
Royal Perth Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6000
Country
Australia
Individual Site Status
Recruiting
Facility Name
Sir Charles Gairdner Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Individual Site Status
Recruiting
Facility Name
Fiona Stanley Hospital
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
Individual Site Status
Recruiting
Facility Name
St John of God Subiaco
City
Subiaco
State/Province
Western Australia
ZIP/Postal Code
6008
Country
Australia
Individual Site Status
Recruiting
Facility Name
AZ Sint-Jan
City
Brugge
ZIP/Postal Code
8000
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc Bourgeois, MD
Facility Name
CHU de Charleroi - Hôpital Civil Marie Curie
City
Charleroi
ZIP/Postal Code
6042
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Patrick Biston, MD
Facility Name
Universitair Ziekenhuis Antwerp
City
Edegem
ZIP/Postal Code
2650
Country
Belgium
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philippe Jorens, Prof.
Facility Name
Universitair Ziekenhuis Gent
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pieter Depuydt, Prof.
Facility Name
Foothills Medical Centre
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2W 1S7
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Peter Lougheed Centre
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2W 1S7
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Rockyview General Hospital
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2W 1S7
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
South Health Campus
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2W 1S7
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Royal Alexandra Hospital, Alberta
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5H 3V9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Demetrios Kutsogiannis, MD
Facility Name
University of Alberta Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2C8
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Wendy Sligl, MD
Facility Name
Surrey Memorial Hospital
City
Surrey
State/Province
British Columbia
ZIP/Postal Code
V3V 1Z2
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anish Mitra, MD
Facility Name
St Boniface General Hospital
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2H 2A6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ryan Zarychanski, MD
Facility Name
Health Sciences Centre Winnipeg
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3A 1R9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ryan Zarychanski, MD
Facility Name
Grace Hospital
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3J 3M7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gloria Vazquez-Grande, MD
Facility Name
Dr. Everett Chalmers Regional Hospital
City
Fredericton
State/Province
New Brunswick
ZIP/Postal Code
E3B 4R3
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zeeshan Aslam, MD
Facility Name
The Moncton Hospital
City
Fredericton
State/Province
New Brunswick
ZIP/Postal Code
E3B 4R3
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel Smyth, MD
Facility Name
The Saint John General Hospital
City
Fredericton
State/Province
New Brunswick
ZIP/Postal Code
E3B 4R3
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen Robinson, MD
Facility Name
William Osler Health System
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6R 3J7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexandra Binnie, MD
Facility Name
Brantford General Hospital
City
Brantford
State/Province
Ontario
ZIP/Postal Code
N3R 1G9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Brenda Reeve, MD
Facility Name
Hamilton general Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 8E7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alison Fox-Robichaud, MD
Facility Name
Juravinski Hospital
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 8E7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bram Rochwerg, MD
Facility Name
St. Joseph's Healthcare Hamilton
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8N 4A6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Deborah Cook, MD
Facility Name
Kingston Health Sciences Centre
City
Kingston
State/Province
Ontario
ZIP/Postal Code
K7L 2V7
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Grand River Hospital
City
Kitchener
State/Province
Ontario
ZIP/Postal Code
N2G 4K9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Theresa Liu, MD
Facility Name
St Mary's General Hospital
City
Kitchener
State/Province
Ontario
ZIP/Postal Code
N2M 1B2
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rebecca Kruisselbrink, MD
Facility Name
The Ottawa Hospital
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lauralyn McIntyre, MD
Facility Name
Niagara Health
City
Saint Catharines
State/Province
Ontario
ZIP/Postal Code
L2S 0A9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jennifer Tsang, MD
Facility Name
Thunder Bay General Hospital
City
Thunder Bay
State/Province
Ontario
ZIP/Postal Code
P7B 6V4
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Sunnybrook Health Sciences Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rob Fowler, MD
Facility Name
St. Michael's Hospital Unity Health Toronto
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5B 1W8
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Marshall, MD
Facility Name
Mount Sinai Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 1X5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sangeeta Mehta, MD
Facility Name
Toronto General Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2C4
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lorenzo del Sorbo, MD
Facility Name
Toronto Western Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5T 2S8
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elizabeth Wilcox, MD
Facility Name
St Joseph's Health Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M6R 1B5
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
CIUSS Chaudieres-Appalaches (Levis)
City
Lévis
State/Province
Quebec
ZIP/Postal Code
G6V 3Z1
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Patrick Archambault, MD
Facility Name
Hospital Maisonneuve-Rosemont
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H1T 2M4
Country
Canada
Individual Site Status
Active, not recruiting
Facility Name
Hôpital Fleury
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H2B 1K3
Country
Canada
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thomas Hemmerling, MD
Facility Name
Centre Hospitalier de l'Universite de Montreal
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H2X 0A9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Chasse, MD
Facility Name
McGill University Health Centre
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H3H 2R9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kosar Khwaja, MD
Facility Name
Hopital du Sacre-Coeur de Montreal
City
Montréal
State/Province
Quebec
ZIP/Postal Code
H4J 1C5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Albert, MD
Facility Name
CHU de Québec - Université Laval
City
Québec
State/Province
Quebec
ZIP/Postal Code
G1R 2J6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexis Turgeon, MD
Facility Name
IUCPQ-UL
City
Québec
State/Province
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francois Lellouche, MD
Facility Name
Centre Hospitalier de l'Université de Sherbrooke
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1J 3H5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francois Lamontagne, MD
Facility Name
Regina General Hospital
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7K 0M7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eric Sy, MD
Facility Name
Universidad de La Sabana
City
Chía
State/Province
Cundinamarca
Country
Colombia
Individual Site Status
Recruiting
Facility Name
General County Hospital Požega
City
Požega
ZIP/Postal Code
34000
Country
Croatia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zdravko Andrić, MD
Facility Name
University Hospital Centre Zagreb
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ana Vujaklija Brajković, MD
Facility Name
University Hospital for Infectious Diseases
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bruno Barsić, MD
Facility Name
Charité - Universitätsmedizin Berlin - Infektiologie und Pneumologie
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Witzenrath, Prof. Dr.
Facility Name
Charité - Universitätsmedizin Berlin - Nephrologie
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
André Finn, MD
Facility Name
Vivantes Klinikum Neukölln
City
Berlin
ZIP/Postal Code
12351
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lorenz Reill, MD
Facility Name
Universitätsklinikum Köln
City
Cologne
ZIP/Postal Code
50937
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lars Pester
Facility Name
Universitätsklinikum Frankfurt
City
Frankfurt
ZIP/Postal Code
60590
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gernot Rohde, Prof. Dr.
Facility Name
University Medical Center Hamburg-Eppendorf (UKE)
City
Hamburg
ZIP/Postal Code
20251
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stefan Klug, Prof. Dr.
Facility Name
Medizinische Hochschule Hannover
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sascha David, MD
Facility Name
Universitätsklinikum Jena
City
Jena
ZIP/Postal Code
07747
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mathias W. Pletz, Prof. Dr.
Facility Name
Universitätsklinikum Leipzig
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sirak Petros, Prof. Dr.
Facility Name
Universitäts Klinikum Tübingen
City
Tübingen
ZIP/Postal Code
72076
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Siri Göpel, MD
Facility Name
Universitätsklinikum Würzburg
City
Würzburg
ZIP/Postal Code
97080
Country
Germany
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dirk Weismann, MD
Facility Name
Jósa András County Hospital
City
Nyíregyháza
ZIP/Postal Code
4400
Country
Hungary
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gábor Szigligeti, MD
Facility Name
Csolnoky Ferenc Kórház - Veszprem County Hospital
City
Veszprém
ZIP/Postal Code
8200
Country
Hungary
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Béla Gál, MD
Facility Name
Almási Balogh Pál Kórház
City
Ózd
ZIP/Postal Code
3600
Country
Hungary
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
János Bélteczki, MD
Facility Name
Apollo Main Hospital
City
Chennai
State/Province
Tamil Nadu
ZIP/Postal Code
600006
Country
India
Individual Site Status
Active, not recruiting
Facility Name
Apollo First Med Hospital
City
Chennai
State/Province
Tamil Nadu
ZIP/Postal Code
600010
Country
India
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Meghena Mathew, MD
Facility Name
Apollo Vanagaram Hospital
City
Chennai
State/Province
Tamil Nadu
ZIP/Postal Code
600095
Country
India
Individual Site Status
Active, not recruiting
Facility Name
Apollo Speciality Hospital - OMR
City
Chennai
State/Province
Tamil Nadu
ZIP/Postal Code
600096
Country
India
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Deva Jayakumar, MD
Facility Name
Beaumont Hospital
City
Dublin
Country
Ireland
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ger Curley, Prof.
Facility Name
St. Vincent's University Hospital
City
Dublin
Country
Ireland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alistair Nichol, Prof.
Facility Name
University Hospital Galway
City
Galway
Country
Ireland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John Laffey, M.D.
Facility Name
St Marianna University School of Medicine
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
216-8511
Country
Japan
Individual Site Status
Recruiting
Facility Name
Yokohama City University Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
236-0004
Country
Japan
Individual Site Status
Recruiting
Facility Name
St. Marianna University Yokohama City Seibu Hospital
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
241-0811
Country
Japan
Individual Site Status
Recruiting
Facility Name
Saiseikai Kumamoto Hospital
City
Minami
State/Province
Kumamoto
ZIP/Postal Code
861-4193
Country
Japan
Individual Site Status
Recruiting
Facility Name
Osaka City General Hospital
City
Osaka
ZIP/Postal Code
534-0021
Country
Japan
Individual Site Status
Recruiting
Facility Name
Nerima Hikarigaoka Hospital
City
Tokyo
ZIP/Postal Code
130-8575
Country
Japan
Individual Site Status
Recruiting
Facility Name
Tokyo Metropolitan Bokutoh Hospital
City
Tokyo
ZIP/Postal Code
130-8575
Country
Japan
Individual Site Status
Recruiting
Facility Name
Itabashi Chuo Medical Center
City
Tokyo
ZIP/Postal Code
174-0051
Country
Japan
Individual Site Status
Recruiting
Facility Name
Tokyo bay Urayasu-Ichikawa Medical Center
City
Tokyo
ZIP/Postal Code
279-0001
Country
Japan
Individual Site Status
Recruiting
Facility Name
Wakayama Medical University
City
Wakayama
ZIP/Postal Code
641-8509
Country
Japan
Individual Site Status
Recruiting
Facility Name
Chitwan Medical College
City
Bharatpur
ZIP/Postal Code
44200
Country
Nepal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Basanta Gauli, MD
Facility Name
Grande International Hospital
City
Kathmandu
ZIP/Postal Code
44600
Country
Nepal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sushil Khanal, MD
Facility Name
Hospital for Advanced Medicine and Surgery (HAMS)
City
Kathmandu
ZIP/Postal Code
44600
Country
Nepal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hem Paneru, MD
Facility Name
Nepal Mediciti
City
Kathmandu
ZIP/Postal Code
44600
Country
Nepal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Diptesh Aryal, MD
Facility Name
Meander Medisch Centrum
City
Amersfoort
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laura van Gulik, M.D.
Facility Name
Jeroen Bosch Ziekenhuis
City
Den Bosch
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Koen Simons, M.D.
Facility Name
Martini Hospital Groningen
City
Groningen
Country
Netherlands
Individual Site Status
Withdrawn
Facility Name
University Medical Center Groningen
City
Groningen
Country
Netherlands
Individual Site Status
Withdrawn
Facility Name
Leiden University Medical Center
City
Leiden
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Evert De Jonge, Prof.
Facility Name
Canisius Wilhelmina Ziekenhuis
City
Nijmegen
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Oscar Hoiting, M.D.
Facility Name
Radboud University Medical Center
City
Nijmegen
Country
Netherlands
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeroen Schouten, M.D.
Facility Name
University Medical Center Utrecht
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc Bonten, Prof.
First Name & Middle Initial & Last Name & Degree
Lennie Derde, MD
Facility Name
North Shore Hospital
City
Auckland
ZIP/Postal Code
0620
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Everitt, MD
Facility Name
CVICU, Auckland City Hospital
City
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shay McGuinness, MD
Facility Name
DCCM, Auckland City Hospital
City
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Colin McArthur, MD
Facility Name
Middlemore Hospital
City
Auckland
ZIP/Postal Code
2104
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tony Williams, MD
Facility Name
Christchurch Hospital
City
Christchurch
ZIP/Postal Code
8011
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jay Ritzema-Carter, MD
Facility Name
Waikato Hospital
City
Hamilton
ZIP/Postal Code
3204
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert Martynoga, MD
Facility Name
Taranaki Base Hospital
City
New Plymouth
ZIP/Postal Code
4310
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Albrett, MD
Facility Name
Rotorua Hospital
City
Rotorua
ZIP/Postal Code
3010
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ulrike Buehner, MD
Facility Name
Tauranga Hospital
City
Tauranga
ZIP/Postal Code
3112
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Troy Browne, MD
Facility Name
Wellington Regional Hospital
City
Wellington
ZIP/Postal Code
6021
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul Young, MD
Facility Name
Whangarei Hospital
City
Whangarei
ZIP/Postal Code
0148
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ralph Fuchs, MD
Facility Name
Ziauddin University Hospital Clifton Campus
City
Karachi
State/Province
Sindh
ZIP/Postal Code
75000
Country
Pakistan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Madiha Hashmi, MD
Facility Name
Abbasi Shaheed Hospital
City
Karachi
State/Province
Sindh
ZIP/Postal Code
75300
Country
Pakistan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Aneela Kidwai, MD
Facility Name
National Institute of Cardiovascular Diseases, Karachi
City
Karachi
State/Province
Sindh
ZIP/Postal Code
75510
Country
Pakistan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nawal Salahuddin, MD
Facility Name
South City Hospital, Karachi
City
Karachi
State/Province
Sindh
ZIP/Postal Code
75600
Country
Pakistan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nasir Khoso, MD
Facility Name
Ziauddin University North Nazimabad Campus
City
Karachi
State/Province
Sindh
Country
Pakistan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Quratul Ain, MD
Facility Name
Centro Hospitalar do Medio Tejo
City
Abrantes
Country
Portugal
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nuno Catorze, M.D.
Facility Name
Hospital Lusíadas Lisbon
City
Lisboa
Country
Portugal
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nunes Nunes, M.D.
Facility Name
Clinical Hospital of Infectious and Tropical Diseases "Dr. Victor Babes"
City
Bucharest
ZIP/Postal Code
030303
Country
Romania
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Simin-Aysel Florescu, MD
Facility Name
King Abdulaziz Medical City
City
Riyadh
ZIP/Postal Code
14611
Country
Saudi Arabia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yaseen Arabi, MD
Facility Name
Institut Hospital del Mar d'Investigacions Mèdiques
City
Barcelona
Country
Spain
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rosana Munoz, M.D.
Facility Name
Hospital Universitario Reina Sofia
City
Córdoba
Country
Spain
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rafael Leon-Lopez, M.D.
Facility Name
Basildon Hospital
City
Basildon
State/Province
England
ZIP/Postal Code
SS16 5NL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dipak Mukherjee, MD
Facility Name
Basingstoke and North Hampshire Hospital
City
Basingstoke
State/Province
England
ZIP/Postal Code
RG24 9NA
Country
United Kingdom
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Antony Ashton, MD
Facility Name
Royal United Hospital, Bath
City
Bath
State/Province
England
ZIP/Postal Code
BA1 3NG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ian Kerslake, MD
Facility Name
Queen Elizabeth Hospital Birmingham
City
Birmingham
State/Province
England
ZIP/Postal Code
B15 2TH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dhruv Parekh
Facility Name
Birmingham City Hospital
City
Birmingham
State/Province
England
ZIP/Postal Code
B18 7QH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Hulme
Facility Name
Blackburn Hospital
City
Blackburn
State/Province
England
ZIP/Postal Code
BB2 3HH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Srikanth Chukkambotla, MD
Facility Name
Pilgrim's Hospital
City
Boston
State/Province
England
ZIP/Postal Code
PE21 9QS
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manish Chablani
Facility Name
Royal Bournemouth Hospital
City
Bournemouth
State/Province
England
ZIP/Postal Code
BH7 7DW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Schusterbruce, MD
Facility Name
Royal Sussex County Hospital
City
Brighton
State/Province
England
ZIP/Postal Code
BN2 5BE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Barbara Phillips
Facility Name
Southmead Hospital
City
Bristol
State/Province
England
ZIP/Postal Code
BS10 5NB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matt Thomas, MD
Facility Name
Bristol Royal Hospital
City
Bristol
State/Province
England
ZIP/Postal Code
BS2 8EX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeremy Bewley
Facility Name
Queen's Hospital, Burton
City
Burton on Trent
State/Province
England
ZIP/Postal Code
DE13 0RB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Amro Katary
Facility Name
Royal Papworth Hospital
City
Cambridge
State/Province
England
ZIP/Postal Code
CB2 0AY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alain Vuylsteke
Facility Name
Addenbrookes Hospital
City
Cambridge
State/Province
England
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Charlotte Summers, MD
Facility Name
Cumberland Royal Infirmary
City
Carlisle
State/Province
England
ZIP/Postal Code
CA2 7HY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tim Smith
Facility Name
Ashford & St Peters Hospital Trust
City
Chertsey
State/Province
England
ZIP/Postal Code
KT16 0P
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Chesterfield Royal Hospital
City
Chesterfield
State/Province
England
ZIP/Postal Code
S44 5BL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sarah Beavis
Facility Name
Countess of Chester Hospital
City
Chester
State/Province
England
ZIP/Postal Code
CH2 1UL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter Bamford
Facility Name
Colchester Hospital
City
Colchester
State/Province
England
ZIP/Postal Code
CO4 5JL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mohamed Ramali
Facility Name
University Hospital Coventry
City
Coventry
State/Province
England
ZIP/Postal Code
CV2 2DX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christopher Bassford, MD
Facility Name
North Manchester General Hospital
City
Crumpsall
State/Province
England
ZIP/Postal Code
M8 5RB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zoe Borrill
Facility Name
Darlington Memorial Hospital
City
Darlington
State/Province
England
ZIP/Postal Code
DL3 6HX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
James Limb, MD
Facility Name
Darent Valley Hospital
City
Dartford
State/Province
England
ZIP/Postal Code
DA2 8DA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Russells Hall Hospital
City
Dudley
State/Province
England
ZIP/Postal Code
DY1 2HQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Reay
Facility Name
University Hospital of North Durham
City
Durham
State/Province
England
ZIP/Postal Code
DH1 5TW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
James Limb, MD
Facility Name
Royal Devon and Exeter Hospital
City
Exeter
State/Province
England
ZIP/Postal Code
Ex2 5DW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christopher Day
Facility Name
Frimley Park Hospital
City
Frimley
State/Province
England
ZIP/Postal Code
GU16 7 UJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
George Evetts
Facility Name
Queen Elizabeth Hospital
City
Gateshead
State/Province
England
ZIP/Postal Code
NE9 6SX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vanessa Linnett
Facility Name
Medway Maritime Hospital
City
Gillingham
State/Province
England
ZIP/Postal Code
ME7 5NY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Arystarch Makowski
Facility Name
James Paget Kings Lynn Hospital
City
Great Yarmouth
State/Province
England
ZIP/Postal Code
NR31 6LA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Karlikowski
Facility Name
Royal Surrey County Hospital
City
Guildford
State/Province
England
ZIP/Postal Code
GU2 7XX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ben Creagh-Brown
Facility Name
Northwick Park Hospital
City
Harrow
State/Province
England
ZIP/Postal Code
HA1 3UJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jamie Gross
Facility Name
Hereford County Hospital
City
Hereford
State/Province
England
ZIP/Postal Code
HR1 2ER
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Charlotte Small
Facility Name
Barnet Hospital
City
High Barnet
State/Province
England
ZIP/Postal Code
EN5 3DJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rajeev Jha, MD
Facility Name
Huddersfield Hospital
City
Huddersfield
State/Province
England
ZIP/Postal Code
HD3 3EA
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
King George Hospital
City
Ilford
State/Province
England
ZIP/Postal Code
IG3 8YB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mandeep Phull
Facility Name
Ipswich Hospital
City
Ipswich
State/Province
England
ZIP/Postal Code
IP4 5PD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kate Turner
Facility Name
Kettering Hospital
City
Kettering
State/Province
England
ZIP/Postal Code
NN16 8UZ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dhinesh Sundaran
Facility Name
Leeds Teaching Hospitals NHS Trust
City
Leeds
State/Province
England
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elankumaran Paramasivam, MD
Facility Name
Leicester Royal Infirmary
City
Leicester
State/Province
England
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hakeem Yusuff
Facility Name
Glenfield Hospital
City
Leicester
State/Province
England
ZIP/Postal Code
LE3 9QP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hafiz Qureshi
Facility Name
Lincoln County Hospital
City
Lincoln
State/Province
England
ZIP/Postal Code
LN2 5QY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manish Chablani
Facility Name
Liverpool Heart and Chest Hospital
City
Liverpool
State/Province
England
ZIP/Postal Code
L14 3PE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Oana Cole
Facility Name
Alder Hey Hospital
City
Liverpool
State/Province
England
ZIP/Postal Code
L14 5AB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen McWilliam, MD
Facility Name
Royal Liverpool Hospital
City
Liverpool
State/Province
England
ZIP/Postal Code
L7 8XP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ingeborg Welters
Facility Name
University Hospital Aintree
City
Liverpool
State/Province
England
ZIP/Postal Code
L9 7AL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Barbara Borgatta
Facility Name
Croydon University Hospital
City
London
State/Province
England
ZIP/Postal Code
CR7 7YE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sundar Ashok
Facility Name
Royal London Hospital
City
London
State/Province
England
ZIP/Postal Code
E1 1FR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zudin Puthucheary, MD
Facility Name
Whipps Cross Hospital
City
London
State/Province
England
ZIP/Postal Code
E11 1NR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zudin Puthucheary, MD
Facility Name
Newham Hospital
City
London
State/Province
England
ZIP/Postal Code
E13 8SL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zudin Puthucheary, MD
Facility Name
St Barts Hosptial
City
London
State/Province
England
ZIP/Postal Code
EC1A 7BE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zudin Puthucheary, MD
Facility Name
North Middlesex Hospital
City
London
State/Province
England
ZIP/Postal Code
N18 1QX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeronimo Moreno-Cuesta
Facility Name
Royal Free Hospital
City
London
State/Province
England
ZIP/Postal Code
NW3 2QG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mark Deneef
Facility Name
St Thomas' Hospital
City
London
State/Province
England
ZIP/Postal Code
SE1 7EH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manu Shankar-Hari
Facility Name
Guy's Hospital
City
London
State/Province
England
ZIP/Postal Code
SE1 9RT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Manu Shankar-Hari
Facility Name
King's College Hospital
City
London
State/Province
England
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Reena Mehta
Facility Name
St George's Hospital
City
London
State/Province
England
ZIP/Postal Code
SW17 0QT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susannah Leaver
Facility Name
Royal Marsden Hospital
City
London
State/Province
England
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shaman Jhanji
Facility Name
Ryal Brompton
City
London
State/Province
England
ZIP/Postal Code
SW3 6NP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Prijesh Patel
Facility Name
Hammersmith Hospital
City
London
State/Province
England
ZIP/Postal Code
W12 0HS
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen Brett
Facility Name
St Mary's Hospital
City
London
State/Province
England
ZIP/Postal Code
W2 1NY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anthony Gordon
Facility Name
Charing Cross Hospital
City
London
State/Province
England
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Antcliffe
Facility Name
Luton and Dunstable University Hospital
City
Luton
State/Province
England
ZIP/Postal Code
LU4 0DZ
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Maidstone Hospital - Maidstone and Tunbridge Wells NHS Trust
City
Maidstone
State/Province
England
ZIP/Postal Code
ME16 9QQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Golden, MD
Facility Name
Manchester Royal Infirmary
City
Manchester
State/Province
England
ZIP/Postal Code
M13 9WL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Bannardsmith
Facility Name
The Christie Hospital
City
Manchester
State/Province
England
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Amit Patel
Facility Name
Wythenshawe Hospital
City
Manchester
State/Province
England
ZIP/Postal Code
M23 9LT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Peter Alexander
Facility Name
Queen Elizabeth Hospital, Woolwich
City
Margate
State/Province
England
ZIP/Postal Code
CT9 4AN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dan Harding
Facility Name
The James Cook University Hospital
City
Middlesbrough
State/Province
England
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeremy Henning, MD
Facility Name
Milton Keynes University Hospital
City
Milton Keynes
State/Province
England
ZIP/Postal Code
MK6 5LD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Richard Stewart, MD
Facility Name
Royal Victoria Infirmary, Newcastle
City
Newcastle
State/Province
England
ZIP/Postal Code
NE1 4LP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ian McCullagh
Facility Name
Newcastle Freeman Hospital
City
Newcastle
State/Province
England
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ian McCullagh
Facility Name
Northampton General Hospital
City
Northampton
State/Province
England
ZIP/Postal Code
NN1 5BD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Wilkinson, MD
Facility Name
Norfolk and Norwich University Hospital
City
Norwich
State/Province
England
ZIP/Postal Code
NR4 7UY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Simon Fletcher
Facility Name
City Hospital Nottingham
City
Nottingham
State/Province
England
ZIP/Postal Code
NG5 1PB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel Harvey
Facility Name
Queen's Medical Centre - Nottingham University Hospitals NHS Trust
City
Nottingham
State/Province
England
ZIP/Postal Code
NG7 2UH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Daniel Harvey, MD
Facility Name
George Eliot Hospital
City
Nuneaton
State/Province
England
ZIP/Postal Code
CV10 7DJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Divya Khare
Facility Name
Royal Oldham Hospital
City
Oldham
State/Province
England
ZIP/Postal Code
Ol1 2JH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Redmond Tully
Facility Name
Princess Royal University Hospital
City
Orpington
State/Province
England
ZIP/Postal Code
BR6 8ND
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thomas William
Facility Name
John Radcliffe Hospital
City
Oxford
State/Province
England
ZIP/Postal Code
OX3 9DU
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matthew Rowland
Facility Name
Derriford Hospital
City
Plymouth
State/Province
England
ZIP/Postal Code
PL6 8DH
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nikitas Nikitas
Facility Name
Poole Hospital NHS Foundation Trust
City
Poole
State/Province
England
ZIP/Postal Code
BH15 2JB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Henrik Reschreiter, MD
Facility Name
Queen Alexandra Hospital - Portsmouth Hospitals NHS Trust
City
Portsmouth
State/Province
England
ZIP/Postal Code
PO6 3LY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Pogson, MD
Facility Name
Whiston Hospital
City
Prescot
State/Province
England
ZIP/Postal Code
L35 5DR
Country
United Kingdom
Individual Site Status
Terminated
Facility Name
Royal Preston Hospital
City
Preston
State/Province
England
ZIP/Postal Code
PR2 9HT
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shondipon Laha
Facility Name
Royal Berkshire Hospital
City
Reading
State/Province
England
ZIP/Postal Code
RG1 5AN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Andrew Walden, MD
Facility Name
Alexandra Hospital, Redditch
City
Redditch
State/Province
England
ZIP/Postal Code
B98 7UB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olivia Kelsall, MD
Facility Name
Queen's Hospital Romford
City
Romford
State/Province
England
ZIP/Postal Code
RM7 0AG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Rotherham General Hospital
City
Rotherham
State/Province
England
ZIP/Postal Code
S60 2UD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anil Hormis
Facility Name
Salford Royal Hospital
City
Salford
State/Province
England
ZIP/Postal Code
M6 8HD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul Dark
Facility Name
Salisbury District Hospital
City
Salisbury
State/Province
England
ZIP/Postal Code
SP2 8BJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Phil Donnison
Facility Name
Royal Hallamshire Hospital
City
Sheffield
State/Province
England
ZIP/Postal Code
S10 2JF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gary Mills
Facility Name
Northern General Hospital
City
Sheffield
State/Province
England
ZIP/Postal Code
S5 7AU
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gary Mills
Facility Name
Wexham Park Hospital
City
Slough
State/Province
England
ZIP/Postal Code
SL2 4HL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Omar Touma
Facility Name
South Tyneside District Hospital
City
South Shields
State/Province
England
ZIP/Postal Code
NE34 0PL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alistair Roy
Facility Name
Southampton General Hospital
City
Southampton
State/Province
England
ZIP/Postal Code
SO16 6YD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Stepping Hill Hospital
City
Stockport
State/Province
England
ZIP/Postal Code
SK2 7JE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ahmed Zaki
Facility Name
University Hospital of North Tees
City
Stockton-on-Tees
State/Province
England
ZIP/Postal Code
TS19 8PE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Farooq Brohi, MD
Facility Name
Royal Stoke University Hospital
City
Stoke-on-Trent
State/Province
England
ZIP/Postal Code
ST4 6QG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ramprasad Matsa
Facility Name
Sunderland Hospital
City
Sunderland
State/Province
England
ZIP/Postal Code
SR4 7TP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alistair Roy
Facility Name
King's Mill Hospital
City
Sutton In Ashfield
State/Province
England
ZIP/Postal Code
NG17 4JL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul Pulak
Facility Name
Great Western Hospital
City
Swindon
State/Province
England
ZIP/Postal Code
SN3 6BB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Malcolm Watters
Facility Name
Western General Hospital
City
Swindon
State/Province
England
ZIP/Postal Code
SN3 6BB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Name
Musgrove Park Hospital
City
Taunton
State/Province
England
ZIP/Postal Code
TA1 5DA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Richard Innes
Facility Name
Torbay and South Devon Hospital
City
Torquay
State/Province
England
ZIP/Postal Code
TQ2 7AA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adam Revill
Facility Name
Royal Cornwall Hospital
City
Truro
State/Province
England
ZIP/Postal Code
TR1 3LJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Spivey, MD
Facility Name
Tunbridge Wells Hospital - Maidstone and Tunbridge Wells NHS Trust
City
Tunbridge Wells
State/Province
England
ZIP/Postal Code
TN2 4QJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Golden, MD
Facility Name
Harefield Hospital
City
Uxbridge
State/Province
England
ZIP/Postal Code
UB9 6JH
Country
United Kingdom
Individual Site Status
Active, not recruiting
Facility Name
Watford General Hospital
City
Watford
State/Province
England
ZIP/Postal Code
WD18 0HB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Valarie Page
Facility Name
Southend University Hospital
City
Westcliff-on-Sea
State/Province
England
ZIP/Postal Code
ISS0 0RY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mark Saville
Facility Name
West Cumberland Hospital
City
Whitehaven
State/Province
England
ZIP/Postal Code
CA28 8JG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tim Smith
Facility Name
Royal Albert Edward Infirmary
City
Wigan
State/Province
England
ZIP/Postal Code
WN1 2NN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alison Quinn
Facility Name
Royal Hampshire Hospital
City
Winchester
State/Province
England
ZIP/Postal Code
SO22 5DG
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Irina Grecu
Facility Name
Arrow Park Hospital
City
Wirral
State/Province
England
ZIP/Postal Code
CH49 5PE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Girendra Sadera
Facility Name
New Cross Hospital
City
Wolverhampton
State/Province
England
ZIP/Postal Code
WV10 0QP
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Shameer Gopala Pillai
Facility Name
Worcester Royal Hospital
City
Worcester
State/Province
England
ZIP/Postal Code
WR5 1DD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephen Digby
Facility Name
York Hospital
City
York
State/Province
England
ZIP/Postal Code
Y031 8HE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joseph Carter, MD
Facility Name
York Hospital
City
York
State/Province
England
ZIP/Postal Code
YO31 8HE
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Yates
Facility Name
Antrim Area Hospital
City
Antrim
State/Province
Northern Ireland
ZIP/Postal Code
BT41 2RL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Paul Johnston, MD
Facility Name
Royal Victoria Hospital, Belfast
City
Belfast
State/Province
Northern Ireland
ZIP/Postal Code
BT12 6BA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Silversides
Facility Name
Mater Hospital
City
Belfast
State/Province
Northern Ireland
ZIP/Postal Code
BT14 6AB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Silversides
Facility Name
Belfast City Hospital
City
Belfast
State/Province
Northern Ireland
ZIP/Postal Code
BT9 7AB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Silversides, MD
Facility Name
Altnagelvin Hospital
City
Derry
State/Province
Northern Ireland
ZIP/Postal Code
BT47 6SB
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Adrian Donnelly, MD
Facility Name
Aberdeen Royal Infirmary
City
Aberdeen
State/Province
Scotland
ZIP/Postal Code
AB25 2ZN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Callum Kaye, MD
Facility Name
Ninewells Hospital
City
Dundee
State/Province
Scotland
ZIP/Postal Code
DD1 9SY
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pauline Austin
Facility Name
Royal Infirmary of Edinburgh
City
Edinburgh
State/Province
Scotland
ZIP/Postal Code
EH16 4SA
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thomas Craven
Facility Name
Glasgow Royal Infirmary
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G4 0SF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kathryn Puxty
Facility Name
Queen Elizabeth University Hospital, Glasgow
City
Glasgow
State/Province
Scotland
ZIP/Postal Code
G51 4TF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Malcolm Sim
Facility Name
Royal Alexandra Hospital, Glasgow
City
Paisley
State/Province
Scotland
ZIP/Postal Code
PA2 9PN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kevin Rooney
Facility Name
Neville Hall Hospital
City
Abergavenny
State/Province
Wales
ZIP/Postal Code
NP7 7EG
Country
United Kingdom
Individual Site Status
Completed
Facility Name
Glan Clywd Hospital
City
Bodelwyddan
State/Province
Wales
ZIP/Postal Code
LL18 5UJ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Richard Pugh, MD
Facility Name
Princess of Wales Hospital
City
Bridgend
State/Province
Wales
ZIP/Postal Code
CF31 1RQ
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jayaprakash Singh
Facility Name
University Hospital of Wales
City
Cardiff
State/Province
Wales
ZIP/Postal Code
CF14 4XW
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matt Wise
Facility Name
Glangwilli Hospital
City
Carmarthen
State/Province
Wales
ZIP/Postal Code
SA31 2AF
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yvonne Plesnikova
Facility Name
Grange University Hospital
City
Cwmbran
State/Province
Wales
ZIP/Postal Code
NP44 8YN
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Tamas Szakmany, MD
Facility Name
Royal Gwent Hospital
City
Newport
State/Province
Wales
ZIP/Postal Code
NP20 2UB
Country
United Kingdom
Individual Site Status
Completed
Facility Name
Royal Glamorgan Hospital
City
Pontyclun
State/Province
Wales
ZIP/Postal Code
CF72 8XR
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jayaprakash Singh
Facility Name
Morriston Hospital
City
Swansea
State/Province
Wales
ZIP/Postal Code
SA6 6NL
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sureshkumar Gopala Pillai
Facility Name
Wrexham Maelor Hospital
City
Wrexham
State/Province
Wales
ZIP/Postal Code
LL13 7TD
Country
United Kingdom
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
David Southern, MD
12. IPD Sharing Statement
Plan to Share IPD
Yes
Citations:
PubMed Identifier
35315874
Citation
REMAP-CAP Writing Committee for the REMAP-CAP Investigators; Bradbury CA, Lawler PR, Stanworth SJ, McVerry BJ, McQuilten Z, Higgins AM, Mouncey PR, Al-Beidh F, Rowan KM, Berry LR, Lorenzi E, Zarychanski R, Arabi YM, Annane D, Beane A, van Bentum-Puijk W, Bhimani Z, Bihari S, Bonten MJM, Brunkhorst FM, Buzgau A, Buxton M, Carrier M, Cheng AC, Cove M, Detry MA, Estcourt LJ, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Huang DT, Horvat CM, Hunt BJ, Ichihara N, Lamontagne F, Leavis HL, Linstrum KM, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Morpeth SC, Murthy S, Neal MD, Nichol AD, Parke RL, Parker JC, Reyes LF, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Singh V, Tolppa T, Turgeon AF, Turner AM, van de Veerdonk FL, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Webb SA, Gordon AC. Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2022 Apr 5;327(13):1247-1259. doi: 10.1001/jama.2022.2910.
Results Reference
derived
PubMed Identifier
34606578
Citation
Writing Committee for the REMAP-CAP Investigators; Estcourt LJ, Turgeon AF, McQuilten ZK, McVerry BJ, Al-Beidh F, Annane D, Arabi YM, Arnold DM, Beane A, Begin P, van Bentum-Puijk W, Berry LR, Bhimani Z, Birchall JE, Bonten MJM, Bradbury CA, Brunkhorst FM, Buxton M, Callum JL, Chasse M, Cheng AC, Cove ME, Daly J, Derde L, Detry MA, De Jong M, Evans A, Fergusson DA, Fish M, Fitzgerald M, Foley C, Goossens H, Gordon AC, Gosbell IB, Green C, Haniffa R, Harvala H, Higgins AM, Hills TE, Hoad VC, Horvat C, Huang DT, Hudson CL, Ichihara N, Laing E, Lamikanra AA, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, MacLennan S, Marshall J, McAuley DF, McDyer JF, McGlothlin A, McGuinness S, Miflin G, Montgomery S, Mouncey PR, Murthy S, Nichol A, Parke R, Parker JC, Priddee N, Purcell DFJ, Reyes LF, Richardson P, Robitaille N, Rowan KM, Rynne J, Saito H, Santos M, Saunders CT, Serpa Neto A, Seymour CW, Silversides JA, Tinmouth AA, Triulzi DJ, Turner AM, van de Veerdonk F, Walsh TS, Wood EM, Berry S, Lewis RJ, Menon DK, McArthur C, Zarychanski R, Angus DC, Webb SA, Roberts DJ, Shankar-Hari M. Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2021 Nov 2;326(17):1690-1702. doi: 10.1001/jama.2021.18178.
Results Reference
derived
PubMed Identifier
34473343
Citation
Kreuzberger N, Hirsch C, Chai KL, Tomlinson E, Khosravi Z, Popp M, Neidhardt M, Piechotta V, Salomon S, Valk SJ, Monsef I, Schmaderer C, Wood EM, So-Osman C, Roberts DJ, McQuilten Z, Estcourt LJ, Skoetz N. SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19. Cochrane Database Syst Rev. 2021 Sep 2;9(9):CD013825. doi: 10.1002/14651858.CD013825.pub2.
Results Reference
derived
PubMed Identifier
34351722
Citation
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32876697
Citation
Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Buzgau A, Cheng AC, de Jong M, Detry M, Estcourt L, Fitzgerald M, Goossens H, Green C, Haniffa R, Higgins AM, Horvat C, Hullegie SJ, Kruger P, Lamontagne F, Lawler PR, Linstrum K, Litton E, Lorenzi E, Marshall J, McAuley D, McGlothin A, McGuinness S, McVerry B, Montgomery S, Mouncey P, Murthy S, Nichol A, Parke R, Parker J, Rowan K, Sanil A, Santos M, Saunders C, Seymour C, Turner A, van de Veerdonk F, Venkatesh B, Zarychanski R, Berry S, Lewis RJ, McArthur C, Webb SA, Gordon AC; Writing Committee for the REMAP-CAP Investigators; Al-Beidh F, Angus D, Annane D, Arabi Y, van Bentum-Puijk W, Berry S, Beane A, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Cheng A, De Jong M, Derde L, Estcourt L, Goossens H, Gordon A, Green C, Haniffa R, Lamontagne F, Lawler P, Litton E, Marshall J, McArthur C, McAuley D, McGuinness S, McVerry B, Montgomery S, Mouncey P, Murthy S, Nichol A, Parke R, Rowan K, Seymour C, Turner A, van de Veerdonk F, Webb S, Zarychanski R, Campbell L, Forbes A, Gattas D, Heritier S, Higgins L, Kruger P, Peake S, Presneill J, Seppelt I, Trapani T, Young P, Bagshaw S, Daneman N, Ferguson N, Misak C, Santos M, Hullegie S, Pletz M, Rohde G, Rowan K, Alexander B, Basile K, Girard T, Horvat C, Huang D, Linstrum K, Vates J, Beasley R, Fowler R, McGloughlin S, Morpeth S, Paterson D, Venkatesh B, Uyeki T, Baillie K, Duffy E, Fowler R, Hills T, Orr K, Patanwala A, Tong S, Netea M, Bihari S, Carrier M, Fergusson D, Goligher E, Haidar G, Hunt B, Kumar A, Laffan M, Lawless P, Lother S, McCallum P, Middeldopr S, McQuilten Z, Neal M, Pasi J, Schutgens R, Stanworth S, Turgeon A, Weissman A, Adhikari N, Anstey M, Brant E, de Man A, Lamonagne F, Masse MH, Udy A, Arnold D, Begin P, Charlewood R, Chasse M, Coyne M, Cooper J, Daly J, Gosbell I, Harvala-Simmonds H, Hills T, MacLennan S, Menon D, McDyer J, Pridee N, Roberts D, Shankar-Hari M, Thomas H, Tinmouth A, Triulzi D, Walsh T, Wood E, Calfee C, O'Kane C, Shyamsundar M, Sinha P, Thompson T, Young I, Bihari S, Hodgson C, Laffey J, McAuley D, Orford N, Neto A, Detry M, Fitzgerald M, Lewis R, McGlothlin A, Sanil A, Saunders C, Berry L, Lorenzi E, Miller E, Singh V, Zammit C, van Bentum Puijk W, Bouwman W, Mangindaan Y, Parker L, Peters S, Rietveld I, Raymakers K, Ganpat R, Brillinger N, Markgraf R, Ainscough K, Brickell K, Anjum A, Lane JB, Richards-Belle A, Saull M, Wiley D, Bion J, Connor J, Gates S, Manax V, van der Poll T, Reynolds J, van Beurden M, Effelaar E, Schotsman J, Boyd C, Harland C, Shearer A, Wren J, Clermont G, Garrard W, Kalchthaler K, King A, Ricketts D, Malakoutis S, Marroquin O, Music E, Quinn K, Cate H, Pearson K, Collins J, Hanson J, Williams P, Jackson S, Asghar A, Dyas S, Sutu M, Murphy S, Williamson D, Mguni N, Potter A, Porter D, Goodwin J, Rook C, Harrison S, Williams H, Campbell H, Lomme K, Williamson J, Sheffield J, 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Hawcutt D, Rad L, O'Malley L, Whitbread J, Kelsall O, Wild L, Thrush J, Wood H, Austin K, Donnelly A, Kelly M, O'Kane S, McClintock D, Warnock M, Johnston P, Gallagher LJ, Mc Goldrick C, Mc Master M, Strzelecka A, Jha R, Kalogirou M, Ellis C, Krishnamurthy V, Deelchand V, Silversides J, McGuigan P, Ward K, O'Neill A, Finn S, Phillips B, Mullan D, Oritz-Ruiz de Gordoa L, Thomas M, Sweet K, Grimmer L, Johnson R, Pinnell J, Robinson M, Gledhill L, Wood T, Morgan M, Cole J, Hill H, Davies M, Antcliffe D, Templeton M, Rojo R, Coghlan P, Smee J, Mackay E, Cort J, Whileman A, Spencer T, Spittle N, Kasipandian V, Patel A, Allibone S, Genetu RM, Ramali M, Ghosh A, Bamford P, London E, Cawley K, Faulkner M, Jeffrey H, Smith T, Brewer C, Gregory J, Limb J, Cowton A, O'Brien J, Nikitas N, Wells C, Lankester L, Pulletz M, Williams P, Birch J, Wiseman S, Horton S, Alegria A, Turki S, Elsefi T, Crisp N, Allen L, McCullagh I, Robinson P, Hays C, Babio-Galan M, Stevenson H, Khare D, Pinder M, Selvamoni S, Gopinath A, Pugh R, Menzies D, Mackay C, Allan E, Davies G, Puxty K, McCue C, Cathcart S, Hickey N, Ireland J, Yusuff H, Isgro G, Brightling C, Bourne M, Craner M, Watters M, Prout R, Davies L, Pegler S, Kyeremeh L, Arbane G, Wilson K, Gomm L, Francia F, Brett S, Sousa Arias S, Elin Hall R, Budd J, Small C, Birch J, Collins E, Henning J, Bonner S, Hugill K, Cirstea E, Wilkinson D, Karlikowski M, Sutherland H, Wilhelmsen E, Woods J, North J, Sundaran D, Hollos L, Coburn S, Walsh J, Turns M, Hopkins P, Smith J, Noble H, Depante MT, Clarey E, Laha S, Verlander M, Williams A, Huckle A, Hall A, Cooke J, Gardiner-Hill C, Maloney C, Qureshi H, Flint N, Nicholson S, Southin S, Nicholson A, Borgatta B, Turner-Bone I, Reddy A, Wilding L, Chamara Warnapura L, Agno Sathianathan R, Golden D, Hart C, Jones J, Bannard-Smith J, Henry J, Birchall K, Pomeroy F, Quayle R, Makowski A, Misztal B, Ahmed I, KyereDiabour T, Naiker K, Stewart R, Mwaura E, Mew L, Wren L, Willams F, Innes R, Doble P, Hutter 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Results Reference
derived
PubMed Identifier
32267771
Citation
Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA. The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design. Ann Am Thorac Soc. 2020 Jul;17(7):879-891. doi: 10.1513/AnnalsATS.202003-192SD.
Results Reference
derived
Links:
URL
https://www.prepare-europe.eu/About-us/Workpackages/Workpackage-5.html
Description
PREPARE website
URL
http://www.remapcap.org
Description
REMAP-CAP Study Website
Learn more about this trial
Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
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