Randomized Trial of ARCON in Larynx Cancer
Larynx Carcinoma
About this trial
This is an interventional treatment trial for Larynx Carcinoma focused on measuring larynx carcinoma, radiotherapy, carbogen, nicotinamide
Eligibility Criteria
Inclusion Criteria: Pathological confirmed squamous cell carcinoma of the larynx. TNM-classification (UICC 1997, appendix I): T3-4 glottic or supraglottic carcinoma T2 glottic carcinoma with impaired cord mobility or subglottic extension T2 supraglottic carcinoma with invasion of mucosa of base of tongue or vallecula or invasion of the medial wall of the piriform sinus. any N-stage, M0. WHO performance status 0 or 1 (appendix II). Age > 18 years. Written informed consent. Quality of life questionnaire completed. Exclusion Criteria: Prior or concurrent treatment for this tumour. Severe stridor and adequate debulking of airway not possible. Impaired renal function: serum creatinine above upper normal limit. Use of nefrotoxic medication (including ACE-inhibitors) that cannot be discontinued for the duration of the radiation treatment. Impaired hepatic function: ASAT and ALAT more than 1.5 times the upper normal limit. Use of anti-convulsants that cannot be discontinued for the duration of the radiation treatment. History of malignancy during the previous 5 years except basal cell carcinoma of skin, carcinoma in situ of the cervix, or superficial bladder neoplasm (pTa).
Sites / Locations
- Free University Medical Centre
- University Medical Centre Groningen
- Leids University Medical Centre
- Maastro Clinic
- Radboud University Nijmegen Medical Centre
- University Medical centre Utrecht
- Mount Vernon Hospital
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
1
2
Accelerated radiotherapy
ARCON