Real-time fMRI Neurofeedback for Mild/Moderate Depression
Depression Mild, Depression Moderate
About this trial
This is an interventional treatment trial for Depression Mild focused on measuring Neurofeedback, Functional Magnetic Resonance Imaging, Cognitive Behavioral Therapy
Eligibility Criteria
Inclusion Criteria:
- A diagnosis of unipolar depressive disorder on ICD-10 (F32, F33, F34.1)
- Sufficient self-regulation ability (verified with 3 sessions of ALAY EEG neurofeedback)
Exclusion Criteria:
- Serious somatic, mental, or substance abuse problem other than depression
- Depression secondary to other mental or somatic conditions
- Psychotic features in depression or comorbid psychotic disorder
- Serious suicide risk
- Seasonal depression
- Receiving or planning to receive psychotropic medications
- Receiving cardiovascular medications
- General MRI exclusions
- Current pregnancy
- IQ<70 (established with Raven's progressive matrices)
- Previous experience with neurofeedback
Sites / Locations
- Federal Reserch Center of Fundamental and Translational Medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Active Comparator
Active Comparator
Real-time fMRI neurofeedback (rt-fMRI NFB)
Сognitive behavioral therapy (CBT)
EEG neurofeedback (EEG NFB)
The duration of a session was approximately a half-hour. The course duration was 8 sessions. The preferred frequency was once a week, however, the schedule was flexibly adjusted for patients' convenience.
The duration of a session was approximately an hour/hour and a half. The course duration was 8 individual and 8 group sessions and included home assignments. The preferred frequency was twice a week, however, the schedule was flexibly adjusted for patients' convenience and for improving benefits of the treatment.
The duration of a session was approximately a half-hour. The course duration was 16 sessions. The preferred frequency was twice a week, however, the schedule was flexibly adjusted for patients' convenience. Group was preliminarily aborted for lack of time and participants in order to assign more patients to the abovementioned arms.