Remifentanil in Adults With OSA (AROSA)
Apnea, Sleep
About this trial
This is an interventional basic science trial for Apnea, Sleep focused on measuring sensitivity, opioid
Eligibility Criteria
Inclusion Criteria
- 18 to 70 year-old males or non-pregnant females
- Provide informed consent
Exclusion Criteria
- History of liver disease
- pregnant or nursing females
- known history of addiction to drugs or alcohol
- craniofacial anomalies that preclude proper fit of pupillometry goggles
- eye abnormalities that preclude the measurement of pupil diameter
- use of home oxygen
Sites / Locations
- Washington University St Louis School of Medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
targeted infusion of remifentanil untreated OSA
targeted infusion of remifentanil CPAP treated OSA
targeted infusion of remifentanil No OSA
Stepped-dose, targeted infusion of remifentanil with measurement of miosis, respiratory rate, end-expired CO2, and thermal analgesia and plasma drug concentrations. Remifentanil dose will be based on ideal body weight.
Stepped-dose, targeted infusion of remifentanil with measurement of miosis, respiratory rate, end-expired CO2, and thermal analgesia and plasma drug concentrations. Remifentanil dose will be based on ideal body weight.
Stepped-dose, targeted infusion of remifentanil with measurement of miosis, respiratory rate, end-expired CO2, and thermal analgesia and plasma drug concentrations. Remifentanil dose will be based on ideal body weight.