Repeated TMS at Low Frequencies to Reduce Seizure Occurrence
Epilepsy, Status Epilepticus, Epilepsia Partialis Continua
About this trial
This is an interventional treatment trial for Epilepsy
Eligibility Criteria
Long-term protocol:
Inclusion Criteria:
- Experience ≥ 3 seizures/month in the month prior to starting study (any type of seizure will count)
- No status epilepticus in the last 12 months
- No change in medication in last 30 days
Exclusion Criteria:
- Presence of implanted electronic devices (e.g., pacemaker, medication pump, brain or vagus nerve stimulator, cochlear implant)
- Presence of intracranial metal (e.g., aneurysm clip)
- Unable to cooperate with non-sedated, navigated TMS testing
Short-term protocol:
Inclusion Criteria:
- Epilepsia partialis continua or status epilepticus
- At least 2 medications failed
- At least 24 hours of acute phase
Exclusion Criteria:
- Presence of implanted electronic devices (e.g., pacemaker, medication pump, brain or vagus nerve stimulator, cochlear implant)
- Presence of intracranial metal (e.g., aneurysm clip)
Sites / Locations
- Baptist Hospital of Miami
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Sham Comparator
Experimental
Group 1: Weekly TMS
Group 2: Monthly TMS
Group 3: Sham TMS
Short-term protocol
LF-rTMS intervention for 2 weeks (5 days per week for total of 10 days) , LF-rTMS 1 session/week for 1 month (4 days), and LF-rTMS 1 session/month for 11 months
LF-rTMS intervention for 2 weeks (5 days per week for total of 10 days), LF-rTMS 1 session/month for 12 months
Sham LF-rTMS for 2 weeks (5 days per week for a total of 10 days), sham LF-rTMS 1 session/week for 1 month (4 days), and sham LF-rTMS 1 session/month for 1 month. After the sham stimulation real LF-rTMS intervention sessions will be delivered as follows: 50% of placebo group will follow group 1 protocol and the other 50% will follow group 2 protocol
LF-rTMS intervention daily for up to 5 days in medically refractory status epilepticus participants only