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Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?

Primary Purpose

Metabolic Syndrome

Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
aerobic exercise
strength training
Sponsored by
Norwegian University of Science and Technology
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Metabolic Syndrome focused on measuring Exercise therapy

Eligibility Criteria

20 Years - 70 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Having metabolic syndrome according to international diabetes foundations definition (IDF).

Exclusion Criteria:

  • Unstable angina pectoris
  • Uncompensated heart failure
  • Myocardial infarction during the past 4 weeks
  • Complex ventricular arrhythmias
  • Kidney failure

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm 3

    Arm Type

    Experimental

    Experimental

    No Intervention

    Arm Label

    aerobic exercise

    strength training

    control group

    Arm Description

    Outcomes

    Primary Outcome Measures

    proinflammatory markers
    circulating interleukin-18 and interleukin-6

    Secondary Outcome Measures

    Full Information

    First Posted
    September 28, 2009
    Last Updated
    December 12, 2012
    Sponsor
    Norwegian University of Science and Technology
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    1. Study Identification

    Unique Protocol Identification Number
    NCT00986024
    Brief Title
    Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?
    Official Title
    Strength Training Versus Aerobic Interval Training to Modify Risk Factors of the Metabolic Syndrome
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    December 2012
    Overall Recruitment Status
    Completed
    Study Start Date
    August 2006 (undefined)
    Primary Completion Date
    March 2007 (Actual)
    Study Completion Date
    March 2007 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Sponsor
    Name of the Sponsor
    Norwegian University of Science and Technology

    4. Oversight

    Data Monitoring Committee
    No

    5. Study Description

    Brief Summary
    The aim of the present study was to evaluate the effects of aerobic interval training versus strength training or a combination of these regimes on factors comprising the metabolic syndrome in order to find the most effective exercise regime for patients with metabolic syndrome.
    Detailed Description
    In the Western world, approximately 25% of young to middle-aged adults have metabolic syndrome. There seem to be a strong age-dependence in the prevalence of the metabolic syndrome, but the incidence rises rapidly within adolescents and middle-aged groups and follows the development of obesity in the general population. Metabolic syndrome confers an increased risk of coronary heart disease, cardiovascular disease, and premature death; therefore, effective and affordable strategies to combat the syndrome would be of great individual and social importance. Despite the general agreement that moderate-intensity physical activity for a minimum of 30 min five days per week or vigorous-intensity aerobic physical activity for a minimum of 20 min three days a week promote and maintain health, the optimal training regime to treat metabolic syndrome and its associated cardiovascular abnormalities remains uncertain.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Metabolic Syndrome
    Keywords
    Exercise therapy

    7. Study Design

    Primary Purpose
    Treatment
    Study Phase
    Not Applicable
    Interventional Study Model
    Parallel Assignment
    Masking
    None (Open Label)
    Allocation
    Randomized
    Enrollment
    31 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    aerobic exercise
    Arm Type
    Experimental
    Arm Title
    strength training
    Arm Type
    Experimental
    Arm Title
    control group
    Arm Type
    No Intervention
    Intervention Type
    Behavioral
    Intervention Name(s)
    aerobic exercise
    Intervention Description
    carried out 3 times per week for 12 weeks
    Intervention Type
    Behavioral
    Intervention Name(s)
    strength training
    Intervention Description
    carried out 3 times per week for 12 weeks
    Primary Outcome Measure Information:
    Title
    proinflammatory markers
    Description
    circulating interleukin-18 and interleukin-6
    Time Frame
    12 weeks

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    20 Years
    Maximum Age & Unit of Time
    70 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: Having metabolic syndrome according to international diabetes foundations definition (IDF). Exclusion Criteria: Unstable angina pectoris Uncompensated heart failure Myocardial infarction during the past 4 weeks Complex ventricular arrhythmias Kidney failure
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Ulrik Wisløff, md prof
    Organizational Affiliation
    Norwegian University of Science and Technology
    Official's Role
    Study Director

    12. IPD Sharing Statement

    Citations:
    PubMed Identifier
    22455564
    Citation
    Stensvold D, Slordahl SA, Wisloff U. Effect of exercise training on inflammation status among people with metabolic syndrome. Metab Syndr Relat Disord. 2012 Aug;10(4):267-72. doi: 10.1089/met.2011.0140. Epub 2012 Mar 28.
    Results Reference
    result

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