Resistance to Aspirin and/or Clopidogrel Among Patients With PAD.
Intermittent Claudication
About this trial
This is an interventional diagnostic trial for Intermittent Claudication focused on measuring Intermittent Claudication, Aspirin resistance, Clopidogrel resistance
Eligibility Criteria
Inclusion Criteria: Atherosclerosis of the lower limbs, defined by one of the following criteria: Ankle-Brachial Pressure Index (ABPI)< 0.9, intermittent claudication, ischaemic pain at rest, ischaemic ulcers or gangrene. Age > 18 years For fertile women: Use of safe contraception (intrauterine contraceptive device, the pill, hormonal skin patches, progestogen injections, progestogen implant, vaginal ring) Exclusion Criteria: Allergy to either Aspirin or Clopidogrel Known bleeding disorder Platelet count < 140 mia/L or > 400 mia/L Intake of NSAID's, SSRI's or Dipyridamol within the preceding 14 days Not radically treated gastrointestinal ulceration within the last 6 month Greater surgical procedures performed within the last 3 month Severe renal disease Severe hepatic disease Breast feeding Pregnancy
Sites / Locations
- Department of Vascular Surgery, Aalborg Hospital
Arms of the Study
Arm 1
Active Comparator
Aspirin
All participants get Aspirin, and platelet reactivity measurements are performed.