Resistant Starch Prebiotic Effects in Chronic Kidney Disease (ReSPECKD)

This is an interventional treatment trial for Chronic Kidney Diseases focused on measuring Chronic Kidney Disease, Resistant Potato Starch, uremic toxins (indoxyl sulphate, p-cresyl sulphate), gut microbiota, metabolomics Read More

Inclusion Criteria:

• Participant is willing and able to give informed consent for participation in the trial.
• Participant has the ability to speak and read English.
• Male or Female, aged 18 years or above. Females of child-bearing potential must agree to use a medically approved method of birth control for the duration of the study. All hormonal birth control must have been in use for a minimum of three months. Acceptable methods of birth control include: Hormonal contraceptives including oral contraceptives, hormone birth control patch, vaginal contraceptive ring, injectable contraceptives, or hormone implant, double-barrier method, intrauterine devices, non-heterosexual lifestyle or agrees to use contraception if planning on changing to heterosexual partner(s), vasectomy of partner at least 6 months prior to screening.
• Estimated glomerular filtration rate (eGFR) <15 mL/min/1.73m^2 for the past 3 months
• In the Investigator's opinion, participant is able and willing to comply with all trial requirements.

Exclusion Criteria:

• The participant is cognitively impaired and cannot give consent or participate in the group program
• The participant has an existing relationship with the research team, such as supervisory relationship (student, employee) or familial relationship (child, spouse, etc)
• Participants who indicate that they cannot consume study treatments.
• Participants who indicates they are allergic to potatoes or corn
• Female participant who is pregnant, lactating or planning pregnancy during the course of the trial.
• History of renal transplant, ongoing dialysis, use of antibiotics (last 3-months), bowel diseases, cancer, surgically removed bowel, or any gastrointestinal surgery (e.g. intestinal resection, gastric bypass, colorectal surgery)
• Inability to consume treatment due to swallowing or GI issues and inability to obtain written informed consent.
• Participating in another interventional trial that could influence the intervention or outcome of this trial.
• Participants with uncontrolled diabetes with a hemoglobin A1C > 10%.
• Participants who consume probiotic supplements.
• Participants with abnormal constrictions of the gastrointestinal tract, diseases of the oesophagus and/or the superior opening of the stomach (cardia), potential or existing intestinal blockage, paralysis of the intestine, megacolon, faecal impaction, appendicitis, a sudden change in bowel habits that has persisted for more than 2 weeks, undiagnosed rectal bleeding, or failure to defaecate following the use of another laxative prod.
• Participants with severe anemia (hemoglobin less than 70).
• Participants taking medications which inhibit peristaltic movement (e.g. opioids,loperamide).
• Participants taking other fiber supplements or able to maintain high fiber/adequate fiber intake through diet.