Restricted or Liberal Antibiotics After Appendectomy - Denver Health (CASA RELAX)
Appendicitis
About this trial
This is an interventional treatment trial for Appendicitis focused on measuring post-operative, antibiotics
Eligibility Criteria
Inclusion Criteria:
- Age ≥ 18 years
- Planned appendectomy (laparoscopic or open) for simple or complicated (perforated or gangrenous) appendicitis
- Working telephone number or reliable method to contact patient after hospital discharge
Exclusion Criteria:
- Unable to consent
- Pregnant Women
- Prisoners
- Immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage AIDS
- Heart failure
- Allergy to bupivacaine
- Unlikely to comply with treatment or follow-up
- Inpatient consultation for appendicitis
- Clinically suspected of sepsis based on Sepsis-3 definition
- Current use of antibiotics for other indications
- Uncontrolled hyperglycemia or Type 1 Diabetes
- Surgeon preference
- Patient preference
- Research team unavailable
Sites / Locations
- Denver Health and Hospital Authority
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Restricted Post-Operative Antibiotics Group
Liberal Post-Operative Antibiotics Group
Participants undergoing standard of care (SOC) with simple appendicitis will not receive post-operative antibiotics. Participants undergoing standard of care with complicated (gangrenous or perforated) appendicitis will receive up to 24 hours of SOC post-operative antibiotics.
Participants undergoing standard of care with simple appendicitis will receive 24 hours of post-operative SOC antibiotics Participants undergoing standard of care with complicated (gangrenous or perforated) appendicitis will receive 4 days of post-operative SOC antibiotics.