Resveratrol-Leucine Metabolite Synergy in Pre-diabetes

This is an interventional treatment trial for Impaired Glucose Tolerance focused on measuring Impaired glucose tolerance, pre-diabetes,glycemic control,, supplements Read More

Inclusion Criteria:

• Impaired fasting glucose as defined by American Diabetes Association criteria: fasting plasma glucose level from 5.6 mmol/L (100 mg/dL) to 6.9 mmol/L (125 mg/dL)
• Body mass index (BMI) 25-34.9
• Age 18 and above• Weight stable: no more than 1 kg weight gain or loss during past 12 weeks

Exclusion Criteria:

• Fasting glucose >126 or <99 mg/dL
• BMI < 25 or >35
• Current/previous diagnosis of diabetes
• History of eating disorder or presence of active gastrointestinal disorders such as malabsorption syndromes
• Pregnancy or lactation Anemia, defined as hemoglobin level less than 10g/dl.
• Use of obesity pharmacotherapeutic agents within the last 6 months
• Use of over-the-counter anti-obesity agents (e.g. those containing phenylpropylamine , ephedrine and/or caffeine) within the last 3 months
• Chronic use of anti-inflammatory agents within the last four weeks
• Use of antioxidant supplements within the last four weeks including selenium, vitamin E, vitamin C and/or carotenoids
• Use of supplements containing any of the study compounds within the past four weeks
• Recent (current or past 12 weeks) use of any psychotropic medication
• Recent (past four weeks) initiation of or change in an exercise program
• Recent (past twelve weeks) initiation of hormone replacement therapy or change in HRT regimen
• Recent (past twelve weeks) initiation of hormonal birth control or change in hormonal birth control regimen
• Recent (past 12-weeks) history of tobacco use
• Any Condition that the P.I. considers adverse to the participant