rhBNP in Type 3 Pulmonary Hypertension
Group 3 Pulmonary Hypertension
About this trial
This is an interventional treatment trial for Group 3 Pulmonary Hypertension focused on measuring rhBNP, Group 3 Pulmonary Hypertension, Right cardiac catheter
Eligibility Criteria
Inclusion Criteria: Hospitalized patients with acute exacerbation of chronic lung diseases, including: chronic obstructive pulmonary disease, bronchiectasis, obsolete pulmonary tuberculosis, obstructive sleep apnea hypopnea syndrome and thoracic or spinal deformity; At rest, the systolic pressure of pulmonary artery measured by right heart Doppler ultrasound was ≥ 50mmHg; At rest, the mean pulmonary artery pressure (mPAP) measured by Swan Ganz catheter was ≥ 25mmHg with PVR ≥ 3WU and PAWP < 15mmHg; Male or female, age ≥ 18 years old, weight ≥ 30kg ~ ≤ 150kg; WHO fc ≥ II. Exclusion Criteria: Any other types of pulmonary hypertension; Other active respiratory diseases (such as active pulmonary tuberculosis, pulmonary fibrosis, etc.); Patients requiring invasive mechanical ventilation; At rest, PAWP measured by Swan Ganz catheter was ≥ 15mmhg; Uncontrolled hypertension; Systolic blood pressure < 90mmHg; Dopamine dose ≥ 5 μ g•kg-1•min-1; At rest, Doppler echocardiography confirmed left ventricular outflow tract obstruction or left ventricular systolic dysfunction (EF ≤ 55%); Acute coronary syndrome; Severe renal insufficiency (GFR < 30ml / min / 1.73m2); Significant anemia; Milrinone or levosimendan was used within 30 days before screening; Allergic to any component of rhBNP; Participated in other clinical trials within 30 days before screening; Unable to complete the visit task.
Sites / Locations
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- Shengjing Hospital of China Medical University
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
recombinant human brain natriuretic peptide
placebo
loading dose 1.5 μg/kg iv, followed by 0.0075 μg/kg·min with micro-pump injection for 72 hours.
loading dose 1.5 μg/kg iv, followed by 0.0075 μg/kg·min with micro-pump injection for 72 hours.