Risk-Based Breast Screening in Young Women (RIBBS)
Breast Neoplasms
About this trial
This is an interventional screening trial for Breast Neoplasms focused on measuring Breast Neoplasms, Cancer Screening, Personalized Medicine, Mammographic Breast Density, Risk Assessment
Eligibility Criteria
Inclusion Criteria: Female Aged 45 years old Resident in the provinces of Padua and Rovigo (Italy) Willing and able to give written informed consent Willing and able to comply with scheduled visits, tests, and other procedures Exclusion Criteria: Recent mammography Personal history of breast carcinoma, either invasive or ductal carcinoma in situ (DCIS) Known BRCA carrier or PALB2 or ≥50% risk Psychiatric or other disorders that are not compatible with compliance to the protocol requirements and follow-up Pregnant or breastfeeding Unable to give informed consent Current participation in another interventional breast screening trial
Sites / Locations
- Istituto Oncologico Veneto (IRCCS)
Arms of the Study
Arm 1
Other
RIBBS arm
This clinical trial is a single-arm study in which asymptomatic 45-year-old women undergo a triple screening test: (1) two-view tomosynthesis of both breasts; (2) calculation of volumetric breast density (VBD); (3) assessment of breast cancer risk using the Tyrer-Cuzick model. Mean VBD and lifetime risk (LTR) are used to determine the type of imaging and frequency of subsequent screening cycles.