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Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation (CHACRY-1501)

Primary Purpose

Breast Cancer

Status

Recruiting

Phase

Not Applicable

Locations

France

Study Type

Interventional

Intervention

Controlled ovarian hyperstimulation (COH)

Oocyte/embryo freezing

About this trial

This is an interventional prevention trial for Breast Cancer focused on measuring oocyte/embryo cryopreservation

Eligibility Criteria

18 Years - 38 Years (Adult)FemaleDoes not accept healthy volunteers

Inclusion Criteria:

Women with histologically proven breast cancer
Aged 18 to 38 years old
Planned adjuvant chemotherapy
No prior chemotherapy
Affiliated to a public health insurance program
Informed consent signed by the patient

Exclusion Criteria:

Metastatic breast cancer
Planned neo-adjuvant chemotherapy
Hysterectomy
Exclusive adjuvant hormonotherapy
Positive serology for syphilis, hepatitis B or C, or VIH
Contraindication related to use of r-FSH
Pregnant or breastfeeding patients

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Oocyte/embryo cryopreservation

Arm Description

Controlled ovarian hyperstimulation (COH) Oocyte/embryo freezing

Outcomes

Primary Outcome Measures

Quality of oocytes: total number of oocytes preserved

The distribution of the total number of oocytes preserved will be summarized by the mean (standard error) and median (range) and presented with a 95% confidence interval.

Secondary Outcome Measures

Quality of embryos: total number of embryos preserved

Type of oocytes

mature, immature, fractured

Toxicity related to the controlled ovarian stimulation according to NCI CTCAE v4.0 scale

Toxicities will be tabulated with frequencies and percentages by type of adverse events and by grade

Serum AMH measurement

Antral Follicular Count (AFC) measurement

Number of Spontaneous or medically assisted pregnancy(ies)

To measure the degree of project completion of subsequent pregnancy(ies)

Rate of patients wishing for re-utilization of their frozen gametes

To assess the number of patients wishing for re-utilization of their frozen gametes

Disease-free survival

defined as the interval between inclusion and the first occurrence of local, regional or distant relapse, estimated using the Kaplan-Meier method

Full Information

NCT ID

NCT02871167

First Posted

July 28, 2016

Last Updated

February 13, 2023

Sponsor

Centre Oscar Lambret

Collaborators

University Hospital, Lille, National Cancer Institute, France, University Hospital, Montpellier

1. Study Identification

Unique Protocol Identification Number

NCT02871167

Brief Title

Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation

Acronym

CHACRY-1501

Official Title

Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation (CHACRY-1501)

Study Type

Interventional

2. Study Status

Record Verification Date

February 2023

Overall Recruitment Status

Recruiting

Study Start Date

December 2016 (undefined)

Primary Completion Date

December 2024 (Anticipated)

Study Completion Date

December 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Centre Oscar Lambret

Collaborators

University Hospital, Lille, National Cancer Institute, France, University Hospital, Montpellier

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

The aim of the study is to perform a French multicenter prospective interventional study in order to assess the feasibility and safety of ovarian hyperstimulation for oocyte / embryo cryopreservation in young women with breast cancer. The oncologic and reproductive benefit / risk ratio will be investigated in the oncology and reproductive area.

Detailed Description

Medical Oncology: Information and collection of consent, Imaging staging, Inclusion Physical examination Contraception advise given Reproductive medicine center: Ovarian reserve assessment: serum anti-mullerian hormone (AMH) measurement and antral follicle count (AFC) by ultrasound. Serology syphilis, hepatitis B and C, HIV (human immunodeficiency virus). In case of embryo cryopreservation, same serology determination for the men. Infertility risk and fertility preservation techniques information. In case of agreement, this technique will be done during the time-interval between surgery and chemotherapy Fertility preservation (COH stimulation, triggering and oocyte retrieval) Adjuvant chemotherapy: The chemotherapy regimen is 3 FEC (fluorouracil epirubicin cyclophosphamide) 100 followed by standard chemotherapy (according to local practice) +/- Trastuzumab. Adjuvant chemotherapy may only begin after the oocyte retrieval. Usual adjuvant chemotherapy is not changed During chemotherapy: Clinical exam before each cycle of chemotherapy AMH, AFC at cycle 6 After chemotherapy: Usual patient monitoring in expert center : physical examination at Month 3 (M3), M6 M9 M12 M18 and M24 and mammography at M9 then annual AMH at Month 3 (M3), M6 M9 M12 M18 and M24 AFC at Month 12 (M12) and M24

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Breast Cancer

Keywords

oocyte/embryo cryopreservation

7. Study Design

Primary Purpose

Prevention

Study Phase

Not Applicable

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

N/A

Enrollment

120 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Oocyte/embryo cryopreservation

Arm Type

Experimental

Arm Description

Controlled ovarian hyperstimulation (COH) Oocyte/embryo freezing

Intervention Type

Procedure

Intervention Name(s)

Controlled ovarian hyperstimulation (COH)

Intervention Description

After information and consent, patients are addressed to a reproductive medicine center. The COH will be performed according to a standardized protocol between surgery and the start of adjuvant chemotherapy. Follicular growth will be achieved with an antagonist protocol and by using high dose recombinant FSH (r-FSH). The triggering of the final follicular and oocyte maturation will be obtained by a GnRH (Gonadotropin Releasing Hormone) agonist injection in order to minimize the risk of ovarian hyper-stimulation.

Intervention Type

Procedure

Intervention Name(s)

Oocyte/embryo freezing

Intervention Description

Egg or embryo freezing will be performed according to a standardized protocol: slow-freezing process for embryo; vitrification technique for oocytes. Cryopreserved oocytes and embryos will be stored in the biological bank of each reproductive medicine center (min. 10 years).

Primary Outcome Measure Information:

Title

Quality of oocytes: total number of oocytes preserved

Description

The distribution of the total number of oocytes preserved will be summarized by the mean (standard error) and median (range) and presented with a 95% confidence interval.

Time Frame

after oocyte retrieval (35-36 hours after triptorelin injection)

Secondary Outcome Measure Information:

Title

Quality of embryos: total number of embryos preserved

Time Frame

at 44-46 hours post intra-cell sperm injection

Title

Type of oocytes

Description

mature, immature, fractured

Time Frame

after oocyte retrieval (35-36 hours after triptorelin injection)

Title

Toxicity related to the controlled ovarian stimulation according to NCI CTCAE v4.0 scale

Description

Toxicities will be tabulated with frequencies and percentages by type of adverse events and by grade

Time Frame

24 months

Title

Serum AMH measurement

Time Frame

baseline, at the end of the first sequence of chemotherapy, at the last injection of treatment, at Month 3, Month 6, Month 9, Month 12, Month 18 and Month 24

Title

Antral Follicular Count (AFC) measurement

Time Frame

baseline, at month 3, at month 12, at month 24

Title

Number of Spontaneous or medically assisted pregnancy(ies)

Description

To measure the degree of project completion of subsequent pregnancy(ies)

Time Frame

up to 10 years after the end of the study or at 43 years old

Title

Rate of patients wishing for re-utilization of their frozen gametes

Description

To assess the number of patients wishing for re-utilization of their frozen gametes

Time Frame

up to 10 years after the end of the study or at 43 years old

Title

Disease-free survival

Description

defined as the interval between inclusion and the first occurrence of local, regional or distant relapse, estimated using the Kaplan-Meier method

Time Frame

through study completion, an average of 5 years

Other Pre-specified Outcome Measures:

Title

Translational research : circulating nucleic acids quantification: cell-free DNA and microRNAs on blood sample

Description

before 1st cycle of adjuvant chemotherapy, during the adjuvant chemotherapy (end of first sequence), at the end of adjuvant chemotherapy

Time Frame

an average of 6 months

10. Eligibility

Sex

Female

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

38 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Women with histologically proven breast cancer Aged 18 to 38 years old Planned adjuvant chemotherapy No prior chemotherapy Affiliated to a public health insurance program Informed consent signed by the patient Exclusion Criteria: Metastatic breast cancer Planned neo-adjuvant chemotherapy Hysterectomy Exclusive adjuvant hormonotherapy Positive serology for syphilis, hepatitis B or C, or VIH Contraindication related to use of r-FSH Pregnant or breastfeeding patients

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

Audrey Maillez, MD

a-mailliez@o-lambret.fr

First Name & Middle Initial & Last Name or Official Title & Degree

Christine Decanter, MD

Phone

+33 3 20 44 68 97

c-decanter@chru-lille.fr

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Audrey Maillez, MD

Organizational Affiliation

Centre Oscar Lambret

Official's Role

Study Director

First Name & Middle Initial & Last Name & Degree

Christine Decanter, MD

Organizational Affiliation

CHRU of Lille - Hôpital Jeanne de Flandre

Official's Role

Study Director

Facility Information:

Facility Name

Hôpital Jean Verdier

City

Bondy

ZIP/Postal Code

93140

Country

France

Individual Site Status

Not yet recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Michael GRYNBERG, PhD

Phone

0148026860

michael.grynberg@aphp.fr

First Name & Middle Initial & Last Name & Degree

Michael GRYNBERG, PhD

Facility Name

Centre Aliénor d'Aquitaine, Hôpital Pellegrin

City

Bordeaux

ZIP/Postal Code

33076

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Vanessa CONRI, MD

Phone

0557820941

vanessa.conri@chu-bordeaux.fr

First Name & Middle Initial & Last Name & Degree

Vanessa CONRI, MD

First Name & Middle Initial & Last Name & Degree

Nathalie TRUFFLANDIER, MD

Facility Name

CHU de Caen

City

Caen

ZIP/Postal Code

14033

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Christine DENOUAL-ZIAD, MD

Phone

0231272059

denoualziad-c@chu-caen.fr

First Name & Middle Initial & Last Name & Degree

Christine DENOUAL-ZIAD, MD

Facility Name

Centre François Baclesse

City

Caen

ZIP/Postal Code

14076

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Djelila ALLOUACHE, MD

Phone

0231455002

dallouache@baclesse.unicancer.fr

First Name & Middle Initial & Last Name & Degree

Djelila ALLOUACHE, MD

First Name & Middle Initial & Last Name & Degree

Christelle LEVY, MD

First Name & Middle Initial & Last Name & Degree

Julien GEFFRELOT, MD

First Name & Middle Initial & Last Name & Degree

Carine SEGURA, MD

First Name & Middle Initial & Last Name & Degree

Katharina GUNZER, MD

First Name & Middle Initial & Last Name & Degree

Iona HRAB, MD

First Name & Middle Initial & Last Name & Degree

George EMILE, MD

First Name & Middle Initial & Last Name & Degree

Audrey FAVEYRIAL, MD

Facility Name

Hôpital Antoine Béclère

City

Clamart

ZIP/Postal Code

92140

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Valérie SCARABIN-CARRE, MD

Phone

0145374201

valerie.scarabin@aphp.fr

First Name & Middle Initial & Last Name & Degree

Valérie SCARABIN-CARRE, MD

First Name & Middle Initial & Last Name & Degree

Vanessa GALLOT, MD

First Name & Middle Initial & Last Name & Degree

Marion PRESSE, MD

Facility Name

Centre Georges François LECLERC

City

Dijon

ZIP/Postal Code

21079

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Isabelle DESMOULINS, MD

IDesmoulins@cgfl.fr

First Name & Middle Initial & Last Name & Degree

Isabelle DESMOULINS, MD

First Name & Middle Initial & Last Name & Degree

Catherine LOUSTALOT, MD

First Name & Middle Initial & Last Name & Degree

Charles COUTANT, PhD

First Name & Middle Initial & Last Name & Degree

Clémentine JANKOWSKI, MD

First Name & Middle Initial & Last Name & Degree

Sabrina DRIDI, MD

First Name & Middle Initial & Last Name & Degree

Julien LE GALL, MD

First Name & Middle Initial & Last Name & Degree

Marie-Martine PADEANO, MD

First Name & Middle Initial & Last Name & Degree

Sylvain LADOIRE, MD

First Name & Middle Initial & Last Name & Degree

Bruno COUDERT, MD

Facility Name

CHU de Dijon

City

Dijon

ZIP/Postal Code

21079

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Paul SAGOT, PhD

Phone

0380293852

paul.sagot@chu-dijon.fr

First Name & Middle Initial & Last Name & Degree

Paul SAGOT, PhD

First Name & Middle Initial & Last Name & Degree

Marjorie ROGER, MD

Facility Name

CHU REUNION site SUD

City

La Réunion

ZIP/Postal Code

97410

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Hélène FLYE SAINTE MARIE, MD

Phone

02 62 71 75 92

helene.flye@chu-reunion.fr

First Name & Middle Initial & Last Name & Degree

Hélène FLYE SAINTE MARIE, MD

First Name & Middle Initial & Last Name & Degree

Lam Foong Fat LAM KAM SANG, MD

First Name & Middle Initial & Last Name & Degree

Florence LAÏ-TIONG, MD

First Name & Middle Initial & Last Name & Degree

Béatrice NAYL, MD

First Name & Middle Initial & Last Name & Degree

Marc GABRIELE, MD

First Name & Middle Initial & Last Name & Degree

Nathalie FONTAINE, MD

First Name & Middle Initial & Last Name & Degree

Coraline GARRAIN, MD

Facility Name

Centre Oscar Lambret

City

Lille

ZIP/Postal Code

59020

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Audrey Maillez, MD

Phone

+33 3 20 29 59 18

a-mailliez@o-lambret.fr

First Name & Middle Initial & Last Name & Degree

Audrey MAILLIEZ, MD

First Name & Middle Initial & Last Name & Degree

Jacques BONNETERRE, PhD

First Name & Middle Initial & Last Name & Degree

Laurence VANLEMMENS, MD

First Name & Middle Initial & Last Name & Degree

Diane PANNIER, MD

First Name & Middle Initial & Last Name & Degree

Natacha STERN, MD

First Name & Middle Initial & Last Name & Degree

Nawale HAJAJI, MD

First Name & Middle Initial & Last Name & Degree

Emilie KACZMAREK, MD

Facility Name

CHRU Hôpital Jeanne de Flandres

City

Lille

ZIP/Postal Code

59037

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Christine DECANTER, MD

Phone

0320446897

c-decanter@chru-lille.fr

First Name & Middle Initial & Last Name & Degree

Christine DECANTER, MD

First Name & Middle Initial & Last Name & Degree

Pauline PLOUVIER, MD

Facility Name

CHU Limoges

City

Limoges

ZIP/Postal Code

87042

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Lise-Marie DURAND, MD

Phone

0555058824

durandlisemarie@yahoo.fr

First Name & Middle Initial & Last Name & Degree

Lise-Marie DURAND, MD

First Name & Middle Initial & Last Name & Degree

Sandrine LAVAU-DENES, MD

First Name & Middle Initial & Last Name & Degree

Laurence VENAT-BOUVET, MD

First Name & Middle Initial & Last Name & Degree

Yves AUBARD, MD

First Name & Middle Initial & Last Name & Degree

Pascal PIVER, MD

Facility Name

CHU Lyon

City

Lyon

ZIP/Postal Code

69229

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Bruno SALLE, MD

Phone

0472129411

bruno.salle@chu-lyon.fr

First Name & Middle Initial & Last Name & Degree

Bruno SALLE, MD

First Name & Middle Initial & Last Name & Degree

Jacqueline SANTAMARIA-LORNAGE, MD

Facility Name

Centre Léon Bérard

City

Lyon

ZIP/Postal Code

69373

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Christine ROUSSET-JABLONSKI, MD

Phone

0478785129

christine.roussetjablonski@lyon.unicancer.fr

First Name & Middle Initial & Last Name & Degree

Christine ROUSSET-JABLONSKI, MD

First Name & Middle Initial & Last Name & Degree

Olivier TREDAN, MD

First Name & Middle Initial & Last Name & Degree

Thomas BACHELOT, MD

First Name & Middle Initial & Last Name & Degree

Isabelle RAY-COQUART, PhD

First Name & Middle Initial & Last Name & Degree

Pierre-Etienne HEUDEL, MD

Facility Name

CHU La Conception

City

Marseille

ZIP/Postal Code

13005

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Blandine COURBIERE, MD

Phone

0491383711

blandine.courbiere@ap-hm.fr

First Name & Middle Initial & Last Name & Degree

Blandine COURBIERE, MD

First Name & Middle Initial & Last Name & Degree

Pauline BOTTIN-DUBERGE, MD

First Name & Middle Initial & Last Name & Degree

Jacqueline SAIAS-MAGNA, MD

Facility Name

Institut Paoli Calmette

City

Marseille

ZIP/Postal Code

13273

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Magali PROVANSAL, MD

Phone

0491229740

provansalm@ipc.unicancer.fr

First Name & Middle Initial & Last Name & Degree

Magali PROVANSAL, MD

First Name & Middle Initial & Last Name & Degree

Jacques CAMERLO, MD

First Name & Middle Initial & Last Name & Degree

Anthony GONCALVES, MD

First Name & Middle Initial & Last Name & Degree

Jean-Marc EXTRA, MD

First Name & Middle Initial & Last Name & Degree

Carole TARPIN, MD

First Name & Middle Initial & Last Name & Degree

Renaud SABATIER, MD

Facility Name

CHRU Montpellier

City

Montpellier

ZIP/Postal Code

34295

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Sophie BRINGER-DEUTSCH, MD

Phone

0467336452

s-bringer_deutsch@chu-montpellier.fr

First Name & Middle Initial & Last Name & Degree

Sophie BRINGER-DEUTSCH, MD

First Name & Middle Initial & Last Name & Degree

Gauthier RATHAT, PhD

First Name & Middle Initial & Last Name & Degree

Delphine TOPART, MD

First Name & Middle Initial & Last Name & Degree

Claire VINCENS, MD

Facility Name

ICM - Val d'Aurelle

City

Montpellier

ZIP/Postal Code

34298

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Séverine GUIU, MD

Phone

0467613043

severin.guiu@icm.unicancer.fr

First Name & Middle Initial & Last Name & Degree

Séverine GUIU, MD

First Name & Middle Initial & Last Name & Degree

Gilles ROMIEU, MD

First Name & Middle Initial & Last Name & Degree

William JACOT, MD

First Name & Middle Initial & Last Name & Degree

Véronique D'HONDT, MD

First Name & Middle Initial & Last Name & Degree

Marie ALEXANDRE, MD

First Name & Middle Initial & Last Name & Degree

Delphine DULIEGE, MD

First Name & Middle Initial & Last Name & Degree

Nelly FIRMIN, MD

First Name & Middle Initial & Last Name & Degree

Stéphane POUDEROUX, MD

First Name & Middle Initial & Last Name & Degree

Marie VIALA, MD

Facility Name

CHRU de Nancy

City

Nancy

ZIP/Postal Code

54000

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Mikael AGOPIANTZ, MD

Phone

0671038224

m.agopiantz@chu-nancy.fr

First Name & Middle Initial & Last Name & Degree

Mikael AGOPIANTZ, MD

First Name & Middle Initial & Last Name & Degree

Catherine LAMY-ZUILY, MD

Facility Name

Institut Curie

City

Paris

ZIP/Postal Code

75005

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Florence COUSSY, MD

florence.coussy@curie.fr

First Name & Middle Initial & Last Name & Degree

Florence COUSSY, MD

First Name & Middle Initial & Last Name & Degree

Coraline DUBOT, MD

First Name & Middle Initial & Last Name & Degree

Florence COUSSY, MD

First Name & Middle Initial & Last Name & Degree

Virginie FOURCHOTTE, MD

First Name & Middle Initial & Last Name & Degree

Roman ROUZIER, MD

Facility Name

Hôpital Cochin

City

Paris

ZIP/Postal Code

75014

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Pietro SANTULLI, MD

Phone

0158413709

pietro.santulli@icch.aphp.fr

First Name & Middle Initial & Last Name & Degree

Pietro SANTULLI, MD

First Name & Middle Initial & Last Name & Degree

Mathilde BOURDON, MD

First Name & Middle Initial & Last Name & Degree

Vanessa GAYET, MD

First Name & Middle Initial & Last Name & Degree

Chloé MAINGNIEN, MD

Facility Name

Hôpital TENON

City

Paris

ZIP/Postal Code

75020

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Nathalie CHABBERT-BUFFET, PhD

nathalie.chabbert-buffet@aphp.fr

First Name & Middle Initial & Last Name & Degree

Nathalie CHABBERT-BUFFET, PhD

First Name & Middle Initial & Last Name & Degree

Jean-Pierre LOTZ, MD

First Name & Middle Initial & Last Name & Degree

Joseph GLIGOROV, PhD

First Name & Middle Initial & Last Name & Degree

Emmanuelle MATHIEU D'ARGENT, MD

First Name & Middle Initial & Last Name & Degree

Lise SELLERET, MD

First Name & Middle Initial & Last Name & Degree

Sandrine RICHARD, MD

First Name & Middle Initial & Last Name & Degree

Adoracion ESTESO, MD

Facility Name

CHU Rouen

City

Rouen

ZIP/Postal Code

76031

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Maria LETAILLEUR, MD

Phone

02 32 88 87 44

Maria.Letailleur@chu-rouen.fr

First Name & Middle Initial & Last Name & Degree

Maria LETAILLEUR, MD

Facility Name

Centre Henri Becquerel

City

Rouen

ZIP/Postal Code

76038

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Marianne LEHEURTEUR, MD

Phone

0232082575

marianne.leheurteur@chb.unicancer.fr

First Name & Middle Initial & Last Name & Degree

Marianne LEHEURTEUR, MD

First Name & Middle Initial & Last Name & Degree

Jean Chirstophe THERY, MD

First Name & Middle Initial & Last Name & Degree

Emmanuel DE GOURNAY, MD

Facility Name

Institut Curie

City

Saint-Cloud

ZIP/Postal Code

92210

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Florence COUSSY, MD

florence.coussy@curie.fr

First Name & Middle Initial & Last Name & Degree

Florence COUSSY, MD

First Name & Middle Initial & Last Name & Degree

Anika BENSEN, MD

First Name & Middle Initial & Last Name & Degree

Sophie FRANCK, MD

First Name & Middle Initial & Last Name & Degree

Jean-Yves PIERGA, MD

First Name & Middle Initial & Last Name & Degree

François Clément BIDARD, MD

First Name & Middle Initial & Last Name & Degree

Etienne BRAIN, MD

First Name & Middle Initial & Last Name & Degree

Luc CABEL, MD

First Name & Middle Initial & Last Name & Degree

Delphine HEQUET, MD

First Name & Middle Initial & Last Name & Degree

Florence LEREBOURS, MD

First Name & Middle Initial & Last Name & Degree

Yuting WANG, MD

Facility Name

Hôpital Universitaire de Strasbourg

City

Strasbourg

ZIP/Postal Code

67091

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Olivier PIRRELLO, MD

Phone

0388628300

olivier.pirrello@CHRU-strasbourg.fr

First Name & Middle Initial & Last Name & Degree

Philippe BARTHELEMY, MD

First Name & Middle Initial & Last Name & Degree

Olivier PIRRELLO, MD

First Name & Middle Initial & Last Name & Degree

Philippe BARTHELEMY, MD

First Name & Middle Initial & Last Name & Degree

Laure DE COCK, MD

First Name & Middle Initial & Last Name & Degree

Jeanine OHL, MD

First Name & Middle Initial & Last Name & Degree

Catherine RONGIERES, MD

Facility Name

Oncopole-CHU Toulouse

City

Toulouse

ZIP/Postal Code

31059

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Clémentine COHADE, MD

Phone

0567771102

cohade.c@chu-toulouse.fr

First Name & Middle Initial & Last Name & Degree

Clémentine COHADE, MD

First Name & Middle Initial & Last Name & Degree

Jean PARINAUD, PhD

First Name & Middle Initial & Last Name & Degree

Roger LEANDRI, MD

First Name & Middle Initial & Last Name & Degree

Marion DESLANDRES, MD

Facility Name

Institut de Cancérologie de Lorraine

City

Vandoeuvre les nancy

ZIP/Postal Code

54519

Country

France

Individual Site Status

Recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Mathilde DEBLOCK, MD

Phone

0383598574

m.deblock@nancy.unicancer.fr

First Name & Middle Initial & Last Name & Degree

Mathilde DEBLOCK, MD

First Name & Middle Initial & Last Name & Degree

Maria RIOS, MD

First Name & Middle Initial & Last Name & Degree

Vincent MASSARD, MD

First Name & Middle Initial & Last Name & Degree

Anne KIEFFER, MD

First Name & Middle Initial & Last Name & Degree

Lionel UWER, MD

Facility Name

Institut Gustave Roussy

City

Villejuif

ZIP/Postal Code

94805

Country

France

Individual Site Status

Not yet recruiting

Facility Contact:

First Name & Middle Initial & Last Name & Degree

Enrica BENTIVEGNA, MD

Phone

0142115668

enrica.bentivegna@gustaveroussy.fr

First Name & Middle Initial & Last Name & Degree

Enrica BENTIVEGNA, MD

First Name & Middle Initial & Last Name & Degree

Suzette DELALOGE, MD

12. IPD Sharing Statement

Plan to Share IPD

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Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation

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Risk of Infertility Related to Adjuvant Chemotherapy for Early Breast Cancer: Oocyte/Embryo Cryopreservation (CHACRY-1501)

Breast Cancer

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

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