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Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease (COMPASS)

Primary Purpose

Prevention & Control

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Rivaroxaban (Xarelto, BAY59-7939)
Rivaroxaban (Xarelto, BAY59-7939)
Aspirin
Aspirin placebo
Rivaroxaban placebo
Pantoprazole
Pantoprazole placebo
Sponsored by
Bayer
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Prevention & Control focused on measuring Cardiovascular events, Rivaroxaban, Xarelto, Anticoagulant, Blood thinner, Aspirin, ASA, Coronary artery disease, CAD, Peripheral artery disease, PAD, Artery disease, Coronary artery bypass graft, Stroke, Heart attack, Angina, Arterial vascular disease, Myocardial infarction, MI, Cardiovascular Death, CV Death, Heart disease

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

- Meet criteria for CAD and/or PAD

Subjects with CAD must also meet at least one of the following criteria:

  • Age ≥65, or
  • Age <65 and documented atherosclerosis or revascularization involving at least 2 vascular beds, or at least 2 additional risk factors

Exclusion Criteria:

  • Stroke within 1 month or any history of hemorrhagic or lacunar stroke
  • Severe heart failure with known ejection fraction <30% or New York Heart Association (NYHA) class III or IV symptoms
  • Estimated glomerular filtration rate (eGFR)<15 mL/min
  • Need for dual antiplatelet therapy, other non-aspirin antiplatelet therapy, or oral anticoagulant therapy

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Active Comparator

Arm Label

Rivaroxaban 2.5mg + Aspirin 100mg

Rivaroxaban 5mg + Aspirin Placebo

Rivaroxaban Placebo + Aspirin 100mg

Arm Description

Participants received rivaroxaban 2.5 mg twice daily (bid) and aspirin 100 mg once daily (od). All doses were provided in tablet form for oral administration. Participants who did not have a continuous need to take a proton pump inhibitor (PPI), were additionally randomized 1:1 to receive pantoprazole 40 mg (tablet form for oral administration, od) or matching placebo od. Participants who consented to LTOLE part received open label rivaroxaban 2.5 mg bid and aspirin 100 mg od in LTOLE part.

Participants received rivaroxaban 5 mg bid and aspirin placebo od. All doses were provided in tablet form for oral administration. Participants who did not have a continuous need to take a PPI, were additionally randomized 1:1 to receive pantoprazole 40 mg (tablet form for oral administration, od) or matching placebo od. Participants who consented to LTOLE part received open label rivaroxaban 2.5 mg bid and aspirin 100 mg od in LTOLE part.

Participants received rivaroxaban placebo bid and aspirin 100 mg od. All doses were provided in tablet form for oral administration. Participants who did not have a continuous need to take a PPI, were randomized 1:1 to receive pantoprazole 40 mg (tablet form for oral administration, od) or matching placebo od. Participants who consented to LTOLE part received open label rivaroxaban 2.5 mg bid and aspirin 100 mg od in LTOLE part.

Outcomes

Primary Outcome Measures

The First Occurrence of the Composite Primary Efficacy Outcome, Myocardial Infarction (MI), Stroke, or Cardiovascular (CV) Death
Count of participants and time from randomization to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis.
The First Occurrence of the Primary Safety Outcome Major Bleeding Based on a Modification of the International Society on Thrombosis and Haemostasis (ISTH) Criteria
Modified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day). Count of participants and time from randomization to the first occurrence of the primary safety outcome major bleeding were evaluated. Hazard ratios were calculated and reported as statistical analysis.

Secondary Outcome Measures

The First Occurrence of Myocardial Infarction (MI), Ischemic Stroke, Acute Limb Ischemia (ALI), or Coronary Heart Disease (CHD) Death
Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CHD death were evaluated. Hazard ratios were calculated and reported as statistical analysis.
The First Occurrence of MI, Ischemic Stroke, ALI, or Cardiovascular (CV) Death
Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis.
All-cause Mortality
Count of participants and time from randomization to death by all cause were evaluated. Hazard ratios were calculated and reported as statistical analysis.

Full Information

First Posted
January 24, 2013
Last Updated
November 3, 2022
Sponsor
Bayer
Collaborators
Population Health Research Institute, Janssen Research & Development, LLC
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1. Study Identification

Unique Protocol Identification Number
NCT01776424
Brief Title
Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease
Acronym
COMPASS
Official Title
A Randomized Controlled Trial of Rivaroxaban for the Prevention of Major Cardiovascular Events in Patients With Coronary or Peripheral Artery Disease (COMPASS - Cardiovascular OutcoMes for People Using Anticoagulation StrategieS).
Study Type
Interventional

2. Study Status

Record Verification Date
November 2022
Overall Recruitment Status
Completed
Study Start Date
February 28, 2013 (Actual)
Primary Completion Date
July 21, 2017 (Actual)
Study Completion Date
June 15, 2021 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Bayer
Collaborators
Population Health Research Institute, Janssen Research & Development, LLC

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The primary objectives of this study are: To determine whether rivaroxaban 2.5 mg twice daily (bid) + aspirin 100 mg once daily (od) compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction, stroke, or cardiovascular death in subjects with coronary artery disease (CAD) or peripheral artery disease (PAD); To determine whether rivaroxaban 5 mg bid compared with aspirin 100 mg od reduces the risk of a composite of myocardial infarction, stroke or cardiovascular death in subjects with CAD or PAD.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Prevention & Control
Keywords
Cardiovascular events, Rivaroxaban, Xarelto, Anticoagulant, Blood thinner, Aspirin, ASA, Coronary artery disease, CAD, Peripheral artery disease, PAD, Artery disease, Coronary artery bypass graft, Stroke, Heart attack, Angina, Arterial vascular disease, Myocardial infarction, MI, Cardiovascular Death, CV Death, Heart disease

7. Study Design

Primary Purpose
Prevention
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Masking Description
Participants who consented to COMPASS long-term open-label extension (LTOLE) part received open label rivaroxaban 2.5 mg bid and aspirin 100 mg od in LTOLE part and no blinding procedures were applicable to the LTOLE part.
Allocation
Randomized
Enrollment
27395 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Rivaroxaban 2.5mg + Aspirin 100mg
Arm Type
Experimental
Arm Description
Participants received rivaroxaban 2.5 mg twice daily (bid) and aspirin 100 mg once daily (od). All doses were provided in tablet form for oral administration. Participants who did not have a continuous need to take a proton pump inhibitor (PPI), were additionally randomized 1:1 to receive pantoprazole 40 mg (tablet form for oral administration, od) or matching placebo od. Participants who consented to LTOLE part received open label rivaroxaban 2.5 mg bid and aspirin 100 mg od in LTOLE part.
Arm Title
Rivaroxaban 5mg + Aspirin Placebo
Arm Type
Experimental
Arm Description
Participants received rivaroxaban 5 mg bid and aspirin placebo od. All doses were provided in tablet form for oral administration. Participants who did not have a continuous need to take a PPI, were additionally randomized 1:1 to receive pantoprazole 40 mg (tablet form for oral administration, od) or matching placebo od. Participants who consented to LTOLE part received open label rivaroxaban 2.5 mg bid and aspirin 100 mg od in LTOLE part.
Arm Title
Rivaroxaban Placebo + Aspirin 100mg
Arm Type
Active Comparator
Arm Description
Participants received rivaroxaban placebo bid and aspirin 100 mg od. All doses were provided in tablet form for oral administration. Participants who did not have a continuous need to take a PPI, were randomized 1:1 to receive pantoprazole 40 mg (tablet form for oral administration, od) or matching placebo od. Participants who consented to LTOLE part received open label rivaroxaban 2.5 mg bid and aspirin 100 mg od in LTOLE part.
Intervention Type
Drug
Intervention Name(s)
Rivaroxaban (Xarelto, BAY59-7939)
Intervention Description
Tablet, 2.5 mg, twice daily, oral
Intervention Type
Drug
Intervention Name(s)
Rivaroxaban (Xarelto, BAY59-7939)
Intervention Description
Tablet, 5 mg, twice daily, oral
Intervention Type
Drug
Intervention Name(s)
Aspirin
Intervention Description
Tablet, 100 mg, once daily, oral
Intervention Type
Drug
Intervention Name(s)
Aspirin placebo
Intervention Description
Aspirin matching placebo, once daily, oral
Intervention Type
Drug
Intervention Name(s)
Rivaroxaban placebo
Intervention Description
Rivaroxaban matching placebo, twice daily, oral
Intervention Type
Drug
Intervention Name(s)
Pantoprazole
Intervention Description
Tablet, 40 mg, once daily, oral, for participants who were not on a PPI and who were randomized to pantoprazole
Intervention Type
Drug
Intervention Name(s)
Pantoprazole placebo
Intervention Description
Pantoprazole matching placebo, once daily, oral, for participants who were not on a PPI and who were randomized to pantoprazole placebo
Primary Outcome Measure Information:
Title
The First Occurrence of the Composite Primary Efficacy Outcome, Myocardial Infarction (MI), Stroke, or Cardiovascular (CV) Death
Description
Count of participants and time from randomization to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis.
Time Frame
For each participant, the first occurrence of the composite primary efficacy outcome after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.
Title
The First Occurrence of the Primary Safety Outcome Major Bleeding Based on a Modification of the International Society on Thrombosis and Haemostasis (ISTH) Criteria
Description
Modified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day). Count of participants and time from randomization to the first occurrence of the primary safety outcome major bleeding were evaluated. Hazard ratios were calculated and reported as statistical analysis.
Time Frame
For each participant, the first occurrence of modified ISTH major bleeding after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.
Secondary Outcome Measure Information:
Title
The First Occurrence of Myocardial Infarction (MI), Ischemic Stroke, Acute Limb Ischemia (ALI), or Coronary Heart Disease (CHD) Death
Description
Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CHD death were evaluated. Hazard ratios were calculated and reported as statistical analysis.
Time Frame
For each participant, the first occurrence of MI, ALI, or CHD death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.
Title
The First Occurrence of MI, Ischemic Stroke, ALI, or Cardiovascular (CV) Death
Description
Count of participants and time from randomization to the first occurrence of MI, ischemic stroke, ALI, or CV death were evaluated. Hazard ratios were calculated and reported as statistical analysis.
Time Frame
For each participant, the first occurrence of MI, ischemic stroke, ALI, or CV death after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.
Title
All-cause Mortality
Description
Count of participants and time from randomization to death by all cause were evaluated. Hazard ratios were calculated and reported as statistical analysis.
Time Frame
For each participants, death by any cause after randomization up until the global rivaroxaban/aspirin outcomes cut-off date (06 FEB 2017) was considered. The mean time in follow-up until that date was 702 days.
Other Pre-specified Outcome Measures:
Title
The First Occurrence of the Composite Primary Efficacy Outcome, Myocardial Infarction (MI), Stroke, or Cardiovascular (CV) Death in LTOLE Part
Description
Count of participants from COMPASS LTOLE initiation visit to the first occurrence of the composite primary efficacy outcome, MI, stroke, or CV death were evaluated. LTOLE: long-term open-lable extension
Time Frame
For each participant, the first occurrence of the composite primary efficacy outcome after from COMPASS LTOLE initiation visit up until last LTOLE part contact date was considered. The mean time in follow-up was 428 days.
Title
The First Occurrence of the Primary Safety Outcome Major Bleeding Based on a Modification of the International Society on Thrombosis and Haemostasis (ISTH) Criteria in LTOLE Part
Description
Modified ISTH major bleeding is defined as: i) Fatal bleeding, or ii) Symptomatic bleeding in a critical area or organ, such as intraarticular, intracranial, intramuscular with compartment syndrome, intraocular, intraspinal, liver, pancreas, pericardial, respiratory, retroperitoneal, adrenal gland or kidney; or bleeding into the surgical site requiring reoperation, or iii) Bleeding leading to hospitalization (major bleeding also includes presentation to an acute care facility with discharge on the same day). Count of participants from COMPASS LTOLE initiation visit to the first occurrence of the primary safety outcome major bleeding was evaluated. LTOLE: long-term open-lable extension
Time Frame
For each participant, the first occurrence of modified ISTH major bleeding from COMPASS LTOLE initiation visit up until 2 days after the last treatment in LTOLE part was considered. The mean time in follow-up was 421 days.
Title
All-cause Mortality in LTOLE Part
Description
Count of participants from COMPASS LTOLE initiation visit to death by all cause were evaluated. LTOLE: long-term open-lable extension
Time Frame
For each participants, death by any cause after COMPASS LTOLE initiation visit up until the the last LTOLE part contact date was considered. The mean time in follow-up until that date was 428 days.

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: - Meet criteria for CAD and/or PAD Subjects with CAD must also meet at least one of the following criteria: Age ≥65, or Age <65 and documented atherosclerosis or revascularization involving at least 2 vascular beds, or at least 2 additional risk factors Exclusion Criteria: Stroke within 1 month or any history of hemorrhagic or lacunar stroke Severe heart failure with known ejection fraction <30% or New York Heart Association (NYHA) class III or IV symptoms Estimated glomerular filtration rate (eGFR)<15 mL/min Need for dual antiplatelet therapy, other non-aspirin antiplatelet therapy, or oral anticoagulant therapy
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bayer Study Director
Organizational Affiliation
Bayer
Official's Role
Study Director
Facility Information:
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
City
Anaheim
State/Province
California
ZIP/Postal Code
92801
Country
United States
City
Laguna Hills
State/Province
California
ZIP/Postal Code
92653
Country
United States
City
Northridge
State/Province
California
ZIP/Postal Code
91324
Country
United States
City
Palo Alto
State/Province
California
ZIP/Postal Code
94304-1207
Country
United States
City
Santa Rosa
State/Province
California
ZIP/Postal Code
95494
Country
United States
City
Sylmar
State/Province
California
ZIP/Postal Code
91342
Country
United States
City
Torrance
State/Province
California
ZIP/Postal Code
90502-2004
Country
United States
City
Norwalk
State/Province
Connecticut
ZIP/Postal Code
06851
Country
United States
City
Stamford
State/Province
Connecticut
ZIP/Postal Code
06905
Country
United States
City
Trumbull
State/Province
Connecticut
ZIP/Postal Code
06611
Country
United States
City
Atlantis
State/Province
Florida
ZIP/Postal Code
33462
Country
United States
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
City
Coral Springs
State/Province
Florida
ZIP/Postal Code
33065
Country
United States
City
Jacksonville Beach
State/Province
Florida
ZIP/Postal Code
32250
Country
United States
City
Largo
State/Province
Florida
ZIP/Postal Code
33770
Country
United States
City
New Port Richey
State/Province
Florida
ZIP/Postal Code
34653
Country
United States
City
Safety Harbor
State/Province
Florida
ZIP/Postal Code
34695
Country
United States
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
City
Meridian
State/Province
Idaho
ZIP/Postal Code
83716
Country
United States
City
Arlington Heights
State/Province
Illinois
ZIP/Postal Code
60005
Country
United States
City
Hazel Crest
State/Province
Illinois
ZIP/Postal Code
60429
Country
United States
City
Davenport
State/Province
Iowa
ZIP/Postal Code
52803
Country
United States
City
West Des Moines
State/Province
Iowa
ZIP/Postal Code
50266
Country
United States
City
Crestview Hills
State/Province
Kentucky
ZIP/Postal Code
41017-5460
Country
United States
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21215
Country
United States
City
Haverhill
State/Province
Massachusetts
ZIP/Postal Code
01830
Country
United States
City
Alpena
State/Province
Michigan
ZIP/Postal Code
49707
Country
United States
City
Jackson
State/Province
Michigan
ZIP/Postal Code
49201
Country
United States
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63136
Country
United States
City
Kalispell
State/Province
Montana
ZIP/Postal Code
59901
Country
United States
City
New Brunswick
State/Province
New Jersey
ZIP/Postal Code
08901
Country
United States
City
Cortlandt Manor
State/Province
New York
ZIP/Postal Code
10567
Country
United States
City
Kingston
State/Province
New York
ZIP/Postal Code
12401
Country
United States
City
Saratoga Springs
State/Province
New York
ZIP/Postal Code
12866
Country
United States
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27713
Country
United States
City
Pinehurst
State/Province
North Carolina
ZIP/Postal Code
28374
Country
United States
City
Elyria
State/Province
Ohio
ZIP/Postal Code
44035
Country
United States
City
Sandusky
State/Province
Ohio
ZIP/Postal Code
44870
Country
United States
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43606
Country
United States
City
Doylestown
State/Province
Pennsylvania
ZIP/Postal Code
18901
Country
United States
City
Langhorne
State/Province
Pennsylvania
ZIP/Postal Code
19047
Country
United States
City
Yardley
State/Province
Pennsylvania
ZIP/Postal Code
19067
Country
United States
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57108
Country
United States
City
Dallas
State/Province
Texas
ZIP/Postal Code
75216-7167
Country
United States
City
Houston
State/Province
Texas
ZIP/Postal Code
77030-4298
Country
United States
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
City
Bellevue
State/Province
Washington
ZIP/Postal Code
98004-4623
Country
United States
City
Puyallup
State/Province
Washington
ZIP/Postal Code
98372
Country
United States
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
City
Adrogue
State/Province
Buenos Aires
ZIP/Postal Code
1846
Country
Argentina
City
Bahía Blanca
State/Province
Buenos Aires
ZIP/Postal Code
8000
Country
Argentina
City
Coronel Suarez
State/Province
Buenos Aires
ZIP/Postal Code
B7540GHD
Country
Argentina
City
Junín
State/Province
Buenos Aires
ZIP/Postal Code
B6000BHA
Country
Argentina
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
1900
Country
Argentina
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
B1902AGY
Country
Argentina
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
B1902CNF
Country
Argentina
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
B1902COS
Country
Argentina
City
Mar del Plata
State/Province
Buenos Aires
ZIP/Postal Code
B7600FZN
Country
Argentina
City
Merlo
State/Province
Buenos Aires
ZIP/Postal Code
B1722COV
Country
Argentina
City
Munro
State/Province
Buenos Aires
ZIP/Postal Code
B1605DSX
Country
Argentina
City
Quilmes
State/Province
Buenos Aires
ZIP/Postal Code
1878
Country
Argentina
City
Ramos Mejía
State/Province
Buenos Aires
ZIP/Postal Code
B1740ETD
Country
Argentina
City
San Martín
State/Province
Buenos Aires
ZIP/Postal Code
1650
Country
Argentina
City
San Nicolás
State/Province
Buenos Aires
ZIP/Postal Code
B2900DMH
Country
Argentina
City
Vicente López
State/Province
Buenos Aires
ZIP/Postal Code
B1602ABQ
Country
Argentina
City
Zárate
State/Province
Buenos Aires
ZIP/Postal Code
B2800DGH
Country
Argentina
City
Buenos Aires
State/Province
Ciudad Auton. De Buenos Aires
ZIP/Postal Code
C1119ACN
Country
Argentina
City
Buenos Aires
State/Province
Ciudad Auton. De Buenos Aires
ZIP/Postal Code
C1428ART
Country
Argentina
City
Buenos Aires
State/Province
Ciudad Auton. De Buenos Aires
ZIP/Postal Code
C1440AAD
Country
Argentina
City
Ciudad Autón. de Buenos Aires
State/Province
Ciudad Auton. De Buenos Aires
ZIP/Postal Code
C1425AGC
Country
Argentina
City
Villa Allende
State/Province
Córdoba
Country
Argentina
City
Villa María
State/Province
Córdoba
ZIP/Postal Code
X5900JKA
Country
Argentina
City
Santa Rosa
State/Province
La Pampa
ZIP/Postal Code
6300
Country
Argentina
City
Rafaela
State/Province
Santa Fe
ZIP/Postal Code
S2300MMA
Country
Argentina
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
2000
Country
Argentina
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2005PAF
Country
Argentina
City
Rosario
State/Province
Santa Fe
Country
Argentina
City
Venado Tuerto
State/Province
Santa Fe
ZIP/Postal Code
S2600KUE
Country
Argentina
City
San Miguel de Tucumán
State/Province
Tucuman
ZIP/Postal Code
4000
Country
Argentina
City
San Miguel de Tucumán
State/Province
Tucuman
ZIP/Postal Code
T4000IFL
Country
Argentina
City
Ciudad Auton. de Buenos Aires
ZIP/Postal Code
C1023AAB
Country
Argentina
City
Ciudad Auton. de Buenos Aires
ZIP/Postal Code
C1181ACL
Country
Argentina
City
Ciudad Auton. de Buenos Aires
ZIP/Postal Code
C1405BUB
Country
Argentina
City
Corrientes
ZIP/Postal Code
3400
Country
Argentina
City
Córdoba
ZIP/Postal Code
X5000AAW Córdoba
Country
Argentina
City
Córdoba
ZIP/Postal Code
X5000AAX
Country
Argentina
City
Córdoba
ZIP/Postal Code
X5003DCE
Country
Argentina
City
Córdoba
ZIP/Postal Code
X5003DCP
Country
Argentina
City
Córdoba
ZIP/Postal Code
X5004CDT
Country
Argentina
City
Córdoba
ZIP/Postal Code
X5006IKK
Country
Argentina
City
Salta
ZIP/Postal Code
A4406CLA
Country
Argentina
City
San Juan
ZIP/Postal Code
5400
Country
Argentina
City
San luis
ZIP/Postal Code
5700
Country
Argentina
City
Santa Fe
ZIP/Postal Code
S3000FWO
Country
Argentina
City
Bruce
State/Province
Australian Capital Territory
ZIP/Postal Code
2617
Country
Australia
City
Gosford
State/Province
New South Wales
ZIP/Postal Code
2250
Country
Australia
City
New Lambton Heights
State/Province
New South Wales
ZIP/Postal Code
2305
Country
Australia
City
Taree
State/Province
New South Wales
ZIP/Postal Code
2430
Country
Australia
City
Birtinya
State/Province
Queensland
ZIP/Postal Code
4575
Country
Australia
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4064
Country
Australia
City
Redcliffe
State/Province
Queensland
ZIP/Postal Code
4020
Country
Australia
City
Woolloongabba
State/Province
Queensland
ZIP/Postal Code
4102
Country
Australia
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
City
Hobart
State/Province
Tasmania
ZIP/Postal Code
7000
Country
Australia
City
Launceston
State/Province
Tasmania
ZIP/Postal Code
7250
Country
Australia
City
Geelong
State/Province
Victoria
ZIP/Postal Code
3220
Country
Australia
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3052
Country
Australia
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3181
Country
Australia
City
Prahran
State/Province
Victoria
ZIP/Postal Code
3181
Country
Australia
City
Murdoch
State/Province
Western Australia
ZIP/Postal Code
6150
Country
Australia
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
City
Antwerpen
ZIP/Postal Code
2020
Country
Belgium
City
Bonheiden
ZIP/Postal Code
2820
Country
Belgium
City
Brugge
ZIP/Postal Code
8000
Country
Belgium
City
Bruxelles - Brussel
ZIP/Postal Code
1070
Country
Belgium
City
Charleroi
ZIP/Postal Code
6000
Country
Belgium
City
Genk
ZIP/Postal Code
3600
Country
Belgium
City
Hasselt
ZIP/Postal Code
3500
Country
Belgium
City
Kortrijk
ZIP/Postal Code
8500
Country
Belgium
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
City
Liege
ZIP/Postal Code
4000
Country
Belgium
City
Roeselare
ZIP/Postal Code
8800
Country
Belgium
City
Goiania
State/Province
Goiás
ZIP/Postal Code
74223 130
Country
Brazil
City
Belo Horizonte
State/Province
Minas Gerais
ZIP/Postal Code
30150-240
Country
Brazil
City
Uberaba
State/Province
Minas Gerais
ZIP/Postal Code
38025-260
Country
Brazil
City
Uberlândia
State/Province
Minas Gerais
ZIP/Postal Code
38400-368
Country
Brazil
City
Campina Grande do Sul
State/Province
Parana
ZIP/Postal Code
83430 000
Country
Brazil
City
Curitiba
State/Province
Parana
ZIP/Postal Code
80730-150
Country
Brazil
City
Canoas
State/Province
Rio Grande Do Sul
ZIP/Postal Code
92425-900
Country
Brazil
City
Pelotas
State/Province
Rio Grande Do Sul
ZIP/Postal Code
96015-290
Country
Brazil
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90.620-001
Country
Brazil
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90020-090
Country
Brazil
City
Porto Alegre
State/Province
Rio Grande Do Sul
ZIP/Postal Code
90840-440
Country
Brazil
City
Porto Alegre
State/Province
Rio Grande Do Sul
Country
Brazil
City
Blumenau
State/Province
Santa Catarina
ZIP/Postal Code
89010 500
Country
Brazil
City
Campinas
State/Province
Sao Paulo
ZIP/Postal Code
13010-001
Country
Brazil
City
Campinas
State/Province
Sao Paulo
ZIP/Postal Code
13020-421
Country
Brazil
City
Campinas
State/Province
Sao Paulo
ZIP/Postal Code
13060904
Country
Brazil
City
Matão
State/Province
Sao Paulo
ZIP/Postal Code
15990-060
Country
Brazil
City
São José do Rio Preto
State/Province
Sao Paulo
ZIP/Postal Code
15015-750
Country
Brazil
City
São José do Rio Preto
State/Province
Sao Paulo
ZIP/Postal Code
15090
Country
Brazil
City
São Paulo
State/Province
Sao Paulo
ZIP/Postal Code
01506-001
Country
Brazil
City
São Paulo
State/Province
Sao Paulo
ZIP/Postal Code
04012-909
Country
Brazil
City
Votuporanga
State/Province
Sao Paulo
Country
Brazil
City
Sao Paulo
ZIP/Postal Code
05403-000
Country
Brazil
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4Z6
Country
Canada
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
City
New Westminster
State/Province
British Columbia
ZIP/Postal Code
V3L 3W4
Country
Canada
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8R 4R2
Country
Canada
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2H 0R8
Country
Canada
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2H 2A6
Country
Canada
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R2V 4W3
Country
Canada
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3T 2E8
Country
Canada
City
Moncton
State/Province
New Brunswick
ZIP/Postal Code
E1G 1A7
Country
Canada
City
Saint John
State/Province
New Brunswick
ZIP/Postal Code
E2L 4L2
Country
Canada
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A7
Country
Canada
City
Brampton
State/Province
Ontario
ZIP/Postal Code
L6W 2X7
Country
Canada
City
Burlington
State/Province
Ontario
ZIP/Postal Code
L7M 4Y1
Country
Canada
City
Burlington
State/Province
Ontario
ZIP/Postal Code
L7R 1E2
Country
Canada
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 6V6
Country
Canada
City
Cambridge
State/Province
Ontario
ZIP/Postal Code
N1R 7R1
Country
Canada
City
Grimsby
State/Province
Ontario
ZIP/Postal Code
L3M 1P3
Country
Canada
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8M 1K7
Country
Canada
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 5A5
Country
Canada
City
London
State/Province
Ontario
ZIP/Postal Code
N6G 2M1
Country
Canada
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5K 2L3
Country
Canada
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 2P6
Country
Canada
City
Newmarket
State/Province
Ontario
ZIP/Postal Code
L3Y 8C3
Country
Canada
City
Oakville
State/Province
Ontario
ZIP/Postal Code
L6K 3W7
Country
Canada
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1J 2J9
Country
Canada
City
Oshawa
State/Province
Ontario
ZIP/Postal Code
L1J 2K1
Country
Canada
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K2H 8T5
Country
Canada
City
Peterborough
State/Province
Ontario
ZIP/Postal Code
K9J 0B2
Country
Canada
City
Scarborough
State/Province
Ontario
ZIP/Postal Code
M1E 5E9
Country
Canada
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E 1H5
Country
Canada
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E 6C3
Country
Canada
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
City
Waterloo
State/Province
Ontario
ZIP/Postal Code
ON N2T 0C1
Country
Canada
City
Windsor
State/Province
Ontario
ZIP/Postal Code
N8X 5A6
Country
Canada
City
Chicoutimi
State/Province
Quebec
ZIP/Postal Code
G7H 5H6
Country
Canada
City
Laval
State/Province
Quebec
ZIP/Postal Code
H7M 3L9
Country
Canada
City
Levis
State/Province
Quebec
ZIP/Postal Code
G6V 4Z5
Country
Canada
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2W 1T8
Country
Canada
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3G 1A4
Country
Canada
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1H 5N4
Country
Canada
City
Terrebonne
State/Province
Quebec
ZIP/Postal Code
J6V 2H2
Country
Canada
City
Thetford Mines
State/Province
Quebec
ZIP/Postal Code
G6G 2V4
Country
Canada
City
Trois-Rivieres
State/Province
Quebec
ZIP/Postal Code
G8Z 4K4
Country
Canada
City
Ontario
ZIP/Postal Code
P3E 5M4
Country
Canada
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
City
Temuco
State/Province
Araucanía
ZIP/Postal Code
2170000
Country
Chile
City
Temuco
State/Province
Araucanía
ZIP/Postal Code
4781156
Country
Chile
City
Temuco
State/Province
Araucanía
ZIP/Postal Code
4791348
Country
Chile
City
Concepción
State/Province
Bío-Bío
ZIP/Postal Code
4070038
Country
Chile
City
Osorno
State/Province
Los Lagos
ZIP/Postal Code
5311092
Country
Chile
City
Valdivia
State/Province
Los Lagos
Country
Chile
City
Providencia
State/Province
Santiago
ZIP/Postal Code
7500520
Country
Chile
City
San Miguel
State/Province
Santiago
ZIP/Postal Code
8910108
Country
Chile
City
Viña del Mar
State/Province
Valparaíso
ZIP/Postal Code
2570017
Country
Chile
City
Santiago
ZIP/Postal Code
7500739
Country
Chile
City
Santiago
Country
Chile
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510080
Country
China
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510100
Country
China
City
Wudan
State/Province
Hubei
ZIP/Postal Code
430022
Country
China
City
Wuhan
State/Province
Hubei
Country
China
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410011
Country
China
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210006
Country
China
City
Nanjing
State/Province
Jiangsu
ZIP/Postal Code
210029
Country
China
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130000
Country
China
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130033
Country
China
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110004
Country
China
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710061
Country
China
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310003
Country
China
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310016
Country
China
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325000
Country
China
City
Beijing
ZIP/Postal Code
100029
Country
China
City
Beijing
ZIP/Postal Code
100034
Country
China
City
Beijing
ZIP/Postal Code
100038
Country
China
City
Beijing
ZIP/Postal Code
100088
Country
China
City
Beijing
ZIP/Postal Code
100730
Country
China
City
Beijing
Country
China
City
Shanghai
ZIP/Postal Code
200001
Country
China
City
Shanghai
ZIP/Postal Code
200003
Country
China
City
Shanghai
ZIP/Postal Code
200025
Country
China
City
Shanghai
ZIP/Postal Code
200030
Country
China
City
Shanghai
ZIP/Postal Code
200032
Country
China
City
Shanghai
ZIP/Postal Code
200080
Country
China
City
Barranquilla
State/Province
Atlántico
Country
Colombia
City
Cartagena
State/Province
Bolívar
Country
Colombia
City
Manizales
State/Province
Caldas
Country
Colombia
City
Montería
State/Province
Córdoba
ZIP/Postal Code
230002
Country
Colombia
City
Pasto
State/Province
Nariño
Country
Colombia
City
Armenia
State/Province
Quindío
Country
Colombia
City
Pereira
State/Province
Risaralda
Country
Colombia
City
Bucaramanga
State/Province
Santander
Country
Colombia
City
Floridablanca
State/Province
Santander
ZIP/Postal Code
681004
Country
Colombia
City
Espinal
State/Province
Tolima
Country
Colombia
City
Cali
State/Province
Valle Del Cauca
ZIP/Postal Code
760032
Country
Colombia
City
Barranquilla
Country
Colombia
City
Santafe de Bogotá
Country
Colombia
City
Brno
ZIP/Postal Code
625 00
Country
Czechia
City
Brno
ZIP/Postal Code
656 91
Country
Czechia
City
Ceske Budejovice
ZIP/Postal Code
370 01
Country
Czechia
City
Cesky Krumlov
ZIP/Postal Code
381 27
Country
Czechia
City
Hodonin
ZIP/Postal Code
695 01
Country
Czechia
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
City
Jablonec nad Nisou
ZIP/Postal Code
466 60
Country
Czechia
City
Kolin
ZIP/Postal Code
280 02
Country
Czechia
City
Liberec
ZIP/Postal Code
460 63
Country
Czechia
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
City
Ostrava
ZIP/Postal Code
708 52
Country
Czechia
City
Ostrava
ZIP/Postal Code
728 80
Country
Czechia
City
Pardubice
ZIP/Postal Code
530 03
Country
Czechia
City
Praha 10
ZIP/Postal Code
100 34
Country
Czechia
City
Praha 13
ZIP/Postal Code
158 00
Country
Czechia
City
Praha 2
ZIP/Postal Code
128 08
Country
Czechia
City
Praha 4
ZIP/Postal Code
140 21
Country
Czechia
City
Praha 5
ZIP/Postal Code
150 06
Country
Czechia
City
Praha 5
ZIP/Postal Code
150 30
Country
Czechia
City
Praha 6
ZIP/Postal Code
169 02
Country
Czechia
City
Slany
ZIP/Postal Code
274 01
Country
Czechia
City
Susice
ZIP/Postal Code
342 01
Country
Czechia
City
Trebic
ZIP/Postal Code
674 01
Country
Czechia
City
Trinec
ZIP/Postal Code
739 61
Country
Czechia
City
Uherske Hradiste
ZIP/Postal Code
686 68
Country
Czechia
City
Zlin
ZIP/Postal Code
762 75
Country
Czechia
City
Aalborg
ZIP/Postal Code
DK-9000
Country
Denmark
City
Aarhus N
ZIP/Postal Code
8200
Country
Denmark
City
Hellerup
ZIP/Postal Code
2900
Country
Denmark
City
Holbaek
ZIP/Postal Code
4300
Country
Denmark
City
Hvidovre
ZIP/Postal Code
2650
Country
Denmark
City
Kolding
ZIP/Postal Code
6000
Country
Denmark
City
København Ø
ZIP/Postal Code
2100
Country
Denmark
City
København
ZIP/Postal Code
DK-2400
Country
Denmark
City
Viborg
ZIP/Postal Code
8800
Country
Denmark
City
Guayaquil
State/Province
Guayas
Country
Ecuador
City
Quito
State/Province
Pichincha
ZIP/Postal Code
0
Country
Ecuador
City
Quito
Country
Ecuador
City
Kuopio
ZIP/Postal Code
70100
Country
Finland
City
Kuusankoski
ZIP/Postal Code
45700
Country
Finland
City
Tampere
ZIP/Postal Code
33200
Country
Finland
City
Turku
ZIP/Postal Code
FIN-20520
Country
Finland
City
Vantaa
ZIP/Postal Code
01600
Country
Finland
City
Amiens cedex 1
ZIP/Postal Code
80054
Country
France
City
Clermont Ferrand
ZIP/Postal Code
63000
Country
France
City
Limoges Cedex
ZIP/Postal Code
87042
Country
France
City
Montpellier
ZIP/Postal Code
34059
Country
France
City
Nice
ZIP/Postal Code
06280
Country
France
City
NIMES cedex 9
ZIP/Postal Code
30029
Country
France
City
Paris Cedex 15
ZIP/Postal Code
75908
Country
France
City
Paris
ZIP/Postal Code
75012
Country
France
City
Paris
ZIP/Postal Code
75018
Country
France
City
Saint-priest-en-jarez
ZIP/Postal Code
42270
Country
France
City
Nürnberg
State/Province
Bayern
ZIP/Postal Code
90402
Country
Germany
City
Würzburg
State/Province
Bayern
ZIP/Postal Code
97078
Country
Germany
City
Bad Homburg
State/Province
Hessen
ZIP/Postal Code
61348
Country
Germany
City
Frankfurt
State/Province
Hessen
ZIP/Postal Code
60596
Country
Germany
City
Kassel
State/Province
Hessen
ZIP/Postal Code
34128
Country
Germany
City
Bielefeld
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
33604
Country
Germany
City
Dortmund
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
44137
Country
Germany
City
Wuppertal
State/Province
Nordrhein-Westfalen
ZIP/Postal Code
42117
Country
Germany
City
Magdeburg
State/Province
Sachsen-Anhalt
ZIP/Postal Code
39120
Country
Germany
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01067
Country
Germany
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
04289
Country
Germany
City
Berlin
ZIP/Postal Code
12351
Country
Germany
City
Berlin
ZIP/Postal Code
12559
Country
Germany
City
Berlin
ZIP/Postal Code
13353
Country
Germany
City
Bottrop
ZIP/Postal Code
46242
Country
Germany
City
Frankfurt
ZIP/Postal Code
65929
Country
Germany
City
Hamburg
ZIP/Postal Code
20099
Country
Germany
City
Warendorf
ZIP/Postal Code
48231
Country
Germany
City
Balatonfured
ZIP/Postal Code
8230
Country
Hungary
City
Budapest
ZIP/Postal Code
1085
Country
Hungary
City
Budapest
ZIP/Postal Code
1115
Country
Hungary
City
Budapest
ZIP/Postal Code
H-1096
Country
Hungary
City
Budapest
ZIP/Postal Code
H-1125
Country
Hungary
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
City
Mosonmagyarovar
ZIP/Postal Code
9200
Country
Hungary
City
Pecs
ZIP/Postal Code
7624
Country
Hungary
City
Sopron
ZIP/Postal Code
9400
Country
Hungary
City
Szekesfehervar
ZIP/Postal Code
8000
Country
Hungary
City
Szekszard
ZIP/Postal Code
7100
Country
Hungary
City
Ballinasloe
State/Province
Co. Galway
Country
Ireland
City
Cork
Country
Ireland
City
Dublin
ZIP/Postal Code
9
Country
Ireland
City
Dublin
ZIP/Postal Code
D07 R2WY
Country
Ireland
City
Dublin
ZIP/Postal Code
D08 NHY1
Country
Ireland
City
Galway
Country
Ireland
City
Afula
ZIP/Postal Code
1834111
Country
Israel
City
Ashkelon
ZIP/Postal Code
7830604
Country
Israel
City
Bnei Brak
Country
Israel
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
City
Haifa
ZIP/Postal Code
3436212
Country
Israel
City
Holon
ZIP/Postal Code
5822012
Country
Israel
City
Nahariya
ZIP/Postal Code
2210001
Country
Israel
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
City
Tel Aviv
Country
Israel
City
Zefat
ZIP/Postal Code
1311001
Country
Israel
City
Caserta
State/Province
Campania
ZIP/Postal Code
81027
Country
Italy
City
Bologna
State/Province
Emilia-Romagna
ZIP/Postal Code
40133
Country
Italy
City
Forlì Cesena
State/Province
Emilia-Romagna
ZIP/Postal Code
47100
Country
Italy
City
Ravenna
State/Province
Emilia-Romagna
ZIP/Postal Code
48010
Country
Italy
City
Trieste
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
34149
Country
Italy
City
Udine
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33038
Country
Italy
City
Udine
State/Province
Friuli-Venezia Giulia
ZIP/Postal Code
33057
Country
Italy
City
Udine
State/Province
Friuli-Venezia Giulia
Country
Italy
City
Brescia
State/Province
Lombardia
ZIP/Postal Code
25123
Country
Italy
City
Cremona
State/Province
Lombardia
ZIP/Postal Code
26100
Country
Italy
City
Pavia
State/Province
Lombardia
ZIP/Postal Code
27100
Country
Italy
City
Ancona
State/Province
Marche
ZIP/Postal Code
60126
Country
Italy
City
Isernia
State/Province
Molise
ZIP/Postal Code
86170
Country
Italy
City
Foggia
State/Province
Puglia
ZIP/Postal Code
71100
Country
Italy
City
Lecce
State/Province
Puglia
ZIP/Postal Code
73042
Country
Italy
City
Catania
State/Province
Sicilia
ZIP/Postal Code
95126
Country
Italy
City
Palermo
State/Province
Sicilia
ZIP/Postal Code
90146
Country
Italy
City
Arezzo
State/Province
Toscana
ZIP/Postal Code
52044
Country
Italy
City
Firenze
State/Province
Toscana
ZIP/Postal Code
50053
Country
Italy
City
Perugia
State/Province
Umbria
ZIP/Postal Code
06024
Country
Italy
City
Terni
State/Province
Umbria
ZIP/Postal Code
05100
Country
Italy
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
453-8511
Country
Japan
City
Toyoake
State/Province
Aichi
ZIP/Postal Code
470-1192
Country
Japan
City
Kisarazu
State/Province
Chiba
ZIP/Postal Code
292-8535
Country
Japan
City
Matsudo
State/Province
Chiba
ZIP/Postal Code
270-2251
Country
Japan
City
Imabari
State/Province
Ehime
ZIP/Postal Code
794-0006
Country
Japan
City
Matsuyama
State/Province
Ehime
ZIP/Postal Code
790-0062
Country
Japan
City
Kasuga
State/Province
Fukuoka
ZIP/Postal Code
816-0864
Country
Japan
City
Kitakyushu
State/Province
Fukuoka
ZIP/Postal Code
802-8555
Country
Japan
City
Miyako-gun
State/Province
Fukuoka
ZIP/Postal Code
800-0344
Country
Japan
City
Onga-gun
State/Province
Fukuoka
ZIP/Postal Code
811-4342
Country
Japan
City
Maebashi
State/Province
Gunma
ZIP/Postal Code
371-0821
Country
Japan
City
Onomichi
State/Province
Hiroshima
ZIP/Postal Code
722-8503
Country
Japan
City
Asahikawa
State/Province
Hokkaido
ZIP/Postal Code
070-0038
Country
Japan
City
Asahikawa
State/Province
Hokkaido
ZIP/Postal Code
070-8610
Country
Japan
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
006-0852
Country
Japan
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
006-8555
Country
Japan
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-0004
Country
Japan
City
Tomakomai
State/Province
Hokkaido
ZIP/Postal Code
053-8567
Country
Japan
City
Kobe
State/Province
Hyogo
ZIP/Postal Code
654-0026
Country
Japan
City
Takarazuka
State/Province
Hyogo
ZIP/Postal Code
665-0873
Country
Japan
City
Kaga
State/Province
Ishikawa
ZIP/Postal Code
922-8522
Country
Japan
City
Miura-gun
State/Province
Kanagawa
ZIP/Postal Code
240-0116
Country
Japan
City
Sagamihara
State/Province
Kanagawa
ZIP/Postal Code
252-0375
Country
Japan
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
232-0024
Country
Japan
City
Naha
State/Province
Okinawa
ZIP/Postal Code
902-8511
Country
Japan
City
Kishiwada
State/Province
Osaka
ZIP/Postal Code
596-0042
Country
Japan
City
Takatsuki
State/Province
Osaka
ZIP/Postal Code
569-1096
Country
Japan
City
Tokorozawa
State/Province
Saitama
ZIP/Postal Code
359-1141
Country
Japan
City
Komatsushima
State/Province
Tokushima
ZIP/Postal Code
773-8502
Country
Japan
City
Akishima
State/Province
Tokyo
ZIP/Postal Code
196-0003
Country
Japan
City
Bunkyo-ku
State/Province
Tokyo
ZIP/Postal Code
113-8431
Country
Japan
City
Itabashi-ku
State/Province
Tokyo
ZIP/Postal Code
173-8610
Country
Japan
City
Shimonoseki
State/Province
Yamaguchi
ZIP/Postal Code
750-0061
Country
Japan
City
Chiba
ZIP/Postal Code
263-0043
Country
Japan
City
Fukuoka
ZIP/Postal Code
812-0033
Country
Japan
City
Fukuoka
ZIP/Postal Code
814-0180
Country
Japan
City
Gifu
ZIP/Postal Code
500-8384
Country
Japan
City
Gifu
ZIP/Postal Code
500-8717
Country
Japan
City
Kumamoto
ZIP/Postal Code
861-4193
Country
Japan
City
Kyoto
ZIP/Postal Code
600-8558
Country
Japan
City
Kyoto
ZIP/Postal Code
601-1495
Country
Japan
City
Kyoto
ZIP/Postal Code
615-8256
Country
Japan
City
Osaka
ZIP/Postal Code
530-0001
Country
Japan
City
Osaka
ZIP/Postal Code
530-8480
Country
Japan
City
Osaka
ZIP/Postal Code
540-0006
Country
Japan
City
Osaka
ZIP/Postal Code
543-0035
Country
Japan
City
Osaka
ZIP/Postal Code
558-8558
Country
Japan
City
Osaka
ZIP/Postal Code
559-0012
Country
Japan
City
Wonju
State/Province
Gang''weondo
ZIP/Postal Code
26426
Country
Korea, Republic of
City
Goyang-si
State/Province
Gyeonggido
ZIP/Postal Code
10326
Country
Korea, Republic of
City
Seongnam-si
State/Province
Gyeonggido
ZIP/Postal Code
463-707
Country
Korea, Republic of
City
Jeju
State/Province
Jejudo
ZIP/Postal Code
690767
Country
Korea, Republic of
City
Seoul
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
150-713
Country
Korea, Republic of
City
Busan
ZIP/Postal Code
614-735
Country
Korea, Republic of
City
Daejeon
ZIP/Postal Code
302-718
Country
Korea, Republic of
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
City
Seoul
ZIP/Postal Code
110-744
Country
Korea, Republic of
City
Seoul
ZIP/Postal Code
134-727
Country
Korea, Republic of
City
Batu Caves, Selangor
ZIP/Postal Code
68100
Country
Malaysia
City
Kedah
ZIP/Postal Code
05460
Country
Malaysia
City
Kuala Lumpur
ZIP/Postal Code
50400
Country
Malaysia
City
Kuala Lumpur
ZIP/Postal Code
59100
Country
Malaysia
City
Selangor
ZIP/Postal Code
47000
Country
Malaysia
City
Sungai Buloh Selangor
ZIP/Postal Code
47000
Country
Malaysia
City
Amsterdam
ZIP/Postal Code
1091 AC
Country
Netherlands
City
Apeldoorn
ZIP/Postal Code
7334 DZ
Country
Netherlands
City
Arnhem
ZIP/Postal Code
6815 AD
Country
Netherlands
City
Breda
ZIP/Postal Code
4818 CK
Country
Netherlands
City
Delft
ZIP/Postal Code
2625 AD
Country
Netherlands
City
Den Bosch
ZIP/Postal Code
5223 GZ
Country
Netherlands
City
Deventer
ZIP/Postal Code
7416 SE
Country
Netherlands
City
Doetinchem
ZIP/Postal Code
7009 BL
Country
Netherlands
City
Drachten
ZIP/Postal Code
9205 NN
Country
Netherlands
City
EDE
ZIP/Postal Code
6716 RP
Country
Netherlands
City
Gorinchem
ZIP/Postal Code
4204 AA
Country
Netherlands
City
Gouda
ZIP/Postal Code
2803 HH
Country
Netherlands
City
Groningen
ZIP/Postal Code
9721 SW
Country
Netherlands
City
Heerlen
ZIP/Postal Code
6401 CX
Country
Netherlands
City
Helmond
ZIP/Postal Code
5707 HA
Country
Netherlands
City
Hoogeveen
ZIP/Postal Code
7909 AA
Country
Netherlands
City
Hoorn
ZIP/Postal Code
1624 NP
Country
Netherlands
City
Leeuwarden
ZIP/Postal Code
8901 BR
Country
Netherlands
City
Meppel
ZIP/Postal Code
7943 KA
Country
Netherlands
City
Nijmegen
ZIP/Postal Code
6532 SZ
Country
Netherlands
City
Roermond
ZIP/Postal Code
6043 CV
Country
Netherlands
City
Roosendaal
ZIP/Postal Code
4708 AE
Country
Netherlands
City
Rotterdam
ZIP/Postal Code
3045 PM
Country
Netherlands
City
Rotterdam
ZIP/Postal Code
3083 AN
Country
Netherlands
City
Sneek
ZIP/Postal Code
8601 ZK
Country
Netherlands
City
Tiel
ZIP/Postal Code
4002 WP
Country
Netherlands
City
Zwolle
ZIP/Postal Code
8011 JW
Country
Netherlands
City
Batangas
Country
Philippines
City
Cebu City
ZIP/Postal Code
6000
Country
Philippines
City
Dagupan City
ZIP/Postal Code
2400
Country
Philippines
City
Dasmarinas
ZIP/Postal Code
4114
Country
Philippines
City
Iloilo City
ZIP/Postal Code
5000
Country
Philippines
City
Laoag City
ZIP/Postal Code
2900
Country
Philippines
City
Manila
ZIP/Postal Code
1000
Country
Philippines
City
Manila
Country
Philippines
City
Metro Manila
ZIP/Postal Code
1502
Country
Philippines
City
Muntinlupa City
ZIP/Postal Code
1780
Country
Philippines
City
Palawan
ZIP/Postal Code
5300
Country
Philippines
City
Pasig city
ZIP/Postal Code
1605
Country
Philippines
City
Quezon City
ZIP/Postal Code
1102
Country
Philippines
City
Quezon City
ZIP/Postal Code
1109
Country
Philippines
City
Quezon City
ZIP/Postal Code
NCR 1100
Country
Philippines
City
Tacloban City
ZIP/Postal Code
6500
Country
Philippines
City
Gdansk
ZIP/Postal Code
80 -126
Country
Poland
City
Kielce
ZIP/Postal Code
25-315
Country
Poland
City
Krakow
ZIP/Postal Code
30-002
Country
Poland
City
Krakow
ZIP/Postal Code
31-271
Country
Poland
City
Krakow
ZIP/Postal Code
31-501
Country
Poland
City
Krakow
ZIP/Postal Code
31-534
Country
Poland
City
Lodz
ZIP/Postal Code
91-347
Country
Poland
City
Tarnow
ZIP/Postal Code
33-100
Country
Poland
City
Wroclaw
ZIP/Postal Code
53-114
Country
Poland
City
Timisoara
State/Province
Timis
ZIP/Postal Code
300254
Country
Romania
City
Brasov
ZIP/Postal Code
500326
Country
Romania
City
Bucharest
ZIP/Postal Code
011461
Country
Romania
City
Bucharest
ZIP/Postal Code
021659
Country
Romania
City
Bucharest
ZIP/Postal Code
022322
Country
Romania
City
Bucharest
ZIP/Postal Code
041915
Country
Romania
City
Bucharest
ZIP/Postal Code
042122
Country
Romania
City
Bucharest
ZIP/Postal Code
050098
Country
Romania
City
Bucharest
ZIP/Postal Code
061114
Country
Romania
City
Bucuresti
ZIP/Postal Code
50659
Country
Romania
City
Cluj Napoca
ZIP/Postal Code
400001
Country
Romania
City
Iasi
ZIP/Postal Code
700503
Country
Romania
City
Iasi
ZIP/Postal Code
700732
Country
Romania
City
Targu Mures
ZIP/Postal Code
540124
Country
Romania
City
Targu Mures
ZIP/Postal Code
540136
Country
Romania
City
Timisoara
ZIP/Postal Code
300310
Country
Romania
City
Barnaul
ZIP/Postal Code
656038
Country
Russian Federation
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
City
Moscow
ZIP/Postal Code
101990
Country
Russian Federation
City
Moscow
ZIP/Postal Code
107084
Country
Russian Federation
City
Moscow
ZIP/Postal Code
111539
Country
Russian Federation
City
Moscow
ZIP/Postal Code
117556
Country
Russian Federation
City
Moscow
ZIP/Postal Code
119435
Country
Russian Federation
City
Moscow
ZIP/Postal Code
121309
Country
Russian Federation
City
Moscow
ZIP/Postal Code
127206
Country
Russian Federation
City
Novosibirsk
ZIP/Postal Code
630089
Country
Russian Federation
City
Tomsk
ZIP/Postal Code
634012
Country
Russian Federation
City
Zhukovskiy
ZIP/Postal Code
140160
Country
Russian Federation
City
Bratislava
ZIP/Postal Code
811 04
Country
Slovakia
City
Bratislava
ZIP/Postal Code
813 69
Country
Slovakia
City
Kosice
ZIP/Postal Code
040 22
Country
Slovakia
City
Nitra
ZIP/Postal Code
94901
Country
Slovakia
City
Presov
ZIP/Postal Code
080 81
Country
Slovakia
City
Vrable
ZIP/Postal Code
952 01
Country
Slovakia
City
Pinelands
State/Province
Eastern Cape
ZIP/Postal Code
7503
Country
South Africa
City
Port Elizabeth
State/Province
Eastern Cape
ZIP/Postal Code
6014
Country
South Africa
City
Bloemfontein
State/Province
Freestate
ZIP/Postal Code
9300
Country
South Africa
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2157
Country
South Africa
City
Cape Town
State/Province
Western Cape
ZIP/Postal Code
7531
Country
South Africa
City
Observatory
State/Province
Western Cape
ZIP/Postal Code
7925
Country
South Africa
City
Pinelands
State/Province
Western Cape
ZIP/Postal Code
7405
Country
South Africa
City
Worcester
State/Province
Western Cape
ZIP/Postal Code
6850
Country
South Africa
City
Somerset West
ZIP/Postal Code
7130
Country
South Africa
City
Göteborg
ZIP/Postal Code
413 45
Country
Sweden
City
Helsingborg
ZIP/Postal Code
251 87
Country
Sweden
City
Kristianstad
ZIP/Postal Code
291 85
Country
Sweden
City
Skellefteå
ZIP/Postal Code
931 86
Country
Sweden
City
Stockholm
ZIP/Postal Code
111 35
Country
Sweden
City
Stockholm
ZIP/Postal Code
114 46
Country
Sweden
City
Stockholm
ZIP/Postal Code
141 86
Country
Sweden
City
Stockholm
ZIP/Postal Code
171 76
Country
Sweden
City
Vällingby
ZIP/Postal Code
162 68
Country
Sweden
City
Örebro
ZIP/Postal Code
701 85
Country
Sweden
City
Östersund
ZIP/Postal Code
831 83
Country
Sweden
City
Lugano
State/Province
Ticino
ZIP/Postal Code
6900
Country
Switzerland
City
Dnipropetrovsk
ZIP/Postal Code
49 006
Country
Ukraine
City
Kharkiv
ZIP/Postal Code
61002
Country
Ukraine
City
Kharkiv
ZIP/Postal Code
61039
Country
Ukraine
City
Kharkiv
ZIP/Postal Code
61176
Country
Ukraine
City
Kiev
ZIP/Postal Code
02 091
Country
Ukraine
City
Kiev
ZIP/Postal Code
02660
Country
Ukraine
City
Kiev
ZIP/Postal Code
03 049
Country
Ukraine
City
Lviv
ZIP/Postal Code
790 34
Country
Ukraine
City
Lviv
ZIP/Postal Code
79044
Country
Ukraine
City
Lviv
ZIP/Postal Code
79659
Country
Ukraine
City
Simferopol
ZIP/Postal Code
95006
Country
Ukraine
City
Vinnitsa
ZIP/Postal Code
21029
Country
Ukraine
City
Zaporozhye
ZIP/Postal Code
69 000
Country
Ukraine
City
Zaporozhye
ZIP/Postal Code
69118
Country
Ukraine
City
Belfast
State/Province
Antrim
ZIP/Postal Code
BT16 1RH
Country
United Kingdom
City
Londonderry Co. Londonderry
State/Province
Derry
ZIP/Postal Code
BT47 6SB
Country
United Kingdom
City
Basildon
State/Province
Essex
ZIP/Postal Code
SS16 5NL
Country
United Kingdom
City
Stevenage
State/Province
Hertfordshire
ZIP/Postal Code
SG1 4AB
Country
United Kingdom
City
Blackpool
State/Province
Lancashire
ZIP/Postal Code
FY4 3AD
Country
United Kingdom
City
Harrow
State/Province
London
ZIP/Postal Code
HA1 3UJ
Country
United Kingdom
City
Portadown
State/Province
North Ireland
Country
United Kingdom
City
Middlesborough
State/Province
North Yorkshire
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
City
Northampton
State/Province
Northamptonshire
ZIP/Postal Code
NN1 5BD
Country
United Kingdom
City
Hardwick
State/Province
Stockton-on-Tees
ZIP/Postal Code
TS29 6NH
Country
United Kingdom
City
Nuneaton
State/Province
Warwickshire
ZIP/Postal Code
CV10 7DJ
Country
United Kingdom
City
West Bromich
State/Province
West Midlands
ZIP/Postal Code
B71 4HJ
Country
United Kingdom
City
Wolverhampton
State/Province
West Midlands
ZIP/Postal Code
WV10 0QP
Country
United Kingdom
City
Worcester
State/Province
Worcestershire
ZIP/Postal Code
WR5 1DD
Country
United Kingdom

12. IPD Sharing Statement

Plan to Share IPD
No
IPD Sharing Plan Description
Availability of this study's data will later be determined according to Bayer's commitment to the EFPIA/PhRMA "Principles for responsible clinical trial data sharing". This pertains to scope, timepoint and process of data access. As such, Bayer commits to sharing upon request from qualified researchers patient-level clinical trial data, study-level clinical trial data, and protocols from clinical trials in patients for medicines and indications approved in the US and EU as necessary for conducting legitimate research. This applies to data on new medicines and indications that have been approved by the EU and US regulatory agencies on or after January 01, 2014. Interested researchers can use www.clinicalstudydatarequest.com to request access to anonymized patient-level data and supporting documents from clinical studies to conduct research. Information on the Bayer criteria for listing studies and other relevant information is provided in the Study sponsors section of the portal.
Citations:
PubMed Identifier
35383832
Citation
Eikelboom JW, Bosch J, Connolly SJ, Tyrwitt J, Fox KAA, Muehlhofer E, Neumann C, Tasto C, Bangdiwala SI, Diaz R, Alings M, Dagenais GR, Leong DP, Lonn EM, Avezum A, Piegas LS, Widimsky P, Parkhomenko AN, Bhatt DL, Branch KRH, Probstfield JL, Lopez-Jaramillo P, Ryden L, Pogosova N, Keltai K, Keltai M, Ertl G, Stoerk S, Dans AL, Lanas F, Liang Y, Zhu J, Torp-Pedersen C, Maggioni AP, Commerford PJ, Guzik TJ, Vanassche T, Verhamme P, O'Donnell M, Tonkin AM, Varigos JD, Vinereanu D, Felix C, Kim JH, Ibrahim KS, Lewis BS, Metsarinne KP, Aboyans V, Steg PG, Hori M, Kakkar A, Anand SS, Lamy A, Sharma M, Yusuf S. Long-Term Treatment with the Combination of Rivaroxaban and Aspirin in Patients with Chronic Coronary or Peripheral Artery Disease: Outcomes During the Open Label Extension of the COMPASS trial. Eur Heart J Cardiovasc Pharmacother. 2022 Dec 2;8(8):786-795. doi: 10.1093/ehjcvp/pvac023.
Results Reference
background
PubMed Identifier
29540326
Citation
Anand SS, Caron F, Eikelboom JW, Bosch J, Dyal L, Aboyans V, Abola MT, Branch KRH, Keltai K, Bhatt DL, Verhamme P, Fox KAA, Cook-Bruns N, Lanius V, Connolly SJ, Yusuf S. Major Adverse Limb Events and Mortality in Patients With Peripheral Artery Disease: The COMPASS Trial. J Am Coll Cardiol. 2018 May 22;71(20):2306-2315. doi: 10.1016/j.jacc.2018.03.008. Epub 2018 Mar 11.
Results Reference
result
Citation
Anand SS, Bosch J, Eikelboom JW, Connolly SJ, Diaz R, Widimsky P, Aboyans V, Alings M, Kakkar AK, Keltai K, Maggioni AP, Lewis BS, Störk S, Zhu J, Lopez-Jaramillo P, O'Donnell M, Commerford PJ, Vinereanu D, Pogosova N, Ryden L, Fox KAA, Bhatt DL, Misselwitz F, Varigos JD, Vanassche T, Avezum AA, Chen E, Branch K, Leong DP, Bangdiwala SI, Hart RG, Yusuf S. Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017 Nov 10. pii: S0140-6736(17)32409-1. doi: 10.1016/S0140-6736(17)32409-1. PMID:29132880
Results Reference
result
Citation
Connolly SJ, Eikelboom JW, Bosch J, Dagenais G, Dyal L, Lanas F, Metsarinne K, O'Donnell M, Dans AL, Ha JW, Parkhomenko AN, Avezum AA, Lonn E, Lisheng L, Torp-Pedersen C, Widimsky P, Maggioni AP, Felix C, Keltai K, Hori M, Yusoff K, Guzik TJ, Bhatt DL, Branch KRH, Cook Bruns N, Berkowitz SD, Anand SS, Varigos JD, Fox KAA, Yusuf S. Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017 Nov 10. pii: S0140-6736(17)32458-3. doi: 10.1016/S0140-6736(17)32458-3. PMID:29132879
Results Reference
result
PubMed Identifier
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Darmon A, Bhatt DL, Elbez Y, Aboyans V, Anand S, Bosch J, Branch KR, Connolly SJ, Dyal L, Eikelboom JW, Fox KAA, Keltai K, Probstfield J, Yusuf S, Abtan J, Sorbets E, Eagle KA, Ducrocq G, Steg PG. External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry. Eur Heart J. 2018 Mar 1;39(9):750-757a. doi: 10.1093/eurheartj/ehx658.
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Kruger PC, Anand SS, de Vries TAC, Eikelboom JW. Patients with Peripheral Artery Disease in the COMPASS Trial. Eur J Vasc Endovasc Surg. 2018 Dec;56(6):772-773. doi: 10.1016/j.ejvs.2018.08.010. Epub 2018 Sep 10. No abstract available.
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Lamy A, Eikelboom J, Sheth T, Connolly S, Bosch J, Fox KAA, Zhu J, Lonn E, Dagenais G, Widimsky P, Branch KRH, Bhatt DL, Zheng Z, Straka Z, Dagenais F, Kong Y, Marsden T, Lee SF, Copland I, Yusuf S. Rivaroxaban, Aspirin, or Both to Prevent Early Coronary Bypass Graft Occlusion: The COMPASS-CABG Study. J Am Coll Cardiol. 2019 Jan 22;73(2):121-130. doi: 10.1016/j.jacc.2018.10.048.
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Sharma M, Hart RG, Connolly SJ, Bosch J, Shestakovska O, Ng KKH, Catanese L, Keltai K, Aboyans V, Alings M, Ha JW, Varigos J, Tonkin A, O'Donnell M, Bhatt DL, Fox K, Maggioni A, Berkowitz SD, Bruns NC, Yusuf S, Eikelboom JW. Stroke Outcomes in the COMPASS Trial. Circulation. 2019 Feb 26;139(9):1134-1145. doi: 10.1161/CIRCULATIONAHA.118.035864.
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Coppens M, Weitz JI, Eikelboom JWA. Synergy of Dual Pathway Inhibition in Chronic Cardiovascular Disease. Circ Res. 2019 Feb;124(3):416-425. doi: 10.1161/CIRCRESAHA.118.313141.
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Moayyedi P, Eikelboom JW, Bosch J, Connolly SJ, Dyal L, Shestakovska O, Leong D, Anand SS, Stork S, Branch KRH, Bhatt DL, Verhamme PB, O'Donnell M, Maggioni AP, Lonn EM, Piegas LS, Ertl G, Keltai M, Cook Bruns N, Muehlhofer E, Dagenais GR, Kim JH, Hori M, Steg PG, Hart RG, Diaz R, Alings M, Widimsky P, Avezum A, Probstfield J, Zhu J, Liang Y, Lopez-Jaramillo P, Kakkar A, Parkhomenko AN, Ryden L, Pogosova N, Dans A, Lanas F, Commerford PJ, Torp-Pedersen C, Guzik T, Vinereanu D, Tonkin AM, Lewis BS, Felix C, Yusoff K, Metsarinne K, Fox KAA, Yusuf S; COMPASS Investigators. Pantoprazole to Prevent Gastroduodenal Events in Patients Receiving Rivaroxaban and/or Aspirin in a Randomized, Double-Blind, Placebo-Controlled Trial. Gastroenterology. 2019 Aug;157(2):403-412.e5. doi: 10.1053/j.gastro.2019.04.041. Epub 2019 May 2.
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Fox KAA, Eikelboom JW, Shestakovska O, Connolly SJ, Metsarinne KP, Yusuf S. Rivaroxaban Plus Aspirin in Patients With Vascular Disease and Renal Dysfunction: From the COMPASS Trial. J Am Coll Cardiol. 2019 May 14;73(18):2243-2250. doi: 10.1016/j.jacc.2019.02.048.
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Cairns JA, Eikelboom JW, Shestakovska O, Yusuf S, DeMets D. Monitoring Emerging Data From the COMPASS Trial of an Antithrombotic Agent. J Am Coll Cardiol. 2019 Jun 4;73(21):2769-2772. doi: 10.1016/j.jacc.2019.03.479. No abstract available.
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Moayyedi P, Eikelboom JW, Bosch J, Connolly SJ, Dyal L, Shestakovska O, Leong D, Anand SS, Stork S, Branch KRH, Bhatt DL, Verhamme PB, O'Donnell M, Maggioni AP, Lonn EM, Piegas LS, Ertl G, Keltai M, Bruns NC, Muehlhofer E, Dagenais GR, Kim JH, Hori M, Steg PG, Hart RG, Diaz R, Alings M, Widimsky P, Avezum A, Probstfield J, Zhu J, Liang Y, Lopez-Jaramillo P, Kakkar AK, Parkhomenko AN, Ryden L, Pogosova N, Dans AL, Lanas F, Commerford PJ, Torp-Pedersen C, Guzik TJ, Vinereanu D, Tonkin AM, Lewis BS, Felix C, Yusoff K, Metsarinne KP, Fox KAA, Yusuf S; COMPASS Investigators. Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin. Gastroenterology. 2019 Sep;157(3):682-691.e2. doi: 10.1053/j.gastro.2019.05.056. Epub 2019 May 29.
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Kruger PC, Guzik TJ, Eikelboom JW. How can the results of the COMPASS trial benefit patients with coronary or peripheral artery disease in Poland? Kardiol Pol. 2019 Aug 23;77(7-8):661-669. doi: 10.33963/KP.14855. Epub 2019 May 30.
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Branch KR, Probstfield JL, Eikelboom JW, Bosch J, Maggioni AP, Cheng RK, Bhatt DL, Avezum A, Fox KAA, Connolly SJ, Shestakovska O, Yusuf S. Rivaroxaban With or Without Aspirin in Patients With Heart Failure and Chronic Coronary or Peripheral Artery Disease. Circulation. 2019 Aug 13;140(7):529-537. doi: 10.1161/CIRCULATIONAHA.119.039609. Epub 2019 Jun 5.
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Anand SS, Eikelboom JW, Dyal L, Bosch J, Neumann C, Widimsky P, Avezum AA, Probstfield J, Cook Bruns N, Fox KAA, Bhatt DL, Connolly SJ, Yusuf S; COMPASS Trial Investigators. Rivaroxaban Plus Aspirin Versus Aspirin in Relation to Vascular Risk in the COMPASS Trial. J Am Coll Cardiol. 2019 Jul 2;73(25):3271-3280. doi: 10.1016/j.jacc.2019.02.079.
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de Vries TI, Eikelboom JW, Bosch J, Westerink J, Dorresteijn JAN, Alings M, Dyal L, Berkowitz SD, van der Graaf Y, Fox KAA, Visseren FLJ. Estimating individual lifetime benefit and bleeding risk of adding rivaroxaban to aspirin for patients with stable cardiovascular disease: results from the COMPASS trial. Eur Heart J. 2019 Dec 7;40(46):3771-3778a. doi: 10.1093/eurheartj/ehz404.
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Eikelboom JW, Connolly SJ, Bosch J, Shestakovska O, Aboyans V, Alings M, Anand SS, Avezum A, Berkowitz SD, Bhatt DL, Cook-Bruns N, Felix C, Fox KAA, Hart RG, Maggioni AP, Moayyedi P, O'Donnell M, Ryden L, Verhamme P, Widimsky P, Zhu J, Yusuf S. Bleeding and New Cancer Diagnosis in Patients With Atherosclerosis. Circulation. 2019 Oct 29;140(18):1451-1459. doi: 10.1161/CIRCULATIONAHA.119.041949. Epub 2019 Sep 12.
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Perera KS, Ng KKH, Nayar S, Catanese L, Dyal L, Sharma M, Connolly SJ, Yusuf S, Bosch J, Eikelboom JW, Hart RG. Association Between Low-Dose Rivaroxaban With or Without Aspirin and Ischemic Stroke Subtypes: A Secondary Analysis of the COMPASS Trial. JAMA Neurol. 2020 Jan 1;77(1):43-48. doi: 10.1001/jamaneurol.2019.2984.
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Eikelboom JW, Bosch JJ, Connolly SJ, Shestakovska O, Dagenais GR, Hart RG, Leong DP, O'Donnell M, Fox KAA, Bhatt DL, Cairns JA, Tasto C, Berkowitz SD, Cook Bruns N, Muehlhofer E, Diaz R, Maggioni AP, Yusuf S. Major Bleeding in Patients With Coronary or Peripheral Artery Disease Treated With Rivaroxaban Plus Aspirin. J Am Coll Cardiol. 2019 Sep 24;74(12):1519-1528. doi: 10.1016/j.jacc.2019.07.065.
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Welsh RC, Peterson ED, De Caterina R, Bode C, Gersh B, Eikelboom JW. Applying contemporary antithrombotic therapy in the secondary prevention of chronic atherosclerotic cardiovascular disease. Am Heart J. 2019 Dec;218:100-109. doi: 10.1016/j.ahj.2019.09.006. Epub 2019 Oct 23.
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Schiele F, Puymirat E, Ferrieres J, Simon T, Fox KAA, Eikelboom J, Danchin N; FAST-MI investigators. The FAST-MI 2005-2010-2015 registries in the light of the COMPASS trial: The COMPASS criteria applied to a post-MI population. Int J Cardiol. 2019 Mar 1;278:7-13. doi: 10.1016/j.ijcard.2018.11.138. Epub 2018 Dec 3.
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Liang Y, Zhu J, Liu L, Anand SS, Connolly SJ, Bosch J, Guzik TJ, O'Donnell M, Dagenais GR, Fox KA, Shestakovska O, Berkowitz SD, Muehlhofer E, Keller L, Yusuf S, Eikelboom JW; COMPASS Investigators. Efficacy and safety of rivaroxaban plus aspirin in women and men with chronic coronary or peripheral artery disease. Cardiovasc Res. 2021 Feb 22;117(3):942-949. doi: 10.1093/cvr/cvaa100. Erratum In: Cardiovasc Res. 2021 May 25;117(6):1577.
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Bhatt DL, Eikelboom JW, Connolly SJ, Steg PG, Anand SS, Verma S, Branch KRH, Probstfield J, Bosch J, Shestakovska O, Szarek M, Maggioni AP, Widimsky P, Avezum A, Diaz R, Lewis BS, Berkowitz SD, Fox KAA, Ryden L, Yusuf S; COMPASS Steering Committee and Investigators. Role of Combination Antiplatelet and Anticoagulation Therapy in Diabetes Mellitus and Cardiovascular Disease: Insights From the COMPASS Trial. Circulation. 2020 Jun 9;141(23):1841-1854. doi: 10.1161/CIRCULATIONAHA.120.046448. Epub 2020 Mar 28.
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Steffel J, Eikelboom JW, Anand SS, Shestakovska O, Yusuf S, Fox KAA. The COMPASS Trial: Net Clinical Benefit of Low-Dose Rivaroxaban Plus Aspirin as Compared With Aspirin in Patients With Chronic Vascular Disease. Circulation. 2020 Jul 7;142(1):40-48. doi: 10.1161/CIRCULATIONAHA.120.046048. Epub 2020 May 21. Erratum In: Circulation. 2020 Jul 7;142(1):e23.
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Kaplovitch E, Eikelboom JW, Dyal L, Aboyans V, Abola MT, Verhamme P, Avezum A, Fox KAA, Berkowitz SD, Bangdiwala SI, Yusuf S, Anand SS. Rivaroxaban and Aspirin in Patients With Symptomatic Lower Extremity Peripheral Artery Disease: A Subanalysis of the COMPASS Randomized Clinical Trial. JAMA Cardiol. 2021 Jan 1;6(1):21-29. doi: 10.1001/jamacardio.2020.4390. Erratum In: JAMA Cardiol. 2021 Feb 1;6(2):246.
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Guzik TJ, Ramasundarahettige C, Pogosova N, Lopez-Jaramillo P, Dyal L, Berkowitz SD, Muehlhofer E, Bhatt DL, Fox KAA, Yusuf S, Eikelboom JW. Rivaroxaban Plus Aspirin in Obese and Overweight Patients With Vascular Disease in the COMPASS Trial. J Am Coll Cardiol. 2021 Feb 9;77(5):511-525. doi: 10.1016/j.jacc.2020.11.061.
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Sen J, Tonkin A, Varigos J, Fonguh S, Berkowitz SD, Yusuf S, Verhamme P, Vanassche T, Anand SS, Fox KAA, Eikelboom JW, Amerena J; COMPASS Trial Investigators. Risk stratification of cardiovascular complications using CHA2DS2-VASc and CHADS2 scores in chronic atherosclerotic cardiovascular disease. Int J Cardiol. 2021 Aug 15;337:9-15. doi: 10.1016/j.ijcard.2021.04.067. Epub 2021 May 3.
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Lamy A, Browne A, Sheth T, Zheng Z, Dagenais F, Noiseux N, Chen X, Bakaeen FG, Brtko M, Stevens LM, Alboom M, Lee SF, Copland I, Salim Y, Eikelboom J; COMPASS Investigators. Skeletonized vs Pedicled Internal Mammary Artery Graft Harvesting in Coronary Artery Bypass Surgery: A Post Hoc Analysis From the COMPASS Trial. JAMA Cardiol. 2021 Sep 1;6(9):1042-1049. doi: 10.1001/jamacardio.2021.1686. Erratum In: JAMA Cardiol. 2021 Aug 18;:null.
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Eikelboom JW, Bhatt DL, Fox KAA, Bosch J, Connolly SJ, Anand SS, Avezum A, Berkowitz SD, Branch KRH, Dagenais GR, Felix C, Guzik TJ, Hart RG, Maggioni AP, Muehlhofer E, Sharma M, Shestakovska O, Yusuf S. Mortality Benefit of Rivaroxaban Plus Aspirin in Patients With Chronic Coronary or Peripheral Artery Disease. J Am Coll Cardiol. 2021 Jul 6;78(1):14-23. doi: 10.1016/j.jacc.2021.04.083.
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29132880
Citation
Anand SS, Bosch J, Eikelboom JW, Connolly SJ, Diaz R, Widimsky P, Aboyans V, Alings M, Kakkar AK, Keltai K, Maggioni AP, Lewis BS, Stork S, Zhu J, Lopez-Jaramillo P, O'Donnell M, Commerford PJ, Vinereanu D, Pogosova N, Ryden L, Fox KAA, Bhatt DL, Misselwitz F, Varigos JD, Vanassche T, Avezum AA, Chen E, Branch K, Leong DP, Bangdiwala SI, Hart RG, Yusuf S; COMPASS Investigators. Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet. 2018 Jan 20;391(10117):219-229. doi: 10.1016/S0140-6736(17)32409-1. Epub 2017 Nov 10.
Results Reference
derived
PubMed Identifier
29132879
Citation
Connolly SJ, Eikelboom JW, Bosch J, Dagenais G, Dyal L, Lanas F, Metsarinne K, O'Donnell M, Dans AL, Ha JW, Parkhomenko AN, Avezum AA, Lonn E, Lisheng L, Torp-Pedersen C, Widimsky P, Maggioni AP, Felix C, Keltai K, Hori M, Yusoff K, Guzik TJ, Bhatt DL, Branch KRH, Cook Bruns N, Berkowitz SD, Anand SS, Varigos JD, Fox KAA, Yusuf S; COMPASS investigators. Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet. 2018 Jan 20;391(10117):205-218. doi: 10.1016/S0140-6736(17)32458-3. Epub 2017 Nov 10. Erratum In: Lancet. 2017 Dec 21;:
Results Reference
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Rivaroxaban for the Prevention of Major Cardiovascular Events in Coronary or Peripheral Artery Disease

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