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Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)

Primary Purpose

COPD, COPD Exacerbation, Lung Diseases

Status
Completed
Phase
Phase 4
Locations
International
Study Type
Interventional
Intervention
Roflumilast
Placebo
Sponsored by
AstraZeneca
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for COPD focused on measuring COPD, Exacerbations, Roflumilast, Daliresp

Eligibility Criteria

40 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • 1. Male or female patients at least 40 years of age
  • 2. History of COPD (according to Global Initiative for Chronic Obstructive Lung Disease [GOLD] 2010) for at least 12 months prior to Screening (Visit 1) associated with chronic productive cough for 3 months in each of 2 consecutive years (with other causes of productive cough excluded). Only patients with chronic bronchitis will be included (concomitant emphysema is permitted)
  • 3. Forced expiratory volume after 1 second (FEV1)/forced vital capacity (FVC) ratio (postbronchodilator) < 70% at Screening (Visit 1)
  • 4. FEV1 (postbronchodilator) ≤ 50% of predicted at Screening (Visit 1)
  • 5. At least two documented moderate or severe COPD exacerbations within 12 months prior to Screening (Visit 1)
  • 6. Patients must be on FDC LABA/ICS treatment ≥ 3 months prior to Screening (Visit 1)
  • 7. Former smokers (defined as smoking cessation at least 1 year ago) or current smokers (including patients who ceased smoking within the past year) both with a smoking history of at least 20 pack-years

Exclusion Criteria:

  • 1. Moderate or severe COPD exacerbation and/or COPD exacerbations treated with antibiotics or systemic glucocorticosteroids within 4 weeks of Screening (Visit 1) (ie, patients must be clinically stable)
  • 2. Known alpha-1-antitrypsin deficiency
  • 3. Current diagnosis of asthma (either controlled or uncontrolled) (Note: History of childhood asthma is not exclusionary.)
  • 4. Body mass index (BMI) ≥ 45 kg/m2
  • 5. Patients with a history (within 5 years) or current diagnosis of cancer other than basal or squamous cell skin cancer

Sites / Locations

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Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

1

2

Arm Description

Roflumilast

Placebo

Outcomes

Primary Outcome Measures

Rate of Moderate or Severe COPD Exacerbations Per Patient Per Year.
Rate of moderate or severe COPD exacerbations, defined as requiring oral or parenteral glucocorticosteroids (moderate) or requiring hospitalization and/or leading to death (severe), during the double-blind treatment period.

Secondary Outcome Measures

Rate of COPD Exacerbations That Led to Hospitalization or Death (ie, Severe COPD Exacerbations)
Rate of moderate or severe COPD exacerbations, defined as requiring hospitalization and/or leading to death (severe), during the double-blind treatment period.
Rate of Moderate or Severe COPD Exacerbations or COPD Exacerbations Treated With Antibiotics
Rate of moderate or severe COPD exacerbations treated with antibiotics during the double-blind treatment period.
Mean Change in Predose Forced Expiratory Volume in 1 Second (FEV1)
Mean change from randomization (Visit 2) over 52 weeks of treatment in predose forced expiratory volume in 1 second (FEV1)

Full Information

First Posted
September 28, 2011
Last Updated
March 16, 2017
Sponsor
AstraZeneca
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1. Study Identification

Unique Protocol Identification Number
NCT01443845
Brief Title
Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)
Official Title
Study to Evaluate the Effect of Roflumilast 500 μg on Exacerbation Rate in Subjects With Chronic Obstructive Pulmonary Disease (COPD) Treated With a Fixed-Dose Combination of Long-Acting Beta Agonist and Inhaled Corticosteroid (LABA/ICS)
Study Type
Interventional

2. Study Status

Record Verification Date
March 2017
Overall Recruitment Status
Completed
Study Start Date
September 30, 2011 (Actual)
Primary Completion Date
November 30, 2015 (Actual)
Study Completion Date
January 31, 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AstraZeneca

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
To demonstrate the additional benefit of roflumilast when added on to fixed-dose combination (FDC) LABA/ICS in the reduction of exacerbations in subjects with severe to very severe COPD.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
COPD, COPD Exacerbation, Lung Diseases, Respiratory Disorders, Pulmonary Disease, Chronic Obstructive Lung Diseases, Chronic Obstructive Airway Disease
Keywords
COPD, Exacerbations, Roflumilast, Daliresp

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
2354 (Actual)

8. Arms, Groups, and Interventions

Arm Title
1
Arm Type
Experimental
Arm Description
Roflumilast
Arm Title
2
Arm Type
Placebo Comparator
Arm Description
Placebo
Intervention Type
Drug
Intervention Name(s)
Roflumilast
Other Intervention Name(s)
Daliresp
Intervention Description
Roflumilast 500 µg, oral administration, once per day
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Dose-matched placebo, oral administration, once per day.
Primary Outcome Measure Information:
Title
Rate of Moderate or Severe COPD Exacerbations Per Patient Per Year.
Description
Rate of moderate or severe COPD exacerbations, defined as requiring oral or parenteral glucocorticosteroids (moderate) or requiring hospitalization and/or leading to death (severe), during the double-blind treatment period.
Time Frame
Baseline to Week 52
Secondary Outcome Measure Information:
Title
Rate of COPD Exacerbations That Led to Hospitalization or Death (ie, Severe COPD Exacerbations)
Description
Rate of moderate or severe COPD exacerbations, defined as requiring hospitalization and/or leading to death (severe), during the double-blind treatment period.
Time Frame
Week 0 (Visit 2) to Week 52
Title
Rate of Moderate or Severe COPD Exacerbations or COPD Exacerbations Treated With Antibiotics
Description
Rate of moderate or severe COPD exacerbations treated with antibiotics during the double-blind treatment period.
Time Frame
Week 0 (Visit 2) to Week 52
Title
Mean Change in Predose Forced Expiratory Volume in 1 Second (FEV1)
Description
Mean change from randomization (Visit 2) over 52 weeks of treatment in predose forced expiratory volume in 1 second (FEV1)
Time Frame
Week 0 (Visit 2) to Week 52

10. Eligibility

Sex
All
Minimum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: 1. Male or female patients at least 40 years of age 2. History of COPD (according to Global Initiative for Chronic Obstructive Lung Disease [GOLD] 2010) for at least 12 months prior to Screening (Visit 1) associated with chronic productive cough for 3 months in each of 2 consecutive years (with other causes of productive cough excluded). Only patients with chronic bronchitis will be included (concomitant emphysema is permitted) 3. Forced expiratory volume after 1 second (FEV1)/forced vital capacity (FVC) ratio (postbronchodilator) < 70% at Screening (Visit 1) 4. FEV1 (postbronchodilator) ≤ 50% of predicted at Screening (Visit 1) 5. At least two documented moderate or severe COPD exacerbations within 12 months prior to Screening (Visit 1) 6. Patients must be on FDC LABA/ICS treatment ≥ 3 months prior to Screening (Visit 1) 7. Former smokers (defined as smoking cessation at least 1 year ago) or current smokers (including patients who ceased smoking within the past year) both with a smoking history of at least 20 pack-years Exclusion Criteria: 1. Moderate or severe COPD exacerbation and/or COPD exacerbations treated with antibiotics or systemic glucocorticosteroids within 4 weeks of Screening (Visit 1) (ie, patients must be clinically stable) 2. Known alpha-1-antitrypsin deficiency 3. Current diagnosis of asthma (either controlled or uncontrolled) (Note: History of childhood asthma is not exclusionary.) 4. Body mass index (BMI) ≥ 45 kg/m2 5. Patients with a history (within 5 years) or current diagnosis of cancer other than basal or squamous cell skin cancer
Facility Information:
Facility Name
Forest Investigative Site 081
City
Anniston
State/Province
Alabama
ZIP/Postal Code
36207
Country
United States
Facility Name
Forest Investigative Site 065
City
Athens
State/Province
Alabama
ZIP/Postal Code
35611
Country
United States
Facility Name
Forest Investigative Site 131
City
Florence
State/Province
Alabama
ZIP/Postal Code
35630
Country
United States
Facility Name
Forest Investigative Site 073
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Forest Investigative Site 272
City
Mesa
State/Province
Arizona
ZIP/Postal Code
85206
Country
United States
Facility Name
Forest Investigative Site 091
City
Peoria
State/Province
Arizona
ZIP/Postal Code
85381
Country
United States
Facility Name
Forest Investigative Site 034
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85018
Country
United States
Facility Name
Forest Investigative Site 188
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85020
Country
United States
Facility Name
Forest Investigative Site 211
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85028
Country
United States
Facility Name
Forest Investigative Site 247
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85050
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United States
Facility Name
Forest Investigative Site 208
City
Fort Smith
State/Province
Arkansas
ZIP/Postal Code
72901
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United States
Facility Name
Forest Investigative Site 101
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
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United States
Facility Name
Forest Investigative Site 074
City
Bellflower
State/Province
California
ZIP/Postal Code
90706
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United States
Facility Name
Forest Investigative Site 060
City
Fresno
State/Province
California
ZIP/Postal Code
93721
Country
United States
Facility Name
Forest Investigative Site 329
City
Fresno
State/Province
California
ZIP/Postal Code
93726
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United States
Facility Name
Forest Investigative Site 245
City
Fullerton
State/Province
California
ZIP/Postal Code
92835
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United States
Facility Name
Forest Investigative Site 310
City
Garden Grove
State/Province
California
ZIP/Postal Code
92844
Country
United States
Facility Name
Forest Investigative Site 297
City
Lakewood
State/Province
California
ZIP/Postal Code
90712
Country
United States
Facility Name
Forest Investigative Site 116
City
Long Beach
State/Province
California
ZIP/Postal Code
90822
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United States
Facility Name
Forest Investigative Site 085
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
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United States
Facility Name
Forest Investigative Site 241
City
Los Angeles
State/Province
California
ZIP/Postal Code
90073
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United States
Facility Name
Forest Investigative Site 299
City
Northridge
State/Province
California
ZIP/Postal Code
91325
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United States
Facility Name
Forest Investigative Site 213
City
Palo Alto
State/Province
California
ZIP/Postal Code
94555
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United States
Facility Name
Forest Investigative Site 268
City
Pismo Beach
State/Province
California
ZIP/Postal Code
93449
Country
United States
Facility Name
Forest Investigative Site 025
City
Riverside
State/Province
California
ZIP/Postal Code
92506
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United States
Facility Name
Forest Investigative Site 143
City
Roseville
State/Province
California
ZIP/Postal Code
95661
Country
United States
Facility Name
Forest Investigative Site 104
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
Forest Investigative Site 352
City
San Diego
State/Province
California
ZIP/Postal Code
92117
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United States
Facility Name
Forest Investigative Site 038
City
San Diego
State/Province
California
ZIP/Postal Code
92120
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United States
Facility Name
Forest Investigative Site 326
City
San Jose
State/Province
California
ZIP/Postal Code
95124
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United States
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Forest Investigative Site 209
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Torrance
State/Province
California
ZIP/Postal Code
90502
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United States
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Forest Investigative Site 331
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Stamford
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Connecticut
ZIP/Postal Code
06902
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United States
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Forest Investigative Site 017
City
Waterbury
State/Province
Connecticut
ZIP/Postal Code
06708
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United States
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Forest Investigative Site 124
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Newark
State/Province
Delaware
ZIP/Postal Code
19713
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United States
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Forest Investigative Site 196
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
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United States
Facility Name
Forest Investigative Site 224
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
Country
United States
Facility Name
Forest Investigative Site 358
City
Brandon
State/Province
Florida
ZIP/Postal Code
33511
Country
United States
Facility Name
Forest Investigative Site 166
City
Chiefland
State/Province
Florida
ZIP/Postal Code
32626
Country
United States
Facility Name
Forest Investigative Site 111
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Forest Investigative Site 123
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33765
Country
United States
Facility Name
Forest Investigative Site 291
City
Coral Gables
State/Province
Florida
ZIP/Postal Code
33134
Country
United States
Facility Name
Forest Investigative Site 239
City
DeFuniak Springs
State/Province
Florida
ZIP/Postal Code
32435
Country
United States
Facility Name
Forest Investigative Site 001
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Forest Investigative Site 165
City
Fort Walton Beach
State/Province
Florida
ZIP/Postal Code
32547
Country
United States
Facility Name
Forest Investigative Site 102
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32608
Country
United States
Facility Name
Forest Investigative Site 003
City
Hollywood
State/Province
Florida
ZIP/Postal Code
33024
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United States
Facility Name
Forest Investigative Site 023
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
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United States
Facility Name
Forest Investigative Site 077
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Kissimmee
State/Province
Florida
ZIP/Postal Code
34741
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United States
Facility Name
Forest Investigative Site 330
City
Kissimmee
State/Province
Florida
ZIP/Postal Code
34741
Country
United States
Facility Name
Forest Investigative Site 027
City
Miami
State/Province
Florida
ZIP/Postal Code
33015
Country
United States
Facility Name
Forest Investigative Site 229
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Forest Investigative Site 115
City
Miami
State/Province
Florida
ZIP/Postal Code
33175
Country
United States
Facility Name
Forest Investigative Site 339
City
Miami
State/Province
Florida
ZIP/Postal Code
33186
Country
United States
Facility Name
Forest Investigative Site 092
City
Naples
State/Province
Florida
ZIP/Postal Code
34119
Country
United States
Facility Name
Forest Investigative Site 004
City
Orlando
State/Province
Florida
ZIP/Postal Code
32822
Country
United States
Facility Name
Forest Investigative Site 187
City
Ormond Beach
State/Province
Florida
ZIP/Postal Code
32174
Country
United States
Facility Name
Forest Investigative Site 069
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32504
Country
United States
Facility Name
Forest Investigative Site 161
City
Ponte Vedra
State/Province
Florida
ZIP/Postal Code
32081
Country
United States
Facility Name
Forest Investigative Site 087
City
Port Orange
State/Province
Florida
ZIP/Postal Code
32127
Country
United States
Facility Name
Forest Investigative Site 357
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33744
Country
United States
Facility Name
Forest Investigative Site 109
City
St. Cloud
State/Province
Florida
ZIP/Postal Code
34769
Country
United States
Facility Name
Forest Investigative Site 121
City
St. Petersburg
State/Province
Florida
ZIP/Postal Code
33704
Country
United States
Facility Name
Forest Investigative Site 002
City
Tamarac
State/Province
Florida
ZIP/Postal Code
33312
Country
United States
Facility Name
Forest Investigative Site 287
City
Tampa
State/Province
Florida
ZIP/Postal Code
33607
Country
United States
Facility Name
Forest Investigative Site 052
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States
Facility Name
Forest Investigative Site 011
City
Winter Park
State/Province
Florida
ZIP/Postal Code
32789
Country
United States
Facility Name
Forest Investigative Site 348
City
Winter Park
State/Province
Florida
ZIP/Postal Code
32792
Country
United States
Facility Name
Forest Investigative Site 103
City
Canton
State/Province
Georgia
ZIP/Postal Code
30114
Country
United States
Facility Name
Forest Investigative Site 292
City
Dawsonville
State/Province
Georgia
ZIP/Postal Code
30534
Country
United States
Facility Name
Forest Investigative Site 042
City
Duluth
State/Province
Georgia
ZIP/Postal Code
30096
Country
United States
Facility Name
Forest Investigative Site 140
City
Gainesville
State/Province
Georgia
ZIP/Postal Code
30501
Country
United States
Facility Name
Forest Investigative Site 030
City
Lawrenceville
State/Province
Georgia
ZIP/Postal Code
30046
Country
United States
Facility Name
Forest Investigative Site 321
City
Woodstock
State/Province
Georgia
ZIP/Postal Code
30189
Country
United States
Facility Name
Forest Investigative Site 008
City
Coeur d' Alene
State/Province
Idaho
ZIP/Postal Code
83814
Country
United States
Facility Name
Forest Investigative Site 119
City
Eagle
State/Province
Idaho
ZIP/Postal Code
83616
Country
United States
Facility Name
Forest Investigative Site 201
City
Bolingbrook
State/Province
Illinois
ZIP/Postal Code
60490
Country
United States
Facility Name
Forest Investigative Site 206
City
Downers Grove
State/Province
Illinois
ZIP/Postal Code
60515
Country
United States
Facility Name
Forest Investigative Site 136
City
Elk Grove Village
State/Province
Illinois
ZIP/Postal Code
60007
Country
United States
Facility Name
Forest Investigative Site 139
City
Oak Lawn
State/Province
Illinois
ZIP/Postal Code
60453
Country
United States
Facility Name
Forest Investigative Site 227
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61637
Country
United States
Facility Name
Forest Investigative Site 334
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62703
Country
United States
Facility Name
Forest Investigative Site 263
City
Elwood
State/Province
Indiana
ZIP/Postal Code
46036
Country
United States
Facility Name
Forest Investigative Site 342
City
Lafayette
State/Province
Indiana
ZIP/Postal Code
47904
Country
United States
Facility Name
Forest Investigative Site 293
City
Michigan City
State/Province
Indiana
ZIP/Postal Code
46360
Country
United States
Facility Name
Forest Investigative Site 264
City
Muncie
State/Province
Indiana
ZIP/Postal Code
47303
Country
United States
Facility Name
Forest Investigative Site 135
City
Council Bluffs
State/Province
Iowa
ZIP/Postal Code
51503
Country
United States
Facility Name
Forest Investigative Site 256
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Forest Investigative Site 214
City
Olathe
State/Province
Kansas
ZIP/Postal Code
66061
Country
United States
Facility Name
Forest Investigative Site 316
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66606
Country
United States
Facility Name
Forest Investigative Site 301
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67205
Country
United States
Facility Name
Forest Investigative Site 051
City
Bowling Green
State/Province
Kentucky
ZIP/Postal Code
42101
Country
United States
Facility Name
Forest Investigative Site 075
City
Crescent Springs
State/Province
Kentucky
ZIP/Postal Code
41017
Country
United States
Facility Name
Forest Investigative Site 351
City
Hazard
State/Province
Kentucky
ZIP/Postal Code
41701
Country
United States
Facility Name
Forest Investigative Site 068
City
Lexington
State/Province
Kentucky
ZIP/Postal Code
40504
Country
United States
Facility Name
Forest Investigative Site 088
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40215
Country
United States
Facility Name
Forest Investigative Site 053
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Forest Investigative Site 273
City
Lafayette
State/Province
Louisiana
ZIP/Postal Code
70503
Country
United States
Facility Name
Forest Investigative Site 070
City
Opelousas
State/Province
Louisiana
ZIP/Postal Code
70570
Country
United States
Facility Name
Forest Investigative Site 097
City
Sunset
State/Province
Louisiana
ZIP/Postal Code
70584
Country
United States
Facility Name
Forest Investigative Site 128
City
Lewiston
State/Province
Maine
ZIP/Postal Code
04240
Country
United States
Facility Name
Forest Investigative Site 248
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21224
Country
United States
Facility Name
Forest Investigative Site 020
City
Columbia
State/Province
Maryland
ZIP/Postal Code
21044
Country
United States
Facility Name
Forest Investigative Site 072
City
Towson
State/Province
Maryland
ZIP/Postal Code
21204
Country
United States
Facility Name
Forest Investigative Site 106
City
Fall River
State/Province
Massachusetts
ZIP/Postal Code
02720
Country
United States
Facility Name
Forest Investigative Site 044
City
North Dartmouth
State/Province
Massachusetts
ZIP/Postal Code
02747
Country
United States
Facility Name
Forest Investigative Site 350
City
Pittsfield
State/Province
Massachusetts
ZIP/Postal Code
01201
Country
United States
Facility Name
Forest Investigative Site 157
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48106
Country
United States
Facility Name
Forest Investigative Site 341
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Forest Investigative Site 328
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49009
Country
United States
Facility Name
Forest Investigative Site 063
City
Livonia
State/Province
Michigan
ZIP/Postal Code
48152
Country
United States
Facility Name
Forest Investigative Site 322
City
Saint Joseph
State/Province
Michigan
ZIP/Postal Code
49085
Country
United States
Facility Name
Forest Investigative Site 303
City
Edina
State/Province
Minnesota
ZIP/Postal Code
55435
Country
United States
Facility Name
Forest Investigative Site 056
City
Fridley
State/Province
Minnesota
ZIP/Postal Code
55432
Country
United States
Facility Name
Forest Investigative Site 082
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Forest Investigative Site 033
City
Chesterfield
State/Province
Missouri
ZIP/Postal Code
63017
Country
United States
Facility Name
Forest Investigative Site 117
City
Springfield
State/Province
Missouri
ZIP/Postal Code
65803
Country
United States
Facility Name
Forest Investigative Site 098
City
St. Charles
State/Province
Missouri
ZIP/Postal Code
63301
Country
United States
Facility Name
Forest Investigative Site 186
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
Forest Investigative Site 288
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63143
Country
United States
Facility Name
Forest Investigative Site 333
City
Butte
State/Province
Montana
ZIP/Postal Code
59701
Country
United States
Facility Name
Forest Investigative Site 029
City
Missoula
State/Province
Montana
ZIP/Postal Code
59808
Country
United States
Facility Name
Forest Investigative Site 197
City
Bellevue
State/Province
Nebraska
ZIP/Postal Code
68123
Country
United States
Facility Name
Forest Investigative Site 267
City
Fremont
State/Province
Nebraska
ZIP/Postal Code
68025
Country
United States
Facility Name
Forest Investigative Site 337
City
Fremont
State/Province
Nebraska
ZIP/Postal Code
68028
Country
United States
Facility Name
Forest Investigative Site 315
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68506
Country
United States
Facility Name
Forest Investigative Site 108
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68510
Country
United States
Facility Name
Forest Investigative Site 345
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68114
Country
United States
Facility Name
Forest Investigative Site 079
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89014
Country
United States
Facility Name
Forest Investigative Site 270
City
Henderson
State/Province
Nevada
ZIP/Postal Code
89052
Country
United States
Facility Name
Forest Investigative Site 067
City
Cherry Hill
State/Province
New Jersey
ZIP/Postal Code
08003
Country
United States
Facility Name
Forest Investigative Site 327
City
Clifton
State/Province
New Jersey
ZIP/Postal Code
07012
Country
United States
Facility Name
Forest Investigative Site 144
City
Hackensack
State/Province
New Jersey
ZIP/Postal Code
07601
Country
United States
Facility Name
Forest Investigative Site 317
City
Summit
State/Province
New Jersey
ZIP/Postal Code
07901
Country
United States
Facility Name
Forest Investigative Site 226
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11229
Country
United States
Facility Name
Forest Investigative Site 199
City
Great Neck
State/Province
New York
ZIP/Postal Code
11021
Country
United States
Facility Name
Forest Investigative Site 071
City
New York
State/Province
New York
ZIP/Postal Code
10029
Country
United States
Facility Name
Forest Investigative Site 013
City
Rochester
State/Province
New York
ZIP/Postal Code
14618
Country
United States
Facility Name
Forest Investigative Site 066
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Facility Name
Forest Investigative Site 158
City
West Seneca
State/Province
New York
ZIP/Postal Code
14224
Country
United States
Facility Name
Forest Investigative Site 313
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28801
Country
United States
Facility Name
Forest Investigative Site 193
City
Burlington
State/Province
North Carolina
ZIP/Postal Code
27215
Country
United States
Facility Name
Forest Investigative Site 142
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28207
Country
United States
Facility Name
Forest Investigative Site 259
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28277
Country
United States
Facility Name
Forest Investigative Site 019
City
Elizabeth City
State/Province
North Carolina
ZIP/Postal Code
27909
Country
United States
Facility Name
Forest Investigative Site 318
City
Shelby
State/Province
North Carolina
ZIP/Postal Code
28150
Country
United States
Facility Name
Forest Investigative Site 078
City
Shelby
State/Province
North Carolina
ZIP/Postal Code
28152
Country
United States
Facility Name
Forest Investigative Site 176
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28451
Country
United States
Facility Name
Forest Investigative Site 314
City
Winston Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Forest Investigative Site 282
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27103
Country
United States
Facility Name
Forest Investigative Site 164
City
Canton
State/Province
Ohio
ZIP/Postal Code
44718
Country
United States
Facility Name
Forest Investigative Site 061
City
Cincinatti
State/Province
Ohio
ZIP/Postal Code
45231
Country
United States
Facility Name
Forest Investigative Site 149
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
Forest Investigative Site 040
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45242
Country
United States
Facility Name
Forest Investigative Site 280
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
Forest Investigative Site 009
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43213
Country
United States
Facility Name
Forest Investigative Site 353
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45439
Country
United States
Facility Name
Forest Investigative Site 059
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
Forest Investigative Site 154
City
Marion
State/Province
Ohio
ZIP/Postal Code
43302
Country
United States
Facility Name
Forest Investigative Site 346
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43606
Country
United States
Facility Name
Forest Investigative Site 105
City
Zanesville
State/Province
Ohio
ZIP/Postal Code
43701
Country
United States
Facility Name
Forest Investigative Site 167
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73103
Country
United States
Facility Name
Forest Investigative Site 281
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73103
Country
United States
Facility Name
Forest Investigative Site 236
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74135
Country
United States
Facility Name
Forest Investigative Site 285
City
Medford
State/Province
Oregon
ZIP/Postal Code
97501
Country
United States
Facility Name
Forest Investigative Site 289
City
Portland
State/Province
Oregon
ZIP/Postal Code
97220
Country
United States
Facility Name
Forest Investigative Site 218
City
Portland
State/Province
Oregon
ZIP/Postal Code
97227
Country
United States
Facility Name
Forest Investigative Site 086
City
Altoona
State/Province
Pennsylvania
ZIP/Postal Code
16601
Country
United States
Facility Name
Forest Investigative Site 340
City
Beaver
State/Province
Pennsylvania
ZIP/Postal Code
15009
Country
United States
Facility Name
Forest Investigative Site 120
City
Downingtown
State/Province
Pennsylvania
ZIP/Postal Code
19335
Country
United States
Facility Name
Forest Investigative Site 062
City
Erie
State/Province
Pennsylvania
ZIP/Postal Code
16506
Country
United States
Facility Name
Forest Investigative Site 277
City
Norristown
State/Province
Pennsylvania
ZIP/Postal Code
19401
Country
United States
Facility Name
Forest Investigative Site 230
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Forest Investigative Site 205
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
Forest Investigative Site 336
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15221
Country
United States
Facility Name
Forest Investigative Site 364
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15240
Country
United States
Facility Name
Forest Investigative Site 344
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15243
Country
United States
Facility Name
Forest Investigative Site 010
City
Tipton
State/Province
Pennsylvania
ZIP/Postal Code
16684
Country
United States
Facility Name
Forest Investigative Site 064
City
Uniontown
State/Province
Pennsylvania
ZIP/Postal Code
15401
Country
United States
Facility Name
Forest Investigative Site 228
City
Johnston
State/Province
Rhode Island
ZIP/Postal Code
02919
Country
United States
Facility Name
Forest Investigative Site 283
City
Lincoln
State/Province
Rhode Island
ZIP/Postal Code
02865
Country
United States
Facility Name
Forest Investigative Site 365
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02903
Country
United States
Facility Name
Forest Investigative Site 305
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29406
Country
United States
Facility Name
Forest Investigative Site 093
City
Easley
State/Province
South Carolina
ZIP/Postal Code
29640
Country
United States
Facility Name
Forest Investigative Site 257
City
Fort Mill
State/Province
South Carolina
ZIP/Postal Code
29707
Country
United States
Facility Name
Forest Investigative Site 233
City
Gaffney
State/Province
South Carolina
ZIP/Postal Code
29340
Country
United States
Facility Name
Forest Investigative Site 110
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29615
Country
United States
Facility Name
Forest Investigative Site 300
City
Pelzer
State/Province
South Carolina
ZIP/Postal Code
29669
Country
United States
Facility Name
Forest Investigative Site 204
City
Rock Hill
State/Province
South Carolina
ZIP/Postal Code
29732
Country
United States
Facility Name
Forest Investigative Site 021
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29303
Country
United States
Facility Name
Forest Investigative Site 012
City
Union
State/Province
South Carolina
ZIP/Postal Code
29379
Country
United States
Facility Name
Forest Investigative Site 058
City
Rapid City
State/Province
South Dakota
ZIP/Postal Code
57702
Country
United States
Facility Name
Forest Investigative Site 223
City
Bristol
State/Province
Tennessee
ZIP/Postal Code
37620
Country
United States
Facility Name
Forest Investigative Site 050
City
Fayetteville
State/Province
Tennessee
ZIP/Postal Code
37334
Country
United States
Facility Name
Forest Investigative Site 253
City
Shelbyville
State/Province
Tennessee
ZIP/Postal Code
37160
Country
United States
Facility Name
Forest Investigative Site 024
City
Arlington
State/Province
Texas
ZIP/Postal Code
76012
Country
United States
Facility Name
Forest Investigative Site 177
City
Boerne
State/Province
Texas
ZIP/Postal Code
78006
Country
United States
Facility Name
Forest Investigative Site 090
City
Corsicana
State/Province
Texas
ZIP/Postal Code
75110
Country
United States
Facility Name
Forest Investigative Site 172
City
Dallas
State/Province
Texas
ZIP/Postal Code
75246
Country
United States
Facility Name
Forest Investigative Site 237
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Forest Investigative Site 271
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Forest Investigative Site 370
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Forest Investigative Site 195
City
Houston
State/Province
Texas
ZIP/Postal Code
77034
Country
United States
Facility Name
Forest Investigative Site 312
City
Houston
State/Province
Texas
ZIP/Postal Code
77079
Country
United States
Facility Name
Forest Investigative Site 332
City
Huntsville
State/Province
Texas
ZIP/Postal Code
77340
Country
United States
Facility Name
Forest Investigative Site 232
City
Longview
State/Province
Texas
ZIP/Postal Code
75605
Country
United States
Facility Name
Forest Investigative Site 049
City
Tyler
State/Province
Texas
ZIP/Postal Code
75708
Country
United States
Facility Name
Forest Investigative Site 181
City
Colchester
State/Province
Vermont
ZIP/Postal Code
05446
Country
United States
Facility Name
Forest Investigative Site 125
City
Abingdon
State/Province
Virginia
ZIP/Postal Code
24210
Country
United States
Facility Name
Forest Investigative Site 202
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23225
Country
United States
Facility Name
Forest Investigative Site 231
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23229
Country
United States
Facility Name
Forest Investigative Site 045
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23233
Country
United States
Facility Name
Forest Investigative Site 184
City
Spokane
State/Province
Washington
ZIP/Postal Code
99202
Country
United States
Facility Name
Forest Investigative Site 174
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Forest Investigative Site 217
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Forest Investigative Site 335
City
Charleston
State/Province
West Virginia
ZIP/Postal Code
25304
Country
United States
Facility Name
Forest Investigative Site 319
City
Morgantown
State/Province
West Virginia
ZIP/Postal Code
26505
Country
United States
Facility Name
Forest Investigative Site 146
City
West Allis
State/Province
Wisconsin
ZIP/Postal Code
53227
Country
United States
Facility Name
Forest Investigative Site 418
City
Ciudad Autonoma de Buenos Aires
State/Province
Buenos Aires
ZIP/Postal Code
C1425DES
Country
Argentina
Facility Name
Forest Investigative Site 402
City
Florida
State/Province
Buenos Aires
ZIP/Postal Code
B1602DOH
Country
Argentina
Facility Name
Forest Investigative Site 405
City
La Plata
State/Province
Buenos Aires
ZIP/Postal Code
1900
Country
Argentina
Facility Name
Forest Investigative Site 413
City
Mar del Plata
State/Province
Buenos Aires
ZIP/Postal Code
CP 7600
Country
Argentina
Facility Name
Forest Investigative Site 407
City
Parana
State/Province
Entre Rios
ZIP/Postal Code
E3100BHK
Country
Argentina
Facility Name
Forest Investigative Site 406
City
Lanús Este
State/Province
Provincia de Buenos Aires
ZIP/Postal Code
B1824 KAJ
Country
Argentina
Facility Name
Forest Investigative Site 412
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000DBS
Country
Argentina
Facility Name
Forest Investigative Site 409
City
Rosario
State/Province
Santa Fe
ZIP/Postal Code
S2000KZD
Country
Argentina
Facility Name
Forest Investigative Site 403
City
Buenos Aires
ZIP/Postal Code
B1842DID
Country
Argentina
Facility Name
Forest Investigative Site 411
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
C1015ABO
Country
Argentina
Facility Name
Forest Investigative Site 414
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
C1122AAK
Country
Argentina
Facility Name
Forest Investigative Site 419
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
C1426ABP
Country
Argentina
Facility Name
Forest Investigative Site 416
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
C1428DDE
Country
Argentina
Facility Name
Forest Investigative Site 415
City
Derqui Pilar - Buenos Aires
ZIP/Postal Code
B1629ODT
Country
Argentina
Facility Name
Forest Investigative Site 410
City
Florencio Varela
ZIP/Postal Code
1888
Country
Argentina
Facility Name
Forest Investigative Site 417
City
La Plata
ZIP/Postal Code
1900
Country
Argentina
Facility Name
Forest Investigative Site 420
City
Mendoza
ZIP/Postal Code
5500
Country
Argentina
Facility Name
Forest Investigative Site 404
City
Mendoza
ZIP/Postal Code
M5500CCG
Country
Argentina
Facility Name
Forest Investigative Site 401
City
San Miguel de Tucuman
ZIP/Postal Code
T4000IFL
Country
Argentina
Facility Name
Forest Investigative Site 408
City
Santa Fe
ZIP/Postal Code
3000
Country
Argentina
Facility Name
Forest Investigative Site 235
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2K5R7
Country
Canada
Facility Name
Forest Investigative Site 162
City
North Vancouver
State/Province
British Columbia
ZIP/Postal Code
V7M 2H9
Country
Canada
Facility Name
Forest Investigative Site 302
City
Burlington
State/Province
Ontario
ZIP/Postal Code
L7N 3V2
Country
Canada
Facility Name
Forest Investigative Site 185
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2R 1V6
Country
Canada
Facility Name
Forest Investigative Site 127
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N0W8
Country
Canada
Facility Name
Forest Investigative Site 421
City
Talcahuano
ZIP/Postal Code
4270918
Country
Chile
Facility Name
Forest Investigative Site 442
City
Bogota
ZIP/Postal Code
111111
Country
Colombia
Facility Name
Forest Investigative Site 443
City
Bogota
ZIP/Postal Code
111711
Country
Colombia
Facility Name
Forest Investigative Site 461
City
Chieti
ZIP/Postal Code
66013
Country
Italy
Facility Name
Forest Investigative Site 464
City
Roma
ZIP/Postal Code
00168
Country
Italy
Facility Name
Forest Investigative Site 505
City
Batu Caves
ZIP/Postal Code
68100
Country
Malaysia
Facility Name
Forest Investigative Site 501
City
Kuala Lumpur
ZIP/Postal Code
50588
Country
Malaysia
Facility Name
Forest Investigative Site 504
City
Kuala Lumpur
ZIP/Postal Code
59100
Country
Malaysia
Facility Name
Forest Investigative Site 502
City
Kuantan
ZIP/Postal Code
25100
Country
Malaysia
Facility Name
Forest Investigative Site 522
City
Monterrey
State/Province
Nuevo León
ZIP/Postal Code
64460
Country
Mexico
Facility Name
Forest Investigative Site 526
City
Merida
State/Province
Yucatan
ZIP/Postal Code
97070
Country
Mexico
Facility Name
Forest Investigative Site 524
City
Guadalajara
ZIP/Postal Code
44100
Country
Mexico
Facility Name
Forest Investigative Site 521
City
Monterrey
ZIP/Postal Code
64060
Country
Mexico
Facility Name
Forest Investigative Site 543
City
Bellavista
ZIP/Postal Code
Callao 2
Country
Peru
Facility Name
Forest Investigative Site 550
City
Lima
ZIP/Postal Code
Lima 11
Country
Peru
Facility Name
Forest Investigative Site 551
City
Lima
ZIP/Postal Code
Lima 13
Country
Peru
Facility Name
Forest Investigative Site 545
City
Lima
ZIP/Postal Code
Lima 18
Country
Peru
Facility Name
Forest Investigative Site 546
City
Lima
ZIP/Postal Code
Lima 27
Country
Peru
Facility Name
Forest Investigative Site 549
City
Lima
ZIP/Postal Code
Lima 31
Country
Peru
Facility Name
Forest Investigative Site 544
City
Lima
ZIP/Postal Code
Lima 33
Country
Peru
Facility Name
Forest Investigative Site 541
City
Pueblo Libre
ZIP/Postal Code
Lima 21
Country
Peru
Facility Name
Forest Investigative Site 569
City
Cavite
ZIP/Postal Code
4114
Country
Philippines
Facility Name
Forest Investigative Site 567
City
Iloilo City
ZIP/Postal Code
5000
Country
Philippines
Facility Name
Forest Investigative Site 568
City
Iloilo City
ZIP/Postal Code
5000
Country
Philippines
Facility Name
Forest Investigative Site 565
City
Manila
ZIP/Postal Code
1000
Country
Philippines
Facility Name
Forest Investigative Site 563
City
Pasig City
ZIP/Postal Code
1600
Country
Philippines
Facility Name
Forest Investigative Site 562
City
Quezon City
ZIP/Postal Code
1100
Country
Philippines
Facility Name
Forest Investigative Site 564
City
Quezon City
ZIP/Postal Code
1100
Country
Philippines
Facility Name
Forest Investigative Site 566
City
Quezon City
ZIP/Postal Code
1109
Country
Philippines
Facility Name
Forest Investigative Site 561
City
Quezon City
ZIP/Postal Code
1118
Country
Philippines
Facility Name
Forest Investigative Site 585
City
Brasov
ZIP/Postal Code
500112
Country
Romania
Facility Name
Forest Investigative Site 586
City
Bucharest
ZIP/Postal Code
10457
Country
Romania
Facility Name
Forest Investigative Site 587
City
Bucharest
ZIP/Postal Code
30303
Country
Romania
Facility Name
Forest Investigative Site 588
City
Bucharest
ZIP/Postal Code
31298
Country
Romania
Facility Name
Forest Investigative Site 584
City
Bucharest
ZIP/Postal Code
50159
Country
Romania
Facility Name
Forest Investigative Site 582
City
Bucharest
ZIP/Postal Code
50554
Country
Romania
Facility Name
Forest Investigative Site 581
City
Iasi
ZIP/Postal Code
700115
Country
Romania
Facility Name
Forest Investigative Site 583
City
Iasi
ZIP/Postal Code
700115
Country
Romania
Facility Name
Forest Investigative Site 608
City
Barnaul
ZIP/Postal Code
656045
Country
Russian Federation
Facility Name
Forest Investigative Site 602
City
Kazan
ZIP/Postal Code
420015
Country
Russian Federation
Facility Name
Forest Investigative Site 618
City
Kemerovo
ZIP/Postal Code
650000
Country
Russian Federation
Facility Name
Forest Investigative Site 609
City
Krasnodar
ZIP/Postal Code
350012
Country
Russian Federation
Facility Name
Forest Investigative Site 614
City
Krasnoyarsk
ZIP/Postal Code
660022
Country
Russian Federation
Facility Name
Forest Investigative Site 617
City
Moscow
ZIP/Postal Code
125367
Country
Russian Federation
Facility Name
Forest Investigative Site 605
City
Novosibirsk
ZIP/Postal Code
630099
Country
Russian Federation
Facility Name
Forest Investigative Site 600
City
St Petersburg
ZIP/Postal Code
197706
Country
Russian Federation
Facility Name
Forest Investigative Site 612
City
St. Petersburg
ZIP/Postal Code
193231
Country
Russian Federation
Facility Name
Forest Investigative Site 619
City
St. Petersburg
ZIP/Postal Code
194044
Country
Russian Federation
Facility Name
Forest Investigative Site 604
City
St. Petersburg
ZIP/Postal Code
194358
Country
Russian Federation
Facility Name
Forest Investigative Site 611
City
St. Petersburg
ZIP/Postal Code
196084
Country
Russian Federation
Facility Name
Forest Investigative Site 610
City
St. Petersburg
ZIP/Postal Code
196247
Country
Russian Federation
Facility Name
Forest Investigative Site 601
City
St. Petersburg
ZIP/Postal Code
197110
Country
Russian Federation
Facility Name
Forest Investigative Site 606
City
St.Petersburg
ZIP/Postal Code
191025
Country
Russian Federation
Facility Name
Forest Investigative Site 607
City
Tomsk
ZIP/Postal Code
634063
Country
Russian Federation
Facility Name
Forest Investigative Site 620
City
Yaroslavl
ZIP/Postal Code
150003
Country
Russian Federation
Facility Name
Forest Investigative Site 629
City
Knez Selo
State/Province
Nišava District
ZIP/Postal Code
18204
Country
Serbia
Facility Name
Forest Investigative Site 622
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Forest Investigative Site 623
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Forest Investigative Site 624
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Forest Investigative Site 625
City
Beograd
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Forest Investigative Site 628
City
Kragujevac
ZIP/Postal Code
34000
Country
Serbia
Facility Name
Forest Investigative Site 627
City
Sremska Kamenica
ZIP/Postal Code
21204
Country
Serbia
Facility Name
Forest Investigative Site 641
City
Cadiz
ZIP/Postal Code
11009
Country
Spain
Facility Name
Forest Investigative Site 647
City
Loja
ZIP/Postal Code
18300
Country
Spain
Facility Name
Forest Investigative Site 644
City
Salt
ZIP/Postal Code
17190
Country
Spain
Facility Name
Forest Investigative Site 723
City
Kaohsiung Hsien
ZIP/Postal Code
833
Country
Taiwan
Facility Name
Forest Investigative Site 724
City
Puzih City
ZIP/Postal Code
61363
Country
Taiwan
Facility Name
Forest Investigative Site 725
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Forest Investigative Site 722
City
Taipei
ZIP/Postal Code
11490
Country
Taiwan
Facility Name
Forest Investigative Site 662
City
Hat Yai
State/Province
Songkhla
ZIP/Postal Code
90110
Country
Thailand
Facility Name
Forest Investigative Site 664
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Facility Name
Forest Investigative Site 663
City
Bangkok
ZIP/Postal Code
11000
Country
Thailand
Facility Name
Forest Investigative Site 661
City
Muang
ZIP/Postal Code
40002
Country
Thailand
Facility Name
Forest Investigative Site 699
City
Cherkasy
ZIP/Postal Code
18009
Country
Ukraine
Facility Name
Forest Investigative Site 691
City
Dnipropetrovsk
ZIP/Postal Code
49074
Country
Ukraine
Facility Name
Forest Investigative Site 692
City
Donetsk
ZIP/Postal Code
83003
Country
Ukraine
Facility Name
Forest Investigative Site 689
City
Donetsk
ZIP/Postal Code
83099
Country
Ukraine
Facility Name
Forest Investigative Site 690
City
Ivano-Frankivsk
ZIP/Postal Code
76018
Country
Ukraine
Facility Name
Forest Investigative Site 697
City
Kharkiv
ZIP/Postal Code
61035
Country
Ukraine
Facility Name
Forest Investigative Site 693
City
Kharkiv
ZIP/Postal Code
61039
Country
Ukraine
Facility Name
Forest Investigative Site 682
City
Kharkiv
ZIP/Postal Code
61124
Country
Ukraine
Facility Name
Forest Investigative Site 709
City
Kremenchuk
Country
Ukraine
Facility Name
Forest Investigative Site 698
City
Kyiv
ZIP/Postal Code
3049
Country
Ukraine
Facility Name
Forest Investigative Site 683
City
Kyiv
ZIP/Postal Code
3680
Country
Ukraine
Facility Name
Forest Investigative Site 684
City
Kyiv
ZIP/Postal Code
3680
Country
Ukraine
Facility Name
Forest Investigative Site 687
City
Kyiv
ZIP/Postal Code
3680
Country
Ukraine
Facility Name
Forest Investigative Site 685
City
Kyiv
ZIP/Postal Code
4050
Country
Ukraine
Facility Name
Forest Investigative Site 681
City
Lviv
ZIP/Postal Code
79013
Country
Ukraine
Facility Name
Forest Investigative Site 708
City
Mykolayiv
ZIP/Postal Code
54003
Country
Ukraine
Facility Name
Forest Investigative Site 706
City
Poltava
ZIP/Postal Code
36038
Country
Ukraine
Facility Name
Forest Investigative Site 695
City
Sumy
ZIP/Postal Code
40000
Country
Ukraine
Facility Name
Forest Investigative Site 707
City
Vinnitsa
ZIP/Postal Code
21001
Country
Ukraine
Facility Name
Forest Investigative Site 688
City
Zaporizhzhia
ZIP/Postal Code
69600
Country
Ukraine
Facility Name
Forest Investigative Site 696
City
Zaporizhzhya
ZIP/Postal Code
69035
Country
Ukraine
Facility Name
Forest Investigative Site 694
City
Zaporizhzhya
ZIP/Postal Code
69106
Country
Ukraine
Facility Name
Forest Investigative Site 705
City
Zaporizhzhya
ZIP/Postal Code
69118
Country
Ukraine

12. IPD Sharing Statement

Citations:
PubMed Identifier
29763572
Citation
Martinez FJ, Rabe KF, Calverley PMA, Fabbri LM, Sethi S, Pizzichini E, McIvor A, Anzueto A, Alagappan VKT, Siddiqui S, Reisner C, Zetterstrand S, Roman J, Purkayastha D, Bagul N, Rennard SI. Determinants of Response to Roflumilast in Severe Chronic Obstructive Pulmonary Disease. Pooled Analysis of Two Randomized Trials. Am J Respir Crit Care Med. 2018 Nov 15;198(10):1268-1278. doi: 10.1164/rccm.201712-2493OC.
Results Reference
derived
PubMed Identifier
29579254
Citation
Karpefors M, Weatherall J. The Tendril Plot-a novel visual summary of the incidence, significance and temporal aspects of adverse events in clinical trials. J Am Med Inform Assoc. 2018 Aug 1;25(8):1069-1073. doi: 10.1093/jamia/ocy016.
Results Reference
derived
PubMed Identifier
27585384
Citation
Martinez FJ, Rabe KF, Sethi S, Pizzichini E, McIvor A, Anzueto A, Alagappan VK, Siddiqui S, Rekeda L, Miller CJ, Zetterstrand S, Reisner C, Rennard SI. Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting beta2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial. Am J Respir Crit Care Med. 2016 Sep 1;194(5):559-67. doi: 10.1164/rccm.201607-1349OC.
Results Reference
derived
Links:
URL
http://filehosting.pharmacm.com/DownloadService.ashx?client=CTR_MED_7111&studyid=14667&filename=RESPOND%20Protocol_Redacted.pdf
Description
RESPOND Protocol_Redacted

Learn more about this trial

Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)

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