search
Back to results

Role of Oxytocin in Telling and Detecting Lies

Primary Purpose

Dyssocial Behavior

Status
Withdrawn
Phase
Early Phase 1
Locations
Study Type
Interventional
Intervention
Oxytocin
Sponsored by
University of Texas at Austin
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Dyssocial Behavior

Eligibility Criteria

18 Years - 30 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

  • Male

Exclusion Criteria:

  • _____ _____BP > 130/85, HRT > 95 (can be included at discretion of study physician/designee)

    • _____History of seizures
    • _____Neurological Disorder
    • _____Current psychiatric disorder
    • _____Previous psychiatric disorder (can be included at discretion of PI)
    • Date last episode (if > 1 year, include; if <1 year, at discretion of PI)
    • _____Current use of psychoactive drugs
    • _____Previous use of psychoactive drugs (can be included at discretion of PI) _____Date last medicated_____ _____Type of medication___________________________________
    • _____Current use of anticoagulants
    • _____Current use of corticosteroids
    • _____Previous head trauma (can be included at discretion of PI)
    • _____Alcoholism or substance abuse
    • _____Carcinoma of the breast or prostate
    • _____Renal or Hepatic diseases
    • _____Chronic lung diseases
    • _____Cancer
    • _____Liver problems
    • _____Hypertension/Cardiac diseases
    • _____Cardiovascular Disease
    • _____Nephritis
    • _____Diabetes (use of insulin) /Obesity
    • _____Endocrine disease or malignancy
    • _____Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
    • Medication
    • Frequency of episodes____ _____Date of last episode_____
    • _____Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study)
    • Medication _____Frequency of migraines_____ _____Date of last migraine_____
    • _____High levels of physical contact with women or children

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm Type

    Experimental

    Placebo Comparator

    Arm Label

    oxytocin

    placebo

    Arm Description

    Intranasal 24 IU oxytocin self-administration.

    Intranasal placebo. 125 mg of 0.5% cholorobutanol to 50 ml saline, with approximately 5 pH. The solution will then be sterilized using a 0.22 micron filter.

    Outcomes

    Primary Outcome Measures

    Unethical behavior
    To measure unethical behavior, we will calculate whether participants took more money than they actually earned on a problem-solving task.

    Secondary Outcome Measures

    Full Information

    First Posted
    February 5, 2015
    Last Updated
    June 9, 2016
    Sponsor
    University of Texas at Austin
    Collaborators
    Harvard University
    search

    1. Study Identification

    Unique Protocol Identification Number
    NCT02361177
    Brief Title
    Role of Oxytocin in Telling and Detecting Lies
    Official Title
    Role of Oxytocin in Telling and Detecting Lies
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    June 2016
    Overall Recruitment Status
    Withdrawn
    Why Stopped
    Drug not available
    Study Start Date
    January 2016 (undefined)
    Primary Completion Date
    April 2016 (Actual)
    Study Completion Date
    April 2016 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Sponsor
    Name of the Sponsor
    University of Texas at Austin
    Collaborators
    Harvard University

    4. Oversight

    Data Monitoring Committee
    No

    5. Study Description

    Brief Summary
    The investigators are interested in the impact of intranasal oxytocin in unethical behavior.
    Detailed Description
    The objective of this project is to further explore the role of oxytocin in moral judgment and ethical behavior. Oxytocin is a peptide hormone produced in a variety of hypothalamic neurons. It is released into the brain or brought into general circulation through sensory stimuli in a pulsatile fashion. In social psychology research, oxytocin is hypothesized to coordinate both the causes and effects of positive social interactions in a biofeedback loop.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Dyssocial Behavior

    7. Study Design

    Primary Purpose
    Basic Science
    Study Phase
    Early Phase 1
    Interventional Study Model
    Parallel Assignment
    Masking
    ParticipantInvestigatorOutcomes Assessor
    Allocation
    Randomized
    Enrollment
    0 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    oxytocin
    Arm Type
    Experimental
    Arm Description
    Intranasal 24 IU oxytocin self-administration.
    Arm Title
    placebo
    Arm Type
    Placebo Comparator
    Arm Description
    Intranasal placebo. 125 mg of 0.5% cholorobutanol to 50 ml saline, with approximately 5 pH. The solution will then be sterilized using a 0.22 micron filter.
    Intervention Type
    Drug
    Intervention Name(s)
    Oxytocin
    Other Intervention Name(s)
    syntocinon
    Intervention Description
    Intranasal oxytocin is hypothesized to amplify the influence of social norms on unethical behavior.
    Primary Outcome Measure Information:
    Title
    Unethical behavior
    Description
    To measure unethical behavior, we will calculate whether participants took more money than they actually earned on a problem-solving task.
    Time Frame
    130 minutes

    10. Eligibility

    Sex
    Male
    Minimum Age & Unit of Time
    18 Years
    Maximum Age & Unit of Time
    30 Years
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Eligibility Criteria
    Inclusion Criteria: Male Exclusion Criteria: _____ _____BP > 130/85, HRT > 95 (can be included at discretion of study physician/designee) _____History of seizures _____Neurological Disorder _____Current psychiatric disorder _____Previous psychiatric disorder (can be included at discretion of PI) Date last episode (if > 1 year, include; if <1 year, at discretion of PI) _____Current use of psychoactive drugs _____Previous use of psychoactive drugs (can be included at discretion of PI) _____Date last medicated_____ _____Type of medication___________________________________ _____Current use of anticoagulants _____Current use of corticosteroids _____Previous head trauma (can be included at discretion of PI) _____Alcoholism or substance abuse _____Carcinoma of the breast or prostate _____Renal or Hepatic diseases _____Chronic lung diseases _____Cancer _____Liver problems _____Hypertension/Cardiac diseases _____Cardiovascular Disease _____Nephritis _____Diabetes (use of insulin) /Obesity _____Endocrine disease or malignancy _____Asthma (can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study) Medication Frequency of episodes____ _____Date of last episode_____ _____Migraines(can be included as discretion of study physician/designee, if episodes are infrequent, nonmedicated, and no active problems at time of study) Medication _____Frequency of migraines_____ _____Date of last migraine_____ _____High levels of physical contact with women or children
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Robert A Josephs, PhD
    Organizational Affiliation
    utaustin
    Official's Role
    Principal Investigator

    12. IPD Sharing Statement

    Citations:
    PubMed Identifier
    15931222
    Citation
    Kosfeld M, Heinrichs M, Zak PJ, Fischbacher U, Fehr E. Oxytocin increases trust in humans. Nature. 2005 Jun 2;435(7042):673-6. doi: 10.1038/nature03701.
    Results Reference
    result

    Learn more about this trial

    Role of Oxytocin in Telling and Detecting Lies

    We'll reach out to this number within 24 hrs