rTMS for the Treatment of Freezing of Gait in Parkinson's Disease
Parkinson's Disease
About this trial
This is an interventional treatment trial for Parkinson's Disease focused on measuring freezing of gait, rTMS, fMRI
Eligibility Criteria
Inclusion Criteria:
- Idiopathic PD patients.
- Presenting with FOG.
- The mini-mental state examination questionnaire score above 24 points.
Exclusion Criteria:
- Other neurological or psychiatric disorders.
- History of epilepsy, seizures or convulsions.
- Metal implantation.
- History of exposure to rTMS in the past (to minimizing risk of unblinding sham condition).
Sites / Locations
- Xuanwu Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
High-frequency rTMS
Sham rTMS
Patients randomized to this group will receive rTMS delivering over the supplementary motor area (SMA). Each treatment consists 1000 pulses (5-second burst of 10Hz rTMS, repeated 20 times at every minute ).Stimulus intensity is 90% of resting motor threshold. A figure-of-8 coil is connected to a biphasic magnetic stimulator, and the induced current is perpendicular to the midline.
Patients randomized to this group will receive the sham rTMS. The procedure is same as used in patients receiving experimental rTMS, except that the coil is angled 90° away.