rTMS in Chronic Poststroke Dysphagia
Deglutition Disorders
About this trial
This is an interventional treatment trial for Deglutition Disorders focused on measuring Transcranial Magnetic Stimulation, Dysphagia, Stroke
Eligibility Criteria
Inclusion Criteria:
- age > 20 years old, diagnosed of subcortical stroke(including ischemic or hemorrhagic type) by CT or MRI image study
- sustained the symptoms of dysphagia more than one month after stroke.
- Functional Oral Intake Scale (FOIS) between 1 to 5 score
- Maintenance on sitting balance over 15 minutes
Exclusion Criteria:
- Disturbed consciousness, unable to communicate and obey order through gesture or language
- Disease or trauma involved central neural system, such as Parkinson's disease, traumatic brain injury, brain tumor or multiple sclerosis
- Any disorder inducing dysphagia, such as nasopharyngeal cancer(NPC) or cervical cancer
- Metal Implants or pacemaker
- Global aphasia or cognitive impairment
- History of epilepsy
- Pregnancy
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Placebo Comparator
Experimental
Experimental
Placebo Comparator
bilateral rTMS
unilateral rTMS
control group of rTMS
bilateral iTBS
unilateral iTBS
control group of iTBS
5 hertz(Hz), 1000 pulses, 90% resting motor threshold(RMT) stimulation on bilateral motor cortex of suprahyoid muscle for 15 minutes.
5 hertz(Hz), 1000 pulses, 90% RMT stimulation on motor cortex of suprahyoid muscle at ipsilateral side as the lesion for 15 minutes; sham stimulation on motor cortex of suprahyoid muscle at contra-lateral side as the lesion for 15 minutes.
Sham stimulation on motor cortex of suprahyoid muscle at contra-lateral side as the lesion for 15 minutes.
600 pulses iTBS stimulation on bilateral motor cortex of suprahyoid muscle for 15 minutes.
600 pulses iTBS on motor cortex of suprahyoid muscle at ipsilateral side as the lesion for 15 minutes; sham stimulation on motor cortex of suprahyoid muscle at contra-lateral side as the lesion for 15 minutes.
Sham stimulation on motor cortex of suprahyoid muscle at contra-lateral side as the lesion for 15 minutes.