S0002 - A Program to Quit Smoking With or Without Bupropion in Treating Patients With Stage I or II Non-Small Cell Lung Cancer Who Have Undergone Surgery
Lung Cancer
About this trial
This is an interventional prevention trial for Lung Cancer focused on measuring non-small cell lung cancer, stage I non-small cell lung cancer, stage II non-small cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of stage I or II non-small cell lung cancer with complete resection of all disease Must be free of recurrent or progressive disease Current smoker defined as: Smoked at least 100 cigarettes in entire life AND Currently smoking some days or every day Must establish a quit date that falls within 30 days after registration, but 7 days after physician advice and start of bupropion or placebo therapy PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Zubrod 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Cardiovascular: Not within an immediate post-infarction period No uncontrolled arrhythmias No unstable angina No uncontrolled hypertension (unstable blood pressure, diastolic pressure 90 mm Hg or greater) Other: Must be able to read, speak, and understand English Must be willing to allow testing of saliva for cotinine levels No history of seizures No history of eating disorders No known drug-drug interactions between nicotine patch and/or bupropion and patient's current or planned medications including chemotherapy and antiemetics No concurrent psychiatric diagnosis that would preclude study compliance PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Concurrent adjuvant chemotherapy allowed Endocrine therapy: No concurrent systemic steroids Radiotherapy: Concurrent adjuvant radiotherapy allowed Surgery: See Disease Characteristics Recovered from prior surgery Other: Prior neoadjuvant therapy allowed At least 14 days since prior medications containing bupropion (e.g., Wellbutrin or Wellbutrin SR) No other concurrent medications that contain bupropion (e.g., Wellbutrin or Wellbutrin SR) No concurrent monoamine oxidase inhibitors No concurrent medications that lower seizure threshold (e.g., antipsychotics, antidepressants, or theophylline) No other concurrent nicotine replacement therapy
Sites / Locations
- Northeast Alabama Regional Medical Center
- MBCCOP - Gulf Coast
- CCOP - Western Regional, Arizona
- Veterans Affairs Medical Center - Phoenix (Carl T. Hayden)
- Veterans Affairs Medical Center - Tucson
- Arizona Cancer Center at University of Arizona Health Sciences Center
- University of Arkansas for Medical Sciences
- Veterans Affairs Medical Center - Little Rock (McClellan)
- City of Hope Comprehensive Cancer Center
- Rebecca and John Moores UCSD Cancer Center
- USC/Norris Comprehensive Cancer Center and Hospital
- Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
- Veterans Affairs Medical Center - West Los Angeles
- Jonsson Comprehensive Cancer Center, UCLA
- Veterans Affairs Outpatient Clinic - Martinez
- CCOP - Bay Area Tumor Institute
- Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center
- University of California Davis Cancer Center
- Veterans Affairs Medical Center - San Diego
- UCSF Comprehensive Cancer Center
- Veterans Affairs Medical Center - San Francisco
- CCOP - Santa Rosa Memorial Hospital
- David Grant Medical Center
- University of Colorado Cancer Center at University of Colorado Health Sciences Center
- Veterans Affairs Medical Center - Denver
- CCOP - Christiana Care Health Services
- Lombardi Cancer Center of Georgetown University Medical Center
- MBCCOP - Howard University Cancer Center
- Walter Reed Army Medical Center
- Veterans Affairs Medical Center - Washington, DC
- Broward General Medical Center
- Memorial Regional Hospital Comprehensive Cancer Center
- CCOP - Mount Sinai Medical Center
- Florida Hospital Cancer Institute
- Palm Beach Cancer Institute
- CCOP - Atlanta Regional
- MBCCOP - Hawaii
- MBCCOP - University of Illinois at Chicago
- Veterans Affairs Medical Center - Chicago (Westside Hospital)
- University of Chicago Cancer Research Center
- Louis A. Weiss Memorial Hospital
- CCOP - Central Illinois
- Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
- Loyola University Medical Center
- West Suburban Center for Cancer Care
- Saint Anthony Medical Center
- CCOP - Carle Cancer Center
- Fort Wayne Medical Oncology and Hematology, Incorporated
- CCOP - Northern Indiana CR Consortium
- CCOP - Iowa Oncology Research Association
- Holden Comprehensive Cancer Center at University of Iowa
- Kansas Cancer Institute at the University of Kansas Medical Center
- CCOP - Wichita
- Veterans Affairs Medical Center - Wichita
- Veterans Affairs Medical Center - Lexington
- Albert B. Chandler Medical Center, University of Kentucky
- Baptist Hospital East - Louisville
- MBCCOP - LSU Health Sciences Center
- Tulane University School of Medicine
- Veterans Affairs Medical Center - New Orleans
- Louisiana State University Health Sciences Center - Shreveport
- Veterans Affairs Medical Center - Shreveport
- Marlene and Stewart Greenebaum Cancer Center, University of Maryland
- Veterans Affairs Medical Center - Baltimore
- Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
- Cancer Research Center at Boston Medical Center
- University of Massachusetts Memorial Medical Center - University Campus
- Veterans Affairs Medical Center - Ann Arbor
- CCOP - Michigan Cancer Research Consortium
- University of Michigan Comprehensive Cancer Center
- Barbara Ann Karmanos Cancer Institute
- Veterans Affairs Medical Center - Detroit
- Josephine Ford Cancer Center at Henry Ford Hospital
- CCOP - Grand Rapids
- CCOP - Beaumont
- Lakeland Medical Center - St. Joseph
- Providence Hospital - Southfield
- Veterans Affairs Medical Center - Minneapolis
- University of Minnesota Cancer Center
- Mayo Clinic Cancer Center
- Veterans Affairs Medical Center - Biloxi
- University of Mississippi Medical Center
- Veterans Affairs Medical Center - Jackson
- Veterans Affairs Medical Center - Columbia (Truman Memorial)
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- Veterans Affairs Medical Center - Kansas City
- CCOP - Kansas City
- Barnes-Jewish Hospital
- St. Louis University Health Sciences Center
- Missouri Baptist Cancer Center
- CCOP - St. Louis-Cape Girardeau
- CCOP - Cancer Research for the Ozarks
- CCOP - Montana Cancer Consortium
- University of Nebraska Medical Center
- CCOP - Southern Nevada Cancer Research Foundation
- Veterans Affairs Medical Center - Las Vegas
- Norris Cotton Cancer Center at Dartmouth Medical School
- Cooper University Hospital
- Veterans Affairs Medical Center - Albuquerque
- MBCCOP - University of New Mexico HSC
- Veterans Affairs Medical Center - Albany
- Veterans Affairs Medical Center - Buffalo
- Elmhurst Hospital Center
- Queens Cancer Center of Queens Hospital
- CCOP - North Shore University Hospital
- North Shore University Hospital
- Memorial Sloan-Kettering Cancer Center
- New York Weill Cornell Cancer Center at Cornell University
- Mount Sinai Medical Center, NY
- Herbert Irving Comprehensive Cancer Center at Columbia University
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- State University of New York - Upstate Medical University
- Veterans Affairs Medical Center - Syracuse
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
- Veterans Affairs Medical Center - Asheville
- Lineberger Comprehensive Cancer Center, UNC
- NorthEast Oncology Associates
- Veterans Affairs Medical Center - Durham
- Duke Comprehensive Cancer Center
- Cape Fear Valley Health System
- Lenoir Memorial Hospital Cancer Center
- FirstHealth Moore Regional Hospital
- New Hanover Regional Medical Center
- CCOP - Southeast Cancer Control Consortium
- Comprehensive Cancer Center at Wake Forest University
- Veterans Affairs Medical Center - Fargo
- Veterans Affairs Medical Center - Cincinnati
- Charles M. Barrett Cancer Center at University Hospital
- Cleveland Clinic Taussig Cancer Center
- CCOP - Columbus
- Arthur G. James Cancer Hospital - Ohio State University
- Veterans Affairs Medical Center - Dayton
- CCOP - Dayton
- University of Oklahoma Health Sciences Center
- Veterans Affairs Medical Center - Oklahoma City
- Cancer Institute at Oregon Health and Science University
- Veterans Affairs Medical Center - Portland
- CCOP - Columbia River Oncology Program
- Western Pennsylvania Hospital
- CCOP - MainLine Health
- Lifespan: The Miriam Hospital
- Veterans Affairs Medical Center - Charleston
- Hollings Cancer Center at Medical University of South Carolina
- CCOP - Greenville
- CCOP - Upstate Carolina
- University of Tennessee Cancer Institute
- Danville Radiation Therapy Center
- Harrington Cancer Center
- Veterans Affairs Medical Center - Amarillo
- Veterans Affairs Medical Center - Dallas
- Brooke Army Medical Center
- University of Texas Medical Branch
- University of Texas - MD Anderson Cancer Center
- Veterans Affairs Medical Center - Houston
- University of Texas Health Science Center at San Antonio
- Veterans Affairs Medical Center - San Antonio (Murphy)
- Veterans Affairs Medical Center - Temple
- CCOP - Scott and White Hospital
- Huntsman Cancer Institute
- Veterans Affairs Medical Center - Salt Lake City
- Green Mountain Oncology Group
- Vermont Cancer Center at University of Vermont
- Veterans Affairs Medical Center - White River Junction
- Martha Jefferson Hospital
- Virginia Oncology Associates - Norfolk
- MBCCOP - Massey Cancer Center
- Oncology and Hematology Associates of Southwest Virginia, Inc.
- CCOP - Virginia Mason Research Center
- Veterans Affairs Medical Center - Seattle
- CCOP - Northwest
- Madigan Army Medical Center
- St. Mary's Medical Center
- CCOP - St. Vincent Hospital Cancer Center, Green Bay
- CCOP - Marshfield Clinic Research Foundation
- Ministry Medical Group - Northern Region
- University of Puerto Rico School of Medicine Medical Sciences Campus
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
Behavioral Intervention + Placebo
Behavioral Intervention + Bupropion
Smoking cessation intervention , nicotine replacement, psychosocial assessment and care, and placebo.
Smoking cessation intervention, nicotine replacement, psychosocial assessment and care, and bupropion hydrochloride .