S0220: Chemoradiotherapy Followed By Surgery and Docetaxel in Treating Patients With Pancoast Tumors
Lung Cancer
About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring stage II non-small cell lung cancer, stage IIIA non-small cell lung cancer, stage IIIB non-small cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed non-small cell lung cancer Any of the following stages due to involvement of the superior sulcus: Stage IIB (T3, N0), IIIA (T3, N1), or IIIB (T4, N0-1) Newly diagnosed Primary bronchogenic Must meet 1 of the following tumor involvement criteria: An apical tumor associated with the Pancoast syndrome (arm or shoulder pain and/or neurologic findings corresponding to the roots of C-8 and/or T-1 or the inferior trunk of the bronchial plexus with or without Horner's syndrome) without rib or vertebral body involvement Superior sulcus tumors with involvement of the chest wall (T3), usually ribs 1 and 2 by CT scan or MRI, with or without an associated Pancoast syndrome Superior sulcus tumors with invasion of the vertebral bodies or involvement of the subclavian vessels (T4) by CT scan or MRI, with or without an associated Pancoast syndrome No more than 1 parenchymal lesion in the same lung or in both lungs No involvement of the following lymph node groups as determined by mediastinal exploration* (i.e., mediastinoscopy, mediastinotomy, thoracoscopy, or thoracotomy) within the past 42 days: Single-level or multi-level ipsilateral or contralateral mediastinal nodal (N2 or N3) disease by mediastinoscopy, thoracoscopy, mediastinotomy, thoracotomy, or transbronchial Wang needle biopsy, regardless of whether enlarged nodes are visible or not on chest x-ray or CT scan Supraclavicular (scalene) nodes Any nodes evident on physical exam must be biopsied by fine needle aspiration or open biopsy Left upper lobe tumors with left vocal cord paralysis by indirect laryngoscopy (presumes N2 nodes in the A-P window) NOTE: *Mediastinal exploration is not required for patients whose mediastinum is negative by both positron-emission tomography (PET) and CT scan No pleural effusions except if 1 of the following criteria are met: Pleural effusion present before mediastinoscopy or thoracotomy with negative cytology on 2 separate thoracenteses Pleural effusion present only after exploratory or staging thoracotomy, with negative cytology on a single thoracentesis Present only on CT scan and too small to tap No pericardial effusions or superior vena cava syndrome No brain metastases by CT scan or MRI No evidence of distant metastatic disease by bone scan or PET Must be a candidate for potential future pulmonary resection PATIENT CHARACTERISTICS: Age Not specified Performance status Zubrod 0-2 Patients with Zubrod performance status 2 must have an albumin level at least 0.85 times lower limit of normal and weight loss no greater than 10% Life expectancy Not specified Hematopoietic Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic Bilirubin no greater than 1.5 times upper limit of normal (ULN)* SGOT or SGPT no greater than 1.5 times ULN* NOTE: *Unless due to a documented benign disease Renal Creatinine clearance at least 50 mL/min Cardiovascular No myocardial infarction within the past 3 months No active angina No unstable heart rhythms No clinically evident congestive heart failure Pulmonary Preresection FEV_1 at least 2.0 L OR Predicted postresection FEV_1 greater than 1.0 L Other Not pregnant or nursing Fertile patients must use effective contraception No uncontrolled peptic ulcer disease No grade 2 or greater sensory neuropathy No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy No concurrent colony-stimulating factors during chemoradiotherapy or course 1 of consolidation therapy Chemotherapy No prior chemotherapy for lung cancer Endocrine therapy Not specified Radiotherapy No prior radiotherapy to the neck or thorax No concurrent intensity-modulated radiotherapy Surgery Prior exploratory thoracotomy allowed only for diagnosis or staging purposes Other No concurrent amifostine
Sites / Locations
- Mobile Infirmary Medical Center
- Poudre Valley Hospital
- Mayo Clinic - Jacksonville
- Rush-Copley Cancer Care Center
- Joliet Oncology-Hematology Associates, Limited - West
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
- Regional Cancer Center at Memorial Medical Center
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- Saint Anthony Memorial Health Centers
- Holden Comprehensive Cancer Center at University of Iowa
- Cancer Center of Kansas, PA - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, PA - El Dorado
- Cancer Center of Kansas, PA - Kingman
- Southwest Medical Center
- Cancer Center of Kansas, PA - Newton
- Cancer Center of Kansas, PA - Parsons
- Cancer Center of Kansas, PA - Pratt
- Cancer Center of Kansas, PA - Salina
- Cancer Center of Kansas, PA - Wellington
- Associates in Womens Health, PA - North Review
- Cancer Center of Kansas, PA - Medical Arts Tower
- Cancer Center of Kansas, PA - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas, PA - Winfield
- Hickman Cancer Center at Bixby Medical Center
- Saint Joseph Mercy Cancer Center
- CCOP - Michigan Cancer Research Consortium
- Battle Creek Health System Cancer Care Center
- Mecosta County Medical Center
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- Butterworth Hospital at Spectrum Health
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Health Care
- Metro Health Hospital
- Van Elslander Cancer Center at St. John Hospital and Medical Center
- Holland Community Hospital
- Foote Memorial Hospital
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Haematology-Oncology Associates of Ohio and Michigan, PC
- Sparrow Regional Cancer Center
- Community Cancer Center of Monroe
- Mercy Memorial Hospital - Monroe
- Hackley Hospital
- Seton Cancer Institute at Saint Mary's - Saginaw
- Providence Cancer Institute at Providence Hospital - Southfield Campus
- Munson Medical Center
- St. John Macomb Hospital
- Duluth Clinic Cancer Center - Duluth
- CCOP - Duluth
- Miller - Dwan Medical Center
- Mayo Clinic Cancer Center
- Willmar Cancer Center at Rice Memorial Hospital
- University of Mississippi Cancer Clinic
- Veterans Affairs Medical Center - Columbia (Truman Memorial)
- Ellis Fischel Cancer Center at University of Missouri - Columbia
- Arch Medical Services, Incorporated at Center for Cancer Care and Research
- Missouri Baptist Cancer Center
- CCOP - Montana Cancer Consortium
- Hematology-Oncology Centers of the Northern Rockies - Billings
- Northern Rockies Radiation Oncology Center
- St. Vincent Healthcare Cancer Care Services
- Billings Clinic - Downtown
- Bozeman Deaconess Cancer Center
- St. James Healthcare Cancer Care
- Big Sky Oncology
- Great Falls Clinic - Main Facility
- Sletten Cancer Institute at Benefis Healthcare
- St. Peter's Hospital
- Glacier Oncology, PLLC
- Kalispell Medical Oncology at KRMC
- Kalispell Regional Medical Center
- Community Medical Center
- Guardian Oncology and Center for Wellness
- Montana Cancer Specialists at Montana Cancer Center
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Wayne Memorial Hospital, Incorporated
- Kinston Medical Specialists
- Rutherford Hospital
- Bismarck Cancer Center
- Medcenter One Hospital Cancer Care Center
- Mid Dakota Clinic, PC
- St. Alexius Medical Center Cancer Center
- Wood County Oncology Center
- Charles M. Barrett Cancer Center at University Hospital
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
- Fremont Memorial Hospital
- St. Rita's Medical Center
- Lima Memorial Hospital
- Northwest Ohio Oncology Center
- St. Luke's Hospital
- St. Charles Mercy Hospital
- Toledo Clinic - Oregon
- Firelands Regional Medical Center
- North Coast Cancer Care, Incorporated
- Flower Hospital Cancer Center
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical University of Ohio Cancer Center
- CCOP - Toledo Community Hospital
- Toledo Clinic, Incorporated - Main Clinic
- Fulton County Health Center
- Northwest Cancer Specialists at Rose Quarter Cancer Center
- AnMed Cancer Center
- CCOP - Upstate Carolina
- Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- MBCCOP - Meharry Medical College - Nashville
- American Fork Hospital
- Sandra L. Maxwell Cancer Center
- Logan Regional Hospital
- Cottonwood Hospital Medical Center
- Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
- Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
- Utah Valley Regional Medical Center - Provo
- Dixie Regional Medical Center - East Campus
- LDS Hospital
- Utah Cancer Specialists at UCS Cancer Center
- University of Virginia Cancer Center
- Fredericksburg Oncology, Incorporated
- Auburn Regional Center for Cancer Care
- St. Joseph Cancer Center
- Olympic Hematology and Oncology
- Providence Centralia Hospital
- St. Francis Hospital
- Columbia Basin Hematology
- Providence St. Peter Hospital Regional Cancer Center
- Good Samaritan Cancer Center
- Fred Hutchinson Cancer Research Center
- Harborview Medical Center
- Minor and James Medical, PLLC
- Group Health Central Hospital
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- Polyclinic First Hill
- University Cancer Center at University of Washington Medical Center
- Cancer Care Northwest - Spokane South
- Franciscan Cancer Center at St. Joseph Medical Center
- Allenmore Hospital
- CCOP - Northwest
- MultiCare Regional Cancer Center at Tacoma General Hospital
- St. Clare Hospital
- Northwest Cancer Specialists at Vancouver Cancer Center
- Wenatchee Valley Medical Center
- Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
- University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
- Welch Cancer Center at Sheridan Memorial Hospital
Arms of the Study
Arm 1
Experimental
Etoposide, Cisplatin, Thoracic RT, Surgery, Docetaxel