S0301 Cyclosporine, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia
Leukemia
About this trial
This is an interventional treatment trial for Leukemia focused on measuring adult acute monocytic leukemia (M5b), adult acute megakaryoblastic leukemia (M7), adult acute minimally differentiated myeloid leukemia (M0), adult acute myeloblastic leukemia with maturation (M2), adult acute myeloblastic leukemia without maturation (M1), adult acute myelomonocytic leukemia (M4), adult acute monoblastic leukemia (M5a), untreated adult acute myeloid leukemia, adult acute myeloid leukemia with t(8;21)(q22;q22), adult acute myeloid leukemia with t(16;16)(p13;q22), adult acute myeloid leukemia with inv(16)(p13;q22), adult acute myeloid leukemia with 11q23 (MLL) abnormalities, adult pure erythroid leukemia (M6b), adult erythroleukemia (M6a)
Eligibility Criteria
DISEASE CHARACTERISTICS: Morphologically confirmed acute myeloid leukemia (AML) Differential diagnosis of AML based on FAB classification system M0-M7 (No M3) No blastic transformation of chronic myelogenous leukemia Must be currently registered on protocols SWOG-9007 and SWOG-S9910 PATIENT CHARACTERISTICS: Age 56 and over Performance status Zubrod 0-3 (for patients 56 to 60 years of age) OR Zubrod 0-2 (for patients 61 to 70 years of age) OR Zubrod 0-1 (for patients 71 years of age and over) Life expectancy Not specified Hematopoietic Not specified Hepatic Bilirubin no greater than 2 times upper limit of normal (ULN) unless elevated unconjugated hyperbilirubinemia is secondary to Gilbert's syndrome or hemolysis and not to liver dysfunction AST and/or ALT no greater than 4 times ULN Renal Creatinine no greater than 1.5 times ULN AND/OR Creatinine clearance greater than 40 mL/min Cardiovascular Left ventricular function normal Ejection fraction at least 50% by MUGA or echocardiogram No unstable cardiac arrhythmias No unstable angina Other Not pregnant or nursing Fertile patients must use effective contraception No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated stage I or II cancer that is currently in complete remission PRIOR CONCURRENT THERAPY: Biologic therapy No concurrent pegfilgrastim Chemotherapy At least 30 days since prior low-dose cytarabine (less than 100 mg/m^2/day) for myelodysplastic syndromes and recovered Prior hydroxyurea to control high cell counts allowed No prior systemic chemotherapy for acute leukemia Concurrent single-dose intrathecal chemotherapy allowed Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified
Sites / Locations
- Mobile Infirmary Medical Center
- Arizona Cancer Center at University of Arizona Health Sciences Center
- Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
- Mercy Regional Cancer Center at Mercy Medical Center
- St. Luke's Mountain States Tumor Institute - Boise
- Saint Anthony's Hospital at Saint Anthony's Health Center
- Good Samaritan Regional Health Center
- Cancer Center of Kansas, PA - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, PA - El Dorado
- Cancer Center of Kansas, PA - Kingman
- Southwest Medical Center
- Cancer Center of Kansas, PA - Newton
- Cancer Center of Kansas, PA - Parsons
- Cancer Center of Kansas, PA - Pratt
- Cancer Center of Kansas, PA - Salina
- Tammy Walker Cancer Center at Salina Regional Health Center
- Stormont-Vail Cancer Center
- St. Francis Comprehensive Cancer Center
- Cancer Center of Kansas, PA - Wellington
- Associates in Womens Health, PA - North Review
- Cancer Center of Kansas, PA - Medical Arts Tower
- Cancer Center of Kansas, PA - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas, PA - Winfield
- Tulane Cancer Center
- Louisiana State University Health Sciences Center - Monroe
- Feist-Weiller Cancer Center at Louisiana State University Health Sciences
- University of Michigan Comprehensive Cancer Center
- Battle Creek Health System Cancer Care Center
- Bay Regional Medical Center
- Mecosta County Medical Center
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Health Care
- Spectrum Health Hospital - Butterworth Campus
- Metropolitan Hospital
- Holland Community Hospital
- Hackley Hospital
- Providence Cancer Institute at Providence Hospital - Southfield Campus
- Munson Medical Center
- University of Mississippi Medical Center
- Saint Francis Medical Center
- Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
- David C. Pratt Cancer Center at St. John's Mercy
- CCOP - St. Louis-Cape Girardeau
- CCOP - Montana Cancer Consortium
- Hematology-Oncology Centers of the Northern Rockies - Billings
- Northern Rockies Radiation Oncology Center
- St. Vincent Healthcare
- Deaconess Billings Clinic - Downtown
- Bozeman Deaconess Hospital
- St. James Community Hospital
- Big Sky Oncology
- Great Falls Clinic
- Sletten Regional Cancer Institute at Benefis Healthcare
- St. Peter's Hospital
- Glacier Oncology, PLLC
- Kalispell Medical Oncology
- Kalispell Regional Medical Center
- Community Medical Center
- Clinic of Dr. Judy L. Schmidt
- Montana Cancer Specialists at Montana Cancer Center
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Highland Hospital of Rochester
- Interlakes Oncology/Hematology PC
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- Wayne Memorial Hospital, Incorporated
- Wayne Radiation Oncology
- Rutherford Hospital
- Wilson Medical Center
- McDowell Cancer Center at Akron General Medical Center
- Adena Regional Medical Center
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Riverside Cancer Services
- Mount Carmel Health - West Hospital
- Doctors Hospital at Ohio Health
- Grady Memorial Hospital
- Fairfield Medical Center
- Strecker Cancer Center at Marietta Memorial Hospital
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- Mercy Medical Center
- Community Hospital of Springfield and Clark County
- Mount Carmel Cancer Services at Mount Carmel St. Ann's Hospital
- Tod Children's Hospital - Forum Health
- Genesis - Good Samaritan Hospital
- AnMed Health Cancer Center
- CCOP - Upstate Carolina
- Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- CCOP - Scott and White Hospital
- Huntsman Cancer Institute at University of Utah
- Group Health Central Hospital
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- Cancer Care Northwest - Spokane South
- Welch Cancer Center at Sheridan Memorial Hospital