S9912 Combination Chemo in Stage III Ovarian Cancer,
Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
About this trial
This is an interventional treatment trial for Fallopian Tube Cancer focused on measuring stage III ovarian epithelial cancer, peritoneal cavity cancer, fallopian tube cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage III ovarian epithelial, fallopian tube, or primary peritoneal carcinoma Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis and/or regional lymph node metastasis No tumors of borderline or low malignant potential only Mixed Mullerian tumors allowed Must have optimal disease defined as no residual lesions after resection or residual disease such that no single lesion measures greater than 1 cm in diameter Must have undergone staging exploratory laparotomy with tumor debulking within the past 70 days PATIENT CHARACTERISTICS: Age: Not specified Performance status: SWOG 0-1 Life expectancy: Not specified Hematopoietic: Granulocyte count ≥ 1,500/mm^3 Platelet count ≥ 100,000/mm^3 Hepatic: Bilirubin ≤ 2 times upper limit of normal (ULN) SGOT or SGPT ≤ 2 times ULN Renal: Creatinine clearance ≥ 50 mL/min Cardiovascular: No congestive heart failure No cardiac arrhythmia No myocardial infarction or unstable angina within the past 6 months Patients with a history of myocardial disease must not have ischemia or pathologic arrhythmias and must have an ejection fraction > 50% by MUGA Other: Not pregnant or nursing Fertile patients must use effective contraception No active or uncontrolled infection No concurrent fever No grade 2 or greater sensory neuropathy No severe gastrointestinal symptoms (i.e., partial obstruction) and/or bleeding, diarrhea, or abdominal tenderness suggestive of peritoneal irritation or infection No erythema or tenderness of abdominal incision or port site suggestive of underlying infection No other malignancy within the past five years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy: No prior immunotherapy for ovarian cancer Chemotherapy: No prior chemotherapy for ovarian cancer Endocrine therapy: Not specified Radiotherapy: No prior pelvic radiotherapy for ovarian cancer Surgery: See Disease Characteristics Recovered from all reversible surgery-related toxic effects Other: No other concurrent antitumor treatment No concurrent antibiotics for infection of undetermined etiology
Sites / Locations
- Arizona Cancer Center at University of Arizona Health Sciences Center
- University of California Davis Cancer Center
- City of Hope Comprehensive Cancer Center
- Saint Rose Hospital
- Valley Memorial Hospital
- Highland General Hospital
- CCOP - Bay Area Tumor Institute
- Summit Medical Center
- J.C. Robinson, M.D. Regional Cancer Center
- Pearlman Comprehensive Cancer Center at South Georgia Medical Center
- St. Luke's Mountain States Tumor Institute - Boise
- Saint Anthony's Hospital at Saint Anthony's Health Center
- Good Samaritan Regional Health Center
- Cancer Center of Kansas - Chanute
- Cancer Center of Kansas - Dodge City
- Cancer Center of Kansas, P.A. - El Dorado
- Cancer Center of Kansas - Kingman
- Southwest Medical Center
- Cancer Center of Kansas - Newton
- Cancer Center of Kansas, P.A. - Parsons
- Pratt Cancer Center of Kansas
- Cancer Center of Kansas - Salina
- Salina Regional Health Center
- Cancer Center of Kansas - Wellington
- Associates in Womens Health
- Cancer Center of Kansas, P.A.
- Cancer Center of Kansas, P.A. - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Wesley Medical Center
- Cancer Center of Kansas - Winfield
- Cancer Care Center at Battle Creek Health System
- Bay Regional Medical Center
- Mecosta County General Hospital
- Breslin Cancer Center at Ingham Regional Medical Center
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Mercy Medical Center
- Spectrum Health Cancer Care - Butterworth Campus
- Metropolitan Hospital
- Spectrum Health Hospital - Blodgett Campus
- Holland Community Hospital
- Hackley Hospital
- Northern Michigan Hospital
- Mercy Hospital
- Munson Medical Center
- St. Francis Medical Center
- Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
- CCOP - St. Louis-Cape Girardeau
- David C. Pratt Cancer Center at St. John's Mercy
- CCOP - Montana Cancer Consortium
- Deaconess Billings Clinic - Downtown
- Hematology-Oncology Centers of the Northern Rockies - Billings
- Northern Rockies Radiation Oncology Center
- St. Vincent Healthcare
- Deaconess Billings Clinic Cancer Center
- Bozeman Deaconess Hospital
- Internal Medicine Associates of Bozeman
- St. James Community Hospital
- Big Sky Oncology
- Great Falls Clinic
- Sletten Regional Cancer Institute
- St. Peter's Hospital
- Glacier Oncology, PLLC
- Kalispell Medical Oncology
- Kalispell Regional Medical Center
- Eastern Montana Cancer Center
- Community Medical Center
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Montana Cancer Specialists at Montana Cancer Center
- Judy L. Schmidt, MD, FACP, P. C.
- Good Samaritan Health Systems
- Wayne Memorial Hospital, Incorporated
- Rutherford Hospital
- MedCentral - Mansfield Hospital
- Salem Hospital Regional Cancer Center
- Rose Ramer Cancer Clinic at Anderson Area Medical Center
- Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- Harrington Cancer Center
- Doctor's Hospital of Laredo
- Huntsman Cancer Institute at University of Utah
- Danville Regional Medical Center
- Auburn Regional Center for Cancer Care
- St. Joseph Hospital Community Cancer Center
- Olympic Hematology and Oncology
- Providence Hospital
- St. Francis Hospital
- Cancer Care Center at Skagit Valley Hospital
- Providence St. Peter Hospital Regional Cancer Center
- Capital Medical Center
- Good Samaritan Cancer Center
- Fred Hutchinson Cancer Research Center
- Group Health Central Hospital
- Harborview Medical Center
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- University Cancer Center at University of Washington Medical Center
- Cancer Care Northwest - Spokane South
- Allenmore Hospital
- CCOP - Northwest
- St. Joseph Medical Center at Franciscan Health System
- St. Clare Hospital
- Central Washington Hospital
- Wenatchee Valley Clinic
- Camden-Clark Memorial Hospital
- Welch Cancer Center
Arms of the Study
Arm 1
Experimental
Paclitaxel/cisplatin/Liposomal Doxorubicin
paclitaxel, cisplatin and liposomal doxorubicin