Safety and Effectiveness of L2-7001 (Interleukin-2) in HIV-Positive Patients Receiving Anti-HIV Therapy
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Recombinant Proteins, Injections, Subcutaneous, Interleukin-2, Dose-Response Relationship, Drug, CD4 Lymphocyte Count, Anti-HIV Agents, Viral Load, Pharmacokinetics
Eligibility Criteria
Inclusion Criteria Patients may be eligible for this study if they: Are HIV-positive. Have a viral load below 10,000 copies/ml. Have a CD4 count between 300 and 500 cells/mm3. Have been on stable anti-HIV therapy for 4 months. Patients must be taking at least 2 drugs, 1 of which must be a protease inhibitor or a nonnucleoside drug (NNRTI). Are at least 18 years old. Agree to use an effective barrier method of birth control, such as condoms, during the study. Exclusion Criteria Patients will not be eligible for this study if they: Have an AIDS-defining illness. (Patients who have had an AIDS-defining illness that was cured may still be eligible.) Have an alcohol or drug abuse problem that the doctors feel would affect their ability to participate. Have cancer requiring chemotherapy. Have a history of autoimmune disease. Have uncontrolled diabetes or certain thyroid problems. Have mental illness or other serious medical condition that the doctors feel would affect their ability to participate. Have received IL-2 in the past. Have taken corticosteroids or certain medications that affect the immune system in the past 4 weeks. Have taken hydroxyurea in the past 4 months. Are pregnant or breast-feeding.
Sites / Locations
- Sorra Research Ctr / Med Forum
- Pacific Oaks Research
- Orange County Ctr for Special Immunology
- St Lukes Medical Group
- Kaiser Foundation Hospital
- Denver Inf Disease Consultants
- Dupont Circle Physicians Group
- Community AIDS Resource Inc
- Steinhart Medical Associates
- Specialty Med Care Ctrs of South Florida Inc
- AIDS Research Alliance - Chicago
- Northstar Med Clinic
- Fenway Community Health Ctr
- North Jersey Community Research Initiative
- Albany Med College
- Anderson Clinical Research Inc
- Associates in Med and Mental Health
- Research and Education Group
- Anderson Clinical Research
- Central Texas Clinical Research
- N Texas Ctr for AIDS & Clin Rsch
- Gathe, Joseph, M.D.
- Virginia Mason Med Ctr