Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring HIV-1, Drug Therapy, Combination, Zidovudine, Lamivudine, Drug Combinations, RNA, Viral, Reverse Transcriptase Inhibitors, Anti-HIV Agents, Viral Load, abacavir, efavirenz
Eligibility Criteria
Inclusion Criteria Patients may be eligible for this study if they: Are at least 13 years old. Are HIV-positive. Have a viral load of at least 5,000 copies/ml. Agree to use adequate and reliable methods of birth control. Note: Hormonal birth control is not considered adequate. Provide written consent of a parent or guardian, if under 18 years of age. Exclusion Criteria Patients will not be eligible for this study if they: Have taken nonnucleoside reverse transcriptase inhibitors. Have taken other anti-HIV drugs for 2 weeks or more. Have an opportunistic (AIDS-related) infection. Are pregnant or breast-feeding. Have had hepatitis within the past 6 months. Are allergic to the study drugs or their ingredients. Have a mental, physical, or substance abuse disorder. Have a serious medical condition, such as diabetes, congestive heart failure, or other heart disease. Have a gastrointestinal disorder that affects drug absorption or makes it difficult to take medication by mouth. Have received within 4 weeks before study entry, or may require during the study period, radiation therapy, chemotherapy, or drugs that affect the immune system (such as steroid drugs, interleukins, vaccines, or interferons). Have received an HIV vaccine within 3 months before study entry, or are scheduled to receive one during the study period. Require foscarnet or other drugs that are shown to be effective against HIV. Are taking astemizole, cisapride, midazolam, triazolam, or ergot derivatives. Are taking experimental drugs. Are unlikely to complete the study or take the drugs.
Sites / Locations
- Phoenix Body Positive
- Health for Life Clinic
- Orange County Ctr for Special Immunology
- Pacific Horizons Med Group
- Beacon Clinic / Boulder Community Hosp
- Georgetown Univ Med Ctr
- Dupont Circle Physicians Group
- Infectious Disease Consultants
- North Broward Hosp District / HIV Clinical Research
- SBMA Research
- Univ of Miami / Jackson Memorial Hosp
- Infectious Disease Specialists of Atlanta
- Cook County Gen Hosp / Division of Infect Diseases
- Northstar Med Clinic
- University of Louisville / ID Division
- HIV Outpatient Clinics / LA State Univ Med Ctr
- Boston Med Ctr
- Dr Paul Benson
- Hennepin County Med Ctr
- Regions Hosp / HIV/AIDS Program
- CRC of Mississippi
- Wellness Ctr / Las Vegas
- Hackensack University Medical Center
- NJCRI
- SUNY / Health Sciences Ctr at Brooklyn
- Aaron Diamond AIDS Rsch Ctr / Rockefeller Univ
- ID Consultants
- East Carolina Univ School of Medicine
- Summa Health System
- Univ of Oklahoma Infectious Disease Institute
- Associates in Med and Mental Health
- Univ of Tennessee Med Ctr at Knoxville
- Texas Tech Health Sciences Ctr
- AIDS Outreach Center
- Metroplex Infectious Disease
- Tarrant County Infectious Diseases Associates
- Therapeutic Concepts
- Diversified Med Practices, PA
- Infectious Diseases Associates of Houston
- Infectious Disease Physicians Inc
- Infectious Disease Consultants
- Swedish Med Ctr