Safety and Efficacy of Prophylactic Arterial Embolization in the Treatment of Angiography-negative Acute Upper Gastrointestinal Bleeding
Acute Gastrointestinal Bleeding
About this trial
This is an interventional treatment trial for Acute Gastrointestinal Bleeding
Eligibility Criteria
Inclusion Criteria:
- Age: 18~75 years old (including 18 years old and 75 years old);
- Bleeding of gastric or duodenal ulcers that have failed endoscopic therapy;
- Anastomotic bleeding after gastrointestinal anastomosis;
- Anastomotic bleeding after cholangioenterostomy;
- Bleeding after ERCP;
- There were no indirect signs of contrast agent spillage and bleeding in angiography.
Exclusion Criteria:
- Age: <18 years old or >75 years old;
- Rupture and bleeding of gastric fundus esophageal varices;
- Active bleeding can be seen on angiography;
- Upper gastrointestinal bleeding caused by other causes other than the inclusion criteria;
- Unexplained upper gastrointestinal bleeding;
- Those who have undergone interventional therapy in the past;
- Allergy to iodine-containing contrast agents;
- Uncorrectable coagulation dysfunction and uncontrolled systemic infection;
- There is functional failure of important organs (heart, liver, kidney, etc.);
- History of gastrointestinal radiotherapy in the past 1 year;
- Those who are not expected to complete the follow-up;
- Expected survival shorter than 6 months.
Sites / Locations
- Shanghai 10th People's HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Prophylic Embolization
Sham Embolization
Prophylactic arterial embolization is performed for the artery in the diseased blood supply area. The embolization material: gelatin sponge particles are recommended, and micro-steel ring can be used as an auxiliary if necessary; after operation, symptomatic and supportive treatment such as acid suppression, hemostasis, blood transfusion, and fluid replacement are given according to the condition.
After the angiography was completed, no embolization was performed, the catheter was withdrawn, the vascular sheath was removed, and symptomatic and supportive treatments such as acid suppression, hemostasis, blood transfusion, and fluid replacement were given.