Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke
Acute Ischemic Stroke
About this trial
This is an interventional treatment trial for Acute Ischemic Stroke
Eligibility Criteria
Inclusion Criteria:
- 1) Age≥18 years, regardless of sex.
- 2) Patients with clinically definite diagnosis of acute ischemic stroke and able to commence RIC treatment within 72 hours of stroke onset.
- 3) Baseline NIHSS ≥ 4, ≤ 24.
- 4) Baseline mRS ≤ 2;
- 5) Signed and dated informed consent is obtained.
Exclusion Criteria:
- 1) Patients who undergo thrombolytic therapy or endovascular treatment.
- 2) The patients who had the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture, or vascular injury in the upper limb. Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc.
- 3) Other intracranial lesions, such as cerebrovascular malformation cerebral venous diseases, tumors,s and other diseases involving the brain.
- 4) Pregnant or lactating women.
- 5) Previous remote ischemic conditioning therapy or similar treatment.
- 6) Severe hepatic and renal dysfunction.
- 7) Patients with a life expectancy of less than 3 months or patients unable to complete the study for other reasons.
- 8) Unwilling to be followed up or treated for poor compliance.
- 9) He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission.
- 10) Other conditions that the researchers think are not suitable for the group.
Sites / Locations
- The First Hospital of Jilin UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
RIC+Standard medical treatment
Sham RIC+Standard medical treatment
Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by inflation of a blood pressure cuff to 200 mm Hg. RIC will be conducted twice daily for 7 consecutive days. Additionally, the patients will be treated with standard medical treatment according to the Guidelines for diagnosis and treatment of acute ischemic stroke in China 2014.
Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min reperfusion. Limb ischemia was induced by inflation of a blood pressure cuff to 60 mm Hg. RIC will be conducted twice daily for 7 consecutive days. Additionally, the patients will be treated with standard medical treatment according to the Guidelines for diagnosis and treatment of acute ischemic stroke in China 2014.