Safety and Efficacy Study of Levofloxacin Combined With Endovascular Thrombectomy for Acute Ischemic Stroke

Inclusion Criteria: Age 18-65 years. Patients with clinically confirmed acute ischemic stroke, CTA or DSA confirmed anterior circulation large vessel occlusion (ICA, M1/proximal M2 segment of MCA, tandem lesions), received emergency thrombectomy and successful recanalization (mTICI≥2b). mRS≤2 before stroke onset. Signed and dated informed consent is obtained. Levofloxacin/simulant treatment initiated with in 24h of endovascular thrombectomy. Exclusion Criteria: Patients using glucocorticoids, antiarrhythmic drugs (class I and class III antiarrhythmic drugs: quinidine, procaine amine, lidocaine, phenytoin sodium, verapamil, etc.), and quinolones within 14 days; Patients with other diseases that may aggravate adverse drug reactions, such as ventricular arrhythmias, prolonged QT interval (male: QTc>430ms, female: QTc>450ms), severe cardiac insufficiency (NYHA functional grade ≥ III), myasthenia gravis, peripheral neuropathy, seizures, tendon-related diseases, severe immune system-related diseases, hematological diseases, active hepatitis or cirrhosis, serious respiratory diseases; Abnormal liver and kidney function: glutamic oxaloacetic transaminase or glutamic pyruvic transaminase exceeds 3 times the upper limit of normal; Direct bilirubin or indirect bilirubin more than 3 times the normal upper limit; Blood creatinine exceeds 1.1 times the upper limit of normal; Creatinine clearance rate≤50ml/min; Urea nitrogen≥ 20mg/dL; Ion disorders: hyponatremia (Na<130mmol/L), hypokalemia (K<3.5mmol/L), hyperkalemia (K>5.5mmol/L); Fasting blood glucose lower than 3.9 mmol/L; Patients with symptomatic intracranial hemorrhage confirmed by clinical signs and imaging before randomization; Patients allergy to fluoroquinolones or other antibiotics; Patients with a life expectancy less than 3 months or patients unable to complete the study for other reasons; Not willing to be followed up or poor treatment compliance; Patients who are participating in other clinical studies, or have participated in other clinical studies within 3 months before enrollment, or have participated in this study; Other conditions not suitable for enrollment.