Safety and Ocular Pharmacokinetics After 1 Drop of T1225 0.5, 1 and 1.5% in 48 Healthy Volunteers
Eye Infections, Bacterial
About this trial
This is an interventional treatment trial for Eye Infections, Bacterial
Eligibility Criteria
Inclusion Criteria: Male or female aged from 18 to 45 years old; Written informed consent; Healthy volunteers (without any ocular symptom); Normal ocular examination in both eyes (corrected visual acuity (VA) >= 6/10 - slit lamp examination without clinical relevant abnormalities - tear break-up time (BUT) >= 10 seconds - lachrymal secretion in the Schirmer test >= 10 mm in 5 minutes - lissamine green test total score < 4). Exclusion Criteria: Ocular trauma, infection or inflammation within the last 3 months; Conjunctival hyperaemia score >= 2, watering score >= 2, folliculo-papillary conjunctivitis score >= 2, number of fluorescein-stained punctuations >= 10; Blepharitis, conjunctivitis, uveitis; Ocular laser treatment within the last 3 months; Ocular surgery, including LASIK and PRK, within the last 12 months; Topical ocular treatment during the last month; Ocular antibiotics within the last 7 days; Medication during the study (except paracetamol and contraceptives).
Sites / Locations
- Unité de Pharmacologie Clinique