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Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction

Primary Purpose

Chronic Heart Failure With Reduced Ejection Fraction

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

LCZ696

About this trial

This is an interventional treatment trial for Chronic Heart Failure With Reduced Ejection Fraction focused on measuring LCZ696, chronic heart failure, ARNI, Congestive heart failure (CHF), heart failure (HF), acute heart failure syndrome, congestive cardiac failure (CCF)

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Written informed consent for the extension must be obtained before any assessment is performed.
Patients who have completed PARADIGM-HF (protocol CLCZ696B2314) and are able to be safely enrolled into the open-label trial as judged by the investigator.

Exclusion Criteria:

Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer
History of hypersensitivity or allergy to any of the study drugs, drugs of similar chemical classes, ACEIs, ARBs, or NEP inhibitors as well as known or suspected contraindications to LCZ696
Known history of angioedema
Requirement of simultaneous treatment with both ACEIs and ARBs
Current acute decompensated HF (exacerbation of chronic HF manifested by signs and symptoms that may require intravenous therapy)
Symptomatic hypotension and/or a SBP < 100 mmHg at Visit 1 (screening)
Estimated GFR < 30 mL/min/1.73m^2 as measured by the simplified MDRD formula at Visit 1 (screening)
Presence of bilateral renal artery stenosis
Serum potassium > 5.2 mmol/L at Visit 1 (screening)
Evidence of hepatic disease as determined by any one of the following: AST or ALT values exceeding 3 x ULN at Visit 1, history of hepatic encephalopathy, history of esophageal varices, or history of portacaval shunt
Pregnant or nursing (lactating) women
Women of child-bearing potential
Any condition, not identified in the protocol, that in the opinion of the investigator is likely to prevent the patient from safely tolerating LCZ696 or complying with the requirements of the study.

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

LCZ696

Arm Description

Angiotensin receptor antagonist neprilysin inhibitor (ARNI) with target dose of 200 mg bid

Outcomes

Primary Outcome Measures

Percentage of Participants With Treatment Emergent Adverse Events (AEs), Serious Adverse Events (SAEs) and Deaths as a Measure of Safety and Tolerability of LCZ696

The primary assessments for safety were the reporting of angioedema, AEs suspected to be related to LCZ696, AEs leading to study drug discontinuation and serious adverse events (SAE) including death. The assessment of safety were based primarily on the frequency of adverse events of special interest, sitting systolic and diastolic blood pressure, heart rate, and serious adverse events suspected by the investigators to be related to LCZ696 for the Safety set. Only descriptive analysis done.

Secondary Outcome Measures

Full Information

NCT ID

NCT02226120

First Posted

August 25, 2014

Last Updated

February 19, 2019

Sponsor

Novartis Pharmaceuticals

1. Study Identification

Unique Protocol Identification Number

NCT02226120

Brief Title

Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction

Official Title

A Multicenter Study to Evaluate Safety and Tolerability in Patients With Chronic Heart Failure and Reduced Ejection Fraction From PARADIGM-HF Receiving Open Label LCZ696

Study Type

Interventional

2. Study Status

Record Verification Date

February 2019

Overall Recruitment Status

Completed

Study Start Date

October 16, 2014 (Actual)

Primary Completion Date

December 28, 2017 (Actual)

Study Completion Date

December 28, 2017 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Novartis Pharmaceuticals

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

5. Study Description

Brief Summary

The purpose of this study was to collect safety and tolerability data on LCZ696 in eligible PARADIGM-HF patients who received open-label investigational drug. The parent PARADIGM-HF (NCT01035255) trial was terminated early due to compelling efficacy of LCZ696 in patients with heart failure with reduced ejection fraction (HFrEF) after the final pre-specified interim analysis in March 2014.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Chronic Heart Failure With Reduced Ejection Fraction

Keywords

LCZ696, chronic heart failure, ARNI, Congestive heart failure (CHF), heart failure (HF), acute heart failure syndrome, congestive cardiac failure (CCF)

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

N/A

Enrollment

1980 (Actual)

8. Arms, Groups, and Interventions

Arm Title

LCZ696

Arm Type

Experimental

Arm Description

Angiotensin receptor antagonist neprilysin inhibitor (ARNI) with target dose of 200 mg bid

Intervention Type

Drug

Intervention Name(s)

LCZ696

Intervention Description

Angiotensin receptor antagonist neprilysin inhibitor (ARNI) with target dose of 200 mg bid

Primary Outcome Measure Information:

Title

Percentage of Participants With Treatment Emergent Adverse Events (AEs), Serious Adverse Events (SAEs) and Deaths as a Measure of Safety and Tolerability of LCZ696

Description

Time Frame

From first dose of study treatment to 30 days after last dose of study treatment, up to 30 months.

10. Eligibility

Sex

All

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Written informed consent for the extension must be obtained before any assessment is performed. Patients who have completed PARADIGM-HF (protocol CLCZ696B2314) and are able to be safely enrolled into the open-label trial as judged by the investigator. Exclusion Criteria: Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer History of hypersensitivity or allergy to any of the study drugs, drugs of similar chemical classes, ACEIs, ARBs, or NEP inhibitors as well as known or suspected contraindications to LCZ696 Known history of angioedema Requirement of simultaneous treatment with both ACEIs and ARBs Current acute decompensated HF (exacerbation of chronic HF manifested by signs and symptoms that may require intravenous therapy) Symptomatic hypotension and/or a SBP < 100 mmHg at Visit 1 (screening) Estimated GFR < 30 mL/min/1.73m^2 as measured by the simplified MDRD formula at Visit 1 (screening) Presence of bilateral renal artery stenosis Serum potassium > 5.2 mmol/L at Visit 1 (screening) Evidence of hepatic disease as determined by any one of the following: AST or ALT values exceeding 3 x ULN at Visit 1, history of hepatic encephalopathy, history of esophageal varices, or history of portacaval shunt Pregnant or nursing (lactating) women Women of child-bearing potential Any condition, not identified in the protocol, that in the opinion of the investigator is likely to prevent the patient from safely tolerating LCZ696 or complying with the requirements of the study.

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Novartis Pharmaceuticals

Organizational Affiliation

Novartis Pharmaceuticals

Official's Role

Study Director

Facility Information:

Facility Name

Novartis Investigative Site

City

Huntsville

State/Province

Alabama

ZIP/Postal Code

35801

Country

United States

Facility Name

Novartis Investigative Site

City

Muscle Shoals

State/Province

Alabama

ZIP/Postal Code

35662

Country

United States

Facility Name

Novartis Investigative Site

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72204

Country

United States

Facility Name

Novartis Investigative Site

City

Oceanside

State/Province

California

ZIP/Postal Code

92056

Country

United States

Facility Name

Novartis Investigative Site

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Facility Name

Novartis Investigative Site

City

San Diego

State/Province

California

ZIP/Postal Code

92161

Country

United States

Facility Name

Novartis Investigative Site

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95405

Country

United States

Facility Name

Novartis Investigative Site

City

Boynton Beach

State/Province

Florida

ZIP/Postal Code

33472-2952

Country

United States

Facility Name

Novartis Investigative Site

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50314

Country

United States

Facility Name

Novartis Investigative Site

City

Covington

State/Province

Louisiana

ZIP/Postal Code

70433

Country

United States

Facility Name

Novartis Investigative Site

City

Columbia

State/Province

Maryland

ZIP/Postal Code

21044

Country

United States

Facility Name

Novartis Investigative Site

City

Saginaw

State/Province

Michigan

ZIP/Postal Code

48601

Country

United States

Facility Name

Novartis Investigative Site

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55417

Country

United States

Facility Name

Novartis Investigative Site

City

Fremont

State/Province

Nebraska

ZIP/Postal Code

68025

Country

United States

Facility Name

Novartis Investigative Site

City

New York

State/Province

New York

ZIP/Postal Code

10032

Country

United States

Facility Name

Novartis Investigative Site

City

Rosedale

State/Province

New York

ZIP/Postal Code

11422

Country

United States

Facility Name

Novartis Investigative Site

City

Raleigh

State/Province

North Carolina

ZIP/Postal Code

27610

Country

United States

Facility Name

Novartis Investigative Site

City

Marion

State/Province

Ohio

ZIP/Postal Code

43302

Country

United States

Facility Name

Novartis Investigative Site

City

Rapid City

State/Province

South Dakota

ZIP/Postal Code

57701

Country

United States

Facility Name

Novartis Investigative Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75235

Country

United States

Facility Name

Novartis Investigative Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75251

Country

United States

Facility Name

Novartis Investigative Site

City

Livingston

State/Province

Texas

ZIP/Postal Code

77351

Country

United States

Facility Name

Novartis Investigative Site

City

Spokane

State/Province

Washington

ZIP/Postal Code

99204

Country

United States

Facility Name

Novartis Investigative Site

City

Waukesha

State/Province

Wisconsin

ZIP/Postal Code

53188

Country

United States

Facility Name

Novartis Investigative Site

City

Caba

State/Province

Buenos Aires

ZIP/Postal Code

C1221ADC

Country

Argentina

Facility Name

Novartis Investigative Site

City

Ciudad Autonoma de Bs As

State/Province

Buenos Aires

ZIP/Postal Code

C1119ACN

Country

Argentina

Facility Name

Novartis Investigative Site

City

Mar del Plata

State/Province

Buenos Aires

ZIP/Postal Code

B7600FZN

Country

Argentina

Facility Name

Novartis Investigative Site

City

Quilmes

State/Province

Buenos Aires

ZIP/Postal Code

B1878DVB

Country

Argentina

Facility Name

Novartis Investigative Site

City

Caba

State/Province

Capital Federal

ZIP/Postal Code

C1179AAB

Country

Argentina

Facility Name

Novartis Investigative Site

City

San Salvador de Jujuy

State/Province

Jujuy

ZIP/Postal Code

Y4600ABF

Country

Argentina

Facility Name

Novartis Investigative Site

City

Ciudad de Salta

State/Province

Provincia De Salta

ZIP/Postal Code

A4406BPF

Country

Argentina

Facility Name

Novartis Investigative Site

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

2000

Country

Argentina

Facility Name

Novartis Investigative Site

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000AII

Country

Argentina

Facility Name

Novartis Investigative Site

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000QID

Country

Argentina

Facility Name

Novartis Investigative Site

City

Cordoba

ZIP/Postal Code

5000

Country

Argentina

Facility Name

Novartis Investigative Site

City

Cordoba

ZIP/Postal Code

X5000AAX

Country

Argentina

Facility Name

Novartis Investigative Site

City

Cordoba

ZIP/Postal Code

X5016KET

Country

Argentina

Facility Name

Novartis Investigative Site

City

Corrientes

ZIP/Postal Code

W3400CLH

Country

Argentina

Facility Name

Novartis Investigative Site

City

Formosa

ZIP/Postal Code

P3600

Country

Argentina

Facility Name

Novartis Investigative Site

City

Formosa

ZIP/Postal Code

P3634XAR

Country

Argentina

Facility Name

Novartis Investigative Site

City

Mendoza

ZIP/Postal Code

M5500CHC

Country

Argentina

Facility Name

Novartis Investigative Site

City

San Luis

ZIP/Postal Code

D5702JRS

Country

Argentina

Facility Name

Novartis Investigative Site

City

Santa Fe

ZIP/Postal Code

S3000EOZ

Country

Argentina

Facility Name

Novartis Investigative Site

City

Santa Fe

ZIP/Postal Code

S3000FWO

Country

Argentina

Facility Name

Novartis Investigative Site

City

Santiago del Estero

ZIP/Postal Code

G4200AQK

Country

Argentina

Facility Name

Novartis Investigative Site

City

Brasschaat

ZIP/Postal Code

2930

Country

Belgium

Facility Name

Novartis Investigative Site

City

Gent

ZIP/Postal Code

9000

Country

Belgium

Facility Name

Novartis Investigative Site

City

La Louviere

ZIP/Postal Code

7100

Country

Belgium

Facility Name

Novartis Investigative Site

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Facility Name

Novartis Investigative Site

City

Ronse

ZIP/Postal Code

9600

Country

Belgium

Facility Name

Novartis Investigative Site

City

Salvador

State/Province

ZIP/Postal Code

41810-010

Country

Brazil

Facility Name

Novartis Investigative Site

City

Brasilia

State/Province

ZIP/Postal Code

70390-903

Country

Brazil

Facility Name

Novartis Investigative Site

City

Goiania

State/Province

ZIP/Postal Code

74223-130

Country

Brazil

Facility Name

Novartis Investigative Site

City

Goiania

State/Province

ZIP/Postal Code

74605 050

Country

Brazil

Facility Name

Novartis Investigative Site

City

Goiania

State/Province

ZIP/Postal Code

74823-470

Country

Brazil

Facility Name

Novartis Investigative Site

City

Sao Luis

State/Province

ZIP/Postal Code

65020-070

Country

Brazil

Facility Name

Novartis Investigative Site

City

Uberlandia

State/Province

Mg-cep

ZIP/Postal Code

38411-186

Country

Brazil

Facility Name

Novartis Investigative Site

City

Belo Horizonte

State/Province

ZIP/Postal Code

20180-090

Country

Brazil

Facility Name

Novartis Investigative Site

City

Belo Horizonte

State/Province

ZIP/Postal Code

30150-221

Country

Brazil

Facility Name

Novartis Investigative Site

City

Belem

State/Province

ZIP/Postal Code

66087-660

Country

Brazil

Facility Name

Novartis Investigative Site

City

Recife

State/Province

ZIP/Postal Code

52051-380

Country

Brazil

Facility Name

Novartis Investigative Site

City

Rio de Janeiro

State/Province

ZIP/Postal Code

22280-020

Country

Brazil

Facility Name

Novartis Investigative Site

City

Porto Alegre

State/Province

ZIP/Postal Code

90880-480

Country

Brazil

Facility Name

Novartis Investigative Site

City

Marilia

State/Province

ZIP/Postal Code

17515-000

Country

Brazil

Facility Name

Novartis Investigative Site

City

Ribeirao Preto

State/Province

ZIP/Postal Code

14055-370

Country

Brazil

Facility Name

Novartis Investigative Site

City

Santo Andre

State/Province

ZIP/Postal Code

09190-615

Country

Brazil

Facility Name

Novartis Investigative Site

City

Sao Jose do Rio Preto

State/Province

ZIP/Postal Code

15015-750

Country

Brazil

Facility Name

Novartis Investigative Site

City

Sao Paulo

State/Province

ZIP/Postal Code

01323 000

Country

Brazil

Facility Name

Novartis Investigative Site

City

Sao Paulo

State/Province

ZIP/Postal Code

05403-000

Country

Brazil

Facility Name

Novartis Investigative Site

City

Votuporanga

State/Province

ZIP/Postal Code

15500-003

Country

Brazil

Facility Name

Novartis Investigative Site

City

Haskovo

ZIP/Postal Code

6300

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Pleven

ZIP/Postal Code

5800

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Plovdiv

ZIP/Postal Code

4000

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Shumen

ZIP/Postal Code

9700

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sofia

ZIP/Postal Code

1233

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sofia

ZIP/Postal Code

1309

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sofia

ZIP/Postal Code

1431

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sofia

ZIP/Postal Code

1527

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Sofia

ZIP/Postal Code

1606

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Varna

ZIP/Postal Code

9010

Country

Bulgaria

Facility Name

Novartis Investigative Site

City

Victoria

State/Province

British Columbia

ZIP/Postal Code

V8R4R2

Country

Canada

Facility Name

Novartis Investigative Site

City

Halifax

State/Province

Nova Scotia

ZIP/Postal Code

B3H 2Y9

Country

Canada

Facility Name

Novartis Investigative Site

City

Kitchener

State/Province

Ontario

ZIP/Postal Code

N2M 5N4

Country

Canada

Facility Name

Novartis Investigative Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5B 1W8

Country

Canada

Facility Name

Novartis Investigative Site

City

Weston

State/Province

Ontario

ZIP/Postal Code

M9N 1W4

Country

Canada

Facility Name

Novartis Investigative Site

City

Levis

State/Province

Quebec

ZIP/Postal Code

G6V 4Z5

Country

Canada

Facility Name

Novartis Investigative Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3G 1A4

Country

Canada

Facility Name

Novartis Investigative Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H3T 1E2

Country

Canada

Facility Name

Novartis Investigative Site

City

St-Georges Beauce

State/Province

Quebec

ZIP/Postal Code

G5Y 4T8

Country

Canada

Facility Name

Novartis Investigative Site

City

Temuco

State/Province

Araucania

ZIP/Postal Code

4780000

Country

Chile

Facility Name

Novartis Investigative Site

City

Beroun

State/Province

Czech Republic

ZIP/Postal Code

266 01

Country

Czechia

Facility Name

Novartis Investigative Site

City

Brandys nad Labem

State/Province

Czech Republic

ZIP/Postal Code

250 01

Country

Czechia

Facility Name

Novartis Investigative Site

City

Liberec V Kristianova

State/Province

Czech Republic

ZIP/Postal Code

460 05

Country

Czechia

Facility Name

Novartis Investigative Site

City

Olomouc

State/Province

Czech Republic

ZIP/Postal Code

779 00

Country

Czechia

Facility Name

Novartis Investigative Site

City

Prague 10, Vrsovice

State/Province

Czech Republic

ZIP/Postal Code

10100

Country

Czechia

Facility Name

Novartis Investigative Site

City

Trebic

State/Province

Czech Republic

ZIP/Postal Code

674 01

Country

Czechia

Facility Name

Novartis Investigative Site

City

Bilovec

State/Province

CZE

ZIP/Postal Code

743 01

Country

Czechia

Facility Name

Novartis Investigative Site

City

Kolin

ZIP/Postal Code

280 20

Country

Czechia

Facility Name

Novartis Investigative Site

City

Prague 5

ZIP/Postal Code

150 30

Country

Czechia

Facility Name

Novartis Investigative Site

City

Praha

ZIP/Postal Code

12808

Country

Czechia

Facility Name

Novartis Investigative Site

City

Uherske Hradiste

ZIP/Postal Code

68601

Country

Czechia

Facility Name

Novartis Investigative Site

City

Copenhagen

ZIP/Postal Code

DK-2100

Country

Denmark

Facility Name

Novartis Investigative Site

City

Esbjerg

ZIP/Postal Code

DK-6700

Country

Denmark

Facility Name

Novartis Investigative Site

City

Hellerup

ZIP/Postal Code

DK-2900

Country

Denmark

Facility Name

Novartis Investigative Site

City

Randers

ZIP/Postal Code

8930

Country

Denmark

Facility Name

Novartis Investigative Site

City

Svendborg

ZIP/Postal Code

5700

Country

Denmark

Facility Name

Novartis Investigative Site

City

Vejle

ZIP/Postal Code

7100

Country

Denmark

Facility Name

Novartis Investigative Site

City

Viborg

ZIP/Postal Code

DK-8800

Country

Denmark

Facility Name

Novartis Investigative Site

City

Tallinn

ZIP/Postal Code

13419

Country

Estonia

Facility Name

Novartis Investigative Site

City

Tartu

ZIP/Postal Code

50410

Country

Estonia

Facility Name

Novartis Investigative Site

City

Tampere

ZIP/Postal Code

33520

Country

Finland

Facility Name

Novartis Investigative Site

City

Montpellier cedex 5

State/Province

Herault

ZIP/Postal Code

34059

Country

France

Facility Name

Novartis Investigative Site

City

Paris

ZIP/Postal Code

75015

Country

France

Facility Name

Novartis Investigative Site

City

Dresden

State/Province

Sachsen

ZIP/Postal Code

01099

Country

Germany

Facility Name

Novartis Investigative Site

City

Bad Homburg

ZIP/Postal Code

61348

Country

Germany

Facility Name

Novartis Investigative Site

City

Bad Krozingen

ZIP/Postal Code

79189

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin-Buch

ZIP/Postal Code

13125

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin

ZIP/Postal Code

10369

Country

Germany

Facility Name

Novartis Investigative Site

City

Berlin

ZIP/Postal Code

13405

Country

Germany

Facility Name

Novartis Investigative Site

City

Dessau-Roßlau

ZIP/Postal Code

06846

Country

Germany

Facility Name

Novartis Investigative Site

City

Dresden

ZIP/Postal Code

01307

Country

Germany

Facility Name

Novartis Investigative Site

City

Dresden

ZIP/Postal Code

01309

Country

Germany

Facility Name

Novartis Investigative Site

City

Elsterwerda

ZIP/Postal Code

04910

Country

Germany

Facility Name

Novartis Investigative Site

City

Frankfurt

ZIP/Postal Code

60488

Country

Germany

Facility Name

Novartis Investigative Site

City

Frankfurt

ZIP/Postal Code

65929

Country

Germany

Facility Name

Novartis Investigative Site

City

Hamburg

ZIP/Postal Code

22291

Country

Germany

Facility Name

Novartis Investigative Site

City

Hamburg

ZIP/Postal Code

22765

Country

Germany

Facility Name

Novartis Investigative Site

City

Huy / OT Anderbeck

ZIP/Postal Code

38836

Country

Germany

Facility Name

Novartis Investigative Site

City

Ingelheim

ZIP/Postal Code

55218

Country

Germany

Facility Name

Novartis Investigative Site

City

Kelkheim

ZIP/Postal Code

65779

Country

Germany

Facility Name

Novartis Investigative Site

City

Koethen

ZIP/Postal Code

06366

Country

Germany

Facility Name

Novartis Investigative Site

City

Künzelsau

ZIP/Postal Code

74653

Country

Germany

Facility Name

Novartis Investigative Site

City

Leipzig

ZIP/Postal Code

04109

Country

Germany

Facility Name

Novartis Investigative Site

City

Leipzig

ZIP/Postal Code

04129

Country

Germany

Facility Name

Novartis Investigative Site

City

Leipzig

ZIP/Postal Code

04315

Country

Germany

Facility Name

Novartis Investigative Site

City

Loehne

ZIP/Postal Code

32584

Country

Germany

Facility Name

Novartis Investigative Site

City

Muehldorf

ZIP/Postal Code

84453

Country

Germany

Facility Name

Novartis Investigative Site

City

Muehlheim An Der Ruhr

ZIP/Postal Code

45468

Country

Germany

Facility Name

Novartis Investigative Site

City

Offenbach

ZIP/Postal Code

63073

Country

Germany

Facility Name

Novartis Investigative Site

City

Wermsdorf

ZIP/Postal Code

04779

Country

Germany

Facility Name

Novartis Investigative Site

City

Wetzlar-Naunheim

ZIP/Postal Code

35584

Country

Germany

Facility Name

Novartis Investigative Site

City

Weyhe

ZIP/Postal Code

28844

Country

Germany

Facility Name

Novartis Investigative Site

City

Guatemala

State/Province

Ciudad

ZIP/Postal Code

01010

Country

Guatemala

Facility Name

Novartis Investigative Site

City

Guatemala City

ZIP/Postal Code

01010

Country

Guatemala

Facility Name

Novartis Investigative Site

City

Guatemala City

ZIP/Postal Code

01015

Country

Guatemala

Facility Name

Novartis Investigative Site

City

Hong Kong SAR

Country

Hong Kong

Facility Name

Novartis Investigative Site

City

Hong Kong

ZIP/Postal Code

HONG KONG

Country

Hong Kong

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

1096

Country

Hungary

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

1122

Country

Hungary

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

1125

Country

Hungary

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

1134

Country

Hungary

Facility Name

Novartis Investigative Site

City

Budapest

ZIP/Postal Code

1145

Country

Hungary

Facility Name

Novartis Investigative Site

City

Debrecen

ZIP/Postal Code

4032

Country

Hungary

Facility Name

Novartis Investigative Site

City

Nyiregyháza

ZIP/Postal Code

4400

Country

Hungary

Facility Name

Novartis Investigative Site

City

Szekesfehervar

ZIP/Postal Code

H-8000

Country

Hungary

Facility Name

Novartis Investigative Site

City

Szekszard

ZIP/Postal Code

7100

Country

Hungary

Facility Name

Novartis Investigative Site

City

Zalaegerszeg

ZIP/Postal Code

8900

Country

Hungary

Facility Name

Novartis Investigative Site

City

Guntur

State/Province

Andhra Pradesh

ZIP/Postal Code

522001

Country

India

Facility Name

Novartis Investigative Site

City

Dehli

State/Province

Delhi

ZIP/Postal Code

110080

Country

India

Facility Name

Novartis Investigative Site

City

Ahmedabad

State/Province

Gujarat

ZIP/Postal Code

380 051

Country

India

Facility Name

Novartis Investigative Site

City

Ahmedabad

State/Province

Gujarat

ZIP/Postal Code

380054

Country

India

Facility Name

Novartis Investigative Site

City

Anand

State/Province

Gujarat

ZIP/Postal Code

388325

Country

India

Facility Name

Novartis Investigative Site

City

Surat

State/Province

Gujarat

ZIP/Postal Code

395 002

Country

India

Facility Name

Novartis Investigative Site

City

Surat

State/Province

Gujrat

ZIP/Postal Code

395002

Country

India

Facility Name

Novartis Investigative Site

City

Vadodara

State/Province

Gujrat

ZIP/Postal Code

390015

Country

India

Facility Name

Novartis Investigative Site

City

Mumbai

State/Province

Maharashtra

ZIP/Postal Code

400012

Country

India

Facility Name

Novartis Investigative Site

City

Nagpur

State/Province

Maharashtra

ZIP/Postal Code

400012

Country

India

Facility Name

Novartis Investigative Site

City

Nagpur

State/Province

Maharashtra

ZIP/Postal Code

440010

Country

India

Facility Name

Novartis Investigative Site

City

Nashik

State/Province

Maharashtra

ZIP/Postal Code

422 005

Country

India

Facility Name

Novartis Investigative Site

City

Nashik

State/Province

Maharashtra

ZIP/Postal Code

422002

Country

India

Facility Name

Novartis Investigative Site

City

Nashik

State/Province

Maharashtra

ZIP/Postal Code

422005

Country

India

Facility Name

Novartis Investigative Site

City

Pune

State/Province

Maharashtra

ZIP/Postal Code

411 011

Country

India

Facility Name

Novartis Investigative Site

City

Pune

State/Province

Maharashtra

ZIP/Postal Code

411011

Country

India

Facility Name

Novartis Investigative Site

City

Ludhiana

State/Province

Punjab

ZIP/Postal Code

141002

Country

India

Facility Name

Novartis Investigative Site

City

Bikaner

State/Province

Rajasthan

ZIP/Postal Code

334003

Country

India

Facility Name

Novartis Investigative Site

City

Hyderabad

State/Province

Telangana

ZIP/Postal Code

500 063

Country

India

Facility Name

Novartis Investigative Site

City

Indore

ZIP/Postal Code

452014

Country

India

Facility Name

Novartis Investigative Site

City

Ashkelon

ZIP/Postal Code

78278

Country

Israel

Facility Name

Novartis Investigative Site

City

Hadera

ZIP/Postal Code

38100

Country

Israel

Facility Name

Novartis Investigative Site

City

Haifa

ZIP/Postal Code

3436212

Country

Israel

Facility Name

Novartis Investigative Site

City

Haifa

ZIP/Postal Code

3525408

Country

Israel

Facility Name

Novartis Investigative Site

City

Jerusalem

ZIP/Postal Code

91120

Country

Israel

Facility Name

Novartis Investigative Site

City

Petach Tikva

ZIP/Postal Code

49100

Country

Israel

Facility Name

Novartis Investigative Site

City

Rehovot

ZIP/Postal Code

76100

Country

Israel

Facility Name

Novartis Investigative Site

City

Safed

ZIP/Postal Code

13100

Country

Israel

Facility Name

Novartis Investigative Site

City

Aosta

State/Province

ZIP/Postal Code

11100

Country

Italy

Facility Name

Novartis Investigative Site

City

Cortona

State/Province

ZIP/Postal Code

52044

Country

Italy

Facility Name

Novartis Investigative Site

City

Bergamo

State/Province

ZIP/Postal Code

24127

Country

Italy

Facility Name

Novartis Investigative Site

City

Treviglio

State/Province

ZIP/Postal Code

24047

Country

Italy

Facility Name

Novartis Investigative Site

City

Cosenza

State/Province

ZIP/Postal Code

87100

Country

Italy

Facility Name

Novartis Investigative Site

City

Cona

State/Province

ZIP/Postal Code

44100

Country

Italy

Facility Name

Novartis Investigative Site

City

Genova

State/Province

ZIP/Postal Code

16132

Country

Italy

Facility Name

Novartis Investigative Site

City

Pozzilli

State/Province

ZIP/Postal Code

86077

Country

Italy

Facility Name

Novartis Investigative Site

City

Lido di Camaiore

State/Province

ZIP/Postal Code

55041

Country

Italy

Facility Name

Novartis Investigative Site

City

Milazzo

State/Province

ZIP/Postal Code

98057

Country

Italy

Facility Name

Novartis Investigative Site

City

Pisa

State/Province

ZIP/Postal Code

56126

Country

Italy

Facility Name

Novartis Investigative Site

City

Pescia

State/Province

Point

ZIP/Postal Code

51017

Country

Italy

Facility Name

Novartis Investigative Site

City

Pavia

State/Province

ZIP/Postal Code

27100

Country

Italy

Facility Name

Novartis Investigative Site

City

Ariccia

State/Province

ZIP/Postal Code

00041

Country

Italy

Facility Name

Novartis Investigative Site

City

Roma

State/Province

ZIP/Postal Code

00163

Country

Italy

Facility Name

Novartis Investigative Site

City

Salerno

State/Province

ZIP/Postal Code

84131

Country

Italy

Facility Name

Novartis Investigative Site

City

Sassari

State/Province

ZIP/Postal Code

07100

Country

Italy

Facility Name

Novartis Investigative Site

City

Wonju

State/Province

Gangwon-Do

ZIP/Postal Code

26426

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Suwon

State/Province

Gyeonggi-do

ZIP/Postal Code

16499

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Seoul

State/Province

Korea

ZIP/Postal Code

05505

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Seoul

State/Province

Seocho-gu

ZIP/Postal Code

06591

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Daegu

ZIP/Postal Code

705 718

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Daegu

ZIP/Postal Code

705703

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Seoul

ZIP/Postal Code

05355

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Seoul

ZIP/Postal Code

156-707

Country

Korea, Republic of

Facility Name

Novartis Investigative Site

City

Daugavpils

ZIP/Postal Code

LV-5417

Country

Latvia

Facility Name

Novartis Investigative Site

City

Ventspils

ZIP/Postal Code

LV-3601

Country

Latvia

Facility Name

Novartis Investigative Site

City

Kaunas

ZIP/Postal Code

LT-49387

Country

Lithuania

Facility Name

Novartis Investigative Site

City

Kedainiai

ZIP/Postal Code

LT-57164

Country

Lithuania

Facility Name

Novartis Investigative Site

City

Vilnius

ZIP/Postal Code

LT-08661

Country

Lithuania

Facility Name

Novartis Investigative Site

City

Kuala Lumpur

ZIP/Postal Code

50400

Country

Malaysia

Facility Name

Novartis Investigative Site

City

Kuala Lumpur

ZIP/Postal Code

59100

Country

Malaysia

Facility Name

Novartis Investigative Site

City

San Juan del Rio

State/Province

Queretaro

ZIP/Postal Code

76800

Country

Mexico

Facility Name

Novartis Investigative Site

City

Aguascalientes

ZIP/Postal Code

20230

Country

Mexico

Facility Name

Novartis Investigative Site

City

San Luis Potosi

ZIP/Postal Code

78200

Country

Mexico

Facility Name

Novartis Investigative Site

City

San Luis Potosí

ZIP/Postal Code

78200

Country

Mexico

Facility Name

Novartis Investigative Site

City

Breda

State/Province

ZIP/Postal Code

4818

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Amersfoort

ZIP/Postal Code

3813 TZ

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Arnhem

ZIP/Postal Code

6815 AD

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Blaricum

ZIP/Postal Code

1261 AN

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Delft

ZIP/Postal Code

2625 AD

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Den Bosch

ZIP/Postal Code

5223 GZ

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Ede

ZIP/Postal Code

6716 RP

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Gorinchem

ZIP/Postal Code

4204 AA

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Hardenberg

ZIP/Postal Code

7770 AA

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Harderwijk

ZIP/Postal Code

3840 AC

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Heerenveen

ZIP/Postal Code

8441 PW

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Hengelo

ZIP/Postal Code

7555 DL

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Sneek

ZIP/Postal Code

8601 ZK

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Tilburg

ZIP/Postal Code

5022 GC

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Veldhoven

ZIP/Postal Code

5504 DB

Country

Netherlands

Facility Name

Novartis Investigative Site

City

Panama City

ZIP/Postal Code

0816-02351

Country

Panama

Facility Name

Novartis Investigative Site

City

Panama City

Country

Panama

Facility Name

Novartis Investigative Site

City

Bellavista

State/Province

Lima

ZIP/Postal Code

CALLAO 02

Country

Peru

Facility Name

Novartis Investigative Site

City

Jesus Maria

State/Province

Lima

ZIP/Postal Code

Country

Peru

Facility Name

Novartis Investigative Site

City

La Molina

State/Province

Lima

ZIP/Postal Code

Country

Peru

Facility Name

Novartis Investigative Site

City

San Borja

State/Province

Lima

ZIP/Postal Code

Country

Peru

Facility Name

Novartis Investigative Site

City

San Isidro

State/Province

Lima

ZIP/Postal Code

Country

Peru

Facility Name

Novartis Investigative Site

City

San Miguel

State/Province

Lima

ZIP/Postal Code

Country

Peru

Facility Name

Novartis Investigative Site

City

Arequipa

ZIP/Postal Code

AREQ01

Country

Peru

Facility Name

Novartis Investigative Site

City

Lipa City

State/Province

Batangas

ZIP/Postal Code

4217

Country

Philippines

Facility Name

Novartis Investigative Site

City

Quezon City

State/Province

Manila

ZIP/Postal Code

1100

Country

Philippines

Facility Name

Novartis Investigative Site

City

Pasig City

ZIP/Postal Code

1605

Country

Philippines

Facility Name

Novartis Investigative Site

City

Quezon City

ZIP/Postal Code

1100

Country

Philippines

Facility Name

Novartis Investigative Site

City

Quezon City

ZIP/Postal Code

1102

Country

Philippines

Facility Name

Novartis Investigative Site

City

Gdynia

ZIP/Postal Code

81-472

Country

Poland

Facility Name

Novartis Investigative Site

City

Gdynia

ZIP/Postal Code

81-548

Country

Poland

Facility Name

Novartis Investigative Site

City

Lublin

ZIP/Postal Code

20-857

Country

Poland

Facility Name

Novartis Investigative Site

City

Vila Real

State/Province

Portuigal

ZIP/Postal Code

5000-508

Country

Portugal

Facility Name

Novartis Investigative Site

City

Covilha

ZIP/Postal Code

6200-251

Country

Portugal

Facility Name

Novartis Investigative Site

City

Guimaraes

ZIP/Postal Code

4835-044

Country

Portugal

Facility Name

Novartis Investigative Site

City

Lisboa

ZIP/Postal Code

1449-005

Country

Portugal

Facility Name

Novartis Investigative Site

City

Portalegre

ZIP/Postal Code

7300-853

Country

Portugal

Facility Name

Novartis Investigative Site

City

Porto

ZIP/Postal Code

4200-319

Country

Portugal

Facility Name

Novartis Investigative Site

City

Setubal

ZIP/Postal Code

2910-446

Country

Portugal

Facility Name

Novartis Investigative Site

City

Bucharest

State/Province

District 1

Country

Romania

Facility Name

Novartis Investigative Site

City

Bucuresti

State/Province

District 1

ZIP/Postal Code

014461

Country

Romania

Facility Name

Novartis Investigative Site

City

Craiova

State/Province

Jud. Dolj

ZIP/Postal Code

200497

Country

Romania

Facility Name

Novartis Investigative Site

City

Timisoara

State/Province

Timis

ZIP/Postal Code

300362

Country

Romania

Facility Name

Novartis Investigative Site

City

Bucharest

ZIP/Postal Code

050098

Country

Romania

Facility Name

Novartis Investigative Site

City

Bucuresti

ZIP/Postal Code

011728

Country

Romania

Facility Name

Novartis Investigative Site

City

Craiova

ZIP/Postal Code

200642

Country

Romania

Facility Name

Novartis Investigative Site

City

Deva

ZIP/Postal Code

330084

Country

Romania

Facility Name

Novartis Investigative Site

City

Timisoara

ZIP/Postal Code

300041

Country

Romania

Facility Name

Novartis Investigative Site

City

Timisoara

ZIP/Postal Code

300736

Country

Romania

Facility Name

Novartis Investigative Site

City

Ekaterinburg

ZIP/Postal Code

620137

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Ivanovo

ZIP/Postal Code

153012

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Kazan

ZIP/Postal Code

420012

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Kemerovo

ZIP/Postal Code

650002

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Kirov

ZIP/Postal Code

610027

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Krasnodar

ZIP/Postal Code

350012

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

101990

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

115280

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

115516

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

117198

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

119881

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

121309

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

121552

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Moscow

ZIP/Postal Code

127473

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

N. Novgorod

ZIP/Postal Code

603003

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

N.Novgorod

ZIP/Postal Code

603005

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Nizhnii Novgorod

ZIP/Postal Code

603126

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Novosibirsk-117

ZIP/Postal Code

630117

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Orenburg

ZIP/Postal Code

460000

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Orenburg

ZIP/Postal Code

460040

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Perm

ZIP/Postal Code

614097

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Rostov-on-Don

ZIP/Postal Code

344022

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

S-Petersburg

ZIP/Postal Code

194354

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saint Petersburg

ZIP/Postal Code

197022

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saint Petersburg

ZIP/Postal Code

197341

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saint Petersburg

ZIP/Postal Code

199106

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saint-Petersburg

ZIP/Postal Code

191144

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saint-Petersburg

ZIP/Postal Code

194044

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Saratov

ZIP/Postal Code

410012

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Smolensk

ZIP/Postal Code

214018

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

St-Petersburg

ZIP/Postal Code

194017

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

St-Petersburg

ZIP/Postal Code

194295

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

St-Petersburg

ZIP/Postal Code

196084

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Tula

ZIP/Postal Code

300053

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Vladimir

ZIP/Postal Code

600020

Country

Russian Federation

Facility Name

Novartis Investigative Site

City

Singapore

ZIP/Postal Code

169609

Country

Singapore

Facility Name

Novartis Investigative Site

City

Singapore

ZIP/Postal Code

308433

Country

Singapore

Facility Name

Novartis Investigative Site

City

Brezno

State/Province

Slovak Republic

ZIP/Postal Code

977 42

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Kosice

State/Province

Slovak Republic

ZIP/Postal Code

040 22

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Levice

State/Province

Slovak Republic

ZIP/Postal Code

93401

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Presov

State/Province

Slovak Republic

ZIP/Postal Code

08001

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Svidnik

State/Province

Slovak Republic

ZIP/Postal Code

08901

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Bratislava

ZIP/Postal Code

821 07

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Bratislava

ZIP/Postal Code

842 31

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Bratislava

ZIP/Postal Code

851 07

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Kosice

ZIP/Postal Code

040 01

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Lucenec

ZIP/Postal Code

984 01

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Martin

ZIP/Postal Code

036 01

Country

Slovakia

Facility Name

Novartis Investigative Site

City

Bloemfontein

State/Province

Free State

ZIP/Postal Code

9301

Country

South Africa

Facility Name

Novartis Investigative Site

City

Soweto

State/Province

Gauteng

ZIP/Postal Code

2013

Country

South Africa

Facility Name

Novartis Investigative Site

City

Durban

State/Province

Kwa-Zulu Natal

ZIP/Postal Code

4052

Country

South Africa

Facility Name

Novartis Investigative Site

City

Cape Town

State/Province

Western Cape

ZIP/Postal Code

7405

Country

South Africa

Facility Name

Novartis Investigative Site

City

Alberton

ZIP/Postal Code

1449

Country

South Africa

Facility Name

Novartis Investigative Site

City

Bloemfontein

ZIP/Postal Code

9301

Country

South Africa

Facility Name

Novartis Investigative Site

City

Cape Town

ZIP/Postal Code

7405

Country

South Africa

Facility Name

Novartis Investigative Site

City

Cape Town

ZIP/Postal Code

7505

Country

South Africa

Facility Name

Novartis Investigative Site

City

Durban

ZIP/Postal Code

4110

Country

South Africa

Facility Name

Novartis Investigative Site

City

Johannesburg

ZIP/Postal Code

2193

Country

South Africa

Facility Name

Novartis Investigative Site

City

Kempton Park

ZIP/Postal Code

1620

Country

South Africa

Facility Name

Novartis Investigative Site

City

Pretoria

ZIP/Postal Code

0121

Country

South Africa

Facility Name

Novartis Investigative Site

City

Pretoria

ZIP/Postal Code

0184

Country

South Africa

Facility Name

Novartis Investigative Site

City

Worcester

ZIP/Postal Code

6850

Country

South Africa

Facility Name

Novartis Investigative Site

City

Malaga

State/Province

Andalucia

ZIP/Postal Code

29010

Country

Spain

Facility Name

Novartis Investigative Site

City

Marbella

State/Province

Andalucia

ZIP/Postal Code

29600

Country

Spain

Facility Name

Novartis Investigative Site

City

Sevilla

State/Province

Andalucia

ZIP/Postal Code

41014

Country

Spain

Facility Name

Novartis Investigative Site

City

Sant Joan Despi

State/Province

Cataluna

ZIP/Postal Code

08970

Country

Spain

Facility Name

Novartis Investigative Site

City

Barcelona

State/Province

Catalunya

ZIP/Postal Code

08003

Country

Spain

Facility Name

Novartis Investigative Site

City

Barcelona

State/Province

Catalunya

ZIP/Postal Code

08035

Country

Spain

Facility Name

Novartis Investigative Site

City

Valencia

State/Province

Comunidad Valenciana

ZIP/Postal Code

46010

Country

Spain

Facility Name

Novartis Investigative Site

City

Valencia

State/Province

Comunidad Valenciana

ZIP/Postal Code

46015

Country

Spain

Facility Name

Novartis Investigative Site

City

A Coruna

State/Province

Galicia

ZIP/Postal Code

15006

Country

Spain

Facility Name

Novartis Investigative Site

City

La Coruna

State/Province

Galicia

ZIP/Postal Code

15006

Country

Spain

Facility Name

Novartis Investigative Site

City

Santiago de Compostela

State/Province

Galicia

ZIP/Postal Code

15706

Country

Spain

Facility Name

Novartis Investigative Site

City

Vigo

State/Province

Galicia

ZIP/Postal Code

36211

Country

Spain

Facility Name

Novartis Investigative Site

City

Alcala de Henares

State/Province

Madrid

ZIP/Postal Code

28805

Country

Spain

Facility Name

Novartis Investigative Site

City

Mostoles

State/Province

Madrid

ZIP/Postal Code

28935

Country

Spain

Facility Name

Novartis Investigative Site

City

Madrid

ZIP/Postal Code

28007

Country

Spain

Facility Name

Novartis Investigative Site

City

Madrid

ZIP/Postal Code

28222

Country

Spain

Facility Name

Novartis Investigative Site

City

Stockholm

State/Province

ZIP/Postal Code

141 86

Country

Sweden

Facility Name

Novartis Investigative Site

City

Goteborg

ZIP/Postal Code

416 85

Country

Sweden

Facility Name

Novartis Investigative Site

City

Göteborg

ZIP/Postal Code

416 85

Country

Sweden

Facility Name

Novartis Investigative Site

City

Karlshamn

ZIP/Postal Code

37480

Country

Sweden

Facility Name

Novartis Investigative Site

City

Motala

ZIP/Postal Code

59185

Country

Sweden

Facility Name

Novartis Investigative Site

City

Changhua

ZIP/Postal Code

50006

Country

Taiwan

Facility Name

Novartis Investigative Site

City

Kaohsiung

ZIP/Postal Code

82445

Country

Taiwan

Facility Name

Novartis Investigative Site

City

Taichung

ZIP/Postal Code

40447

Country

Taiwan

Facility Name

Novartis Investigative Site

City

Taipei

ZIP/Postal Code

10002

Country

Taiwan

Facility Name

Novartis Investigative Site

City

Taipei

ZIP/Postal Code

11217

Country

Taiwan

Facility Name

Novartis Investigative Site

City

Taipei

ZIP/Postal Code

114

Country

Taiwan

Facility Name

Novartis Investigative Site

City

Yilan

ZIP/Postal Code

26058

Country

Taiwan

Facility Name

Novartis Investigative Site

City

Taladkwan

State/Province

Nonthaburi

ZIP/Postal Code

11000

Country

Thailand

Facility Name

Novartis Investigative Site

City

Khon Kaen

State/Province

THA

ZIP/Postal Code

40002

Country

Thailand

Facility Name

Novartis Investigative Site

City

Muang

ZIP/Postal Code

12120

Country

Thailand

Facility Name

Novartis Investigative Site

City

Istanbul

ZIP/Postal Code

34093

Country

Turkey

Facility Name

Novartis Investigative Site

City

Istanbul

ZIP/Postal Code

34304

Country

Turkey

Facility Name

Novartis Investigative Site

City

Izmir

ZIP/Postal Code

35040

Country

Turkey

Facility Name

Novartis Investigative Site

City

Izmir

ZIP/Postal Code

35340

Country

Turkey

Facility Name

Novartis Investigative Site

City

Kocaeli

ZIP/Postal Code

41380

Country

Turkey

Facility Name

Novartis Investigative Site

City

Sivas

ZIP/Postal Code

58140

Country

Turkey

Facility Name

Novartis Investigative Site

City

Durham

State/Province

County Durham

ZIP/Postal Code

DH1 5TW

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Dorchester

State/Province

Dorset

ZIP/Postal Code

DT1 2JY

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Basingstoke

State/Province

Hampshire

ZIP/Postal Code

RG24 9NA

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Portsmouth

State/Province

Hampshire

ZIP/Postal Code

PO6 3LY

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Inverness

State/Province

Invernesshire

ZIP/Postal Code

IV2 3RE

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Oldham

State/Province

Lancashire

ZIP/Postal Code

OL1 2JH

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Leicester

State/Province

Leicestershire

ZIP/Postal Code

LE2 7LX

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Craigavon

State/Province

Northern Ireland

ZIP/Postal Code

BT63 5QQ

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Dundee

State/Province

Perthshire

ZIP/Postal Code

DD1 9SY

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Taunton

State/Province

Somerset

ZIP/Postal Code

TA1 5DA

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Yeovil

State/Province

Somerset

ZIP/Postal Code

BA21 4AT

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Sheffield

State/Province

South Yorkshire

ZIP/Postal Code

S10 2JF

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Redhill

State/Province

Surrey

ZIP/Postal Code

RH1 5RH

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

South Shields

State/Province

Tyne And Wear

ZIP/Postal Code

NE34 0PL

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Sunderland

State/Province

Tyne And Wear

ZIP/Postal Code

SR4 7TP

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Dudley

State/Province

West Midlands

ZIP/Postal Code

DY1 2HQ

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Cheshire

ZIP/Postal Code

CW1 4QJ

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Coventry

ZIP/Postal Code

CV2 2DX

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Exeter

ZIP/Postal Code

EX2 5AX

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Kent

ZIP/Postal Code

DA2 8DA

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Manchester

ZIP/Postal Code

M13 9WL

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Milton Keynes

ZIP/Postal Code

MK6 5LD

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Newport

ZIP/Postal Code

NP20 2UB

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Newport

ZIP/Postal Code

P030 5TG

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Norwich

ZIP/Postal Code

NR4 7UY

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Poole

ZIP/Postal Code

BH15 2JB

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Rotherham

ZIP/Postal Code

S60 2OD

Country

United Kingdom

Facility Name

Novartis Investigative Site

City

Worcester

ZIP/Postal Code

WR5 1DD

Country

United Kingdom

12. IPD Sharing Statement

Plan to Share IPD

Undecided

IPD Sharing Plan Description

Novartis is committed to sharing with qualified external researchers, access to patient-level data and supporting clinical documents from eligible studies. These requests are reviewed and approved by an independent review panel on the basis of scientific merit. All data provided is anonymized to respect the privacy of patients who have participated in the trial in line with applicable laws and regulations. This trial data availability is according to the criteria and process described on www.clinicalstudydatarequest.com

Learn more about this trial

Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction

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Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection Fraction

Chronic Heart Failure With Reduced Ejection Fraction

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial